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NATURE, ISSN 0028-0836, 07/2016, Volume 535, Issue 7611, pp. 252 - 252
Journal Article
Tetrahedron: Asymmetry, ISSN 0957-4166, 05/2015, Volume 26, Issue 10-11, pp. 553 - 559
Celgene’s Otezla® (apremilast) is the first and only PDE4 inhibitor approved by the US FDA for the treatment of plaque psoriasis and psoriatic arthritis. The... 
CHEMISTRY, ORGANIC | CHEMISTRY, PHYSICAL | KETONES | STEREOSELECTIVE HYDROGENATION | CHEMISTRY, INORGANIC & NUCLEAR | Enantiomers | Hydrogenation
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Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7611, p. 252
Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the... 
Drugs | Proteins | Enzymes | Ligands | Mutation | Cancer therapies | Cancer
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2011, Volume 19, Issue 21, pp. 6356 - 6374
A series of 1,1-diarylalkene derivatives were prepared to optimize the properties of CC-5079 ( ), a dual inhibitor of tubulin polymerization and... 
Antitubulin | HCT-116 | Anticancer | Combretastatin A-4 (CA-4) | Tumor necrosis factor-α (TNF-α) | Phosphodiesterase 4 (PDE4) | CHEMISTRY, MEDICINAL | VASCULAR DISRUPTING AGENTS | Tumor necrosis factor-alpha (TNF-alpha) | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | COMBRETUM-CAFFRUM | ANTITUMOR-ACTIVITY | ALDOL CONDENSATION | POTENT INHIBITOR | CYCLIC-AMP | BIOLOGICAL EVALUATION | COMBRETASTATIN ANALOGS | STRUCTURAL MODIFICATIONS | Benzene Derivatives - chemical synthesis | Tubulin Modulators - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Alkenes - chemical synthesis | Tubulin Modulators - chemical synthesis | Tubulin - metabolism | Colorectal Neoplasms - drug therapy | Inhibitory Concentration 50 | Phosphodiesterase Inhibitors - chemical synthesis | Antineoplastic Agents - pharmacology | Phosphodiesterase Inhibitors - chemistry | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Benzene Derivatives - pharmacology | Colorectal Neoplasms - metabolism | Tubulin Modulators - chemistry | Magnetic Resonance Spectroscopy | HCT116 Cells | Models, Molecular | Phosphodiesterase Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Molecular Dynamics Simulation | Alkenes - chemistry | Animals | Cell Proliferation - drug effects | Mice | Benzene Derivatives - chemistry | Alkenes - pharmacology | Antimitotic agents | Polymerization | Care and treatment | Tubulins | Antineoplastic agents | Cancer
Journal Article
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Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2006, Volume 14, Issue 9, pp. 3131 - 3143
where R is CH CH N(CH ) ; CH CH(CH )N(CH ) ; CH CH N(CH CH ) ; CH CH N(–CH CH CH CH –); CH CH N(–CH (CH ) CH –); CH CH N(–CH CH OCH CH –); CH CH CH N(CH ) ; CH... 
Dibenzo[ c, h][2,6]naphthyridin-5-ones | Antitumor | Topoisomerase I | Cytotoxic
Journal Article
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