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by Li, B and Saba, JD
TRANSLATIONAL CANCER RESEARCH, ISSN 2218-676X, 08/2018, Volume 7, Issue S7, pp. S810 - S812
Journal Article
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 03/2019, Volume 60, Issue 3, pp. 456 - 463
Sphingosine phosphate lyase (SPL) is the final enzyme in the sphingolipid degradative pathway, catalyzing the irreversible cleavage of long-chain base... 
HOMEOSTASIS | sphingosine phosphate lyase insufficiency syndrome | sphingolipids | ADRENAL INSUFFICIENCY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SACCHAROMYCES-CEREVISIAE | DEFICIENCY | SGPL1 | SPHINGOSINE-1-PHOSPHATE LYASE | INHIBITION | METABOLISM | DEGRADATION | sphingosine-1-phosphate | NEPHROTIC SYNDROME | EXPRESSION
Journal Article
Clinical and Experimental Gastroenterology, 06/2014, Volume 7, Issue 1, pp. 205 - 214
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2017, Volume 127, Issue 3, pp. 912 - 928
Journal Article
Translational Cancer Research, ISSN 2218-676X, 10/2015, Volume 4, Issue 5, pp. 469 - 483
Journal Article
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2010, Volume 688, pp. 185 - 205
Conference Proceeding
Advances in Biological Regulation, ISSN 2212-4926, 2012, Volume 52, Issue 1, pp. 17 - 30
Sphingosine phosphate lyase (SPL) is an intracellular enzyme responsible for the irreversible catabolism of the lipid signaling molecule... 
Models, Theoretical | Phosphorylation | Animals | Models, Biological | Humans | Aldehyde-Lyases - metabolism | Sphingolipids - metabolism | Phosphates | Platelet-derived growth factor | Stem cells | Sphingosine | S1P lyase | apoptosis | sphingosine-1-phosphate | hexadecenal | signal transduction | sphingolipids
Journal Article
Nature Medicine, ISSN 1078-8956, 05/2015, Volume 21, Issue 5, pp. 424 - 426
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2010, Volume 6, Issue 9, pp. 689 - 689
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2010, Volume 6, Issue 9, pp. 689 - 689
Journal Article
Translational cancer research, ISSN 2218-676X, 10/2015, Volume 4, Issue 5, p. 469
Colitis-associated colon cancer (CAC) is a pathological condition defined by the development of colon cancer in patients afflicted by Crohn's disease (CD) or... 
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 2010, Volume 6, Issue 9, p. 689
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 6, pp. 724 - 734
ABSTRACT—Sphingosine 1-phosphate (S1P), an evolutionarily conserved bioactive lipid mediator, is now recognized as a potent modulator of cell regulation. In... 
Sphingolipid mediators | Sphingosine kinase | Sphingosine 1-phosphate lyase | Sphingosine 1-phosphate receptors | Sphingosine 1-phosphate phosphatase | NOVO CERAMIDE SYNTHESIS | sphingosine 1-phosphate lyase | CARDIAC & CARDIOVASCULAR SYSTEMS | sphingosine kinase | LIPID PHOSPHATE PHOSPHATASES | LOW-DENSITY-LIPOPROTEIN | SACCHAROMYCES-CEREVISIAE | sphingosine 1-phosphate receptors | HUMAN ENDOTHELIAL-CELLS | LONG-CHAIN BASES | SPHINGOLIPID METABOLISM | SPHINGOSINE-1-PHOSPHATE LYASE | sphingolipid mediators | PROTEIN-COUPLED RECEPTOR | sphingosine 1-phosphate phosphatase | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Lysophospholipids - metabolism | Cardiovascular Diseases - metabolism | Muscle, Smooth, Vascular - metabolism | Receptors, G-Protein-Coupled - metabolism | Species Specificity | Humans | Invertebrates - metabolism | Receptors, Lysophospholipid | Fungi - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Plants - metabolism | Sphingosine - analogs & derivatives | Animals | Cardiovascular System - metabolism | Endothelium, Vascular - metabolism | Myocardium - metabolism | Aldehyde-Lyases - metabolism | Second Messenger Systems - physiology | Membrane Proteins - metabolism | Sphingosine - metabolism | Phosphoric Monoester Hydrolases - metabolism | Receptors, G-Protein-Coupled - drug effects | Vertebrates - metabolism | Receptors, G-Protein-Coupled - physiology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5368 - 5384
Growing evidence supports a link between inflammation and cancer; however, mediators of the transition between inflammation and carcinogenesis remain... 
INTESTINAL INFLAMMATION | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | SPHINGOSINE KINASE 1 | EPITHELIAL-CELLS | GENE | INDUCED COLITIS | CELL-PROLIFERATION | PERSISTENT STAT3 ACTIVATION | CANCER | Lysophospholipids - metabolism | Colonic Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Aldehyde-Lyases - biosynthesis | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | Inflammatory Bowel Diseases - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Neoplasms, Experimental - pathology | Cell Transformation, Neoplastic - genetics | Gene Deletion | Inflammatory Bowel Diseases - genetics | Neoplasms, Experimental - genetics | Sphingosine - metabolism | Aldehyde-Lyases - genetics | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Mice, Transgenic | Signal Transduction - genetics | Anion Transport Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Gene Expression Regulation, Enzymologic | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Animals | Biopsy | Colonic Neoplasms - pathology | RNA, Neoplasm - genetics | Sphingosine - genetics | Mice | MicroRNAs - genetics | Neoplasms, Experimental - metabolism | Anion Transport Proteins - genetics | Colon cancer | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Lyases | Research | Inflammatory bowel disease | Medical research | Kinases | Rodents | Colorectal cancer | Index Medicus | Abridged Index Medicus
Journal Article