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Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2014, Volume 33, Issue 14, pp. 1565 - 1581
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12667 - 12672
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2018, Volume 19, Issue 9, p. 2629
Cardiac diseases are among the most common causes of death globally. Cardiac muscle has limited proliferative capacity, and regenerative therapies are highly... 
Fibroblasts | Direct reprogramming | Cardiomyocytes | Gene therapy | Cardiac regeneration | TRANSCRIPTION FACTORS | DEFINED FACTORS | CARDIOMYOCYTE-LIKE CELLS | MYOCARDIAL-INFARCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | gene therapy | CHEMISTRY, MULTIDISCIPLINARY | cardiomyocytes | PLURIPOTENT STEM-CELLS | RAT HEARTS | cardiac regeneration | fibroblasts | IN-VITRO | direct reprogramming | FUNCTIONAL CARDIOMYOCYTES | GENE-EXPRESSION | HUMAN FIBROBLASTS | MEF2 Transcription Factors - genetics | GATA4 Transcription Factor - metabolism | Epigenesis, Genetic | Heart - physiology | Humans | Gene Expression Regulation | GATA4 Transcription Factor - genetics | T-Box Domain Proteins - genetics | T-Box Domain Proteins - metabolism | Cellular Reprogramming | Regeneration | Animals | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | Cell Differentiation | Fibroblasts - metabolism | Myocardial infarction | Heart | Transcription factors | Cell survival | Cardiac muscle | Gene transfer | Cytokines | Muscles | Recovery of function | Viruses | Gene expression | Coronary artery disease | Molecular modelling | Cardiac function | Fibrosis | Infarction | Heart diseases | Heart attacks | Cardiovascular disease | Efficiency | DNA methylation | Cardiology | Heart failure | Mortality | Medicine | Stem cells | Epigenetics | Pluripotency
Journal Article
Journal of Cardiology, ISSN 0914-5087, 02/2019, Volume 73, Issue 2, pp. 97 - 101
Cardiac muscle has limited proliferative capacity, and regenerative therapies are highly in demand as a new treatment strategy. Pharmacological and... 
Fibroblasts | Direct reprogramming | Regeneration | STEM-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCYTES | MOUSE | CARDIOMYOCYTES | INDUCTION | TRANSPLANTATION | REPAIR | ISCHEMIC CARDIOMYOPATHY | HUMAN FIBROBLASTS | Heart failure | Care and treatment | Usage | Research | Regenerative medicine
Journal Article
Journal Article
Journal of cardiology, 11/2018
Cardiac muscle has limited proliferative capacity, and regenerative therapies are highly in demand as a new treatment strategy. Pharmacological and... 
Journal Article
Circulation Research, ISSN 0009-7330, 10/2012, Volume 111, Issue 9, pp. 1147 - 1156
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A14428 - A14428
The mesoderm arises from pluripotent epiblasts and differentiates into multiple lineages; however, the underlying molecular mechanisms are unclear. Tbx6 is... 
Journal Article
Circulation, ISSN 0009-7322, 11/2018, Volume 138, Issue Suppl_1 Suppl 1, pp. A14577 - A14577
Introduction and HypothesisCardiac direct reprogramming is a technique to convert fibroblasts into induced cardiomyocyte-like cells (iCMs) by overexpressing... 
Journal Article
Regenerative Therapy, ISSN 2352-3204, 12/2019, Volume 11, pp. 95 - 100
Cardiovascular disease is the leading cause of death globally. Cardiomyocytes (CMs) have poor regenerative capacity, and pharmacological therapies have limited... 
Fibroblasts | Direct reprogramming | Regeneration | Cardiomyocytes | Pluripotent stem cells
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 08/2017, Volume 18, Issue 8, p. 1805
Direct reprogramming is a promising approach in regenerative medicine. Overexpression of the cardiac transcription factors Gata4, Mef2c, and Tbx5 (GMT) or GMT... 
Reprogramming | Fibroblast | Cardiomyocyte | Cell cycle | Doxycycline-inducible | TRANSCRIPTION FACTORS | MEF2C | cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | doxycycline-inducible | GATA4 | TBX5 | CHEMISTRY, MULTIDISCIPLINARY | FIBROBLASTS | reprogramming | PLURIPOTENT STEM-CELLS | HEART | fibroblast | cardiomyocyte | FUNCTIONAL CARDIOMYOCYTES | GENERATION | MEF2 Transcription Factors - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Transduction, Genetic | Doxycycline - chemistry | Humans | Tetracycline - pharmacology | GATA4 Transcription Factor - genetics | T-Box Domain Proteins - genetics | Genetic Vectors - genetics | Regenerative Medicine - trends | Gene Expression Regulation - drug effects | Cell Differentiation - genetics | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Trans-Activators - genetics | Transgenes - drug effects | Myocytes, Cardiac - metabolism | Doxycycline - pharmacology | Fibroblasts - cytology | Mice | Cellular Reprogramming - genetics | Fibroblasts - metabolism | Heart | Flow cytometry | Transcription factors | Genes | Fluorescence | Gene expression | Regeneration (physiology) | Polymerase chain reaction | Regeneration | Molecular modelling | DNA microarrays | Doxycycline | Fibroblasts | Transgenes | Heart diseases | Expression vectors
Journal Article
Journal of Neuroscience Methods, ISSN 0165-0270, 04/2019, Volume 317, pp. 149 - 156
The CRISPR/Cas9 technique has undergone many modifications to decrease the effort and shorten the time needed for efficient production of mutant mice. The use... 
Electroporation | CRISPR/Cas9 | Freeze-thawed embryos | Inbred strain | Knock-in | Knockout | RNA | GENE | MOUSE | BIOCHEMICAL RESEARCH METHODS | OOCYTES | NEUROSCIENCES | Embryonic development | Usage | Mice
Journal Article
International Journal of Cardiology, ISSN 0167-5273, 09/2013, Volume 168, Issue 2, pp. e74 - e75
Journal Article
Circulation Reports, ISSN 2434-0790, 11/2019
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 513, Issue 4, pp. 1041 - 1047
Cardiovascular disease is a leading cause of death worldwide. Mammalian cardiomyocytes (CMs) proliferate during embryonic development, whereas they largely... 
Regeneration | Tbx6 | AAV9 | Cardiomyocyte | Cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSDUCTION | IMPROVES CARDIAC-FUNCTION | GENE-TRANSFER SUPERIOR | FIBROBLASTS | BIOPHYSICS | CELL-CYCLE | MICE | EXPRESSION | VECTORS
Journal Article