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by Warren, Helen R and Evangelou, Evangelos and Cabrera, Claudia P and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surenan, Praveen and Liu, Chunyu and Cook, James P and Kraja, Aldi T and nos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P. Segura and O'Reilly, Paul F and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E. Shyong and Said, M. Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T and Padmanabhan, Sandosh and Magi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J. L and Metspalu, Anes and Shields, Denis C and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tonu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C and Chasman, Daniel I and Chakravarti, Aravinda and Newton-Cheh, Christopher and Lindgren, Cecilia M and Levy, Daniel and Kooner, Jaspal S and Keavney, Bernard and Tomaszewski, Maciej and Samani, Nilesh J and Howson, Joanna M. M and Tobin, Martin D and Munroe, Patricia B and Ehret, Georg B and Wain, Louise V and Barnes, Michael R and Tzoulaki, Joanna and Caulfield, Mark J and Elliott, Paul and Vaez, Ahmad and Jansen, Rick and Joehanes, Roby and van der Most, Peter J and Erzurumluoglu, A. Mesut and O'Reilly, Paul and Rose, Lynda M and Verwoert, Germaine C and Hottenga, Jouke-Jan and Strawbridge, Rona J and Arking, Dan E and Hwang, Shih-Jen and Guo, Xiuqing and Kutalik, Zoltan and Trompet, Stella and Shrine, Nick and Teumer, Alexander and Ried, Janina S and Bis, Joshua C and Smith, Albert V and Amin, Najaf and Nolte, Ilja M and Lyytikainen, Leo-Pekka and Mahajan, Anubha and Wareham, Nicholas J and Hofer, Edith and Joshi, Peter K and Kristiansson, Kati and Traglia, Michela and Havulinna, Aki S and Goel, Anuj and Nalls, Mike A and Sober, Siim and Vuckovic, gana and Luan, Jian'an and del Greco, Fabiola M and Ayers, Kristin L and ... and CHARGE BP Exome Consortium and UK Biobank CardioMetab Consortium and GoT2D Genes Consortium and Understanding Soc Sci Grp and Lifelines Cohort Study and Int Consortium Blood Pressure ICBP and BIOS Consortium and ExomeBP Consortium and CHD Exome Consortium and T2D-GENES Consortium and iGEN-BP Consortium and International Consortium of Blood Pressure (ICBP) 1000G Analyses and Understanding Society Scientific group and CHD Exome+ Consortium and Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium and International Genomics of Blood Pressure (iGEN-BP) Consortium and UK Biobank CardioMetabolic Consortium BP working group and GoT2DGenes Consortium and The CHD Exome+ Consortium and The International Consortium of Blood Pressure (ICBP) 1000G Analyses and The International Genomics of Blood Pressure (iGEN-BP) Consortium and The UK Biobank CardioMetabolic Consortium BP working group and The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium and The GoT2DGenes Consortium and The ExomeBP Consortium and The T2D-GENES Consortium and Stockholms universitet and Numerisk analys och datalogi (NADA) and Naturvetenskapliga fakulteten
Nature genetics, ISSN 1061-4036, 2017, Volume 49, Issue 3, pp. 403 - 415
Journal Article
by Pattaro, Cristian and Teumer, Alexander and Gorski, Mathias and Chu, Auey Y and Li, Man and Mijatovic, Vladan and Garnaas, Maija and Tin, Aienne and Sorice, Rossella and Li, Yong and Taliun, Daniel and Olden, Matthias and Foster, Meredith and Yang, Qiong and Chen, Ming-Huei and Pers, Tune H and Johnson, Anew D and Ko, Yi-An and Fuchsberger, Christian and Tayo, Bamidele and Nalls, Michael and Feitosa, Mary F and Isaacs, Aaron and Dehghan, Abbas and d'Adamo, Pio and Adeyemo, Adebowale and Dieffenbach, Aida Karina and Zonderman, Alan B and Nolte, Ilja M and van der Most, Peter J and Wright, Alan F and Shuldiner, Alan R and Morrison, Alanna C and Hofman, Albert and Smith, Albert V and isbach, Albert W and Franke, Ane and Uitterlinden, Ane G and Metspalu, Anes and Tonjes, Anke and Lupo, Antonio and Robino, Antonietta and Johansson, Asa and Demirkan, Ayse and Kollerits, Barbara and Freedman, Barry I and Ponte, Belen and Oostra, Ben A and Paulweber, Bernhard and Kraemer, Bernhard K and Mitchell, Braxton D and Buckley, Brendan M and Peralta, Carmen A and Hayward, Caroline and Helmer, Catherine and Rotimi, Charles N and Shaffer, Christian M and Mueller, Christian and Sala, Cinzia and van Duijn, Cornelia M and Saint-Pierre, Aude and Ackermann, Daniel and Shriner, Daniel and Ruggiero, Daniela and Toniolo, Daniela and Lu, Yingchang and Cusi, Daniele and Czamara, Darina and Ellinghaus, David and Siscovick, David S and Ruderfer, Douglas and Gieger, Christian and Grallert, Harald and Rochtchina, Elena and Atkinson, Elizabeth J and Holliday, Elizabeth G and Boerwinkle, Eric and Salvi, Erika and Bottinger, Erwin P and Murgia, Federico and Rivadeneira, Fernando and Ernst, Florian and Kronenberg, Florian and Hu, Frank B and Navis, Gerjan J and Curhan, Gary C and Ehret, George B and Homuth, Georg and Coassin, Stefan and Thun, Gian-Ani and Pistis, Giorgio and Gambaro, Giovanni and Malerba, Giovanni and Montgomery, Grant W and Eiriksdottir, Gudny and Jacobs, Gunnar and Li, Guo and Wichmann, H-Erich and Campbell, Harry and Schmidt, Helena and ... and CARDIOGRAM and ICBP Consortium and AGEN Consortium and CHARGe-Heart Failure Grp and ECHOGen Consortium and CHARGe-Heart Failure Group and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Medicinsk genetik och genomik
Nature Communications, ISSN 2041-1723, 01/2016, Volume 7, Issue 1, pp. 10023 - 10023
Journal Article
Briefings in Functional Genomics, ISSN 2041-2649, 09/2014, Volume 13, Issue 5, p. 353
  Genome-wide association studies have uncovered hundreds of common genetic variants involved in complex diseases. However, for most complex diseases, these... 
Simulation | Genes | Genomes | Population genetics | Polymorphism
Journal Article
by van der Harst, P and Zhang, W and Mateo Leach, I and Rendon, A and Verweij, N and Sehmi, J and Paul, D.S and Elling, U and Allayee, H and Li, X and Radhakrishnan, A and Tan, S.T and Voss, K and Weichenberger, C.X and Albers, C.A and Al-Hussani, A and Asselbergs, F.W and Ciullo, M and Danjou, F and Dina, C and Esko, T and Evans, D.M and Franke, L and Gogele, M and Hartiala, J and Hersch, M and Holm, H and Hottenga, J.J and Kanoni, S and Kleber, M.E and Lagou, V and Langenberg, C and Lopez, L.M and Lyytikainen, L.P and Melander, O and Murgia, F and Nolte, I.M and O'Reilly, P.F and Padmanabhan, S and Parsa, A and Pirastu, N and Porcu, E and Portas, L and Prokopenko, I and Ried, J.S and Shin, S.Y and Tang, C.S and Teumer, A and Traglia, M and Ulivi, S and Westra, H.J and Yang, J and Zhao, J.H and Anni, F and Abdellaoui, A and Attwood, A and Balkau, B and Bandinelli, S and Bastardot, F and Benyamin, B and Boehm, B.O and Cookson, W.O and Das, D and de Bakker, P.I and de Boer, R.A and de Geus, E.J and de Moor, M.H and Dimitriou, M and Domingues, F.S and Doring, A and Engstrom, G and Eyjolfsson, G.I and Ferrucci, L and Fischer, K and Galanello, R and Garner, S.F and Genser, B and Gibson, Q.D and Girotto, G and Gudbjartsson, D.F and Harris, S.E and Hartikainen, A.L and Hastie, C.E and Hedblad, B and Illig, T and Jolley, J and Kahonen, M and Kema, I.P and Kemp, J.P and Liang, L and Lloyd-Jones, H and Loos, R.J and Meacham, S and Medland, S.E and Meisinger, C and Memari, Y and Mihailov, E and Miller, K and Moffatt, M.F and Nauck, M., et al and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and Kardiovaskulär forskning - epidemiologi and Lund University and EpiHealth: Epidemiology for Health and Cardiovascular Research - Epidemiology and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
Nature, ISSN 0028-0836, 2012, Volume 492, Issue 7429, pp. 369 - 375
Journal Article
Kidney International, ISSN 0085-2538, 02/2013, Volume 83, Issue 2, pp. 196 - 198
Contrary to the apparent impossibility of replicating linkage results across studies on renal outcomes, and denying the general difficulty of identifying... 
UROLOGY & NEPHROLOGY | LINKAGE | SEARCH | Genome-Wide Association Study | Humans | Asian Continental Ancestry Group - genetics | Female | Male | Glomerular Filtration Rate - genetics | Genetic Loci | Genetic Linkage | Index Medicus
Journal Article
Genetic Epidemiology, ISSN 0741-0395, 09/2019, Volume 43, Issue 6, pp. 646 - 656
Genetic association studies have provided new insights into the genetic variability of human complex traits with a focus mainly on continuous or binary traits.... 
association | subphenotypes | disease severity | rare variant | burden tests | COMMON DISEASES | SEQUENCE | GENETICS & HEREDITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | Medicine, Experimental | Medical research | Medical tests | Analysis | Phenotypes | Moyamoya disease | Index Medicus
Journal Article
BMC Genomics, ISSN 1471-2164, 09/2017, Volume 18, Issue 1, pp. 758 - 758
Background: Colon cancer occurrence is increasing worldwide, making it the third most frequent cancer. Although many therapeutic options are available and... 
Protein network | Therapeutic target | Colorectal cancer | Transcriptome | WNT SIGNALING PATHWAY | DNA METHYLATION | TUMOR-SUPPRESSOR GENES | C-MYC ONCOGENE | COLON-CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROSTATE-CANCER | GENETICS & HEREDITY | SQUAMOUS-CELL CARCINOMA | CHRONIC LYMPHOCYTIC-LEUKEMIA | BIOLOGICAL AGGRESSIVENESS | HUMAN HEPATOCELLULAR-CARCINOMA | HT29 Cells | Lovastatin - therapeutic use | Lovastatin - pharmacology | Protein Interaction Maps - drug effects | Colorectal Neoplasms - drug therapy | Colorectal Neoplasms - genetics | Humans | Gene Expression Profiling | Molecular Targeted Therapy | Colorectal Neoplasms - metabolism | Transcription factors | Care and treatment | Messenger RNA | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Drugs | Networks | Deregulation | Target recognition | Wnt protein | Insulin-like growth factor I | Colorectal carcinoma | Leukemia | Genes | Frizzled-related protein 1 | Homeostasis | Lovastatin | Myc protein | Alcohol dehydrogenase | Drug development | Cancer therapies | Cell adhesion & migration | Proteins | β-catenin | Liver cancer | Signal transduction | Antitumor agents | Colon cancer | Pathways | Rodents | DNA methylation | Drug metabolism | Colon | Lipid metabolism | Statins | Interleukin 8 | Deoxyribonucleic acid--DNA | Organs | Metabolism | Gene expression | Patients | Cholesterol | Chemotherapy | Prostate | Apoptosis | Cancer | Index Medicus | Life Sciences | Biochemistry, Molecular Biology | Genomics
Journal Article