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humans (6) 6
index medicus (6) 6
dna methylation (4) 4
glioma - genetics (4) 4
abstracts (3) 3
abstracts from the 20th annual scientific meeting of the society for neuro-oncology (3) 3
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biochemistry & molecular biology (3) 3
cancer (3) 3
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mutation (3) 3
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cells (2) 2
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1. Full Text TCGAbiolinks: An R/Bioconductor package for integrative analysis of TCGA data
by Colaprico, Antonio and Silva, Tiago C and Olsen, Catharina and Garofano, Luciano and Cava, Claudia and Garolini, Davide and Sabedot, Thais S and Malta, Tathiane M and Pagnotta, Stefano M and Castiglioni, Isabella and Ceccarelli, Michele and Bontempi, Gianluca and Noushmehr, Houtan
Nucleic Acids Research, ISSN 0305-1048, 05/2016, Volume 44, Issue 8, pp. e71 - e71
The Cancer Genome Atlas (TCGA) research network has made public a large collection of clinical and molecular phenotypes of more than 10 000 tumor patients... 
CANCER GENOMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SOMATIC GENOMIC LANDSCAPE | SOFTWARE | BIOCONDUCTOR | Computational Biology - methods | Humans | Databases, Genetic | Neoplasms - classification | DNA Methylation - genetics | Statistics as Topic - methods | Genome, Human - genetics | BRCA1 Protein - genetics | Neoplasms - genetics | Biomarkers, Tumor - genetics | Genomics - methods | BRCA2 Protein - genetics | Data Mining - methods | Methods Online
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2. Full Text Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
by Ceccarelli, Michele and Barthel, Floris P and Malta, Tathiane M and Sabedot, Thais S and Salama, Sofie R and Murray, Bradley A and Morozova, Olena and Newton, Yulia and Radenbaugh, Amie and Pagnotta, Stefano M and Anjum, Samreen and Wang, Jiguang and Wang, Zhining and Manyam, Ganiraju and Zoppoli, Pietro and Ling, Shiyun and Rao, Arvind and Rao, Arjun A and Rao, Ganesh and Grifford, Mia and Cherniack, Andrew D and Zhang, Wei and Zhang, Jiashan and Zhang, Jianhua and Zhang, Hailei and Poisson, Laila and Carlotti, Carlos Gilberto and Tirapelli, Daniela Pretti da Cunha and Mikkelsen, Tom and Lau, Ching C and Yung, W.K. Alfred and Rabadan, Raul and Huse, Jason and Brat, Daniel J and Lehman, Norman L and Barnholtz-Sloan, Jill S and Zheng, Siyuan and Hess, Kenneth and Meyerson, Matthew and Beroukhim, Rameen and Cooper, Lee and Akbani, Rehan and Wrensch, Margaret and Haussler, David and Aldape, Kenneth D and Laird, Peter W and Gutmann, David H and Arachchi, Harindra and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Barnett, Gene and Baylin, Stephen and Bell, Sue and Benz, Christopher and Bir, Natalie and Black, Keith L and Bodenheimer, Tom and Boice, Lori and Bootwalla, Moiz S and Bowen, Jay and Bristow, Christopher A and Butterfield, Yaron S.N and Chen, Qing-Rong and Chin, Lynda and Cho, Juok and Chuah, Eric and Chudamani, Sudha and Coetzee, Simon G and Cohen, Mark L and Colman, Howard and Couce, Marta and D’Angelo, Fulvio and Davidsen, Tanja and Davis, Amy and Demchok, John A and Devine, Karen and Ding, Li and Duell, Rebecca and Elder, J. Bradley and Eschbacher, Jennifer M and Fehrenbach, Ashley and Ferguson, Martin and Frazer, Scott and Fuller, Gregory and Fulop, Jordonna and Gabriel, Stacey B and Garofano, Luciano and Gastier-Foster, Julie M and Gehlenborg, Nils and Gerken, Mark and Getz, Gad and Giannini, Caterina and Gibson, William J and Hadjipanayis, Angela and Hayes, D. Neil and Heiman, David I and Hermes, Beth and Hilty, Joe and Hoadley, Katherine A and ... and TCGA Res Network and TCGA Research Network
Cell, ISSN 0092-8674, 01/2016, Volume 164, Issue 3, pp. 550 - 563
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification.... 
CELLS | TERT PROMOTER MUTATIONS | GRADE II | GLIOBLASTOMA | IDH1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOMIC ANALYSIS | PILOCYTIC ASTROCYTOMA | EXPRESSION | CANCER | BRAIN-TUMORS | CELL BIOLOGY | Promoter Regions, Genetic | Cell Proliferation | Signal Transduction | Epigenesis, Genetic | Humans | Middle Aged | Brain Neoplasms - pathology | Transcriptome | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | X-linked Nuclear Protein | Telomere | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | DNA Methylation | Telomerase - genetics | Glioma - pathology | Adult | Mutation | Nuclear Proteins - genetics | DNA Helicases - genetics | Cluster Analysis | Genetic research | Development and progression | Methylation | Gliomas | Analysis | Genomics
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3. Full Text Abstract 2413: SIRT1 regulatesMxd1throughout melanoma progression
by Meliso, Fabiana M and Micali, Danilo and Silva, Camila T and Sabedot, Thais S and Coetzee, Simon G and Koch, Adrian and Fahlbusch, Fabian B and Noushmehr, Houtan and Schneider-Stock, Regine and Jasiulionis, Miriam G
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 2413 - 2413
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4. Full Text Glioma CpG island methylator phenotype (G-CIMP): Biological and clinical implications
by Malta, Tathiane M and De Souza, Camila F and Sabedot, Thais S and Silva, Tiago C and Mosella, Maritza S and Kalkanis, Steven N and Snyder, James and Castro, Ana Valeria B and Noushmehr, Houtan
Neuro-Oncology, ISSN 1522-8517, 04/2018, Volume 20, Issue 5, pp. 608 - 620
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical properties. Despite advances in surgical techniques and clinical... 
CpG island methylator phenotype (CIMP) | DNA methylation | molecular subtypes | G-CIMP (glioma-CIMP) | IDH mutation | glioma progression | IDH2 MUTATIONS | SOLID TUMORS | INTEGRATED GENOMIC ANALYSIS | CANCER GENOME | MGMT PROMOTER METHYLATION | OLIGODENDROGLIAL TUMORS | PREDICTIVE-VALUE | CLINICAL NEUROLOGY | MOLECULAR CLASSIFICATION | ONCOLOGY | GRADE GLIOMAS | Glioma - genetics | DNA Methylation | Phenotype | Epigenomics | Glioma - pathology | Humans | CpG Islands | Mutation | Genome, Human | Reviews | Editor's Choice
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5. Full Text RGBM: regularized gradient boosting machines for identification of the transcriptional regulators of discrete glioma subtypes
by Mall, Raghvendra and Cerulo, Luigi and Garofano, Luciano and Frattini, Veronique and Kunji, Khalid and Bensmail, Halima and Sabedot, Thais S and Noushmehr, Houtan and Lasorella, Anna and Iavarone, Antonio and Ceccarelli, Michele
Nucleic Acids Research, ISSN 0305-1048, 04/2018, Volume 46, Issue 7, pp. e39 - e39
Abstract We propose a generic framework for gene regulatory network (GRN) inference approached as a feature selection problem. GRNs obtained using Machine... 
PATHWAYS | GENE-EXPRESSION DATA | BAYESIAN NETWORKS | L-CURVE | RECONSTRUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALGORITHM | LASSO | FUSIONS | NETWORK INFERENCE | POSED PROBLEMS | Glioma - genetics | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Algorithms | Gene Regulatory Networks - genetics | Glioma - classification | Microtubule-Associated Proteins - genetics | Nucleotide Motifs - genetics | Glioma - pathology | Humans | Transcription Factors - genetics | Machine Learning | Gene Expression Regulation, Neoplastic - genetics | Methods Online
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6. Full Text GENE-58. ACTIVE TRANSCRIPTION START SITES OF MENINGIOMA SAMPLES ASSOCIATED WITH RISK OF RECURRENCE
by Malta, Tathiane and Sarraf Sabedot, Thais and Carlotti jr, Carlos and Noushmehr, Houtan
Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi110 - vi110
Abstract Meningiomas are mostly benign brain tumors but have a substantial risk of recurrence, sometimes to more aggressive subtypes. Recently, a DNA... 
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7. Full Text Metabolic Reprogramming Associated with Aggressiveness Occurs in the G-CIMP-High Molecular Subtypes of IDH1mut Lower Grade Gliomas
by Victor, Ruiz-Rodado and Malta, Tathiane M and Seki, Tomohiro and Lita, Adrian and Dowdy, Tyrone and Celiku, Orieta and Cavazos-Saldana, Alejandra and Li, Aiguo and Liu, Yang and Han, Sue and Zhang, Wei and Song, Hua and Davis, Dionne and Lee, Sunmin and Trepel, Jane B and Sabedot, Thais S and Munasinghe, Jeeva and Yang, Chunzhang and Herold-Mende, Christel and Gilbert, Mark R and Krishna Cherukuri, Murali and Noushmehr, Houtan and Larion, Mioara
Neuro-Oncology, ISSN 1522-8517, 10/2019
Abstract Background Early detection of increased aggressiveness of brain tumors is a major challenge in the field of neuro-oncology because of the inability of... 
Index Medicus
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8. Full Text A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence
by de Souza, Camila Ferreira and Sabedot, Thais S and Malta, Tathiane M and Stetson, Lindsay and Morozova, Olena and Sokolov, Artem and Laird, Peter W and Wiznerowicz, Maciej and Iavarone, Antonio and Snyder, James and deCarvalho, Ana and Sanborn, Zachary and McDonald, Kerrie L and Friedman, William A and Tirapelli, Daniela and Poisson, Laila and Mikkelsen, Tom and Carlotti, Carlos G and Kalkanis, Steven and Zenklusen, Jean and Salama, Sofie R and Barnholtz-Sloan, Jill S and Noushmehr, Houtan
Cell Reports, ISSN 2211-1247, 04/2018, Volume 23, Issue 2, pp. 637 - 651
Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have... 
intra-subtype heterogeneity | predictive biomarkers | G-CIMP-high | malignant transformation and recurrence | longitudinal gliomas | DNA methylation | G-CIMP-low | IDH mutation | stem cell-like glioblastoma | STEM-CELLS | GLIOBLASTOMA | IDH1 | INTEGRATED GENOMIC ANALYSIS | CENTRAL-NERVOUS-SYSTEM | MUTATIONS | RADIOTHERAPY | BRAIN | ADJUVANT TEMOZOLOMIDE | REVEALS | CELL BIOLOGY
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9. Full Text Detection of Glioma and Prognostic Subtypes by Noninvasive Circulating Cell-Free DNA Methylation Markers
by Lee, Ian Yu and Sabedot, Thais and Malta, Tathiane and Snyder, James and Wells, Michael and DeCarvalho, Ana and Mukherjee, Abir and Chitale, Dhananjay and Asmaro, Karam P and Robin, Adam M and Rosenblum, Mark L and Mikkelsen, Tom and Rock, Jack P and Poisson, Laila and Walbert, Tobias and Kalkanis, Steven N and Castro, Anavaleria and Noushmehr, Houtan
Neurosurgery, ISSN 0148-396X, 09/2019, Volume 66, Issue Supplement_1
Abstract INTRODUCTION Genome-wide DNA methylation profiling has shown that epigenetic abnormalities are biologically important in glioma and can be used to... 
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10. Full Text Candidate Regulatory Elements in Coding and Noncoding Regions are Associated With Invasive Behavior in Pituitary Tumors
by Asmaro, Karam P and Mosella, Maritza S and Wells, Michael and Sabedot, Thais and Malta, Tathiane and Nelson, Kevin and Snyder, James and DeCarvalho, Ana and Mukherjee, Abir and Chitale, Dhananjay and Aho, Todd and Robin, Adam M and Rosenblum, Mark L and Mikkelsen, Tom and Poisson, Laila and Lee, Ian Y and Walbert, Tobias and Bhan, Arti and Kalkanis, Steven N and Rock, Jack P and Noushmehr, Houtan and Castro, Anavaleria
Neurosurgery, ISSN 0148-396X, 09/2019, Volume 66, Issue Supplement_1
Abstract INTRODUCTION Unique genome-wide DNA methylation patterns have been shown to define pituitary tumors (PT) by functional subtypes and play a relevant... 
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11. Full Text A non-functional galanin receptor-2 in a multiple sclerosis patient
by Garcia-Rosa, Sheila and Trivella, Daniela Bb and Marques, Vanessa D and Serafim, Rodolfo B and Pereira, José Gc and Lorenzi, Julio Cc and Molfetta, Greice A and Christo, Paulo P and Olival, Guilherme S and Marchitto, Vania Bt and Brum, Doralina G and Sabedot, Thais S and Noushmehr, Houtan and Farias, Alessandro S and Santos, Leonilda Mb and Nogueira-Machado, José A and Souza, Jorge Es and Romano, Camila M and Conde, Rodrigo M and Santos, Antonio C and Guerreiro, Carlos T and Schreuder, Willem H and Gleber-Netto, Frederico O and Amorim, Maria and Valieris, Renan and Silva, Israel Tojal da and Silva, Wilson A and Nunes, Diana N and Oliveira, Paulo Sl and Valente, Valeria and Arruda, Maria Augusta and Hill, Stephen J and Barreira, Amilton A and Dias-Neto, Emmanuel
Pharmacogenomics Journal, ISSN 1470-269X, 02/2019, Volume 19, Issue 1, pp. 72 - 82
Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease that affects approximately 2.5 million people globally. Even though the etiology of MS... 
CELLS | INTERNALIZATION | ACTIVATION | PROTEIN | NEURITE OUTGROWTH | IN-VIVO | GENETICS & HEREDITY | NEURONS | PHARMACOLOGY & PHARMACY | KNOCKOUT MICE | EXPRESSION | INSIGHTS | Amino Acid Sequence | Cell Line | Humans | Multiple Sclerosis - genetics | Signal Transduction - genetics | Case-Control Studies | Young Adult | Phosphorylation - genetics | Base Sequence | HEK293 Cells | Polymorphism, Single Nucleotide - genetics | Receptor, Galanin, Type 2 - genetics | Adult | Female | Galanin - genetics | Multiple sclerosis | Care and treatment | Cell receptors | Development and progression | Genetic aspects | Single nucleotide polymorphisms | Health aspects | Phosphorylation | Nuclear magnetic resonance--NMR | G protein-coupled receptors | Transcription | Calcium | Galanin | Pathogenesis | Amino acids | Confocal microscopy | Ventricles (cerebral) | AKT protein | Hypothalamus | NF-AT protein | Gene sequencing | Proteins | Etiology | Recombinant | Neurodegenerative diseases | Blood cells | Environmental factors | Neurological diseases | Signaling | Magnetic resonance imaging | Microscopy | Internalization | Cell lines | Ventricle | Endosomes
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12. Full Text GENE-07. GENOMIC ENHANCER METHYLATION IS ASSOCIATED WITH BIOLOGICAL AND CLINICAL FEATURES IN PITUITARY TUMORS
by Mosella, Maritza and Malta, Tathiane and Sabedot, Thais and Felicella, Michelle and Aho, Todd and Poisson, Laila and deCarvalho, Ana and Snyder, James and Lee, Ian and Kalkanis, Steven and Walbert, Tobias and Noushmehr, Houtan and Rock, Jack and Castro, Ana Valeria
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi104 - vi104
Abstract The importance of enhancers has been recently highlighted in a pan-can transcriptomic analysis that revealed causal interaction between active... 
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13. Full Text GENE-13. GENOMIC FUNCTIONAL ENHANCERS DEFINE POTENTIAL TUMORIGENESIS OF G-CIMP-LOW (IDH-MUTANT ASTROCYTOMA) TUMORS INDEPENDENT OF PROMOTER METHYLATION
by Sabedot, Thais and deCarvalho, Ana and Poisson, Laila and Snyder, James and Walbert, Tobias and Lee, Ian and Kalkanis, Steven and Berman, Benjamin and Noushmehr, Houtan
Neuro-Oncology, ISSN 1522-8517, 11/2018, Volume 20, Issue suppl_6, pp. vi105 - vi105
Abstract Glioma CpG-island methylator phenotype (G-CIMP) is associated with IDH mutation and presents better clinical outcomes than for IDH wildtype gliomas.... 
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14. Full Text GENT-33. EPIGENETIC ALTERATIONS AT INTERGENIC REGIONS ASSOCIATED WITH PROGRESSION IN A SUBSET OF IDH MUTANT GLIOMAS
by Sabedot, Thais Sarraf and Malta, Tathiane and Ceccarelli, Michele and Dihn, Huy and Berman, Benjamin and Noushmehr, Houtan
Neuro-Oncology, ISSN 1522-8517, 11/2016, Volume 18, Issue suppl_6, pp. vi81 - vi81
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15. Full Text Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
by Brat, Daniel J and Verhaak, Roel G. W and Aldape, Kenneth D and Yung, W. K. Alfred and Salama, Sofie R and Cooper, Lee A. D and Rheinbay, Esther and Miller, C. Ryan and Vitucci, Mark and Morozova, Olena and Robertson, A. Gordon and Noushmehr, Houtan and Laird, Peter W and Cherniack, Andrew D and Akbani, Rehan and Huse, Jason T and Ciriello, Giovanni and Poisson, Laila M and Barnholtz-Sloan, Jill S and Berger, Mitchel S and Brennan, Cameron and Colen, Rivka R and Colman, Howard and Flanders, Adam E and Giannini, Caterina and Grifford, Mia and Iavarone, Antonio and Jain, Rajan and Joseph, Isaac and Kim, Jaegil and Kasaian, Katayoon and Mikkelsen, Tom and Murray, Bradley A and O'Neill, Brian Patrick and Pachter, Lior and Parsons, Donald W and Sougnez, Carrie and Sulman, Erik P and Vandenberg, Scott R and Van Meir, Erwin G and Von Deimling, Andreas and Zhang, Hailei and Crain, Daniel and Lau, Kevin and Mallery, David and Morris, Scott and Paulauskis, Joseph and Penny, Robert and Shelton, Troy and Sherman, Mark and Yena, Peggy and Black, Aaron and Bowen, Jay and Dicostanzo, Katie and Gastier-Foster, Julie and Leraas, Kristen M and Lichtenberg, Tara M and Pierson, Christopher R and Ramirez, Nilsa C and Taylor, Cynthia and Weaver, Stephanie and Wise, Lisa and Zmuda, Erik and Davidsen, Tanja and Demchok, John A and Eley, Greg and Ferguson, Martin L and Hutter, Carolyn M and Shaw, Kenna R. Mills and Ozenberger, Bradley A and Sheth, Margi and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean Claude and Ayala, Brenda and Baboud, Julien and Chudamani, Sudha and Jensen, Mark A and Liu, Jia and Pihl, Todd and Raman, Rohini and Wan, Yunhu and Wu, Ye and Ally, Adrian and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Baylin, Stephen B and Beroukhim, Rameen and Bootwalla, Moiz S and Bowlby, Reanne and Bristow, Christopher A and Brooks, Denise and Butterfield, Yaron and Carlsen, Rebecca and Carter, Scott and Chin, Lynda and Chu, Andy and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 26, pp. 2481 - 2498
The Cancer Genome Atlas consortium analyzed 293 lower-grade gliomas obtained from adult patients. The integration of genomic and clinical data shows that... 
MOLECULAR-GENETICS | MEDICINE, GENERAL & INTERNAL | TERT PROMOTER MUTATIONS | OLIGODENDROGLIOMA | LANDSCAPE | IDH1 | CLASSIFICATION | TUMORS | CHEMOTHERAPY | FREQUENT ATRX | 1P/19Q LOSS | Glioma - mortality | Signal Transduction | Humans | Middle Aged | Kaplan-Meier Estimate | Proportional Hazards Models | Male | Sequence Analysis, DNA | Glioma - metabolism | Glioma - genetics | Chromosomes, Human, Pair 19 | Genes, p53 | Chromosomes, Human, Pair 1 | Neoplasm Grading | Glioblastoma - genetics | Adolescent | Adult | Female | Aged | DNA, Neoplasm - analysis | Mutation | Cluster Analysis | Usage | Gene mutations | Gliomas | Analysis | Exome sequencing | Genetic aspects | Diagnosis | Research | Risk factors | Genomic analysis | Nucleotide sequence | Copy number | p53 Protein | Genomics | Glioblastoma | MiRNA | Gene expression | Glioma | DNA methylation | Cancer | Tumors | Statistical analysis | Brain cancer | Genomes | Cancer therapies | Consent | Medical prognosis | MicroRNAs | Classification | Deoxyribonucleic acid--DNA
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