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Trends in Molecular Medicine, ISSN 1471-4914, 02/2019, Volume 25, Issue 2, p. 74
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 02/2019, Volume 25, Issue 2, pp. 74 - 76
Recent studies revealed that cellular prion protein on neurons bind Alzheimer’s amyloid-β oligomers, causing neurotoxic effects. A new article in by Gunther... 
cellular prion protein | Alzheimer’s disease | amyloid-β oligomers | cognition | antagonist
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 08/2017, Volume 114, Issue 33, p. 8681
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 02/2019, Volume 25, Issue 2, pp. 74 - 76
Recent studies revealed that cellular prion protein on neurons bind Alzheimer's amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports... 
amyloid-β oligomers | cellular prion protein | cognition | Alzheimer's disease | antagonist | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMPAIRMENT | CELL BIOLOGY
Journal Article
Neuron, ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 296 - 302
Journal Article
Neuroscience Letters, ISSN 0304-3940, 10/2015, Volume 607, p. 97
* Brain pericytes express higher levels of PDGFR[beta] than arterial vascular smooth muscle cells. * Hypoxia and amyloid-[beta] (A[beta]) peptide lead to... 
Physiological aspects | Brain | Platelet-derived growth factor | Medical colleges | Nervous system diseases | Peptides | Permeability | Dementia | Endothelium
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 68, Issue 3, pp. 409 - 427
Journal Article
Brain Pathology, ISSN 1015-6305, 07/2014, Volume 24, Issue 4, pp. 371 - 386
Journal Article
Molecular Neurodegeneration, ISSN 1750-1326, 10/2018, Volume 13, Issue 1
Clearance at the blood-brain barrier (BBB) plays an important role in removal of Alzheimer's amyloid-[beta] (A[beta]) toxin from brain both in humans and... 
Blood-brain barrier | Amyloid beta-protein | Physiological aspects | Development and progression | Genetic aspects | Research | Alzheimer's disease
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4(1). APOE4 is a major genetic risk factor for Alzheimer's disease(2,3) and is associated with... 
OXIDATIVE STRESS | DEMENTIA | PROTEIN | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | COGNITIVE IMPAIRMENT | NEURODEGENERATION | MICE | APOE | BLOOD-BRAIN-BARRIER | EXPRESSION | Neurons - pathology | Apolipoprotein E4 - genetics | Apolipoproteins E - deficiency | Cerebrovascular Circulation - physiology | Humans | Blood-Brain Barrier - physiopathology | NF-kappa B - metabolism | Apolipoproteins E - metabolism | Microcirculation | Matrix Metalloproteinase 9 - metabolism | Apolipoprotein E2 - deficiency | Apolipoprotein E4 - deficiency | Apolipoprotein E3 - deficiency | Blood-Brain Barrier - physiology | Neurons - metabolism | Cyclophilin A - metabolism | Apolipoprotein E4 - metabolism | Neurodegenerative Diseases - pathology | Apolipoprotein E2 - genetics | Pericytes - metabolism | Mice, Transgenic | Hippocampus - pathology | Neurodegenerative Diseases - metabolism | Apolipoprotein E3 - metabolism | Apolipoprotein E2 - metabolism | Blood-Brain Barrier - drug effects | Cyclophilin A - antagonists & inhibitors | Hippocampus - metabolism | Apolipoprotein E3 - genetics | Animals | Apolipoproteins E - genetics | Mice | Cyclophilin A - deficiency | Cyclophilin | Brain cells | Physiological aspects | Development and progression | Apolipoproteins | Properties | Alzheimer's disease | Proteins | Studies | Rodents | Index Medicus
Journal Article
Nature reviews. Neurology, ISSN 1759-4758, 3/2018, Volume 14, Issue 3, pp. 133 - 150
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain microvessels that has sealed cell-to-cell contacts, and is sheathed by mural... 
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 03/2014, Volume 111, Issue 11, pp. E1035 - E1042
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 01/2013, Volume 33, Issue s1, pp. S87 - S100
The evidence that neurovascular dysfunction is an integral part of Alzheimers disease (AD) pathogenesis has continued to emerge in the last decade. Changes in... 
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 10/2012, Volume 136, Issue 1, p. 94
Low-density lipoprotein receptor-related protein-1 (LRP1) is the main cell surface receptor involved in brain and systemic clearance of the Alzheimer's disease... 
Low density lipoproteins | Physiological aspects | Health aspects | Alzheimer's disease
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2013, Volume 110, Issue 36, pp. 14771 - 14776
Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could... 
Quantification | Parenchyma | Homeostasis | Copper | Capillaries | Alzheimers disease | Potable water | Blood brain barrier | Endothelial cells | Blood plasma | BACE1 | Environmental | Cerebrovascular | BBB | Toxicity | toxicity | ALZHEIMERS-DISEASE BRAIN | environmental | MULTIDISCIPLINARY SCIENCES | BARRIER | cerebrovascular | PEPTIDE | PRION PROTEIN | SERUM COPPER | MOUSE MODEL | A-BETA | WILSONS-DISEASE | PRECURSOR-PROTEIN | CHOROID-PLEXUS | Age Factors | Humans | Capillaries - drug effects | Metabolic Clearance Rate | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | Time Factors | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Tumor Suppressor Proteins - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Copper - metabolism | Homeostasis - drug effects | Amyloid beta-Peptides - pharmacokinetics | Capillaries - metabolism | Cell Survival - drug effects | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Copper - pharmacology | Receptors, LDL - metabolism | Mice, Transgenic | Iodine Radioisotopes - pharmacokinetics | Blotting, Western | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Amyloid beta-Protein Precursor - genetics | Animals | Endothelial Cells - cytology | Mice | Endothelial Cells - drug effects | Index Medicus | Biological Sciences
Journal Article