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by Wang, Mingxun and Carver, Jeremy J and Phelan, Vanessa V and Sanchez, Laura M and Garg, Neha and Peng, Yao and Nguyen, Don Duy and Watrous, Jeramie and Kapono, Clifford A and Luzzatto-Knaan, Tal and Porto, Carla and Bouslimani, Amina and Melnik, Alexey V and Meehan, Michael J and Liu, Wei-Ting and Crüsemann, Max and Boudreau, Paul D and Esquenazi, Eduardo and Sandoval-Calderón, Mario and Kersten, Roland D and Pace, Laura A and Quinn, Robert A and Duncan, Katherine R and Hsu, Cheng-Chih and Floros, Dimitrios J and Gavilan, Ronnie G and Kleigrewe, Karin and Northen, Trent and Dutton, Rachel J and Parrot, Delphine and Carlson, Erin E and Aigle, Bertrand and Michelsen, Charlotte F and Jelsbak, Lars and Sohlenkamp, Christian and Pevzner, Pavel and Edlund, Anna and McLean, Jeffrey and Piel, Jörn and Murphy, Brian T and Gerwick, Lena and Liaw, Chih-Chuang and Yang, Yu-Liang and Humpf, Hans-Ulrich and Maansson, Maria and Keyzers, Robert A and Sims, Amy C and Johnson, Andrew R and Sidebottom, Ashley M and Sedio, Brian E and Klitgaard, Andreas and Larson, Charles B and Boya, Cristopher A.P and Torres-Mendoza, Daniel and Gonzalez, David J and Silva, Denise B and Marques, Lucas M and Demarque, Daniel P and Pociute, Egle and O'Neill, Ellis C and Briand, Enora and Helfrich, Eric J. N and Granatosky, Eve A and Glukhov, Evgenia and Ryffel, Florian and Houson, Hailey and Mohimani, Hosein and Kharbush, Jenan J and Zeng, Yi and Vorholt, Julia A and Kurita, Kenji L and Charusanti, Pep and McPhail, Kerry L and Nielsen, Kristian Fog and Vuong, Lisa and Elfeki, Maryam and Traxler, Matthew F and Engene, Niclas and Koyama, Nobuhiro and Vining, Oliver B and Baric, Ralph and Silva, Ricardo R and Mascuch, Samantha J and Tomasi, Sophie and Jenkins, Stefan and Macherla, Venkat and Hoffman, Thomas and Agarwal, Vinayak and Williams, Philip G and Dai, Jingqui and Neupane, Ram and Gurr, Joshua and Rodríguez, Andrés M. C and Lamsa, Anne and Zhang, Chen and Dorrestein, Kathleen and Duggan, Brendan M and Almaliti, Jehad and Allard, Pierre-Marie and Phapale, Prasad and ...
Nature Biotechnology, ISSN 1087-0156, 09/2016, Volume 34, Issue 8, pp. 828 - 837
Journal Article
2009, 1. Aufl., Progress in inflammation research., ISBN 9783764386801, xi, 244
With the recent definition of the Th17 cell subset, a new paradigm in innate and adaptive immunity has been established. This book describes the function of... 
Treatment | Cytokines | T cells | Autoimmune diseases | Clinical & internal medicine | Allergology | Biomedicine | Immunology | Rheumatology | Infectious Diseases | Pharmacology/Toxicology | Cell Biology
Book
Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 91 - 97
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that... 
CELL LUNG-CANCER | MELANOMA | MICROENVIRONMENT | INTESTINAL MICROBIOTA | CYCLOPHOSPHAMIDE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | ANTITUMOR IMMUNITY | NIVOLUMAB | CD4 Antigens - immunology | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Gastrointestinal Microbiome - genetics | Fecal Microbiota Transplantation | Anti-Bacterial Agents - therapeutic use | Feces - microbiology | Metagenome - genetics | Neoplasms - therapy | Animals | Receptors, CCR - immunology | Interleukin-12 - immunology | Receptors, CXCR3 - immunology | T-Lymphocytes - immunology | Mice | Gastrointestinal Microbiome - immunology | Verrucomicrobia - genetics | Verrucomicrobia - immunology | Care and treatment | Cell receptors | Microbiota (Symbiotic organisms) | Immunotherapy | Epithelial tumors | Physiological aspects | Health aspects | Methods | Apoptosis | PD-1 protein | Lung | Interleukin | Microbiomes | Transplantation | Lymphocytes T | Anticancer properties | Microbiota | Lymphocytes | Bacteria | Feces | Supplementation | Gnotobiotics | Kidneys | Melanoma | Dietary supplements | Interleukin 12 | Abundance | CXCR3 protein | Patients | CD4 antigen | Immune checkpoint | Antibiotics | Flora | PD-L1 protein | Relative abundance | Antitumor activity | CCR9 protein | Tumors | Kidney transplantation | Cancer | Index Medicus | Life Sciences
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 859 - 870
The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates caspase-1 and mediates the release of interleukin 1β (IL-1β) and... 
NIH 3T3 Cells | Asthma - metabolism | Inflammasomes - metabolism | Oligonucleotide Array Sequence Analysis | NLR Family, Pyrin Domain-Containing 3 Protein | Interferon Regulatory Factors - metabolism | Gene Expression Profiling | Th2 Cells - immunology | Promoter Regions, Genetic - genetics | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Neoplasms, Experimental - immunology | Asthma - immunology | Neoplasms, Experimental - genetics | Trans-Activators - genetics | Female | Interleukin-4 - genetics | Carrier Proteins - immunology | Trans-Activators - immunology | Interleukin-4 - metabolism | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Interferon Regulatory Factors - genetics | Gene Expression Regulation, Neoplastic - immunology | Signal Transduction - genetics | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Th2 Cells - metabolism | Asthma - genetics | Blotting, Western | Inflammasomes - genetics | Mice, Knockout | Carrier Proteins - genetics | Cell Differentiation - immunology | Interleukin-4 - immunology | Interferon Regulatory Factors - immunology | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Neoplasms, Experimental - metabolism | Promoter Regions, Genetic - immunology | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 598 - 605
Complex interactions between the host and the gut microbiota govern intestinal homeostasis but remain poorly understood. Here we reveal a relationship between... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | ACTIVATION | ADAPTER PROTEIN CARD9 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERLEUKIN-22 | PREVALENCE | IDENTIFICATION | IL-22 | CELL BIOLOGY | RESPONSES | INFLAMMATORY-BOWEL-DISEASE | BACTERIAL-INFECTION | Humans | Inflammatory Bowel Diseases - immunology | Middle Aged | Colitis - pathology | Colon - immunology | Male | Gene Expression Profiling | Chromatography, High Pressure Liquid | Tryptophan - metabolism | CARD Signaling Adaptor Proteins - genetics | Young Adult | Colitis - chemically induced | Interleukins - immunology | Inflammatory Bowel Diseases - genetics | Adult | Female | Colitis - immunology | Cytokines - immunology | CARD Signaling Adaptor Proteins - immunology | Colon - pathology | Gastrointestinal Microbiome - genetics | Lactobacillus - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Fecal Microbiota Transplantation | Dextran Sulfate - toxicity | Mice, Knockout | Animals | Tryptophan - immunology | Adolescent | RNA, Ribosomal, 16S - genetics | Colon - microbiology | Mice | Gastrointestinal Microbiome - immunology | Receptors, Aryl Hydrocarbon - immunology | Inflammatory bowel diseases | Microbiota (Symbiotic organisms) | Physiological aspects | Tryptophan | Development and progression | Genetic aspects | Research | Risk factors | Care and treatment | Immune response | Analysis | Dosage and administration | Colitis | Health aspects | Inflammatory bowel disease | Microorganisms | Metabolism | Digestive system | Immune system | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 05/2014, Volume 349, Issue 2, pp. 209 - 220
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2013, Volume 19, Issue 1, pp. 57 - 64
Chemotherapeutic agents are widely used for cancer treatment. In addition to their direct cytotoxic effects, these agents harness the host's immune system,... 
MEDICINE, RESEARCH & EXPERIMENTAL | CANCER-CHEMOTHERAPY | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GEMCITABINE | BETA | CELL BIOLOGY | 5-FLUOROURACIL | INHIBITION | MICROENVIRONMENT | ANTITUMOR IMMUNITY | BEARING MICE | T-CELLS | Neoplasms - metabolism | Cell Proliferation | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cathepsin B - genetics | Humans | Caspase 1 - metabolism | Deoxycytidine - pharmacology | Signal Transduction - immunology | Neoplasms - genetics | RNA Interference | Female | Antineoplastic Agents - pharmacology | Interleukin-1beta - biosynthesis | Dendritic Cells - metabolism | bcl-2-Associated X Protein - genetics | Interleukin-17 - secretion | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Cathepsin B - metabolism | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Cell Line, Tumor | Fluorouracil - pharmacology | Mice | Mice, Inbred BALB C | RNA, Small Interfering | Receptors, Interleukin-1 - antagonists & inhibitors | Deoxycytidine - analogs & derivatives | Chemotherapy | Gemcitabine | Cathepsins | Physiological aspects | Dosage and administration | Research | Health aspects | Fluorouracil | Cancer | Cells | Inflammatory diseases | Tumors | Index Medicus | Engineering Sciences | Automatic
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 349, Issue 2, pp. 209 - 220
Journal Article
European Journal of Immunology, ISSN 0014-2980, 06/2011, Volume 41, Issue 6, pp. 1675 - 1686
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2013, Volume 123, Issue 2, pp. 700 - 711
Journal Article
Science, ISSN 0036-8075, 11/2013, Volume 342, Issue 6161, pp. 971 - 976
Journal Article