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Analytical Chemistry, ISSN 0003-2700, 09/2017, Volume 89, Issue 17, pp. 8931 - 8941
A barrier to the use of hydrogen exchange-mass spectrometry (HX-MS) in many contexts, especially analytical characterization of various protein therapeutic... 
PEPTIDE GROUP | CHEMISTRY, ANALYTICAL | FOLDING PROBLEM | STABILITY | EXPANSION | PROPENSITY | TIME WINDOW | CONFORMATIONAL DYNAMICS | PARAMETERS | PROTEINS | IGG1 MONOCLONAL-ANTIBODY | Chemical reactions | Usage | Chemical properties | Arginine | Methyl groups
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 09/2019, Volume 1867, Issue 9, pp. 787 - 793
Type III secretion systems are used by many Gram-negative bacteria to inject effector proteins into eukaryotic cells to subvert their normal activities.... 
Type III secretion system | Protein stability | SctD | DOMAIN | YSCD | PROTEIN EXPORT | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARCHITECTURE | CONFORMATIONAL STABILITY | III SECRETION SYSTEMS | Proteins | Phylogeny
Journal Article
Biomacromolecules, ISSN 1525-7797, 07/2018, Volume 19, Issue 7, pp. 2391 - 2400
The interactions among biomacromolecules within insect cuticle may offer new motifs for biomimetic material design. CPR27 is an abundant protein in the rigid... 
TRIBOLIUM-CASTANEUM | RED FLOUR BEETLE | HYDROGELS | DESIGN | POLYMER SCIENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | SILKWORM | MEDICINE | BOMBYX-MORI | CHITIN | EXPRESSION | MAJOR CUTICULAR PROTEINS | Animals | Tribolium - chemistry | Chitosan - analogs & derivatives | Insect Proteins - chemistry | Amino Acid Motifs
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 04/2019, Volume 16, Issue 4, pp. 1563 - 1572
Autoimmune diseases are believed to be highly dependent on loss of immune tolerance to self-antigens. Currently, no treatments have been successful clinically... 
autoimmune diseases | type 1 diabetes | insulin | soluble antigen array | B cell antigen receptors | valency | anergized | epitope | ex vivo | tolerance | SYSTEM | MEDICINE, RESEARCH & EXPERIMENTAL | EFFICACY | MULTIPLE-SCLEROSIS | MEMORY | RITUXIMAB | PHARMACOLOGY & PHARMACY | THERAPIES | ANERGY | MICE | BINDING | LYMPHOCYTE DEPLETION
Journal Article
MOLECULAR PHARMACEUTICS, ISSN 1543-8384, 03/2019, Volume 16, Issue 3, pp. 1119 - 1131
Oral administration is advantageous compared to the commonly used parenteral administration for local therapeutic uses of biologics or mucosal vaccines, since... 
MEDICINE, RESEARCH & EXPERIMENTAL | lysozyme | PHARMACEUTICALS | STABILIZATION | INDENTATION | aggregation | TABLETABILITY | STRENGTH | protein stability | MECHANICAL-PROPERTIES | DELIVERY | protein tablet | protein structure | BSA | MOISTURE-CONTENT | PHARMACOLOGY & PHARMACY | HARDNESS | compression
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2019, Volume 293, pp. 36 - 47
Glatiramer acetate (GA) is widely prescribed for the treatment of relapsing-remitting multiple sclerosis, however, the mechanism of action is still not fully... 
Glatiramer acetate | Multiple Sclerosis | Copaxone | SC injection simulation | Copaxone (R) | MECHANISM | SPECIFICITY | COPOLYMERS | CHEMISTRY, MULTIDISCIPLINARY | MYELIN BASIC-PROTEIN | MULTIPLE-SCLEROSIS | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | T-CELLS
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2019, Volume 108, Issue 10, pp. 3372 - 3381
Oxidation of therapeutic proteins (TPs) can lead to changes in their pharmacokinetics, biological activity and immunogenicity. Metal impurities such as iron... 
secondary structure | oxidation | mass spectrometry | iron oxide nanoparticles | methionine | protein
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 06/2019
In this work, we continue to examine excipient effects on the reversible self-association (RSA) of 2 different IgG1 monoclonal antibodies (mAb-J and mAb-C). We... 
Journal Article
Journal of pharmaceutical sciences, ISSN 0022-3549, 06/2019
Many challenges limit the formulation of antibodies as high-concentration liquid dosage forms including elevated solution viscosity, decreased physical... 
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 10/2019
Journal Article
Expert Opinion on Drug Delivery, ISSN 1742-5247, 11/2016, Volume 13, Issue 11, pp. 1501 - 1502
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 12/2017, Volume 106, Issue 12, pp. 3474 - 3485
A novel protein adjuvant double-mutant heat-labile toxin, LT (R192G/L211A) or dmLT, is in preclinical and early clinical development with various vaccine... 
vaccine | adjuvant | ETEC | dmLT | stability | mucosal | THERMAL-STABILITY | CHEMISTRY, MEDICINAL | B SURFACE-ANTIGEN | FORMULATION | CHEMISTRY, MULTIDISCIPLINARY | MUCOSAL ADJUVANTS | ANTHRAX PROTECTIVE ANTIGEN | IMMUNOGENICITY | PHARMACOLOGY & PHARMACY | ENTEROTOXIGENIC ESCHERICHIA-COLI | VACCINE ANTIGENS | DEAMIDATION | CHOLERA-TOXIN
Journal Article
Langmuir, ISSN 0743-7463, 01/2016, Volume 32, Issue 2, pp. 496 - 504
Shear thinning behavior, often observed in shear viscosity tests of IgG therapeutic molecules, could lead to significant disparities in the projections for the... 
ANTIBODIES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | PROTEINS | ADSORPTION | CHEMISTRY, MULTIDISCIPLINARY | CHALLENGES | Viscosity | Surface Tension | Thermodynamics | Air - analysis | Polysorbates - chemistry | Solutions | Rheology | Immunoglobulin G - chemistry | Water - chemistry | Suspensions
Journal Article
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