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1. Full Text Data Analysis with Competing Risks and Intermediate States. R. B. Geskus (2015). Texts in Statistical Science Series. Boca Raton, FL: Chapman & Hall/CRC. 277 pages, ISBN: 9781466570351
: Book review
by Saadati, Maral
Biometrical Journal, ISSN 0323-3847, 07/2016, Volume 58, Issue 4, pp. 995 - 995
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2. Full Text Statistical challenges of high-dimensional methylation data
: M. SAADATI AND A. BENNER
by Saadati, Maral and Benner, Axel
Statistics in Medicine, ISSN 0277-6715, 12/2014, Volume 33, Issue 30, pp. 5347 - 5357
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3. Statistical challenges of high-dimensional methylation data
by Saadati, Maral and Benner, Axel
Statistics in Medicine, ISSN 0277-6715, 12/2014, Volume 33, Issue 30, pp. 5347 - 5347
With the fast growing field of epigenetics comes the need to better understand the intricacies of DNA methylation data analysis. High-throughput profiling... 
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4. Full Text Joint Models for Longitudinal and Time-to-Event Data with Applications in R. Dimitris Rizopoulos (2012). Boca Raton: Chapman & Hall/CRC Texts in Statistical Science Series. 261 pages, ISBN: 978-1439872864
: Book review
by Saadati, Maral
Biometrical Journal, ISSN 0323-3847, 09/2013, Volume 55, Issue 5, pp. 816 - 817
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5. Full Text Telomerase activation by genomic rearrangements in high-risk neuroblastoma
by Peifer, Martin and Hertwig, Falk and Roels, Frederik and Dreidax, Daniel and Gartlgruber, Moritz and Menon, Roopika and Krämer, Andrea and Roncaioli, Justin L and Sand, Frederik and Heuckmann, Johannes M and Ikram, Fakhera and Schmidt, Rene and Ackermann, Sandra and Engesser, Anne and Kahlert, Yvonne and Vogel, Wenzel and Altmüller, Janine and Nürnberg, Peter and Thierry-Mieg, Jean and Thierry-Mieg, Danielle and Mariappan, Aruljothi and Heynck, Stefanie and Mariotti, Erika and Henrich, Kai-Oliver and Gloeckner, Christian and Bosco, Graziella and Leuschner, Ivo and Schweiger, Michal R and Savelyeva, Larissa and Watkins, Simon C and Shao, Chunxuan and Bell, Emma and Höfer, Thomas and Achter, Viktor and Lang, Ulrich and Theissen, Jessica and Volland, Ruth and Saadati, Maral and Eggert, Angelika and De Wilde, Bram and Berthold, Frank and Peng, Zhiyu and Zhao, Chen and Shi, Leming and Ortmann, Monika and Büttner, Reinhard and Perner, Sven and Hero, Barbara and Schramm, Alexander and Schulte, Johannes H and Herrmann, Carl and O'Sullivan, Roderick J and Westermann, Frank and Thomas, Roman K and Fischer, Matthias
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 700 - 704
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system(1). Roughly half of these tumours regress spontaneously or are cured by... 
TERT PROMOTER MUTATIONS | MELANOMA | GENE | ENHANCERS | LANDSCAPE | MULTIDISCIPLINARY SCIENCES | Chromatin - metabolism | Oncogene Proteins - genetics | Prognosis | Humans | Neuroblastoma - enzymology | RNA, Messenger - analysis | Infant | Risk | X-linked Nuclear Protein | DNA Methylation | Telomerase - genetics | Cell Transformation, Neoplastic - genetics | Recombination, Genetic - genetics | Telomerase - metabolism | N-Myc Proto-Oncogene Protein | Nuclear Proteins - genetics | DNA Helicases - genetics | Gene Expression Regulation, Neoplastic - genetics | Neuroblastoma - pathology | Chromosomes, Human, Pair 5 - genetics | Neuroblastoma - genetics | RNA, Messenger - genetics | Gene Silencing | Up-Regulation - genetics | Genome, Human - genetics | Neuroblastoma - classification | Cell Line, Tumor | Enhancer Elements, Genetic - genetics | Gene Amplification - genetics | Enzyme Activation - genetics | Chromatin - genetics | Translocation, Genetic - genetics | Genomics | Physiological aspects | Development and progression | Genetic aspects | Research | Neuroblastoma | Telomerase | Genes | Nervous system | Mutation | Kinases | Chromosomes | Tumors
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6. Full Text Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
by Reissfelder, Christoph and Stamova, Slava and Gossmann, Christina and Braun, Marion and Bonertz, Andreas and Walliczek, Ute and Grimm, Mario and Rahbari, Nuh N and Koch, Moritz and Saadati, Maral and Benner, Axel and Büchler, Markus W and Jäger, Dirk and Halama, Niels and Khazaie, Khashayarsha and Weitz, Jürgen and Beckhove, Philipp
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 739 - 751
The composition of tumor-targeted T cell infiltrates is a major prognostic factor in colorectal cancer (CRC) outcome; however, the functional role of these... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNE CELLS | METASTASIS | CELL RESPONSES | MEMORY | IMMUNOTHERAPY | CHEMOKINES | BONE-MARROW | TNF-ALPHA | BREAST | INFILTRATION | Physiological aspects | Prognosis | T cells | Properties | Analysis | Colorectal cancer | Studies | Antigens | Survival analysis | Cloning | Medical prognosis | Biomarkers | Cytotoxicity | Software | Patients | Tumors
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7. Full Text Biomarker discovery study of inflammatory proteins for colorectal cancer early detection demonstrated importance of screening setting validation
by Qian, Jing and Tikk, Kaja and Werner, Simone and Balavarca, Yesilda and Saadati, Maral and Hechtner, Marlene and Brenner, Hermann
Journal of Clinical Epidemiology, ISSN 0895-4356, 12/2018, Volume 104, pp. 24 - 34
Most studies identifying inflammatory markers for early detection of colorectal cancer (CRC) were conducted using clinically manifest cases. We aimed to... 
Biomarkers | Inflammation | Clinical setting | Early detection | Colorectal cancer | Screening setting | COLONOSCOPY | POSTTRAUMATIC-STRESS-DISORDER | MARKERS | RISK | SERUM | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | DNA | HEALTH CARE SCIENCES & SERVICES | BLOOD | Proteins | Algorithms | Oncology, Experimental | Diagnosis | Research | Epidemiology | Cancer | Colorectal carcinoma | Medical screening | Patients | Cancer therapies | Studies | Training | Screening | Sensitivity | Colonoscopy | Population | Bioindicators | Diagnostic systems
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8. Full Text Marginal variable screening for survival endpoints
by Edelmann, Dominic and Hummel, Manuela and Hielscher, Thomas and Saadati, Maral and Benner, Axel
Biometrical journal. Biometrische Zeitschrift, ISSN 0323-3847, 08/2019
When performing survival analysis in very high dimensions, it is often required to reduce the number of covariates using preliminary screening. During the last... 
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9. Full Text Analysis of prognostic factors in patients with newly diagnosed diffuse large B-cell lymphoma and skeletal involvement
by Lehners, Nicola and Krämer, Isabelle and Saadati, Maral and Benner, Axel and Ho, Anthony D and Witzens-Harig, Mathias
BMC Cancer, ISSN 1471-2407, 02/2017, Volume 17, Issue 1, p. 128
Background: Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this... 
Bone disease | Prognosis | Radiotherapy | Risk factors | Diffuse large B-cell lymphoma | PRIMARY BONE LYMPHOMA | EXTRANODAL LYMPHOMA | MANAGEMENT | R-CHOP | CLINICAL-FEATURES | LESIONS | BIOLOGICAL CHARACTERIZATION | HYPERCALCEMIA | ONCOLOGY | INDEX | RITUXIMAB ERA | Lymphoma, Large B-Cell, Diffuse - drug therapy | Follow-Up Studies | Lymphoma, Large B-Cell, Diffuse - pathology | Humans | Middle Aged | Male | Survival Rate | Bone Neoplasms - pathology | Young Adult | Hypercalcemia - physiopathology | Neoplasm Grading | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Aged, 80 and over | Adult | Female | Aged | Retrospective Studies
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10. Full Text Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models
by Zucknick, Manuela and Saadati, Maral and Benner, Axel
Biometrical Journal, ISSN 0323-3847, 11/2015, Volume 57, Issue 6, pp. 959 - 981
One important task in translational cancer research is the search for new prognostic biomarkers to improve survival prognosis for patients. The use of... 
ℓ1‐Penalized likelihood | Survival | Shrinkage | Penalized likelihood | REGRESSION | REGULARIZATION PATHS | STATISTICS & PROBABILITY | l-Penalized likelihood | VARIABLE SELECTION | PREDICTION | DISTRIBUTIONS | PROPORTIONAL HAZARDS MODEL | SURVIVAL-TIME DATA | COORDINATE DESCENT | MATHEMATICAL & COMPUTATIONAL BIOLOGY | LEUKEMIA | LIKELIHOOD | Prognosis | Biostatistics - methods | Humans | Bayes Theorem | Proportional Hazards Models | Clinical Trials as Topic | Gene Expression Profiling | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Models | Gene expression | Comparative analysis | Genomics
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11. Full Text Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models
: Comparison of frequentist and Bayesian Cox lasso
by Zucknick, Manuela and Saadati, Maral and Benner, Axel
Biometrical Journal, ISSN 0323-3847, 11/2015, Volume 57, Issue 6, pp. 959 - 981
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12. Full Text Applying stability selection to consistently estimate sparse principal components in high-dimensional molecular data
by Sill, Martin and Saadati, Maral and Benner, Axel
Bioinformatics, ISSN 1367-4803, 01/2015, Volume 31, Issue 16, pp. 2683 - 2690
Motivation: Principal component analysis (PCA) is a basic tool often used in bioinformatics for visualization and dimension reduction. However, it is known... 
MATRIX | SINGULAR-VALUE DECOMPOSITION | APPROXIMATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MODEL SELECTION | LASSO | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | RANK | VARIABLE SELECTION | ORACLE PROPERTIES | PCA | Databases, Genetic | Sample Size | Software | Principal Component Analysis - methods | Computer Simulation | Humans | Stability | Computer simulation | Consistency | Tools | Mathematical models | Gene expression | Estimates | Bioinformatics | Original Papers
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13. Full Text Prediction accuracy and variable selection for penalized cause‐specific hazards models
by Saadati, Maral and Beyersmann, Jan and Kopp‐Schneider, Annette and Benner, Axel
Biometrical Journal, ISSN 0323-3847, 03/2018, Volume 60, Issue 2, pp. 288 - 306
We consider modeling competing risks data in high dimensions using a penalized cause‐specific hazards (CSHs) approach. CSHs have conceptual advantages that are... 
competing risks | prediction | penalization | high‐dimensional data | high-dimensional data | REGRESSION | MULTISTATE MODELS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | STATISTICS & PROBABILITY | SUBDISTRIBUTION HAZARDS | REGULARIZATION | TO-EVENT DATA | Risk | Biometry - methods | Urinary Bladder Neoplasms - diagnosis | Humans | Proportional Hazards Models | Statistical models | Computer simulation | Data processing | Hazards | Models | Risk factors | Incidence
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14. Full Text Statistical challenges of high‐dimensional methylation data
by Saadati, Maral and Benner, Axel
Statistics in Medicine, ISSN 0277-6715, 12/2014, Volume 33, Issue 30, pp. 5347 - 5357
With the fast growing field of epigenetics comes the need to better understand the intricacies of DNA methylation data analysis. High‐throughput profiling... 
DNA methylation | beta regression | univariate screening | logit transformation | rank‐based regression | Rank-based regression | Logit transformation | Univariate screening | Beta regression | MEDICINE, RESEARCH & EXPERIMENTAL | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MEDICAL INFORMATICS | rank-based regression | MATHEMATICAL & COMPUTATIONAL BIOLOGY | REGRESSION COEFFICIENTS | STATISTICS & PROBABILITY | Regression Analysis | DNA Methylation | Data Interpretation, Statistical | Epigenomics | Computer Simulation | Humans | Statistics, Nonparametric | Biometry - methods | Methylation | Epigenetic inheritance | Analysis
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15. Full Text Integrative genome-scale analysis identifies epigenetic mechanisms of transcriptional deregulation in unfavorable neuroblastomas
by Henrich, Kai-Oliver and Bender, Sebastian and Saadati, Maral and Dreidax, Daniel and Gartlgruber, Moritz and Shao, Chunxuan and Herrmann, Carl and Wiesenfarth, Manuel and Parzonka, Martha and Wehrmann, Lea and Fischer, Matthias and Duffy, David J and Bell, Emma and Torkov, Alica and Schmezer, Peter and Plass, Christoph and Höfer, Thomas and Benner, Axel and Pfister, Stefan M and Westermann, Frank
Cancer Research, ISSN 0008-5472, 09/2016, Volume 76, Issue 18, pp. 5523 - 5537
The broad clinical spectrum of neuroblastoma ranges from spontaneous regression to rapid progression despite intensive multimodal therapy. This diversity is... 
ISLAND METHYLATOR PHENOTYPE | MYCN | DNA METHYLATION | ONCOLOGY | THERAPEUTIC TARGET | GENE-EXPRESSION | CELL SIGNATURE | PROGNOSTIC-SIGNIFICANCE | CANCER | REVEALS | EZH2 | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Humans | Neuroblastoma - genetics | Kaplan-Meier Estimate | Transcriptome | Child, Preschool | N-Myc Proto-Oncogene Protein - genetics | Infant | Male | DNA Methylation - genetics | Neuroblastoma - mortality | Young Adult | Chromatin Immunoprecipitation | Epigenesis, Genetic - genetics | Adolescent | Cell Line, Tumor | Female | Transcription, Genetic | High-Throughput Nucleotide Sequencing | Child | Infant, Newborn | Neuroblastoma - pathology | Cluster Analysis
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16. Full Text Erratum: Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis (Journal of Clinical Investigation (2015) 125: 2 (739-751) DOI: 10.1172/JCI74894)
by Reissfelder, Christoph and Stamova, Slava and Gossmann, Christina and Braun, Marion and Bonertz, Andreas and Walliczek, Ute and Grimm, Mario and Rahbari, Nuh N and Koch, Moritz and Saadati, Maral and Benner, Axel and Büchler, Markus W and Jäger, Dirk and Halama, Niels and Khazaie, Khashayarsha and Weitz, Jürgen and Beckhove, Philipp
Journal of Clinical Investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, p. 1364
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17. Full Text Corrigendum. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
by Reissfelder, Christoph and Stamova, Slava and Gossmann, Christina and Braun, Marion and Bonertz, Andreas and Walliczek, Ute and Grimm, Mario and Rahbari, Nuh N and Koch, Moritz and Saadati, Maral and Benner, Axel and Büchler, Markus W and Jäger, Dirk and Halama, Niels and Khazaie, Khashayarsha and Weitz, Jürgen and Beckhove, Philipp
The Journal of clinical investigation, 03/2015, Volume 125, Issue 3, p. 1364
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18. Full Text Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
by Reissfelder, Christoph and Stamova, Slava and Gossmann, Christina and Braun, Marion and Bonertz, Andreas and Walliczek, Ute and Grimm, Mario and Rahbari, Nuh N and Koch, Moritz and Saadati, Maral and Benner, Axel and Büchler, Markus W and Jäger, Dirk and Halama, Niels and Khazaie, Khashayarsha and Weitz, Jürgen and Beckhove, Philipp
The Journal of clinical investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 739 - 751
The composition of tumor-targeted T cell infiltrates is a major prognostic factor in colorectal cancer (CRC) outcome; however, the functional role of these... 
Colorectal Neoplasms - mortality | CD8-Positive T-Lymphocytes - pathology | Prospective Studies | Follow-Up Studies | Humans | Neoplasm Proteins - immunology | Gene Expression Regulation, Neoplastic - immunology | Male | Survival Rate | Disease-Free Survival | Colorectal Neoplasms - immunology | Tumor Necrosis Factor-alpha - immunology | Female | Retrospective Studies | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology
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19. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
by Reissfelder, Christoph and Stamova, Slava and Gossmann, Christina and Braun, Marion and Bonertz, Andreas and Walliczek, Ute and Grimm, Mario and Rahbari, Nuh N and Koch, Moritz and Saadati, Maral and Benner, Axel and Buechler, Markus W and Jaeger, Dirk and Halama, Niels and Khazaie, Khashayarsha and Weitz, Juergen and Beckhove, Philipp
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 739 - 739
The composition of tumor-targeted T cell infiltrates is a major prognostic factor in colorectal cancer (CRC) outcome; however, the functional role of these... 
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20. Full Text p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomas
by Dreidax, Daniel and Bannert, Steffen and Henrich, Kai-Oliver and Schröder, Christina and Bender, Sebastian and Oakes, Christopher C and Lindner, Sven and Schulte, Johannes H and Duffy, David and Schwarzl, Thomas and Saadati, Maral and Ehemann, Volker and Benner, Axel and Pfister, Stefan and Fischer, Matthias and Westermann, Frank
Human molecular genetics, ISSN 0964-6906, 12/2014, Volume 23, Issue 25, pp. 6826 - 6837
Uncontrolled cell cycle entry, resulting from deregulated CDK-RB1-E2F pathway activity, is a crucial determinant of neuroblastoma cell malignancy. Here we... 
ISLAND METHYLATOR PHENOTYPE | HIGH-THROUGHPUT ANALYSIS | APOPTOSIS | INCREASED EXPRESSION | INK4 FAMILY | PATHWAY | POOR-PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | GENETICS & HEREDITY | D-DEPENDENT KINASES | MICE LACKING | Neurons - pathology | Oncogene Proteins - genetics | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Child, Preschool | Infant | Male | Neuroblastoma - mortality | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | N-Myc Proto-Oncogene Protein | Neurons - metabolism | Neurons - drug effects | Nuclear Proteins - genetics | Child | Infant, Newborn | Neuroblastoma - pathology | Tretinoin - pharmacology | Cyclin-Dependent Kinase Inhibitor p19 - genetics | Nervous System Neoplasms - mortality | Signal Transduction | Neuroblastoma - genetics | Oncogene Proteins - metabolism | Azacitidine - analogs & derivatives | Nuclear Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p19 - metabolism | Azacitidine - pharmacology | Cell Differentiation - drug effects | Adolescent | Survival Analysis | Cell Line, Tumor | Nervous System Neoplasms - genetics | Neuroblastoma - metabolism | Neoplasm Staging | Nervous System Neoplasms - metabolism | DNA Methylation - drug effects | Nervous System Neoplasms - pathology
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