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article (2) 2
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1. Full Text Genomic analyses identify molecular subtypes of pancreatic cancer
by Bailey, Peter and Chang, David K and Nones, Katia and Johns, Amber L and Patch, Ann-Marie and Gingras, Marie-Claude and Miller, David K and Christ, Angelika N and Bruxner, Tim J. C and Quinn, Michael C and Nourse, Craig and Murtaugh, L. Charles and Harliwong, Ivon and Idrisoglu, Senel and Manning, Suzanne and Nourbakhsh, Ehsan and Wani, Shivangi and Fink, Lynn and Holmes, Oliver and Chin, Venessa and Anderson, Matthew J and Kazakoff, Stephen and Leonard, Conrad and Newell, Felicity and Waddell, Nick and Wood, Scott and Xu, Qinying and Wilson, Peter J and Cloonan, Nicole and Kassahn, Karin S and Taylor, Darrin and Quek, Kelly and Robertson, Alan and Pantano, Lorena and Mincarelli, Laura and Sanchez, Luis N and Evers, Lisa and Wu, Jianmin and Pinese, Mark and Cowley, Mark J and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chantrill, Lorraine A and Mawson, Amanda and Humphris, Jeremy and Chou, Angela and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia V and Giry-Laterriere, Marc and Rooman, Ilse and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Merrett, Neil D and Toon, Christopher W and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Moran-Jones, Kim and Jamieson, Nigel B and Graham, Janet S and Duthie, Fraser and Oien, Karin and Hair, Jane and Grützmann, Robert and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Wolfgang, Christopher L and Morgan, Richard A and Lawlor, Rita T and Corbo, Vincenzo and Bassi, Claudio and Rusev, Borislav and Capelli, Paola and Salvia, Roberto and Tortora, Giampaolo and Mukhopadhyay, Debabrata and Petersen, Gloria M and Munzy, Donna M and Fisher, William E and Karim, Saadia A and Eshleman, James R and Hruban, Ralph H and Pilarsky, Christian and Morton, Jennifer P and Sansom, Owen J and Scarpa, Aldo and Musgrove, Elizabeth A and Bailey, Ulla-Maja Hagbo and Hofmann, Oliver and Sutherland, Robert L and Wheeler, David A and Gill, Anthony J and Gibbs, Richard A and Pearson, John V and Waddell, Nicola and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2016, Volume 531, Issue 7592, pp. 47 - 52
Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-beta,... 
PATHWAYS | METASTASIS | DUCTAL ADENOCARCINOMA | PACKAGE | MULTIDISCIPLINARY SCIENCES | TUMOR | MUTATIONS | DIFFERENTIATION | Pancreatic Neoplasms - metabolism | Prognosis | Hepatocyte Nuclear Factor 3-beta - genetics | Genomics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Hepatocyte Nuclear Factor 3-gamma - genetics | Gene Regulatory Networks | Histone Demethylases - genetics | Tumor Suppressor Protein p53 - genetics | Carcinoma, Pancreatic Ductal - genetics | DNA Methylation | Tumor Suppressor Proteins - genetics | Carcinoma, Pancreatic Ductal - classification | Trans-Activators - genetics | Pancreatic Neoplasms - classification | Transcription, Genetic | Nuclear Proteins - genetics | Carcinoma, Pancreatic Ductal - immunology | Genes, Neoplasm - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Carcinoma, Pancreatic Ductal - pathology | Genome, Human - genetics | Homeodomain Proteins - genetics | Animals | Pancreatic Neoplasms - immunology | Survival Analysis | Cell Line, Tumor | Mice | Physiological aspects | Pancreatic cancer | Methods | Genes | Genomes | Mutation | Gene expression | Tumors
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2. Full Text Mixed Adenoneuroendocrine Carcinomas of the Gastrointestinal Tract: Targeted Next-Generation Sequencing Suggests a Monoclonal Origin of the Two Components
by Scardoni, Maria and Vittoria, Emanuele and Volante, Marco and Rusev, Borislav and Bersani, Samantha and Mafficini, Andrea and Gottardi, Marisa and Giandomenico, Valeria and Malleo, Giuseppe and Butturini, Giovanni and Cingarlini, Sara and Fassan, Matteo and Scarpa, Aldo and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Endokrin tumörbiologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Neuroendocrinology, ISSN 0028-3835, 02/2015, Volume 100, Issue 4, pp. 310 - 316
Background: Mixed adenoneuroendocrine carcinomas (MANECs) of the gastrointestinal tract are rare neoplasms characterized by coexisting exocrine and... 
Original Paper | Mixed adenoneuroendocrine carcinomas | Gastrointestinal tract | Next-generation sequencing | WHO 2010 classification | NEOPLASMS | PANCREATIC NEUROENDOCRINE TUMORS | MTOR PATHWAY | DISTINCT | CELL CARCINOMAS | MOLECULAR PROFILES | NEUROSCIENCES | GENES | ENDOCRINOLOGY & METABOLISM | CLONALITY | ENDOCRINE-EXOCRINE TUMORS | MEN1 | Gastrointestinal Neoplasms - genetics | Humans | Middle Aged | Carcinoma, Neuroendocrine - genetics | Male | Tumor Suppressor Protein p53 - genetics | Gastrointestinal Neoplasms - pathology | Carcinoma, Neuroendocrine - pathology | DNA Mutational Analysis | Aged, 80 and over | Female | Aged | Mutation | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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3. Full Text Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas
by Amato, Eliana and Molin, Marco dal and Mafficini, Andrea and Yu, Jun and Malleo, Giuseppe and Rusev, Borislav and Fassan, Matteo and Antonello, Davide and Sadakari, Yoshihiko and Castelli, Paola and Zamboni, Giuseppe and Maitra, Anirban and Salvia, Roberto and Hruban, Ralph H and Bassi, Claudio and Capelli, Paola and Lawlor, Rita T and Goggins, Michael and Scarpa, Aldo
The Journal of Pathology, ISSN 0022-3417, 07/2014, Volume 233, Issue 3, pp. 217 - 227
Intraductal neoplasms are important precursors to invasive pancreatic cancer and provide an opportunity to detect and treat pancreatic neoplasia before an... 
IPMN | next‐generation sequencing (NGS) | biomarkers | pancreatic tumours | next-generation sequencing (NGS) | PATHWAYS | DUCTAL ADENOCARCINOMA | CONSENSUS | CLASSIFICATION | PATHOLOGY | GNAS MUTATIONS | TUBULOPAPILLARY NEOPLASMS | INACTIVATION | PIK3CA | ONCOLOGY | MUCINOUS NEOPLASMS | EXPRESSION | Immunohistochemistry | Carcinoma, Papillary - genetics | Pancreatic Neoplasms - chemistry | Humans | Middle Aged | Male | DNA Mutational Analysis - methods | Carcinoma, Pancreatic Ductal - genetics | Neoplasms, Cystic, Mucinous, and Serous - genetics | Neoplasm Grading | Aged, 80 and over | Adult | Female | Retrospective Studies | Carcinoma, Papillary - chemistry | Neoplasms, Cystic, Mucinous, and Serous - chemistry | Genetic Predisposition to Disease | Neoplasms, Cystic, Mucinous, and Serous - pathology | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Multiplex Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Papillary - pathology | Carcinoma, Pancreatic Ductal - chemistry | Phenotype | Aged | Biomarkers, Tumor - genetics | High-Throughput Nucleotide Sequencing | Mutation | Dysplasia | Gene mutations | Pancreatic cancer | Genes | Genetic aspects | Tumor proteins | Cancer | Original Papers
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4. Full Text Whole-genome landscape of pancreatic neuroendocrine tumours
by Scarpa, Aldo and Chang, David K and Nones, Katia and Corbo, Vincenzo and Patch, Ann-Marie and Bailey, Peter and Lawlor, Rita T and Johns, Amber L and Miller, David K and Mafficini, Andrea and Rusev, Borislav and Scardoni, Maria and Antonello, Davide and Barbi, Stefano and Sikora, Katarzyna O and Cingarlini, Sara and Vicentini, Caterina and McKay, Skye and Quinn, Michael C.J and Bruxner, Timothy J.C and Christ, Angelika N and Harliwong, Ivon and Idrisoglu, Senel and McLean, Suzanne and Nourse, Craig and Nourbakhsh, Ehsan and Wilson, Peter J and Anderson, Matthew J and Fink, J. Lynn and Newell, Felicity and Waddell, Nick and Holmes, Oliver and Kazakoff, Stephen H and Leonard, Conrad and Wood, Scott and Xu, Qinying and Nagaraj, Shivashankar Hiriyur and Amato, Eliana and Dalai, Irene and Bersani, Samantha and Cataldo, Ivana and Dei Tos, Angelo P and Capelli, Paola and Davì, Maria Vittoria and Landoni, Luca and Malpaga, Anna and Miotto, Marco and Whitehall, Vicki L.J and Leggett, Barbara A and Harris, Janelle L and Harris, Jonathan and Jones, Marc D and Humphris, Jeremy and Chantrill, Lorraine A and Chin, Venessa and Nagrial, Adnan M and Pajic, Marina and Scarlett, Christopher J and Pinho, Andreia and Rooman, Ilse and Toon, Christopher and Wu, Jianmin and Pinese, Mark and Cowley, Mark and Barbour, Andrew and Mawson, Amanda and Humphrey, Emily S and Colvin, Emily K and Chou, Angela and Lovell, Jessica A and Jamieson, Nigel B and Duthie, Fraser and Gingras, Marie-Claude and Fisher, William E and Dagg, Rebecca A and Lau, Loretta M.S and Lee, Michael and Pickett, Hilda A and Reddel, Roger R and Samra, Jaswinder S and Kench, James G and Merrett, Neil D and Epari, Krishna and Nguyen, Nam Q and Zeps, Nikolajs and Falconi, Massimo and Simbolo, Michele and Butturini, Giovanni and Van Buren, George and Partelli, Stefano and Fassan, Matteo and Khanna, Kum Kum and Gill, Anthony J and Wheeler, David A and Gibbs, Richard A and Musgrove, Elizabeth A and Bassi, Claudio and Tortora, Giampaolo and Pederzoli, Paolo and Pearson, John V and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7643, pp. 65 - 71
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges... 
MOLECULAR SUBTYPES | MUTATIONAL PROCESSES | TRANSLOCATION | SUPPRESSOR | PROTEIN | PATHWAY GENES | MULTIDISCIPLINARY SCIENCES | MTOR PATHWAY | TP53 MUTATIONS | CANCER | EWING SARCOMA | Genetic aspects | Nucleotide sequencing | Pancreatic cancer | Methods | DNA sequencing | Genes | Biomarkers | Genomes | Mutation | Signatures | Patients | Tumors | Index Medicus
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5. Full Text Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin‐remodelling genes as major players and a prognostic role for TERT, RB1, MEN1 and KMT2D
by Simbolo, Michele and Mafficini, Andrea and Sikora, Katarzyna O and Fassan, Matteo and Barbi, Stefano and Corbo, Vincenzo and Mastracci, Luca and Rusev, Borislav and Grillo, Federica and Vicentini, Caterina and Ferrara, Roberto and Pilotto, Sara and Davini, Federico and Pelosi, Giuseppe and Lawlor, Rita T and Chilosi, Marco and Tortora, Giampaolo and Bria, Emilio and Fontanini, Gabriella and Volante, Marco and Scarpa, Aldo
The Journal of Pathology, ISSN 0022-3417, 03/2017, Volume 241, Issue 4, pp. 488 - 500
Next‐generation sequencing (NGS) was applied to 148 lung neuroendocrine tumours (LNETs) comprising the four World Health Organization classification... 
targeted sequencing | RB1 | KMT2D | exome sequencing | neuroendocrine | TERT | lung tumours | MEN1 | PATHOLOGY | CANCER | ONCOLOGY | PATHWAY | POOR-PROGNOSIS | MUTATIONS | EXPRESSION | Prognosis | Humans | Middle Aged | Chromatin Assembly and Disassembly - genetics | Lung Neoplasms - pathology | Male | DNA Copy Number Variations | Telomerase - genetics | Adult | Female | Retinoblastoma Binding Proteins - genetics | Neoplasm Proteins - genetics | Lung Neoplasms - genetics | Neuroendocrine Tumors - pathology | Carcinoma, Neuroendocrine - genetics | Proto-Oncogene Proteins - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Sequence Analysis, DNA | Neuroendocrine Tumors - genetics | Carcinoid Tumor - pathology | Small Cell Lung Carcinoma - pathology | Carcinoid Tumor - genetics | Carcinoma, Neuroendocrine - pathology | Italy | Aged | High-Throughput Nucleotide Sequencing | Mutation | Ubiquitin-Protein Ligases - genetics | Cohort Studies | Genetic research | Chromatin | Analysis | Genes | Public health | Tumors | Original Papers | Original Paper
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6. Beyond Pancreatic Cyst Epithelium: Evidence of Ovarian-Like Stroma in EUS-Guided Through-the-Needle Micro-Forceps Biopsy Specimens
by Crinò, Stefano Francesco and Bernardoni, Laura and Gabbrielli, Armando and Capelli, Paola and Salvia, Roberto and Rusev, Borislav Chavdarov and Scarpa, Aldo and Manfrin, Erminia
American Journal of Gastroenterology, ISSN 0002-9270, 07/2018, Volume 113, Issue 7, pp. 1059 - 1060
NEOPLASM | GASTROENTEROLOGY & HEPATOLOGY
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7. Full Text Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma
by Simbolo, Michele and Vicentini, Caterina and Ruzzenente, Andrea and Brunelli, Matteo and Conci, Simone and Fassan, Matteo and Mafficini, Andrea and Rusev, Borislav and Corbo, Vincenzo and Capelli, Paola and Bria, Emilio and Pedron, Serena and Turri, Giona and Lawlor, Rita T and Tortora, Giampaolo and Bassi, Claudio and Guglielmi, Alfredo and Scarpa, Aldo
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 7119 - 13
The incidence and mortality rates of intrahepatic cholangiocarcinoma have been rising worldwide. Few patients present an early-stage disease that is amenable... 
HETEROGENEITY | BILIARY-TRACT CANCER | METAANALYSIS | RECOMMENDATIONS | MULTIDISCIPLINARY SCIENCES | MUTATIONS | TUMORS | CARCINOMA | TRENDS | GENOME | Mutation
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8. Full Text Immunoevolution of mouse pancreatic organoid isografts from preinvasive to metastatic disease
by Filippini, D and D'Agosto, S and Delfino, P and Simbolo, M and Piro, G and Rusev, B and Veghini, L and Cantu, C and Lupo, F and Ugel, S and De Sanctis, F and Bronte, V and Milella, M and Tortora, G and Scarpa, A and Carbone, C and Corbo, V
SCIENTIFIC REPORTS, ISSN 2045-2322, 08/2019, Volume 9, Issue 1, pp. 12286 - 13
Pancreatic ductal adenocarcinoma (PDA) has a highly immunosuppressive microenvironment, which is contributed by the complex interaction between cancer cells... 
SUPPRESSOR | MAINTENANCE | PROGENITORS | T-CELL EXCLUSION | INHIBITION | 7 C7 | DUCTAL ADENOCARCINOMA | IMMUNOTHERAPY | MULTIDISCIPLINARY SCIENCES | TUMOR | CANCER | Adenocarcinoma | Carcinoma | Cell survival | Transforming growth factor-b1 | Syngeneic grafts | CD8 antigen | Pancreatic islet transplantation | Lymphocytes T | Metastasis | Leukocytes | Macrophages | Metastases | Organoids | Stromal cells | Pancreas transplantation | Tumors
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9. Full Text Molecular alterations associated with metastases of solid pseudopapillary neoplasms of the pancreas
by Amato, Eliana and Mafficini, Andrea and Hirabayashi, Kenichi and Lawlor, Rita T and Fassan, Matteo and Vicentini, Caterina and Barbi, Stefano and Delfino, Pietro and Sikora, Katarzyna and Rusev, Borislav and Simbolo, Michele and Esposito, Irene and Antonello, Davide and Pea, Antonio and Sereni, Elisabetta and Ballotta, Maria and Maggino, Laura and Marchegiani, Giovanni and Ohike, Nobuyuki and Wood, Laura D and Salvia, Roberto and Klöppel, Günter and Zamboni, Giuseppe and Scarpa, Aldo and Corbo, Vincenzo
The Journal of Pathology, ISSN 0022-3417, 01/2019, Volume 247, Issue 1, pp. 123 - 134
Solid pseudopapillary neoplasms (SPN) of the pancreas are rare, low‐grade malignant neoplasms that metastasise to the liver or peritoneum in 10–15% of cases.... 
hypoxia | Solid pseudopapillary neoplasms | epigenetic regulators | metastasis | pancreas | COMPONENTS | PHENOTYPE | PATHOLOGY | CANCER | TUMORS | ONCOLOGY | PATHWAY | FRAMEWORK | MUTATIONS | CARCINOMA | BAP1 | REVEALS | Epigenetic inheritance | Metastasis | Tumor proteins | Genomics | Regulators | Deactivation | Transcription | Liver | Genes | Medical treatment | Inactivation | Neoplasms | Metastases | Gene sequencing | Proteins | Alterations | Hypoxia | Mutation | Lesions | Pancreas | Tumors | Peritoneum | Original Papers | Original Paper
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10. Full Text Mutational and copy number asset of primary sporadic neuroendocrine tumors of the small intestine
by Simbolo, Michele and Vicentini, Caterina and Mafficini, Andrea and Fassan, Matteo and Pedron, Serena and Corbo, Vincenzo and Mastracci, Luca and Rusev, Borislav and Pedrazzani, Corrado and Landoni, Luca and Grillo, Federica and Cingarlini, Sara and Rindi, Guido and Luchini, Claudio and Scarpa, Aldo and Lawlor, Rita T
Virchows Archiv, ISSN 0945-6317, 12/2018, Volume 473, Issue 6, pp. 709 - 717
Small intestine neuroendocrine tumors (SI-NETs) represent the most common histotype among small intestine neoplasms, and metastatic disease is usually present... 
Prognostic markers | Pathology | Medicine & Public Health | SRC | Small intestine | Neuroendocrine tumors | PATHOLOGY | Intestinal Neoplasms - mortality | Prognosis | Intestine, Small - pathology | Humans | Middle Aged | Male | DNA Copy Number Variations | Neuroendocrine Tumors - genetics | DNA Mutational Analysis | Neuroendocrine Tumors - mortality | Adult | Female | Aged | Biomarkers, Tumor - genetics | Retrospective Studies | Intestinal Neoplasms - genetics | Anopheles | Analysis | Genes | Genomics | Genetic aspects | Metastasis | Tumor proteins | Copy number | p53 Protein | Genomes | Src protein | Smad4 protein | Neoplasms | Metastases | Gene sequencing | Adenomatous polyposis coli | Survival analysis | Nets | Medical prognosis | Biomarkers | Diagnosis | Chromosomes | Chromosome 18 | Tumors | Original
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11. Full Text Reporting tumor molecular heterogeneity in histopathological diagnosis
by Mafficini, Andrea and Amato, Eliana and Fassan, Matteo and Simbolo, Michele and Antonello, Davide and Vicentini, Caterina and Scardoni, Maria and Bersani, Samantha and Gottardi, Marisa and Rusev, Borislav and Malpeli, Giorgio and Corbo, Vincenzo and Barbi, Stefano and Sikora, Katarzyna O and Lawlor, Rita T and Tortora, Giampaolo and Scarpa, Aldo
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e104979
Background: Detection of molecular tumor heterogeneity has become of paramount importance with the advent of targeted therapies. Analysis for detection should... 
EVOLUTION | SEQUENCING PLATFORMS | LANDSCAPE | ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | GENES | TISSUES | CANCER | CARCINOMA | SOMATIC MUTATIONS | GENOME | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Proto-Oncogene Proteins - genetics | DNA Mutational Analysis - methods | Tumor Suppressor Protein p53 - genetics | Paraffin Embedding | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Neoplasms - genetics | Proto-Oncogene Proteins B-raf - genetics | Base Sequence | Tissue Fixation | High-Throughput Nucleotide Sequencing - methods | Neoplasms - pathology | Immunohistochemistry | Dehydrogenases | p53 Protein | Genomics | Hepatocellular carcinoma | Genomes | Paraffin | Kinases | Ampulla of Vater | Tissues | Medical diagnosis | Cancer therapies | Smad4 protein | Neoplasms | Molecular weight | Cell adhesion & migration | Heterogeneity | Alterations | Pancreatic carcinoma | Intestine | Diagnosis | Pancreas | Gastric cancer | Deoxyribonucleic acid--DNA | Sensitivity analysis | Cloning | Gastrointestinal tract | Pathology | Diagnostic systems | Mutation | Tumors | Cancer | Deoxyribonucleic acid | DNA
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