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American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 6, pp. 706 - 718
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0182371
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 04/2017, Volume 312, Issue 4, pp. F748 - F759
Diabetic nephropathy (DN) remains an unmet medical challenge as its prevalence is projected to continue to increase and specific medicines for treatment remain... 
T-cells | Abatacept | CD80 | B7-1 | Diabetic nephropathy | CTLA4-Fc | Albuminuria | RHEUMATOID-ARTHRITIS | FIBROSIS | PHYSIOLOGY | MACROPHAGES | INJURY | RENAL-DISEASE | NEPHROPATHY | albuminuria | INFLAMMATION | UROLOGY & NEPHROLOGY | MICE | TYPE-2 DIABETES-MELLITUS | EXPRESSION | diabetic nephropathy | Abatacept - pharmacology | Kidney - pathology | Streptozocin | Humans | Kidney - immunology | Diabetic Nephropathies - drug therapy | Diabetic Nephropathies - immunology | Kidney - metabolism | Time Factors | T-Lymphocytes - drug effects | Diet, High-Fat | Diabetes Mellitus, Type 1 - chemically induced | Albuminuria - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Type 1 - immunology | Immunosuppressive Agents - pharmacology | Albuminuria - pathology | Collagen Type IV - metabolism | Cell Line | Diabetic Nephropathies - pathology | Kidney - drug effects | Podocytes - metabolism | B7-1 Antigen - immunology | Diabetic Nephropathies - metabolism | Mice, Inbred C57BL | B7-1 Antigen - metabolism | Diabetes Mellitus, Experimental - immunology | Animals | Podocytes - drug effects | Lymphocyte Activation - drug effects | Albuminuria - drug therapy | Podocytes - immunology | Albuminuria - immunology | T-Lymphocytes - immunology | Drug interactions | Diabetic nephropathies | Development and progression | Dosage and administration | Observations | T cells | Health aspects | Analysis | Antigens | T cell receptors | Diabetes | Medical treatment | Immune system
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, p. e0130648
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 2014, Volume 42, Issue 9, pp. 1401 - 1406
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2017, Volume 12, Issue 12, pp. 917 - 924
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
Physiological Reports, ISSN 2051-817X, 03/2017, Volume 5, Issue 5, pp. e13186 - n/a
Journal Article
Stem Cell Reports, ISSN 2213-6711, 2018, Volume 10, Issue 3, p. 1030
In vivo studies of human brain cellular function face challenging ethical and practical difficulties. Animal models are typically used but display distinct... 
Biological Sciences | Naturvetenskap | Biologiska vetenskaper | Natural Sciences | Cellbiologi | Cell Biology
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2004, Volume 499, Issue 1, pp. 53 - 65
Most previous studies of leukotriene B (LTB ) pharmacology using primary leukocyte cultures and myeloid cell lines do not differentiate between leukotriene BLT... 
Leukotriene B 4 | Fura-2 | Pharmacology | G-protein coupled receptor | Calcium | BLT 1 | BLT | Leukotriene B
Journal Article