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Journal of Biological Chemistry, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11980 - 11991
Vitamin B 12 (cobalamin (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is required for the function of the essential enzymes methionine synthase... 
ABCD4 | Molecular Bases of Disease | homology modeling | cblJ | fluorescence resonance energy transfer (FRET) | cblF | protein-protein interaction | vitamin B12 | inborn error of metabolism | LMBD1 | ABC transporter
Journal Article
Journal Article
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 02/2009, Volume 41, Issue 2, pp. 234 - 239
Vitamin B(12) (cobalamin) is essential in animals for metabolism of branched chain amino acids and odd chain fatty acids, and for remethylation of homocysteine... 
Vitamin B 12 Deficiency - etiology | Transcobalamins - genetics | Humans | Male | Methylmalonic Acid - metabolism | Proteins - isolation & purification | Tissue Distribution | Membrane Transport Proteins - deficiency | Membrane Transport Proteins - genetics | Transcobalamins - isolation & purification | Female | Membrane Transport Proteins - metabolism | Vitamin B 12 Deficiency - metabolism | Child | Methylmalonic Acid - urine | Chromosome Deletion | Lysosome-Associated Membrane Glycoproteins - metabolism | Nucleocytoplasmic Transport Proteins - physiology | Chromosome Mapping | Chromosomes, Human, Pair 6 | Nucleocytoplasmic Transport Proteins - genetics | Polymorphism, Genetic | Proteins - genetics | Nucleocytoplasmic Transport Proteins - metabolism | Proteins - metabolism | Transcobalamins - metabolism | Vitamin B 12 Deficiency - genetics | Hyperhomocysteinemia - genetics | HeLa Cells | Hyperhomocysteinemia - complications | Vitamin B 12 - metabolism | Medical research | Heart surgery | Genes | Vitamin B | Genetics | Medical screening | Chromosomes | Nucleocytoplasmic Transport Proteins | Biochemistry, Molecular Biology | Vitamin B 12 Deficiency | Proteins | Life Sciences | Membrane Transport Proteins | Transcobalamins | Vitamin B 12 | Hyperhomocysteinemia | Methylmalonic Acid | Lysosome-Associated Membrane Glycoproteins | Hela Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2001, Volume 98, Issue 13, pp. 7206 - 7211
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2012, Volume 109, Issue 50, pp. E3434 - E3443
Cystinosin, the lysosomal cystine exporter defective in cystinosis, is the founding member of a family of heptahelical membrane proteins related to... 
Lysosomal storage disease | Secondary active transporter | lysosomal storage disease | SHOTGUN PROTEOMICS | secondary active transporter | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL-CHARACTERIZATION | CONGENITAL DISORDER | NEPHROPATHIC CYSTINOSIS | SACCHAROMYCES-CEREVISIAE | MITOCHONDRIAL PYRUVATE CARRIER | GENE | ARGININE TRANSPORT | BATTEN-DISEASE | L-CANAVANINE | Amino Acid Transport Systems, Basic - genetics | Species Specificity | Saccharomyces cerevisiae - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | DNA, Complementary - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Cystinosis - drug therapy | Saccharomyces cerevisiae - metabolism | Base Sequence | Female | Genes, Fungal | Membrane Proteins - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Drosophila Proteins | DEAD-box RNA Helicases | Amino Acid Transport Systems, Basic - chemistry | Protein Structure, Secondary | Membrane Proteins - genetics | Oocytes - metabolism | Xenopus laevis | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Cystinosis - metabolism | Canavanine - metabolism | Amino Acid Motifs | Animals | Membrane Proteins - chemistry | Cysteamine - therapeutic use | Saccharomyces cerevisiae Proteins - metabolism | Vacuoles - metabolism | Electrophysiological Phenomena | Amino Acid Transport Systems, Basic - metabolism | Caenorhabditis elegans Proteins - genetics | Saccharomyces cerevisiae Proteins - chemistry | Life Sciences | Biochemistry, Molecular Biology | Genomics | Biological Sciences | PNAS Plus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 07/2017, Volume 292, Issue 28, pp. 11980 - 11991
Vitamin B-12 (cobalamin (Cbl)), in the cofactor forms methyl-Cbl and adenosyl-Cbl, is required for the function of the essential enzymes methionine synthase... 
ABCD4 | fluorescence resonance energy transfer (FRET) | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBCELLULAR-LOCALIZATION | FOLLOW-UP | inborn error of metabolism | BINDING CASSETTE PROTEIN | INBORN ERROR | GREEN FLUORESCENT PROTEIN | homology modeling | cblJ | vitamin B-12 | cblF | COENZYME B-12 | PEROXISOMAL MEMBRANE-PROTEIN | protein-protein interaction | ENDOPLASMIC-RETICULUM | LMBD1 | ABC transporter | METHYLMALONIC ACIDURIA | LIVING CELLS | Humans | Protein Multimerization | Lysosomes - enzymology | Recombinant Fusion Proteins - metabolism | ATP-Binding Cassette Transporters - deficiency | ATP-Binding Cassette Transporters - chemistry | Amino Acid Metabolism, Inborn Errors - metabolism | Lysosomes - metabolism | ATP-Binding Cassette Transporters - genetics | Amino Acid Metabolism, Inborn Errors - genetics | Nucleocytoplasmic Transport Proteins - chemistry | ATP-Binding Cassette Transporters - metabolism | Lysosomes - pathology | Protein Interaction Domains and Motifs | Amino Acid Metabolism, Inborn Errors - pathology | Catalytic Domain | Cells, Cultured | Metabolism, Inborn Errors - metabolism | Models, Molecular | Recombinant Fusion Proteins - chemistry | Metabolism, Inborn Errors - genetics | Nucleocytoplasmic Transport Proteins - genetics | Protein Transport | Nucleocytoplasmic Transport Proteins - metabolism | Luminescent Proteins - genetics | Protein Conformation | Molecular Docking Simulation | Nucleocytoplasmic Transport Proteins - deficiency | Structural Homology, Protein | HeLa Cells | Mutation | Metabolism, Inborn Errors - pathology | Vitamin B 12 - metabolism | Cell Line, Transformed | Amino Acid Substitution | Luminescent Proteins - metabolism | Life Sciences | Chemical Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 18, p. E3602
Lysosomes degrade cellular components sequestered by autophagy or extracellular material internalized by endocytosis and phagocytosis. The macromolecule... 
Biodegradation | Fractionation | Lysosomes | Amino acids | Biosynthesis | Selectivity | pH effects | Autophagy | Cytosol | Proteins | Degradation | Hydrolysis | Molecules | Gene silencing | Endocytosis | Sodium | Asparagine | Localization | Transporter | Phagocytosis | Cancer | Glutamine
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 14, pp. 11489 - 11497
Secondary active transporters from the SLC17 protein family are required for excitatory and purinergic synaptic transmission, sialic acid metabolism, and renal... 
CELLS | PROTEIN | VESICULAR GLUTAMATE TRANSPORTERS | MECHANISM | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | BIOLOGICAL PROPERTIES | STORAGE DISORDERS | MAJOR FACILITATOR SUPERFAMILY