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Gastroenterology, ISSN 0016-5085, 2015, Volume 150, Issue 4, pp. 875 - 887.e9
Abstract Background & Aims Histamine sensitizes the nociceptor TRPV1 and has been shown to contribute to visceral hypersensitivity in animals. We investigated... 
Gastroenterology and Hepatology | Sensory Neurons | Drug | Transient Receptor Potential Cation Channel Subfamily V Member 1 | Treatment | PROTEIN-KINASE-C | LINACLOTIDE | COLONIC HYPERSENSITIVITY | DISORDERS | MUTATIONAL ANALYSIS | POTENTIAL VANILLOID 1 | CLINICAL-TRIALS | BINDING-SITE | PLACEBO-CONTROLLED TRIAL | ION CHANNELS | GASTROENTEROLOGY & HEPATOLOGY | Abdominal Pain - prevention & control | Humans | Middle Aged | Male | Young Adult | Receptors, Histamine H1 - drug effects | TRPV Cation Channels - metabolism | Receptors, Histamine H1 - metabolism | Time Factors | Irritable Bowel Syndrome - diagnosis | Rectum - innervation | Pain Threshold - drug effects | Adult | Female | Surveys and Questionnaires | Neurons - metabolism | Neurons - drug effects | Analgesics - adverse effects | Analgesics - therapeutic use | Irritable Bowel Syndrome - metabolism | Butyrophenones - therapeutic use | Double-Blind Method | Abdominal Pain - physiopathology | Irritable Bowel Syndrome - drug therapy | Treatment Outcome | Abdominal Pain - metabolism | Irritable Bowel Syndrome - physiopathology | Remission Induction | Butyrophenones - adverse effects | Histamine H1 Antagonists - adverse effects | Belgium | Histamine H1 Antagonists - therapeutic use | Biopsy | Calcium Signaling - drug effects | Piperidines - therapeutic use | Piperidines - adverse effects | Adolescent | Gastrointestinal Agents - therapeutic use | Quality of Life | Aged | Gastrointestinal Agents - adverse effects | Pain Measurement | Receptor Cross-Talk - drug effects | Drugs | Histamine | Care and treatment | Drug delivery systems | Gastrointestinal diseases | Irritable bowel syndrome | Research institutes | Vehicles
Journal Article
by Feagan, Brian G and Sandborn, William J and Gasink, Christopher and Jacobstein, Douglas and Lang, Yinghua and Friedman, Joshua R and Blank, Marion A and Johanns, Jewel and Gao, Long-Long and Miao, Ye and Adedokun, Omoniyi J and Sands, Bruce E and Hanauer, Stephen B and Vermeire, Severine and Targan, Stephan and Ghosh, Subrata and De Villiers, Willem J and Colombel, Jean-Frederic and Tulassay, Zsolt and Seidler, Ursula and Salzberg, Bruce A and Desreumaux, Pierre and Lee, Scott D and Loftus, Edward V and Dieleman, Levinus A and Katz, Seymour and Rutgeerts, Paul and Bampton, P and Chung, A and Connor, S and Debinski, H and Leong, R and Macrae, F and Pavli, P and Sorrentino, D and van den Bogaerde, J and Vogel, W and Vogelsang, H and Louis, E and Mana, F and Zaltman, C and Aumais, G and Bernstein, C and Bressler, B and Dhalla, S and Marshall, J and Panaccione, R and Ropeleski, M and Stehlik, J and Volfova, M and Brynskov, J and Glerup, H and Abitbol-Selinger, V and Allez, M and Beaugerie, L and Bourreille, A and Cadiot, G and Dupas, J and Grimaud, J and Laharie, D and Lerebours, E and Moreau, J and Baumgart, D and Brand, S and Ebert, M and Ehehalt, R and Hasselblatt, P and Howaldt, S and Klaus, J and Krummenerl, P and Kucharzik, T and Lügering, A and Mudter, J and Preiss, J and Schreiber, S and Stallmach, A and Stein, J and Strauch, U and Salamon, A and Patchett, S and Lahat-Zok, A and Rachmilewitz, D and Annese, V and Bossa, F and Guidi, L and Kohn, A and Rocca, R and Ando, A and Ashida, T and Hanai, H and Ishida, T and Ito, H and Matsumoto, T and Motoya, S and Nakamura, S and Sameshima, Y and Suzuki, Y and Watanabe, K and Yamagami, H and Yamamoto, T and ... and UNITI-IM-UNITI Study Grp and UNITI–IM-UNITI Study Group
New England Journal of Medicine, ISSN 0028-4793, 11/2016, Volume 375, Issue 20, pp. 1946 - 1960
Journal Article
by Patsopoulos, NA and Baranzini, SE and Santaniello, A and Shoostari, P and Cotsapas, C and Wong, G and Beecham, AH and James, T and Replogle, J and Vlachos, IS and McCabe, C and Pers, TH and Brandes, A and White, C and Keenan, B and Cimpean, M and Winn, P and Panteliadis, IP and Robbins, A and Andlauer, TFM and Zarzycki, O and Dubois, B and Goris, A and Sondergaard, HB and Sellebjerg, F and Sorensen, PS and Ullum, H and Thorner, LW and Saarela, J and Cournu-Rebeix, I and Damotte, V and Fontaine, B and Guillot-Noel, L and Lathrop, M and Vukusic, S and Berthele, A and Pongratz, V and Gasperi, C and Graetz, C and Grummel, V and Hemmer, B and Hoshi, M and Knier, B and Korn, T and Lill, CM and Luessi, F and Muhlau, M and Zipp, F and Dardiotis, E and Agliardi, C and Amoroso, A and Barizzone, N and Benedetti, MD and Bernardinelli, L and Cavalla, P and Clarelli, F and Comi, G and Cusi, D and Esposito, F and Ferre, L and Galimberti, D and Guaschino, C and Leone, MA and Martinelli, V and Moiola, L and Salvetti, M and Sorosina, M and Vecchio, D and Zauli, A and Santoro, S and Mancini, N and Zuccala, M and Mescheriakova, J and van Duijn, C and Bos, SD and Celius, EG and Spurkland, A and Comabella, M and Montalban, X and Alfredsson, L and Bomfim, IL and Gomez-Cabrero, D and Hillert, J and Jagodic, M and Linden, M and Piehl, F and Jelcic, I and Martin, R and Sospedra, M and Baker, A and Ban, M and Hawkins, C and Hysi, P and Kalra, S and Karpe, F and Khadake, J and Lachance, G and Molyneux, P and Neville, M and Thorpe, J and ... and Australia New Zealand IBDGC and Int Multiple Sclerosis Genetics Co and Initiative Crohn Colitis and Belgium Genetic Consortiumt and United Kingdom IBDGC and ANZgene and WTCCC2 and IIBDGC and NIDDK IBDGCJ and Wellcome Trust Case Control Conso and International Multiple Sclerosis Genetics Consortium and Örebro universitet and Institutionen för medicinska vetenskaper
SCIENCE, ISSN 0036-8075, 09/2019, Volume 365, Issue 6460, pp. 1417 - 1417
Journal Article
by Romagnoni, A and Jegou, S and Van Steen, K and Wainrib, G and Hugot, JP and Peyrin-Biroulet, L and Chamaillard, M and Colombel, JF and Cottone, M and D'Amato, M and D'Inca, R and Halfvarson, J and Henderson, P and Karban, A and Kennedy, NA and Khan, MA and Lemann, M and Levine, A and Massey, D and Milla, M and Ng, SME and Oikonomou, I and Peeters, H and Proctor, DD and Rahier, JF and Rutgeerts, P and Seibold, F and Stronati, L and Taylor, KM and Torkvist, L and Ublick, K and Van Limbergen, J and Van Gossum, A and Vatn, MH and Zhang, H and Zhang, W and Andrews, JM and Bampton, PA and Barclay, M and Florin, TH and Gearry, R and Krishnaprasad, K and Lawrance, IC and Mahy, G and Montgomery, GW and Radford-Smith, G and Roberts, RL and Simms, LA and Hanigan, K and Croft, A and Amininijad, L and Cleynen, I and Dewit, O and Franchimont, D and Georges, M and Laukens, D and Theatre, E and Vermeire, S and Aumais, G and Baidoo, L and Barrie, AM and Beck, K and Bernard, EJ and Binion, DG and Bitton, A and Brant, SR and Cho, JH and Cohen, A and Croitoru, K and Daly, MJ and Datta, LW and Deslandres, C and Duerr, RH and Dutridge, D and Ferguson, J and Fultz, J and Goyette, P and Greenberg, GR and Haritunians, T and Jobin, G and Katz, S and Lahaie, RG and McGovern, DP and Nelson, L and Ng, SM and Ning, K and Pare, P and Regueiro, MD and Rioux, JD and Ruggiero, E and Schumm, LP and Schwartz, M and Scott, R and Sharma, Y and Silverberg, MS and Spears, D and Steinhart, AH and Stempak, JM and Swoger, JM and Tsagarelis, C and ... and Int Inflammatory Bowel Dis Genetic and International Inflammatory Bowel Disease Genetics Consortium (IIBDGC) and Örebro universitet and Institutionen för medicinska vetenskaper
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10351 - 18
Journal Article
Nature, ISSN 0028-0836, 2012, Volume 491, Issue 7422, pp. 119 - 124
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with... 
HYPER-IGE SYNDROME | RISK LOCI | NETWORK | NUMBER | METAANALYSIS | TUBERCULOSIS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | MUTATIONS | EXPRESSION | Crohn Disease - genetics | Humans | Inflammatory Bowel Diseases - immunology | Colitis, Ulcerative - genetics | Mycobacterium tuberculosis - immunology | Inflammatory Bowel Diseases - physiopathology | Colitis, Ulcerative - immunology | Host-Pathogen Interactions - immunology | Mycobacterium tuberculosis - pathogenicity | Haplotypes - genetics | Mycobacterium - pathogenicity | Mycobacterium Infections - genetics | Inflammatory Bowel Diseases - genetics | Crohn Disease - microbiology | Mycobacterium Infections - microbiology | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Reproducibility of Results | Mycobacterium - immunology | Crohn Disease - immunology | Genome, Human - genetics | Phenotype | Colitis, Ulcerative - microbiology | Host-Pathogen Interactions - genetics | Polymorphism, Single Nucleotide - genetics | Inflammatory Bowel Diseases - microbiology | Crohn Disease - physiopathology | Colitis, Ulcerative - physiopathology | Inflammatory bowel disease | Candidates | Tuberculosis | Architecture | Genetics | Genomes | Diabetes | Gene expression | Health risk assessment | Immune system | Rheumatology and Autoimmunity | Basic Medicine | Medical Genetics | Medicinsk genetik | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
Journal Article
by Anderson, Carl A and Boucher, Gabrielle and Lees, Charlie W and Franke, Ane and D'Amato, Mauro and Taylor, Kent D and Lee, James C and Goyette, Philippe and Imielinski, Marcin and Latiano, Anna and Lagacé, Caroline and Scott, Regan and Amininejad, Leila and Bumpstead, Suzannah and Baidoo, Leonard and Baldassano, Robert N and Barclay, Murray and Bayless, Theodore M and Brand, Stephan and Büning, Carsten and Colombel, Jean-Frédéric and Denson, Lee A and de Vos, Martine and Dubinsky, Marla and Edwards, Cathryn and Ellinghaus, David and Fehrmann, Rudolf S. N and Floyd, James A. B and Florin, Timothy and Franchimont, Denis and Franke, Lude and Georges, Michel and Glas, Jürgen and Glazer, Nicole L and Guthery, Stephen L and Haritunians, Talin and Hayward, Nicholas K and Hugot, Jean-Pierre and Jobin, Gilles and Laukens, Debby and Lawrance, Ian and Lémann, Marc and Levine, Arie and Libioulle, Cecile and Louis, Edouard and McGovern, Dermot P and Milla, Monica and Montgomery, Grant W and Morley, Katherine I and Mowat, Craig and Ng, Aylwin and Newman, William and Ophoff, Roel A and Papi, Laura and Palmieri, Orazio and Peyrin-Biroulet, Laurent and Panés, Julián and Phillips, Anne and Prescott, Natalie J and Proctor, Deborah D and Roberts, Rebecca and Russell, Richard and Rutgeerts, Paul and Sanderson, Jeremy and Sans, Miquel and Schumm, Philip and Seibold, Frank and Sharma, Yashoda and Simms, Lisa A and Seielstad, Mark and Steinhart, A. Hillary and Targan, Stephan R and van den Berg, Leonard H and Vatn, Morten and Verspaget, Hein and Walters, Thomas and Wijmenga, Cisca and Wilson, David C and Westra, Harm-Jan and Xavier, Ramnik J and Zhao, Zhen Z and Ponsioen, Cyriel Y and Andersen, Vibeke and Torkvist, Leif and Gazouli, Maria and Anagnou, Nicholas P and Karlsen, Tom H and Kupcinskas, Limas and Sventoraityte, Jurgita and Mansfield, John C and Kugathasan, Subra and Silverberg, Mark S and Halfvarson, Jonas and Rotter, Jerome I and Mathew, Christopher G and Griffiths, Anne M and Gearry, Richard and Ahmad, Tariq and Brant, Steven R and Chamaillard, Mathias and ... and Hälsoakademin and Örebro universitet
Nature genetics, ISSN 1061-4036, 2011, Volume 43, Issue 3, pp. 246 - 252
Journal Article