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Advanced Synthesis & Catalysis, ISSN 1615-4150, 11/2018, Volume 360, Issue 21, pp. 4104 - 4114
Reaction of various electron‐deficient alkenes, as well as functionalized styrene derivatives with CF3SiMe3−NaI system is studied. Relative reactivity of the... 
Cycloaddition | Cycloalkanes | Ruppert−Prakash reagent | Spiro compounds | Difluorocarbene | Ruppert-Prakash reagent | DIFLUORINATED CYCLOPROPANES | CHEMISTRY, ORGANIC | FLUORINE | CHEMISTRY, APPLIED | THERMAL REARRANGEMENT | Esters | Transition metal compounds | Olefins | Organic acids | Transition metals | Carboxylic acids | Alkenes | Substrates
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 01/2020, Volume 26, Issue 6, p. n/a
Drug discovery uses both natural product sources and synthetic organic chemistry to provide suitable starting points for further optimization. Producing such... 
chemoinformatics | natural products | combinatorial chemistry | drug discovery | organic synthesis | Organic chemistry | Chemistry | Natural products | Chemical bonds | Drug discovery | Biodiversity | Optimization
Journal Article
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 06/2019, Volume 2019, Issue 22, pp. 3636 - 3648
An efficient approach towards introducing (cyclo)alkyl substituents at C‐2, C‐3 or C‐4 positions of the piperidine ring was described. The method relied on the... 
Heteroaliphatic compounds | Metalation | Regioselectivity | Piperidine | Reaction mechanisms | Catalytic hydrogenation | PYRIDINE-DERIVATIVES | SCALE-UP | CATALYTIC-HYDROGENATION | CHEMISTRY, ORGANIC | POTENT INHIBITORS | CENTER-DOT-LICL | CHEMOSELECTIVE REDUCTION | HETEROCYCLES | REGIOSELECTIVE ORTHO-LITHIATION | COUPLING REACTIONS | Hydrogenation
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 08/2019, Volume 2019, Issue 30, pp. 4962 - 4967
Base‐promoted cyclization of N‐Boc‐ω‐(4‐(chloromethyl)oxazol‐5‐yl)alkylamines led to the corresponding “dimerization” products containing fused 10‐, 12‐, and... 
Heterocycles | Cyclization | Oxazoles | Macrocycles | Medium‐sized rings | VU0409551/JNJ-46778212 | ISOXAZOLE | COMPLEXES | THEORETICAL PREDICTION | CHEMISTRY, ORGANIC | LARGE MOLECULES | THERMODYNAMICS | HYDROGEN-BOND BASICITY | OPTIMIZATION | INHIBITORS | DENSITY-FUNCTIONAL THEORY | Medium-sized rings
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 09/2017, Volume 359, Issue 18, pp. 3077 - 3077
The front cover image, provided by Pavel Nosik, Andriy Gerasov, Sergey Ryabukhin, Oleksandr Grygorenko, and Dmitriy Volochnyuk illustrates the synthesis of... 
cycloaddition | bicyclic compounds | difluorocarbene | Ruppert–Prakash reagent | cycloalkanes | Amines | Alkenes | Chemical synthesis | Substrates
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 09/2017, Volume 359, Issue 18, pp. 3126 - 3136
The synthesis of monocyclic, spirocyclic and fused bicyclic secondary amines bearing a gem‐difluorocyclopropane moiety via difluorocyclopropanation of... 
cycloaddition | bicyclic compounds | difluorocarbene | Ruppert–Prakash reagent | cycloalkanes | ACID | BUILDING-BLOCKS | DRUG DISCOVERY | CHEMISTRY, ORGANIC | MEDICINAL CHEMISTRY | Ruppert-Prakash reagent | FLUORINE | OLEFINS | GENERATION | CHEMISTRY, APPLIED | DIFLUOROCARBENE SOURCE | SCAFFOLD | Amines | Synthesis | Alkenes | Substrates
Journal Article
Drug Discovery Today, ISSN 1359-6446, 02/2019, Volume 24, Issue 2, pp. 390 - 402
•A critical assessment of 16 million commercially available compounds.•A comparison of vendors’ offerings.•How the offerings have evolved to meet modern... 
LIBRARIES | PHENOTYPIC DRUG DISCOVERY | COLLECTION | CAPACITY | DESIGN | IMPACT | SCAFFOLD DIVERSITY | PHARMACOLOGY & PHARMACY | GENERATION | CHEMICAL SPACE | LEADLIKENESS | Analysis | Drug discovery
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2019, Volume 2019, Issue 27, pp. 4311 - 4319
Difluorocyclopropanation of N‐vinylazoles with the CF3SiMe3–NaI system was studied. It was found that N‐vinylpyrazoles could be transformed into the... 
Azoles | Cycloalkanes | Organofluorines | Ruppert–Prakash reagent | Building blocks | GEM-DIFLUORINATED CYCLOPROPANES | Ruppert-Prakash reagent | TRIFLUOROMETHYL | BUILDING-BLOCKS | CHEMISTRY, ORGANIC | DERIVATIVES | Hydrogenation
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 06/2019, Volume 2019, Issue 23, pp. 3711 - 3711
The Front Cover shows piperidine derivatives depicted at the magical Rubik's cube, which is falling down from the chemical space to the dark woods of possible... 
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 01/2019, Volume 217, pp. 80 - 89
[Display omitted] •An approach to functionalized 1-pyrazolyl-2,2-difluorocyclopropanes was developed.•The method relied on difluorocyclopropanation with the... 
Lead-oriented synthesis | Cycloalkanes | Organofluorine compounds | Nitrogen heterocycles | Ruppert–Prakash reagent | Transformation | Synthesis | Pyrazoles | Pyrazole | Functional groups | Feasibility studies
Journal Article
Journal of Fluorine Chemistry, ISSN 0022-1139, 08/2019, Volume 224, pp. 61 - 66
[Display omitted] •An approach to 3-substituted piperidines bearing partially fluorinated alkyl groups is developed.•The strategy is based on deoxofluorination... 
Hydrodefluorination | Partially fluorinated alkyl groups | Nitrogen heterocycles | Piperidine | Hydrogenation | BUILDING-BLOCKS | CHEMISTRY, ORGANIC | BOND ACTIVATION | CHEMISTRY, INORGANIC & NUCLEAR | Palladium catalysts | Pyridine | Ketones | Alcohols | Substitutes | Pyridines | Synthesis | Catalysts | Platinum | Palladium | Derivatives | Fluorination
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 07/2019, Volume 2019, Issue 27, pp. 4271 - 4271
The Front Cover shows the “difluoro‐cyclopropanating dragon” (which has been already used to depict the CF3SiMe3 – the NaI system through the series of... 
Journal Article