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Statistics in Medicine, ISSN 0277-6715, 09/2019, Volume 38, Issue 21, pp. 4112 - 4130
Two‐way enriched design (TED) is a novel approach addressing placebo response in clinical trials. It is a two‐stage, randomized, placebo‐controlled trial... 
two‐way enriched design (TED) | placebo response | weighted repeated measures | repeated measures | Clinical trials | Comparative analysis | Methods | Index Medicus
Journal Article
by Wheeler, Eleanor and Leong, Aaron and Liu, Ching-Ti and Hivert, Marie-France and Strawbridge, Rona J and Podmore, Clara and Li, Man and Yao, Jie and Sim, Xueling and Hong, Jaeyoung and Chu, Auey Y and Zhang, Weihua and Wang, Xu and Chen, Peng and Maruthur, Nisa M and Porneala, Bianca C and Sharp, Stephen J and Jia, Yucheng and Kabagambe, Edmond K and Chang, Li-Ching and Chen, Wei-Min and Elks, Cathy E and Evans, Daniel S and Fan, Qiao and Giulianini, Franco and Go, Min Jin and Hottenga, Jouke-Jan and Hu, Yao and Jackson, Anne U and Kanoni, Stavroula and Kim, Young Jin and Kleber, Marcus E and Ladenvall, Claes and Lecoeur, Cecile and Lim, Sing-Hui and Lu, Yingchang and Mahajan, Anubha and Marzi, Carola and Nalls, Mike A and Navarro, Pau and Nolte, Ilja M and Rose, Lynda M and Rybin, Denis V and Sanna, Serena and Shi, Yuan and Stram, Daniel O and Takeuchi, Fumihiko and Tan, Shu Pei and van der Most, Peter J and van Vliet-Ostaptchouk, Jana V and Wong, Anew and Yengo, Loic and Zhao, Wanting and Goel, Anuj and Martinez Larrad, Maria Teresa and Radke, Dorte and Salo, Perttu and Tanaka, Toshiko and van Iperen, Erik P. A and Abecasis, Goncalo and Afaq, Saima and Alizadeh, Behrooz Z and Bertoni, Alain G and Bonnefond, Amelie and Bottcher, Yvonne and Bottinger, Erwin P and Campbell, Harry and Carlson, Olga D and Chen, Chien-Hsiun and Cho, Yoon Shin and Garvey, W. Timothy and Gieger, Christian and Goodarzi, Mark O and Grallert, Harald and Hamsten, Anders and Hartman, Catharina A and Herder, Christian and Hsiung, Chao Agnes and Huang, Jie and Igase, Michiya and Isono, Masato and Katsuya, Tomohiro and Khor, Chiea-Chuen and Kiess, Wieland and Kohara, Katsuhiko and Kovacs, Peter and Lee, Juyoung and Lee, Wen-Jane and Lehne, Benjamin and Li, Huaixing and Liu, Jianjun and Lobbens, Stephane and Luan, Jian'an and Lyssenko, Valeriya and Meitinger, Thomas and Miki, Tetsuro and Miljkovic, Iva and Moon, Sanghoon and Mulas, Antonella and Muller, Gabriele and ... and EPIC-CVD Consortium and EPIC-InterAct Consortium and Lifelines Cohort Study and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
PLoS medicine, ISSN 1549-1277, 2017, Volume 14, Issue 9, pp. e1002383 - e1002383
Journal Article
JAMA, ISSN 0098-7484, 12/2013, Volume 310, Issue 24, pp. 2658 - 2667
Journal Article
JAMA Surgery, ISSN 2168-6254, 07/2017, Volume 152, Issue 7, p. 707
Journal Article
by Fuchsberger, Christian and Flannick, Jason and Teslovich, Tanya M and Mahajan, Anubha and Agarwala, Vineeta and Gaulton, Kyle J and Ma, Clement and Fontanillas, Pierre and Moutsianas, Loukas and McCarthy, Davis J and Rivas, Manuel A and Perry, John R. B and Sim, Xueling and Blackwell, Thomas W and Robertson, Neil R and Rayner, N. William and Cingolani, Pablo and Locke, Adam E and Fernandez Tajes, Juan and Highland, Heather M and Dupuis, Josee and Chines, Peter S and Lindgren, Cecilia M and Hartl, Christopher and Jackson, Anne U and Chen, Han and Huyghe, Jeroen R and van de Bunt, Martijn and Pearson, Richard D and Kumar, Ashish and Müller-Nurasyid, Martina and Grarup, Niels and Stringham, Heather M and Gamazon, Eric R and Lee, Jaehoon and Chen, Yuhui and Scott, Robert A and Below, Jennifer E and Chen, Peng and Huang, Jinyan and Go, Min Jin and Stitzel, Michael L and Pasko, Dorota and Parker, Stephen C. J and Varga, Tibor V and Green, Todd and Beer, Nicola L and Day-Williams, Aaron G and Ferreira, Teresa and Fingerlin, Tasha and Horikoshi, Momoko and Hu, Cheng and Huh, Iksoo and Ikram, Mohammad Kamran and Kim, Bong-Jo and Kim, Yongkang and Kim, Young Jin and Kwon, Min-Seok and Lee, Juyoung and Lee, Selyeong and Lin, Keng-Han and Maxwell, Taylor J and Nagai, Yoshihiko and Wang, Xu and Welch, Ryan P and Yoon, Joon and Zhang, Weihua and Barzilai, Nir and Voight, Benjamin F and Han, Bok-Ghee and Jenkinson, Christopher P and Kuulasmaa, Teemu and Kuusisto, Johanna and Manning, Alisa and Ng, Maggie C. Y and Palmer, Nicholette D and Balkau, Beverley and Stancáková, Alena and Abboud, Hanna E and Boeing, Heiner and Gieaitis, Vilmantas and Prabhakaran, Dorairaj and Gottesman, Omri and Scott, James and Carey, Jason and Kwan, Phoenix and Grant, George and Smith, Joshua D and Neale, Benjamin M and Purcell, Shaun and Butterworth, Adam S and Howson, Joanna M. M and Lee, Heung Man and Lu, Yingchang and Kwak, Soo-Heon and Zhao, Wei and Danesh, John and Lam, Vincent K. L and Park, Kyong Soo and Saleheen, Danish and ... and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Umeå universitet and Medicin
Nature, ISSN 0028-0836, 2016, Volume 536, Issue 7614, pp. 41 - +
Journal Article
by Mahajan, Anubha and Go, Min Jin and Zhang, Weihua and Below, Jennifer E and Gaulton, Kyle J and Ferreira, Teresa and Horikoshi, Momoko and Johnson, Anew D and Ng, Maggie C. Y and Prokopenko, Inga and Saleheen, Danish and Wang, Xu and Zeggini, Eleftheria and Abecasis, Goncalo R and Adair, Linda S and Almgren, Peter and Atalay, Mustafa and Aung, Tin and Baldassarre, Damiano and Balkau, Beverley and Bao, Yuqian and Barnett, Anthony H and Barroso, Ines and Basit, Abdul and Been, Latonya F and Beilby, John and Bell, Graeme I and Benediktsson, Rafn and Bergman, Richard N and Boehm, Bernhard O and Boerwinkle, Eric and Bonnycastle, Lori L and Burtt, Noël and Cai, Qiuyin and Campbell, Harry and Carey, Jason and Cauchi, Stephane and Caulfield, Mark and Chan, Juliana C. N and Chang, Li-Ching and Chang, Tien-Jyun and Chang, Yi-Cheng and Charpentier, Guillaume and Chen, Chien-Hsiun and Chen, Han and Chen, Yuan-Tsong and Chia, Kee-Seng and Chidambaram, Manickam and Chines, Peter S and Cho, Nam H and Cho, Young Min and Chuang, Lee-Ming and Collins, Francis S and Cornelis, Marilyn C and Couper, David J and Crenshaw, Anew T and van Dam, Rob M and Danesh, John and Das, Debashish and de Faire, Ulf and Dedoussis, George and Deloukas, Panos and Dimas, Antigone S and Dina, Christian and Doney, Alex S. F and Donnelly, Peter J and Dorkhan, Mozhgan and van Duijn, Cornelia and Dupuis, Josée and Edkins, Sarah and Elliott, Paul and Emilsson, Valur and Erbel, Raimund and Eriksson, Johan G and Escobedo, Jorge and Esko, Tonu and Eury, Elodie and Florez, Jose C and Fontanillas, Pierre and Forouhi, Nita G and Forsen, Tom and Fox, Caroline and Fraser, Ross M and Frayling, Timothy M and Froguel, Philippe and Frossard, Philippe and Gao, Yutang and Gertow, Karl and Gieger, Christian and Gigante, Bruna and Grallert, Harald and Grant, George B and Groop, Leif C and Groves, Christopher J and Grundberg, Elin and Guiducci, Candace and Hamsten, Anders and Han, Bok-Ghee and Hara, Kazuo and Hassanali, Neelam and ... and South Asian Type Diabet SAT2D Cons and DIAbet Genetics Replication & Meta and Mexican Amer Type 2 Diabet MAT2D C and Asian Genetic Epidemiology Network and Type 2 Diabet Genetic Exploration and South Asian Type 2 Diabetes (SAT2D) Consortium and Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium and Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Mexican American Type 2 Diabetes (MAT2D) Consortium and Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Molekylär medicin and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi
Nature genetics, ISSN 1061-4036, 2014, Volume 46, Issue 3, pp. 234 - 244
Journal Article
Journal of the American Statistical Association, ISSN 0162-1459, 10/2018, Volume 113, Issue 524, pp. 1411 - 1430
In clinical trials, placebo response can affect the inference about efficacy of the studied treatment. It is important to have a robust way to classify trial... 
Latent variable | Clinical trials | SPCD | EM algorithm | Placebo effect | MAXIMUM-LIKELIHOOD | CLINICAL-TRIALS | ENRICHMENT | DISORDERS | STATISTICS & PROBABILITY | TIME | Medical research | Inference | Classification
Journal Article
by Scott, Robert A and Scott, Laura J and Mägi, Reedik and Marullo, Letizia and Gaulton, Kyle J and Kaakinen, Marika and Pervjakova, Natalia and Pers, Tune H and Johnson, Anew D and Eicher, John D and Jackson, Anne U and Ferreira, Teresa and Lee, Yeji and Ma, Clement and Steinthorsdottir, Valgerdur and Thorleifsson, Gudmar and Qi, Lu and Van Zuydam, Natalie R and Mahajan, Anubha and Chen, Han and Almgren, Peter and Voight, Ben F and Grallert, Harald and Müller-Nurasyid, Martina and Ried, Janina S and Rayner, William N and Robertson, Neil and Karssen, Lennart C and van Leeuwen, Elisabeth M and Willems, Sara M and Fuchsberger, Christian and Kwan, Phoenix and Teslovich, Tanya M and Chanda, Pritam and Li, Man and Lu, Yingchang and Dina, Christian and Thuillier, Dorothee and Yengo, Loic and Jiang, Longda and Sparso, Thomas and Kestler, Hans A and Chheda, Himanshu and Eisele, Lewin and Gustafsson, Stefan and Frånberg, Mattias and Strawbridge, Rona J and Benediktsson, Rafn and Hreidarsson, Astradur B and Kong, Augustine and Sigurðsson, Gunnar and Kerrison, Nicola D and Luan, Jian'an and Liang, Liming and Meitinger, Thomas and Roden, Michael and Thorand, Barbara and Esko, Tõnu and Mihailov, Evelin and Fox, Caroline and Liu, Ching-Ti and Rybin, Denis and Isomaa, Bo and Lyssenko, Valeriya and Tuomi, Tiinamaija and Couper, David J and Pankow, James S and Grarup, Niels and Have, Christian T and Jørgensen, Marit E and Jørgensen, Torben and Linneberg, Allan and Cornelis, Marilyn C and van Dam, Rob M and Hunter, David J and Kraft, Peter and Sun, Qi and Edkins, Sarah and Owen, Katharine R and Perry, John Rb and Wood, Anew R and Zeggini, Eleftheria and Tajes-Fernandes, Juan and Abecasis, Goncalo R and Bonnycastle, Lori L and Chines, Peter S and Stringham, Heather M and Koistinen, Heikki A and Kinnunen, Leena and Sennblad, Bengt and Mühleisen, Thomas W and Nöthen, Markus M and Pechlivanis, Sonali and Baldassarre, Damiano and Gertow, Karl and Humphries, Steve E and Tremoli, Elena and Klopp, Norman and Meyer, Julia and Steinbach, Gerald and ... and Diabetes Genetics Replicat and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten and Stockholms universitet and Science for Life Laboratory (SciLifeLab)
Diabetes, ISSN 0012-1797, 11/2017, Volume 66, Issue 11, pp. 2888 - 2902
Journal Article
by Gaulton, Kyle J and Ferreira, Teresa and Lee, Yeji and Raimondo, Anne and Mägi, Reedik and Reschen, Michael E and Mahajan, Anubha and Locke, Adam and Rayner, N. William and Robertson, Neil and Scott, Robert A and Prokopenko, Inga and Scott, Laura J and Green, Todd and Sparso, Thomas and Thuillier, Dorothee and Yengo, Loic and Grallert, Harald and Wahl, Simone and Frånberg, Mattias and Strawbridge, Rona J and Kestler, Hans and Chheda, Himanshu and Eisele, Lewin and Gustafsson, Stefan and Steinthorsdottir, Valgerdur and Thorleifsson, Gudmar and Qi, Lu and Karssen, Lennart C and van Leeuwen, Elisabeth M and Willems, Sara M and Li, Man and Chen, Han and Fuchsberger, Christian and Kwan, Phoenix and Ma, Clement and Linderman, Michael and Lu, Yingchang and Thomsen, Soren K and Rundle, Jana K and Beer, Nicola L and van de Bunt, Martijn and Chalisey, Anil and Kang, Hyun Min and Voight, Benjamin F and Abecasis, Gonçalo R and Almgren, Peter and Baldassarre, Damiano and Balkau, Beverley and Benediktsson, Rafn and Blüher, Matthias and Boeing, Heiner and Bonnycastle, Lori L and Bottinger, Erwin P and Burtt, Noël P and Carey, Jason and Charpentier, Guillaume and Chines, Peter S and Cornelis, Marilyn C and Couper, David J and Crenshaw, Anew T and van Dam, Rob M and Doney, Alex S. F and Dorkhan, Mozhgan and Edkins, Sarah and Eriksson, Johan G and Esko, Tonu and Eury, Elodie and Fadista, João and Flannick, Jason and Fontanillas, Pierre and Fox, Caroline and Franks, Paul W and Gertow, Karl and Gieger, Christian and Gigante, Bruna and Gottesman, Omri and Grant, George B and Grarup, Niels and Groves, Christopher J and Hassinen, Maija and Have, Christian T and Herder, Christian and Holmen, Oddgeir L and Hreidarsson, Astradur B and Humphries, Steve E and Hunter, David J and Jackson, Anne U and Jonsson, Anna and Jørgensen, Marit E and Jørgensen, Torben and Kao, Wen-Hong L and Kerrison, Nicola D and Kinnunen, Leena and Klopp, Norman and Kong, Augustine and Kovacs, Peter and Kraft, Peter and Kravic, Jasmina and Langford, Cordelia and ... and DIAbet Genetics Replication Meta-A and the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten and Stockholms universitet and Science for Life Laboratory (SciLifeLab)
Nature genetics, ISSN 1061-4036, 2015, Volume 47, Issue 12, pp. 1415 - +
Journal Article
by Scott, Robert A and Lagou, Vasiliki and Welch, Ryan P and Wheeler, Eleanor and Montasser, May E and Luan, Jian'an and Mägi, Reedik and Strawbridge, Rona J and Rehnberg, Emil and Gustafsson, Stefan and Kanoni, Stavroula and Rasmussen-Torvik, Laura J and Yengo, Loïc and Lecoeur, Cecile and Shungin, Dmitry and Sanna, Serena and Sidore, Carlo and Johnson, Paul C. D and Jukema, J. Wouter and Johnson, Toby and Mahajan, Anubha and Verweij, Niek and Thorleifsson, Gudmar and Hottenga, Jouke-Jan and Shah, Sonia and Smith, Albert V and Sennblad, Bengt and Gieger, Christian and Salo, Perttu and Perola, Markus and Timpson, Nicholas J and Evans, David M and Pourcain, Beate St and Wu, Ying and Anews, Jeanette S and Hui, Jennie and Bielak, Lawrence F and Zhao, Wei and Horikoshi, Momoko and Navarro, Pau and Isaacs, Aaron and O'Connell, Jeffrey R and Stirrups, Kathleen and Vitart, Veronique and Hayward, Caroline and Esko, Tõnu and Mihailov, Evelin and Fraser, Ross M and Fall, Tove and Voight, Benjamin F and Raychaudhuri, Soumya and Chen, Han and Lindgren, Cecilia M and Morris, Anew P and Rayner, Nigel W and Robertson, Neil and Rybin, Denis and Liu, Ching-Ti and Beckmann, Jacques S and Willems, Sara M and Chines, Peter S and Jackson, Anne U and Kang, Hyun Min and Stringham, Heather M and Song, Kijoung and Tanaka, Toshiko and Peden, John F and Goel, Anuj and Hicks, Anew A and An, Ping and Müller-Nurasyid, Martina and Franco-Cereceda, Anders and Folkersen, Lasse and Marullo, Letizia and Jansen, Hanneke and Oldehinkel, Albertine J and Bruinenberg, Marcel and Pankow, James S and North, Kari E and Forouhi, Nita G and Loos, Ruth J. F and Edkins, Sarah and Varga, Tibor V and Hallmans, Göran and Oksa, Heikki and Antonella, Mulas and Nagaraja, Ramaiah and Trompet, Stella and Ford, Ian and Bakker, Stephan J. L and Kong, Augustine and Kumari, Meena and Gigante, Bruna and Herder, Christian and Munroe, Patricia B and Caulfield, Mark and Antti, Jula and Mangino, Massimo and Small, Kerrin and Miljkovic, Iva and ... and DIAbet Genetics Replication and DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium and Medicinska fakulteten and Institutionen för odontologi and Institutionen för folkhälsa och klinisk medicin and Näringsforskning and Umeå universitet and Medicin
Nature genetics, ISSN 1061-4036, 2012, Volume 44, Issue 9, pp. 991 - +
Journal Article