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Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2014, Volume 21, Issue 9, pp. 803 - 809
Journal Article
Blood, ISSN 0006-4971, 08/2015, Volume 126, Issue 6, pp. 779 - 789
Cereblon (CRBN), a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immunomodulatory drugs lenalidomide and... 
B-CELL LYMPHOMA | COMPLEX | IKAROS | PROTEIN EXPRESSION | GENE-EXPRESSION | C-MYC | LENALIDOMIDE | NON-HODGKINS-LYMPHOMA | HEMATOLOGY | T-CELLS | E3 UBIQUITIN LIGASE | RNA, Small Interfering - genetics | Peptide Hydrolases - genetics | Humans | Gene Expression Regulation, Neoplastic | Interferon Regulatory Factor-7 - genetics | Lymphoma, Large B-Cell, Diffuse - metabolism | Thalidomide - pharmacology | Ikaros Transcription Factor - genetics | Lentivirus - metabolism | Proteolysis - drug effects | Thalidomide - analogs & derivatives | Molecular Mimicry | T-Lymphocytes - metabolism | T-Lymphocytes - drug effects | Lentivirus - genetics | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Ikaros Transcription Factor - metabolism | Interferons - genetics | T-Lymphocytes - pathology | B-Lymphocytes - metabolism | Quinazolinones - pharmacology | Peptide Hydrolases - metabolism | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Piperidones - pharmacology | Interferon Regulatory Factor-7 - metabolism | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Piperidones - chemistry | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Interferons - metabolism | Mice | Quinazolinones - chemistry | Lymphoma, Large B-Cell, Diffuse - genetics | RNA, Small Interfering - metabolism | Lymphoid Neoplasia
Journal Article
British Journal of Haematology, ISSN 0007-1048, 01/2014, Volume 164, Issue 2, pp. 233 - 244
Journal Article
British Journal of Haematology, ISSN 0007-1048, 03/2016, Volume 172, Issue 6, pp. 889 - 901
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 1055 - 1055
Abstract Abstract 1055 Background: Cereblon (CRBN) is a component of the E3 ubiquitin ligase complex including CUL4A, DDB1, and ROC-1, and was found to be the... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 4043 - 4043
Abstract Abstract 4043 Background: Cereblon (CRBN), a component of the DDB1-CUL4A-Roc1 ubiquitin ligase complex, has been identified as a target of the... 
Journal Article
01/2016
Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such... 
HYGIENE | METALLURGY | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HETEROCYCLIC COMPOUNDS | HUMAN NECESSITIES
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