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1. Full Text Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
by Maruyama, Masahiro and Shimada, Hitoshi and Suhara, Tetsuya and Shinotoh, Hitoshi and Ji, Bin and Maeda, Jun and Zhang, Ming-Rong and Trojanowski, John Q and Lee, Virginia M.-Y and Ono, Maiko and Masamoto, Kazuto and Takano, Harumasa and Sahara, Naruhiko and Iwata, Nobuhisa and Okamura, Nobuyuki and Furumoto, Shozo and Kudo, Yukitsuka and Chang, Qing and Saido, Takaomi C and Takashima, Akihiko and Lewis, Jada and Jang, Ming-Kuei and Aoki, Ichio and Ito, Hiroshi and Higuchi, Makoto
Neuron (Cambridge, Mass.), ISSN 0896-6273, 09/2013, Volume 79, Issue 6, pp. 1094 - 1108
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Brain - diagnostic imaging | Age Factors | Aniline Compounds | Humans | Middle Aged | Aminopyridines - pharmacokinetics | Tauopathies - pathology | tau Proteins - metabolism | Male | Positron-Emission Tomography | Benzothiazoles - pharmacokinetics | Alzheimer Disease - pathology | DNA-Binding Proteins - metabolism | Dose-Response Relationship, Drug | Carbon Isotopes - pharmacokinetics | tau Proteins - genetics | Tauopathies - diagnostic imaging | Amyloid beta-Peptides - metabolism | Thiazoles | Female | Disease Models, Animal | Calcium-Binding Proteins | Protein Structure, Secondary | Mice, Inbred C57BL | Mice, Transgenic | DNA-Binding Proteins - genetics | Mutation - genetics | Brain - drug effects | Autoradiography | Magnetic Resonance Imaging | Animals | Microfilament Proteins | Benzothiazoles - chemistry | Brain - pathology | Brain Mapping | Aged | Mice | Alzheimer Disease - diagnostic imaging | Pets | Brain | Medical colleges | School facilities | PET imaging | Neurons | Animal genetic engineering | Comparative analysis | Alzheimer's disease | Education parks | Studies | Pathology | Alzheimers disease | Neurodegeneration | Index Medicus
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2. Full Text Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
by Yoshiyama, Yasumasa and Higuchi, Makoto and Zhang, Bin and Huang, Shu-Ming and Iwata, Nobuhisa and Saido, Takaomi C and Maeda, Jun and Suhara, Tetsuya and Trojanowski, John Q and Lee, Virginia M.-Y
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2007, Volume 53, Issue 3, pp. 337 - 351
HUMDISEASE | MOLNEURO | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Phosphorylation | Humans | Immunosuppressive Agents - therapeutic use | Synapses - pathology | tau Proteins - chemistry | Atrophy | Gliosis - pathology | Microtubules - metabolism | Microglia - physiology | tau Proteins - genetics | Spinal Cord - pathology | Macrophage Activation - physiology | Neurofibrillary Tangles - pathology | Neurofibrillary Tangles - physiology | Solubility | Microscopy, Electron | Amygdala - pathology | Blotting, Western | Nerve Degeneration - pathology | Tacrolimus - therapeutic use | Amyloid Neuropathies - pathology | Animals | Mossy Fibers, Hippocampal - pathology | Aging - physiology | Brain - pathology | Mice | Medical research | Pathology | Spinal cord | Neurodegeneration | Rodents | Mutation | Age | Index Medicus
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3. Full Text Calpain research for drug discovery: Challenges and potential
by Ono, Yasuko and Saido, Takaomi C and Sorimachi, Hiroyuki
Nature reviews. Drug discovery, ISSN 1474-1776, 11/2016, Volume 15, Issue 12, pp. 854 - 876
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Pharmaceutical Research | Animals | Calpain - metabolism | Drug Discovery | Humans | Calpain | Forecasts and trends | Drug discovery | Pharmaceutical industry | Testing | Index Medicus
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4. Full Text Tau binding protein CAPON induces tau aggregation and neurodegeneration
by Hashimoto, Shoko and Matsuba, Yukio and Kamano, Naoko and Mihira, Naomi and Sahara, Naruhiko and Takano, Jiro and Muramatsu, Shin-ichi and Saido, Takaomi C and Saito, Takashi
Nature communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2394 - 2394
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Brain | Phenotypes | Immunoprecipitation | Oligomerization | Neurodegenerative diseases | Pathogenesis | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Accumulation | Nitric-oxide synthase | Proteins | Atrophy | Tau protein | Neurodegeneration | Cell death | Nitric oxide | Mice | Amyloidosis | Alzheimer's disease | Hippocampus | Index Medicus
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5. Full Text Aβ Secretion and Plaque Formation Depend on Autophagy
by Nilsson, Per and Loganathan, Krishnapriya and Sekiguchi, Misaki and Matsuba, Yukio and Hui, Kelvin and Tsubuki, Satoshi and Tanaka, Motomasa and Iwata, Nobuhisa and Saito, Takashi and Saido, Takaomi C
Cell reports (Cambridge), ISSN 2211-1247, 10/2013, Volume 5, Issue 1, pp. 61 - 69
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Immunohistochemistry | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | Amyloid beta-Peptides - secretion | Mice, Transgenic | Autophagy - physiology | Alzheimer Disease - pathology | Animals | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Plaque, Amyloid - metabolism | Mice | Disease Models, Animal | Index Medicus | Medicin och hälsovetenskap
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6. Full Text APP mouse models for Alzheimer's disease preclinical studies
by Sasaguri, Hiroki and Nilsson, Per and Hashimoto, Shoko and Nagata, Kenichi and Saito, Takashi and De Strooper, Bart and Hardy, John and Vassar, Robert and Winblad, Bengt and Saido, Takaomi C
The EMBO journal, ISSN 0261-4189, 09/2017, Volume 36, Issue 17, pp. 2473 - 2487
App knock‐in | amyloid precursor protein | amyloid β peptide | APP transgenic | Alzheimer's disease | App knock-in | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amyloid beta-Protein Precursor - genetics | Animals | Alzheimer Disease | Humans | Disease Models, Animal | Animal models | Neurodegenerative diseases | Transgenic | Presenilin | Amyloid precursor protein | Gene sequencing | Proteins | Studies | Pathology | Molecular modelling | Rodents | Mice | Mutation | Alzheimers disease | Phenotypes | Index Medicus | Neuroscience | Review | Molecular Biology of Disease | Medicin och hälsovetenskap
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