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PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, pp. e0201103 - e0201103
Activation of the beta(2) integrin lymphocyte function-associated antigen-1 (LFA-1) in T cells induces stabilization of proinflammatory AU-rich element... 
TARGET | POSTTRANSCRIPTIONAL REGULATION | ACTIVATED PROTEIN-KINASE-2 | HUR | PROTEIN-KINASE | STABILITY | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | NUCLEAR EXPORT | BINDING PROTEIN | Signal Transduction | Jurkat Cells | Humans | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Cytoplasm - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Proteome | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Mice, Knockout | Animals | ELAV-Like Protein 1 - metabolism | T-Lymphocytes - cytology | T-Lymphocytes - metabolism | Cell Culture Techniques | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | RNA Stability - physiology | Messenger RNA | Research | Genetic regulation | T cells | Protein binding | Regulators | Laboratories | Stabilization | Activation | Biochemistry | Lymphocytes T | Kinases | LFA-1 antigen | Cell adhesion & migration | Proteins | Cell activation | Immunology | Granulocytes | Lymphocytes | Tumor necrosis factor-TNF | Localization | HuR protein | Translocation | Antigens | Cytokines | Internal medicine | Radioactive half-life | Inflammation | Medicine | Ribonucleic acids | TNF inhibitors | Cytoplasm | mRNA stability | Index Medicus
Journal Article
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 11/2018, Volume 29, Issue 11, pp. 2627 - 2640
Background The familial hyperkalemic hypertension (FHHt) cullin 3 (CUL3) mutant does not degrade WNK kinases normally, thereby leading to thiazide-sensitive... 
Cell & Transport Physiology | CYCLIN-E | Na transport | distal tubule | CELL-PROLIFERATION | KELCH-LIKE 3 | HUMAN HYPERTENSION | UBIQUITIN LIGASES | DISEASE-CAUSING MUTATIONS | BLOOD-PRESSURE | CULLIN | PSEUDOHYPOALDOSTERONISM TYPE-II | IN-VIVO | renal hypertension | UROLOGY & NEPHROLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 12, pp. e14450 - e14450
Background: Engagement of the beta 2 integrin, lymphocyte function-associated antigen-1 (LFA-1), results in stabilization of T cell mRNA transcripts containing... 
ACTIVATED PROTEIN-KINASE | INTERCELLULAR-ADHESION MOLECULE-1 | TYROSINE KINASE | BIOLOGY | BINDING-PROTEIN | INTEGRIN LFA-1 | RAC2 | NUCLEAR EXPORT | TRANSGENIC MICE | LYMPHOCYTES | UROKINASE | ELAV-Like Protein 1 | Tumor Necrosis Factor-alpha - metabolism | Cytokines - metabolism | Signal Transduction | Humans | Mice, Inbred C57BL | rac GTP-Binding Proteins - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Neuropeptides - metabolism | Interferon-gamma - metabolism | ELAV Proteins | Integrins - metabolism | MAP Kinase Kinase 3 - metabolism | Animals | GTP Phosphohydrolases - metabolism | T-Lymphocytes - metabolism | Antigens, Surface - metabolism | Mice | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-vav - metabolism | RNA-Binding Proteins - metabolism | rac1 GTP-Binding Protein - metabolism | Messenger RNA | Cytokines | G proteins | T cells | Gene expression | Mitogens | Protein kinases | Integrins | Molecular machines | Phosphorylation | Stabilization | Downstream effects | MKK3 protein | Activation | Lymphocytes T | Kinases | Guanine | LFA-1 antigen | Cell adhesion & migration | Cell activation | Transfection | Lymphocytes | Cascades | Rodents | Tumor necrosis factor-TNF | Guanine nucleotide exchange factor | Protein transport | HuR protein | Spleen | Translocation | Intercellular adhesion molecule 1 | MAP kinase | Rac1 protein | Inflammation | T cell receptors | siRNA | Tumor necrosis factor-α | Rac2 protein | Ribonucleic acid--RNA | Signaling | MKK3 gene | Protein kinase | γ-Interferon | Catabolism | Index Medicus | RNA | Ribonucleic acid
Journal Article
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 11/2016, Volume 37, Issue 2, pp. 328 - 340
OBJECTIVE—The calcium composition of atherosclerotic plaque is thought to be associated with increased risk for cardiovascular events, but whether plaque... 
atherosclerosis | coronary artery disease | macrophages | inflammation | biomarkers | C-REACTIVE PROTEIN | CORONARY-ARTERY CALCIUM | CARDIOVASCULAR EVENTS | VASCULAR CALCIFICATION | VULNERABLE PATIENT | RISK-ASSESSMENT STRATEGIES | COMPUTED-TOMOGRAPHY | IN-VIVO | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | NF-KAPPA-B | Up-Regulation | Prognosis | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Myocytes, Smooth Muscle - pathology | rac GTP-Binding Proteins - deficiency | rac GTP-Binding Proteins - metabolism | Male | Coronary Artery Disease - enzymology | Atherosclerosis - enzymology | Transfection | Interleukin-1beta - metabolism | rac GTP-Binding Proteins - genetics | Coronary Artery Disease - pathology | Inflammation Mediators - metabolism | Aortic Diseases - prevention & control | Vascular Calcification - mortality | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Aorta - enzymology | Aortic Diseases - pathology | Atherosclerosis - pathology | Coronary Vessels - pathology | Genetic Predisposition to Disease | Coronary Vessels - enzymology | Macrophages - pathology | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Neuropeptides - metabolism | Coronary Artery Disease - mortality | Plaque, Atherosclerotic | Vascular Calcification - pathology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Muscle, Smooth, Vascular - enzymology | Atherosclerosis - prevention & control | rac1 GTP-Binding Protein - metabolism | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2014, Volume 211, Issue 1, pp. 29 - 43
Axonal sorting is a crucial event in nerve formation and requires proper Schwann cell proliferation, differentiation, and contact with axons. Any defect in... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONGENITAL MUSCULAR-DYSTROPHY | EXCHANGE FACTOR | MUTANT MICE | MYELINATION | PERIPHERAL NERVOUS-SYSTEM | COP9 SIGNALOSOME | DISTINCT ROLES | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | NEUREGULIN-1 | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2004, Volume 279, Issue 13, pp. 13027 - 13034
Integrin adhesion receptors can act as signaling receptors that transmit information from the extracellular environment to the interior of the cell, affecting... 
SIGNAL-TRANSDUCTION | RECEPTOR TYROSINE KINASES | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | BINDING-PROTEIN | CELL-ADHESION | EXTRACELLULAR-MATRIX | ACTIVATED PROTEIN-KINASES | NUCLEAR-PROTEIN | Cytoskeletal Proteins | Phosphorylation | ran GTP-Binding Protein - genetics | ran GTP-Binding Protein - physiology | Humans | Transcriptional Activation | Cytoplasm - metabolism | Lymphocyte Function-Associated Antigen-1 - metabolism | Tissue Distribution | Transfection | T-Lymphocytes - metabolism | Cell Division | Cloning, Molecular | Cell Differentiation | Cell Membrane - metabolism | Nuclear Proteins - genetics | Fluorescent Antibody Technique, Indirect | Genes, Reporter | Protein Structure, Tertiary | Cell Line | Signal Transduction | Cell Survival | Jurkat Cells | Electrophoresis, Polyacrylamide Gel | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Nuclear Proteins - chemistry | Serine - chemistry | Cell Adhesion | CD18 Antigens - metabolism | Two-Hybrid System Techniques | Adaptor Proteins, Signal Transducing | Animals | Cell Line, Tumor | Cytoskeleton - metabolism | Protein Binding | ran GTP-Binding Protein - chemistry | Mice | Nuclear Proteins - physiology | Pyridines - pharmacology | Subcellular Fractions | COS Cells | DNA, Complementary - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 02/2008, Volume 205, Issue 2, pp. 465 - 477
Journal Article
Journal of Cell Science, ISSN 0021-9533, 01/2009, Volume 122, Issue 2, pp. 268 - 277
Journal Article
Journal Article