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Cancer, ISSN 0008-543X, 02/2012, Volume 118, Issue 4, pp. 1023 - 1031
BACKGROUND: Despite the high complete response rates achieved with fludarabine‐based regimens, relapse is inevitable in chronic lymphocytic leukemia (CLL).... 
B‐cell chronic lymphocytic leukemia/lymphoma 2 | 17p deletion | chronic lymphocytic leukemia | BCL‐2‐associated X protein | p53 | BCL-2-associated X protein | B-cell chronic lymphocytic leukemia/lymphoma 2 | Life Sciences & Biomedicine | Oncology | Science & Technology | Apoptosis - drug effects | Humans | Middle Aged | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Biphenyl Compounds - therapeutic use | Chromosomes, Human, Pair 17 - genetics | Tumor Suppressor Protein p53 - genetics | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | Nitrophenols - therapeutic use | Aged, 80 and over | Female | Smith-Magenis Syndrome | Gene Expression Regulation, Neoplastic - drug effects | bcl-2-Associated X Protein - genetics | Chromosome Deletion | Pharmacogenetics | Cells, Cultured | Treatment Outcome | Imidazoles - pharmacology | Piperazines - therapeutic use | Mutation - genetics | Sulfonamides - pharmacology | Piperazines - pharmacology | Tumor Suppressor Protein p53 - drug effects | bcl-2-Associated X Protein - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - drug effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Antimitotic agents | Chronic lymphocytic leukemia | Dosage and administration | Lymphomas | Antineoplastic agents | Drug therapy | Annexin V | Index Medicus | Abridged Index Medicus | BCL-2 | BAX | CLL
Journal Article
Leukemia, ISSN 1476-5551, 04/2011, Volume 25, Issue 7, pp. 1080 - 1094
The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to... 
targeted therapy | Ras | therapeutic sensitivity | Raf | resistance | ERK | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | ras Proteins - genetics | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Apoptosis - drug effects | raf Kinases - antagonists & inhibitors | Humans | Neoplasm Proteins - physiology | Mitogen-Activated Protein Kinase Kinases - physiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - genetics | Gene Expression Regulation, Leukemic - genetics | raf Kinases - physiology | MAP Kinase Signaling System - genetics | Drug Design | Antineoplastic Agents - pharmacology | Extracellular Signal-Regulated MAP Kinases - physiology | Neoplasm Proteins - genetics | raf Kinases - genetics | ras Proteins - physiology | Cell Division - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Cell Division - drug effects | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Models, Biological | Phosphatidylinositol 3-Kinases - physiology | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Extracellular signal-regulated kinases | Leukemia | Physiological aspects | Genetic aspects | Research | Drug therapy | Health aspects | Mitogen-activated protein kinases | Cancer | Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1064 - 1079
It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The... 
mTOR | translation | sensitivity | PI3K | therapy | resistance | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Humans | Neoplasm Proteins - physiology | PTEN Phosphohydrolase - physiology | Apoptosis - genetics | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - genetics | Gene Expression Regulation, Leukemic - genetics | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Transcription Factors - drug effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | PTEN Phosphohydrolase - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Protein Processing, Post-Translational - drug effects | Drug Design | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Leukemia - genetics | Multiprotein Complexes - drug effects | PTEN Phosphohydrolase - genetics | Proteins - physiology | Transcription Factors - physiology | RNA, Messenger - genetics | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Multiprotein Complexes - physiology | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | Pseudogenes | Signal Transduction - drug effects | Phosphatidylinositol 3-Kinases - physiology | Proteins - drug effects | RNA, Neoplasm - genetics | Protein Biosynthesis - drug effects | MicroRNAs - genetics | Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Genes | Leukemia | Physiological aspects | Development and progression | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Health aspects | Index Medicus
Journal Article