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1. Full Text CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
by Renaud Le Floch and Johanna Chiche and Ibtissam Marchiq and Tanesha Naiken and Karine Ilc and Clare M. Murray and Susan E. Critchlow and Danièle Roux and Marie-Pierre Simon and Jacques Pouysségur
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2011, Volume 108, Issue 40, pp. 16663 - 16668
Malignant tumors exhibit increased dependence on glycolysis, resulting in abundant export of lactic acid, a hypothesized key step in tumorigenesis. Lactic acid... 
Embigin | EMMPRIN | Lactate transport | Cancer metabolism | Warburg effect | IMMUNOGLOBULIN SUPERFAMILY | MONOCARBOXYLATE TRANSPORTER 4 | MULTIDISCIPLINARY SCIENCES | INTRACELLULAR PH | lactate transport | PLASMA-MEMBRANE | CANCER | cancer metabolism | PYRUVATE-KINASE | CARBONIC-ANHYDRASE IX | NA+/H+ ANTIPORT | INHIBITORS | CELL-METABOLISM | Immunohistochemistry | Humans | DNA Primers - genetics | Glycolysis - drug effects | Oxygen Consumption - physiology | Protein Subunits - metabolism | Uracil - pharmacology | Monocarboxylic Acid Transporters - antagonists & inhibitors | Monocarboxylic Acid Transporters - metabolism | Flow Cytometry | Basigin - genetics | Cell Transformation, Neoplastic - genetics | Symporters - antagonists & inhibitors | Muscle Proteins - metabolism | Protein Subunits - genetics | Lactic Acid - metabolism | Gene Silencing | Thiophenes - pharmacology | Gene Knockout Techniques | Symporters - metabolism | Muscle Proteins - genetics | Symporters - genetics | Fluorescent Antibody Technique | Basigin - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Transformation, Neoplastic - drug effects | Monocarboxylic Acid Transporters - genetics | Uracil - analogs & derivatives | Protein Subunits | Cell Proliferation | Lactic Acid | Oxygen Consumption | DNA Primers | Life Sciences | Muscle Proteins | Monocarboxylic Acid Transporters | Thiophenes | Cell Transformation, Neoplastic | Symporters | Glycolysis | Development Biology | Antigens, CD147 | Uracil | Biological Sciences
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2. Full Text Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands
by Bernèche, Simon and Roux, Benoît and Noskov, Sergei Yu
Nature, ISSN 0028-0836, 10/2004, Volume 431, Issue 7010, pp. 830 - 834
Potassium channels are essential for maintaining a normal ionic balance across cell membranes. Central to this function is the ability of such channels to... 
ENERGY | FILTER | MULTIDISCIPLINARY SCIENCES | CONDUCTION | NA+ | SIMULATIONS | MUTATIONS | K+ CHANNEL | PROTEINS | OCCUPANCY | PERMEATION | Potassium - metabolism | Cations - metabolism | Bacterial Proteins - chemistry | Models, Molecular | Substrate Specificity | Sodium - metabolism | Static Electricity | Oxygen - metabolism | Potassium Channels - metabolism | Thermodynamics | Bacterial Proteins - metabolism | Ligands | Potassium Channels - chemistry | Binding Sites | Ion Channel Gating | Proteins | Ions | Membranes | Biochemistry | Potassium
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3. Full Text Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin
by Marchiq, Ibtissam and Le Floch, Renaud and Roux, Danièle and Simon, Marie-Pierre and Pouyssegur, Jacques
Cancer Research, ISSN 0008-5472, 01/2015, Volume 75, Issue 1, pp. 171 - 180
Rapidly growing glycolytic tumors require energy and intracellular pH (pHi) homeostasis through the activity of two major monocarboxylate transporters, MCT1... 
LACTIC-ACID | SURVIVAL | ONCOLOGY | CARBONIC-ANHYDRASE IX | AEROBIC GLYCOLYSIS | GROWTH | TRANSPORTER MCT4 | ENERGY-METABOLISM | HYPOXIA | CANCER | EXPRESSION | Colonic Neoplasms - therapy | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Male | Colonic Neoplasms - metabolism | Phenformin - pharmacology | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Monocarboxylic Acid Transporters - metabolism | Animals | Basigin - genetics | Mice, Nude | Basigin - metabolism | Glycolysis | Cell Proliferation - drug effects | Mice | Monocarboxylic Acid Transporters - genetics
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4. Full Text The architectural design of trees protects them against large herbivores
by Charles‐Dominique, Tristan and Barczi, Jean‐Francois and Le Roux, Elizabeth and Chamaillé‐Jammes, Simon and McArthur, Clare
Functional Ecology, ISSN 0269-8463, 09/2017, Volume 31, Issue 9, pp. 1710 - 1717
Summary Where large browsers are abundant, the survival of trees depends on their ability to deploy defences, either chemical or structural. Structural... 
herbivory | bite rate | spinescence | cage architecture | plant architecture | structural defences | SAVANNA | SEEDLINGS | SIZE | BROWSERS | MAMMALIAN HERBIVORES | THORNS | PLANT STRUCTURAL DEFENSES | STRATEGIES | CHEMISTRY | ECOLOGY | SPINES | Protection and preservation | Evaluation | Goats | Nutrition | Requirements | Architectural design | Trees | Architecture | Cages | Mammals | Nutritional requirements | Stems | Feeding | Leaves | Dry season | Herbivores | Computer security | Life Sciences | Ecosystems | Botanics | Ecology, environment | Vegetal Biology | Biodiversity and Ecology | Biodiversity | Systematics, Phylogenetics and taxonomy | Environmental Sciences
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5. Full Text Simon Heijdens at Design Miami
by Caroline Roux
FT.com, 11/2013
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6. Full Text Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics
by De Angelis, Martin Hrabě and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and Adams, David J and Adams, Niels C and Adler, Thure and Aguilar-Pimentel, Antonio and Ali-Hadji, Dalila and Amann, Gregory and André, Philippe and Atkins, Sarah and Auburtin, Aurelie and Ayadi, Abdel and Becker, Julien and Becker, Lore and Bedu, Elodie and Bekeredjian, Raffi and Birling, Marie-Christine and Blake, Andrew and Bottomley, Joanna and Bowl, Michael R and Brault, Véronique and Busch, Dirk H and Bussell, James N and Calzada-Wack, Julia and Cater, Heather and Champy, Marie-France and Charles, Philippe and Chevalier, Claire and Chiani, Francesco and Codner, Gemma F and Combe, Roy and Cox, Roger and Dalloneau, Emilie and Dierich, André and Di Fenza, Armida and Doe, Brendan and Duchon, Arnaud and Eickelberg, Oliver and Esapa, Chris T and Fertak, Lahcen El and Feigel, Tanja and Emelyanova, Irina and Estabel, Jeanne and Favor, Jack and Flenniken, Ann and Gambadoro, Alessia and Garrett, Lilian and Gates, Hilary and Gerdin, Anna-Karin and Gkoutos, George and Greenaway, Simon and Glasl, Lisa and Goetz, Patrice and Da Cruz, Isabelle Goncalves and Götz, Alexander and Graw, Jochen and Guimond, Alain and Hans, Wolfgang and Hicks, Geoff and Hölter, Sabine M and Höfler, Heinz and Hancock, John M and Hoehndorf, Robert and Hough, Tertius and Houghton, Richard and Hurt, Anja and Ivandic, Boris and Jacobs, Hughes and Jacquot, Sylvie and Jones, Nora and Karp, Natasha A and Katus, Hugo A and Kitchen, Sharon and Klein-Rodewald, Tanja and Klingenspor, Martin and Klopstock, Thomas and Lalanne, Valerie and Leblanc, Sophie and Lengger, Christoph and Le Marchand, Elise and Ludwig, Tonia and Lux, Aline and McKerlie, Colin and Maier, Holger and Mandel, Jean-Louis and Marschall, Susan and Mark, Manuel and Melvin, David G and Meziane, Hamid and Micklich, Kateryna and Mittelhauser, Christophe and Monassier, Laurent and ... and EUMODIC Consortium
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 969 - 978
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the... 
EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | GENOME-WIDE | EMPRESS | KNOCKOUT MICE | ACCESS | RESOURCE | Homozygote | Phenotype | Animals | Genetic Association Studies | Humans | Mice, Inbred C57BL | Molecular Sequence Annotation | Female | Heterozygote | Male | Mutation | Mice, Knockout | Research | Gene mutations | Human genome | Identification and classification | Health aspects | Consortia | Genotype & phenotype | Physiology | Genomes | Metabolism | Power
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7. Full Text Energetics of ion conduction through the K + channel
by Bernèche, Simon and Roux, Benoît
Nature, ISSN 0028-0836, 11/2001, Volume 414, Issue 6859, pp. 73 - 77
K+ channels are transmembrane proteins that are essential for the transmission of nerve impulses. The ability of these proteins to conduct K+ ions at levels... 
BILAYER | FREE-ENERGY CALCULATIONS | MOLECULAR-DYNAMICS | MECHANISM | KCSA | MULTIDISCIPLINARY SCIENCES | SIMULATIONS | SELECTIVITY | POTASSIUM CHANNEL | PERMEATION | WATER | Potassium - metabolism | Potassium Channels - metabolism | Thermodynamics | Energy Metabolism | Models, Molecular | Crystallography, X-Ray | Potassium Channels - chemistry | Protein Conformation | Ion Transport | Diffusion | Bacterial Proteins | Potassium - chemistry | Proteins | Ions | Membranes | Potassium
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8. Full Text Human Memory: Brain-State-Dependent Effects of Stimulation
by Hanslmayr, Simon and Roux, Frederic
Current Biology, ISSN 0960-9822, 05/2017, Volume 27, Issue 10, pp. R385 - R387
A new study shows that direct stimulation of memory-relevant brain areas can enhance memory performance, but only when stimulation is applied during brain... 
Brain | Memory Disorders | Humans | Memory | Analysis
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9. Full Text A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
by Simon, Michelle M and Greenaway, Simon and White, Jacqueline K and Fuchs, Helmut and Gailus-Durner, Valérie and Wells, Sara and Sorg, Tania and Wong, Kim and Bedu, Elodie and Cartwright, Elizabeth J and Dacquin, Romain and Djebali, Sophia and Estabel, Jeanne and Graw, Jochen and Ingham, Neil J and Jackson, Ian J and Lengeling, Andreas and Mandillo, Silvia and Marve, Jacqueline and Meziane, Hamid and Preitner, Frédéric and Puk, Oliver and Roux, Michel and Adams, David J and Atkins, Sarah and Ayadi, Abdel and Becker, Lore and Blake, Andrew and Brooker, Debra and Cater, Heather and Champy, Marie-France and Combe, Roy and Danecek, Petr and Di Fenza, Armida and Gates, Hilary and Gerdin, Anna-Karin and Golini, Elisabetta and Hancock, John M and Hans, Wolfgang and Hölter, Sabine M and Hough, Tertius and Jurdic, Pierre and Keane, Thomas M and Morgan, Hugh and Müller, Werner and Neff, Frauke and Nicholson, George and Pasche, Bastian and Roberson, Laura-Anne and Rozman, Jan and Sanderson, Mark and Santos, Luis and Selloum, Mohammed and Shannon, Carl and Southwel, Anne and Tocchini-Valentini, Glauco P and Vancollie, Valerie E and Westerberg, Henrik and Wurst, Wolfgang and Zi, Min and Yalcin, Binnaz and Ramirez-Solis, Ramiro and Steel, Karen P and Mallon, Ann-Marie and De Angelis, Martin Hrabe and Herault, Yann and Brown, Steve D.M
Genome Biology, ISSN 1474-7596, 2013, Volume 14, Issue 7, pp. R82 - R82
Background: The mouse inbred line C57BL/6J is widely used in mouse genetics and its genome has been incorporated into many genetic reference populations. More... 
Mouse phenotyping | Sequence variation | Gene knockout | C57BL/6 | Mouse inbred lines | mouse phenotyping | VARIANTS | sequence variation | SUBSTRAINS | gene knockout | DATABASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | MICE | SEQUENCING DATA | COMPLEX TRAITS | GENE-FUNCTION | RESOURCE | Eye - pathology | Spleen - immunology | Mice, Inbred C57BL | Genome - genetics | Hypersensitivity - immunology | INDEL Mutation - genetics | Male | Disease Resistance - immunology | Femur - diagnostic imaging | X-Ray Microtomography | Behavior, Animal | Phenotype | Animals | Maze Learning | Listeriosis - immunology | Killer Cells, Natural - immunology | Polymorphism, Single Nucleotide - genetics | Female | Listeriosis - microbiology | Life Sciences | Genetics | Biochemistry, Molecular Biology | Genomics | Research | C57BL
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10. Full Text Theoretical and computational models of biological ion channels
by Roux, Benoît and Allen, Toby and Bernèche, Simon and Im, Wonpil
Quarterly Reviews of Biophysics, ISSN 0033-5835, 2/2004, Volume 37, Issue 1, pp. 15 - 103
The goal of this review is to establish a broad and rigorous theoretical framework to describe ion permeation through biological channels. This framework is... 
Ions - chemistry | Gramicidin - chemistry | Protein Structure, Secondary | Molecular Conformation | Bacterial Proteins - chemistry | Porins - metabolism | Models, Molecular | Models, Statistical | Static Electricity | Thermodynamics | Computer Simulation | Potassium Channels - chemistry | Protein Conformation | Software | Biophysics - methods | Ion Channels - chemistry | CONTINUUM ELECTROSTATICS CALCULATIONS | FREE-ENERGY CALCULATIONS | CATION-PEPTIDE INTERACTIONS | BIOPHYSICS | SOLID-STATE NMR | SINGLE PROTON CONDUCTION | GRAMICIDIN-A CHANNELS | KCSA POTASSIUM CHANNEL | MOLECULAR-DYNAMICS SIMULATIONS | GRADIENT-DRIVEN DIFFUSION | POISSON-NERNST-PLANCK | Ions | Membranes | Models | Permeability
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11. Full Text A Microscopic View of Ion Conduction through the K+Channel
by Simon Bernèche and Benoît Roux
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2003, Volume 100, Issue 15, pp. 8644 - 8648
Recent results from x-ray crystallography and molecular dynamics free-energy simulations have revealed the existence of a number of specific cation-binding... 
Electric potential | Conduction | Ion concentration | Physical Sciences | Roux | Ions | Trajectories | Ion channels | Membrane potential | Modeling | Binding sites | Molecular dynamics | Potential of mean force | Brownian dynamics | Poisson-Boltzmann equation | MOLECULAR-DYNAMICS | KCSA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GRAMICIDIN | MODEL | molecular dynamics | SINGLE PROTON CONDUCTION | potential of mean force | membrane potential | DIFFUSION | POTASSIUM CHANNEL | PERMEATION | Potassium Channels - metabolism | Streptomyces - metabolism | Thermodynamics | Algorithms | Membrane Potentials | Models, Biological | Bacterial Proteins - chemistry | Bacterial Proteins - metabolism | Potassium Channels - chemistry | Ion Transport | Binding Sites | Methanobacterium - metabolism | Poisson–Boltzmann equation
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12. Full Text Latitudinal limits to the predicted increase of the peatland carbon sink with warming
by Gallego-Sala, Angela V and Charman, Dan J and Brewer, Simon and Page, Susan E and Prentice, I. Colin and Friedlingstein, Pierre and Moreton, Steve and Amesbury, Matthew J and Beilman, David W and Björck, Svante and Blyakharchuk, Tatiana and Bochicchio, Christopher and Booth, Robert K and Bunbury, Joan and Camill, Philip and Carless, Donna and Chimner, Rodney A and Clifford, Michael and Cressey, Elizabeth and Courtney-Mustaphi, Colin and De Vleeschouwer, François and de Jong, Rixt and Fialkiewicz-Koziel, Barbara and Finkelstein, Sarah A and Garneau, Michelle and Githumbi, Esther and Hribjlan, John and Holmquist, James and Hughes, Paul D. M and Jones, Chris and Jones, Miriam C and Karofeld, Edgar and Klein, Eric S and Kokfelt, Ulla and Korhola, Atte and Lacourse, Terri and Le Roux, Gael and Lamentowicz, Mariusz and Large, David and Lavoie, Martin and Loisel, Julie and Mackay, Helen and MacDonald, Glen M and Makila, Markku and Magnan, Gabriel and Marchant, Robert and Marcisz, Katarzyna and Martínez Cortizas, Antonio and Massa, Charly and Mathijssen, Paul and Mauquoy, Dmitri and Mighall, Timothy and Mitchell, Fraser J. G and Moss, Patrick and Nichols, Jonathan and Oksanen, Pirita O and Orme, Lisa and Packalen, Maara S and Robinson, Stephen and Roland, Thomas P and Sanderson, Nicole K and Sannel, A. Britta K and Silva-Sánchez, Noemí and Steinberg, Natascha and Swindles, Graeme T and Turner, T. Edward and Uglow, Joanna and Väliranta, Minna and van Bellen, Simon and van der Linden, Marjolein and van Geel, Bas and Wang, Guoping and Yu, Zicheng and Zaragoza-Castells, Joana and Zhao, Yan and Stockholms universitet and Institutionen för naturgeografi and Naturvetenskapliga fakulteten
Nature Climate Change, ISSN 1758-678X, 10/2018, Volume 8, Issue 10, pp. 907 - 913
The carbon sink potential of peatlands depends on the balance of carbon uptake by plants and microbial decomposition. The rates of both these processes will... 
ENVIRONMENTAL SCIENCES | NORTHERN PEATLANDS | DECOMPOSITION | DYNAMICS | ACCUMULATION | ENVIRONMENTAL STUDIES | HOLOCENE CARBON | METEOROLOGY & ATMOSPHERIC SCIENCES | CLIMATE | CYCLE | Carbon sinks | Microorganisms | Climate | Hemispheres | Photosynthetically active radiation | Peatlands | Switches | Radiation | Growing season | Carbon | Accumulation | Uptake | Environmental Sciences | Global Changes | Samhällsvetenskap | Social och ekonomisk geografi | Naturvetenskap | Social Sciences | Social and Economic Geography | Natural Sciences | Earth and Related Environmental Sciences | Geovetenskap och miljövetenskap
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