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1. Full Text A1570 Comparison of hypertension prediction model
by Saitoh, Shigeyuki
Journal of Hypertension, ISSN 0263-6352, 10/2018, Volume 36 Suppl 3, pp. e263 - e263
OBJECTIVES:Classification and Regression Tree (CRT) is one of nonlinear regression analyses and the tree models which are discrimination analysis (tree based... 
Hypertension | Usage | Prognosis | Regression analysis
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2. Full Text Hypertension as a risk for CAD and its management
by Saitoh, Shigeyuki
Journal of the Japanese Coronary Association, ISSN 1341-7703, 2017, Volume 23, Issue 2, pp. 103 - 107
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3. Full Text The Japanese Society of Hypertension guidelines for the management of hypertension (JSH 2014)
by Shimamoto, Kazuaki and Ando, Katsuyuki and Fujita, Toshiro and Hasebe, Naoyuki and Higaki, Jitsuo and Horiuchi, Masatsugu and Imai, Yutaka and Imaizumi, Tsutomu and Ishimitsu, Toshihiko and Ito, Masaaki and Ito, Sadayoshi and Itoh, Hiroshi and Iwao, Hiroshi and Kai, Hisashi and Kario, Kazuomi and Kashihara, Naok and Kawano, Yuhei and Kim-Mitsuyama, Shokei and Kimura, Genjiro and Kohara, Katsuhiko and Komuro, Issei and Kumagai, Hiroo and Matsuura, Hideo and Miura, Katsuyuki and Morishita, Ryuichi and Naruse, Mitsuhide and Node, Koichi and Ohya, Yusuke and Rakugi, Hiromi and Saito, Ikuo and Saitoh, Shigeyuki and Shimada, Kazuyuki and Shimosawa, Tatsuo and Suzuki, Hiromichi and Tamura, Kouichi and Tanahashi, Norio and Tsuchihashi, Takuya and Uchiyama, Makoto and Ueda, Shinichiro and Umemura, Satoshi and Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
Hypertension Research, ISSN 0916-9636, 2014, Volume 37, Issue 4, pp. 253 - 390
Hypertension - drug therapy | Hypertension - therapy | Antihypertensive Agents - therapeutic use | Humans | Index Medicus
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4. Hypertension
by Saitoh, Shigeyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 02/2013, Volume 71, Issue 2, p. 281
As the population of obesity increases by the change of living habits, hypertensive prevalence increases in particularly middle-aged Japanese men. Obesity... 
Body Mass Index | Prevalence | Obesity - complications | Humans | Risk Factors | Insulin Resistance | Hypertension - complications | Hypertension - epidemiology | Obesity - metabolism
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5. Hypertension
by Saitoh, Shigeyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2013, Volume 71, Issue 2, pp. 281 - 285
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6. Full Text Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans
by Kimura, Takehide and Kaneko, Fuminari and Iwamoto, Erika and Saitoh, Shigeyuki and Yamada, Takashi
Experimental Brain Research, ISSN 0014-4819, 1/2019, Volume 237, Issue 1, pp. 47 - 56
Brain-derived neurotrophic factor (BDNF) plays several important roles in nervous system function including neuronal growth and plasticity. The purpose of the... 
Neurology | Neurosciences | Biomedicine | Brain-derived neurotrophic factor | Voluntary exercise | Blood lactate | Neuromuscular electrical stimulation | NEUROPLASTICITY | NEUROSCIENCES | EXERCISE | Knee - physiology | Lactic Acid - blood | Humans | Oxygen Consumption | Male | Brain-Derived Neurotrophic Factor - blood | Young Adult | Knee - innervation | Quadriceps Muscle - physiology | Heart Rate - physiology | Female | Blood Pressure - physiology | Electromyography | Exercise - physiology | Respiration | Electric Stimulation - methods | Isometric Contraction - physiology | Psychological aspects | Usage | Exercise | Research | Electric stimulation | Lactates | Heart beat | Exercise therapy | Knee | Intervention | Physical training | Muscles | Nervous system | Posture | Electrical stimuli | Heart rate | Isometric | Quadriceps muscle | Blood pressure | Lactic acid | Index Medicus
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7. Full Text Independent Link Between Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and FABP4 in a General Population Without Medication
by Furuhashi, Masato, MD, PhD|Omori, Akina, PhD|Matsumoto, Megumi, BSc|Kataoka, Yu, MD, PhD|Tanaka, Marenao, MD, PhD|Moniwa, Norihito, MD, PhD|Ohnishi, Hirofumi, MD, PhD|Yoshida, Hideaki, MD, PhD|Saitoh, Shigeyuki, MD, PhD|Shimamoto, Kazuaki, MD, PhD|Miura, Tetsuji, MD, PhD
American Journal of Cardiology, The, ISSN 0002-9149, 2016, Volume 118, Issue 2, pp. 198 - 203
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to and degrades the low-density lipoprotein (LDL) receptor, leading to hypercholesterolemia and... 
Cardiovascular | HEART-DISEASE | CARDIAC & CARDIOVASCULAR SYSTEMS | ADIPOCYTES | CHOLESTEROL | MACROPHAGES | ACID-BINDING PROTEIN | ATHEROSCLEROSIS | HYPERCHOLESTEROLEMIA | PLASMA PCSK9 LEVELS | HYPERTENSION | DENSITY-LIPOPROTEIN RECEPTOR | Japan - epidemiology | Multivariate Analysis | Age Factors | gamma-Glutamyltransferase - blood | Blood Urea Nitrogen | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Alanine Transaminase - blood | Obesity - blood | Dyslipidemias - blood | C-Reactive Protein - metabolism | Fatty Acid-Binding Proteins - blood | Proprotein Convertase 9 - blood | Cholesterol, LDL - blood | Female | Uric Acid - blood | Glomerular Filtration Rate | Insulin Resistance | Regression Analysis | Waist Circumference | Dyslipidemias - epidemiology | Aspartate Aminotransferases - blood | Obesity - epidemiology | Sex Factors | Triglycerides - blood | Cholesterol, HDL - blood | Creatinine - blood | Aged | Medical colleges | Hypercholesterolemia | Blood cholesterol | Low density lipoproteins | Atherosclerosis | Insulin resistance | Trans fatty acids | Cardiovascular agents | Protein binding | Low density lipoprotein | Regression analysis | Index Medicus | Abridged Index Medicus
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8. Full Text The effects of renin-angiotensin system inhibitors on mortality, cardiovascular events, and renal events in hypertensive patients with diabetes: a systematic review and meta-analysis of randomized controlled trials
by Kunimura, A and Himuro, N and Fujiyoshi, A and Segawa, H and Ohnishi, H and Saitoh, S
HYPERTENSION RESEARCH, ISSN 0916-9636, 05/2019, Volume 42, Issue 5, pp. 669 - 680
Renin-angiotensin system (RAS) inhibitors are often used as a first-line treatment for hypertensive patients with diabetes because of purported benefits, such... 
Hypertension | LIPID-LOWERING TREATMENT | Diabetes mellitus | Renin angiotensin system blockers | Systematic review | ANTIHYPERTENSIVE SURVIVAL EVALUATION | CONVERTING ENZYME-INHIBITORS | NEPHROPATHY | BLOOD-PRESSURE | RECEPTOR ANTAGONIST | Meta-analysis | AMLODIPINE | DISEASE | PERIPHERAL VASCULAR DISEASE | OUTCOMES | ENALAPRIL | Clinical trials | Cardiovascular disease | Diabetes | Mortality
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9. Stratification-system of cardiovascular risk in JSH2009
by Saitoh, Shigeyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 11/2011, Volume 69, Issue 11, p. 1958
Recently, Guidelines for the Management of Hypertension of Japanese Society of Hypertension (JSH2009) has been reported. JSH2009 shows the treatment strategy... 
Cardiovascular Diseases - etiology | Humans | Japan | Middle Aged | Risk Factors | Female | Male | Aged | Hypertension - therapy | Practice Guidelines as Topic
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10. Full Text Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population
by Ishimura, Shutaro and Furuhashi, Masato and Watanabe, Yuki and Hoshina, Kyoko and Fuseya, Takahiro and Mita, Tomohiro and Okazaki, Yusuke and Koyama, Masayuki and Tanaka, Marenao and Akasaka, Hiroshi and Ohnishi, Hirofumi and Yoshida, Hideaki and Saitoh, Shigeyuki and Miura, Tetsuji
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e81318 - e81318
Objective: Fatty acid-binding proteins (FABPs) are a family of 14-15-kDa proteins, and some FABPs have been to be used as biomarkers of tissue injury by leak... 
OBESITY | CAROTID ATHEROSCLEROSIS | PLASMA | INSULIN-RESISTANCE | JAPANESE POPULATION | MYOGLOBIN | MULTIDISCIPLINARY SCIENCES | RENAL-DISEASE | CARDIAC DAMAGE | KNOCKOUT MICE | SERUM RATIO | Phenotype | Public Health Surveillance | Humans | Middle Aged | Risk Factors | Fatty Acid-Binding Proteins - blood | Female | Male | Aged | Biomarkers - blood | Type 2 diabetes | Blood cholesterol | Insulin resistance | Genetic aspects | Research | Binding proteins | Fatty acids | Natriuretic peptides | Protein binding | Heart | Drugs | Brain | Correlation | C-reactive protein | Renal function | Population studies | Lipids | Cardiovascular disease | Adipocytes | Males | Proteins | Genotype & phenotype | Atherosclerosis | Population | Blood pressure | Bioindicators | Lipoproteins (high density) | Age | Brain natriuretic peptide | Obesity | Alanine | Epidermal growth factor receptors | Metabolic diseases | Sex differences | Regression analysis | Metabolism | Insulin | Cholesterol | Glomerular filtration rate | Medicine | Isoforms | Fatty acid-binding protein | Alanine transaminase | Biomarkers | Diabetes | Females | Metabolic disorders | Kidney transplantation | Index Medicus
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11. Full Text FABP4 is secreted from adipocytes by adenyl cyclase‐PKA‐ and guanylyl cyclase‐PKG‐dependent lipolytic mechanisms
by Mita, Tomohiro and Furuhashi, Masato and Hiramitsu, Shinya and Ishii, Junnichi and Hoshina, Kyoko and Ishimura, Shutaro and Fuseya, Takahiro and Watanabe, Yuki and Tanaka, Marenao and Ohno, Kohei and Akasaka, Hiroshi and Ohnishi, Hirofumi and Yoshida, Hideaki and Saitoh, Shigeyuki and Shimamoto, Kazuaki and Miura, Tetsuji
Obesity, ISSN 1930-7381, 02/2015, Volume 23, Issue 2, pp. 359 - 367
ObjectiveFatty acid-binding protein 4 (FABP4) is expressed in adipocytes, and elevated plasma FABP4 level is associated with obesity-mediated metabolic... 
OBESITY | NUTRITION & DIETETICS | AP2 | METABOLISM | BIOMARKER | ACID-BINDING PROTEIN | DEFICIENT | ENDOCRINOLOGY & METABOLISM | ATHEROSCLEROSIS | ELEVATION | FAT | APOLIPOPROTEIN-E | Cyclic AMP-Dependent Protein Kinases - metabolism | Adipocytes - secretion | Glucose Tolerance Test | Blood Glucose - analysis | Fatty Acid-Binding Proteins - secretion | Humans | Middle Aged | Guanylate Cyclase - metabolism | Lipid Metabolism | Male | Adenylyl Cyclases - metabolism | Fatty Acid-Binding Proteins - metabolism | 3T3-L1 Cells | Cyclic GMP-Dependent Protein Kinases - metabolism | Lipolysis | Insulin - metabolism | Animals | Adipocytes - metabolism | Diet, High-Fat | Fatty Acid-Binding Proteins - blood | Adult | Female | Aged | Mice | Studies | Insulin resistance | Insulin | Rodents | Metabolic disorders | Cholesterol | Index Medicus
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12. Full Text Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group (EPOCH-JAPAN)
by Hirakawa, Yoichiro and Ninomiya, Toshiharu and Kiyohara, Yutaka and Murakami, Yoshitaka and Saitoh, Shigeyuki and Nakagawa, Hideaki and Okayama, Akira and Tamakoshi, Akiko and Sakata, Kiyomi and Miura, Katsuyuki and Ueshima, Hirotsugu and Okamura, Tomonori and Evidence Cardiovasc Prevention Obs and Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group (EPOCH-JAPAN)
Journal of Epidemiology, ISSN 0917-5040, 03/2017, Volume 27, Issue 3, pp. 123 - 129
Diabetes mellitus is a strong risk factor for cardiovascular disease. However, the age-specific association of diabetes with cardiovascular risk, especially in... 
Collaborative cohort study | Cardiovascular death | Age-specified cardiovascular risk | Pooled analysis | Diabetes mellitus | FOLLOW-UP | DEATH | BLOOD-PRESSURE | ALL-CAUSE MORTALITY | STROKE | INDIVIDUALS | GENERAL-POPULATION | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | CORONARY-HEART-DISEASE | GLUCOSE-TOLERANCE | Cardiovascular Diseases - etiology | Japan - epidemiology | Diabetes Complications | Age Factors | Cardiovascular Diseases - ethnology | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Coronary Disease - etiology | Male | Coronary Disease - ethnology | Coronary Disease - mortality | Aged, 80 and over | Cardiovascular Diseases - mortality | Diabetes Mellitus - ethnology | Stroke - ethnology | Adult | Female | Aged | Stroke - mortality | Diabetes Mellitus - mortality | Cohort Studies | Elderly people | Heart | Stroke | Mortality | Health risks | Risk reduction | Cardiovascular disease | Risk analysis | Coronary artery disease | Risk factors | Confidence intervals | Heterogeneity | Death | Fatalities | Diabetes | Cardiovascular diseases | Risk management | Heart diseases | Elderly | Age | Geriatrics
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13. Stratification-system of cardiovascular risk in JSH2009
by Saitoh, Shigeyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 2011, Volume 69, Issue 11, pp. 1958 - 1962
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14. The Tanno-Soubetsu study
by Saitoh, Shigeyuki
Nihon rinsho. Japanese journal of clinical medicine, ISSN 0047-1852, 01/2011, Volume 69, pp. 58 - 62
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15. Full Text The combination of abdominal obesity and high-sensitivity C-reactive protein predicts new-onset hypertension in the general Japanese population: The Tanno-Sobetsu study
by Fujii, Mizue and Ohnishi, Hirofumi and Saitoh, Shigeyuki and Akasaka, Hiroshi and Miura, Tetsuji and Mori, Mitsuru
Hypertension Research, ISSN 0916-9636, 06/2015, Volume 38, Issue 6, pp. 426 - 432
The aim of this study was to examine whether the combination of abdominal obesity and high serum levels of high-sensitivity C-reactive protein (hsCRP) improves... 
incidence of hypertension | high-sensitivity CRP | general population | abdominal obesity | BIOMARKERS | INDIVIDUALS | METABOLIC SYNDROME | ENDOTHELIAL DYSFUNCTION | INSULIN-RESISTANCE | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | CORONARY-HEART-DISEASE | INTERLEUKIN-6 | CARDIOVASCULAR RISK | BLOOD-PRESSURE | Japan - epidemiology | Prospective Studies | Humans | Middle Aged | Obesity, Abdominal - diagnosis | Risk Factors | Proportional Hazards Models | Obesity, Abdominal - physiopathology | Male | Hypertension - physiopathology | Incidence | Asian Continental Ancestry Group | Adult | Female | Aged | Blood Pressure - physiology | Hypertension - epidemiology | C-Reactive Protein - analysis | Hypertension - diagnosis | Index Medicus
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16. Full Text Plasma Xanthine Oxidoreductase Activity as a Novel Biomarker of Metabolic Disorders in a General Population
by Furuhashi, Masato and Matsumoto, Megumi and Tanaka, Marenao and Moniwa, Norihito and Murase, Takayo and Nakamura, Takashi and Ohnishi, Hirofumi and Saitoh, Shigeyuki and Shimamoto, Kazuaki and Miura, Tetsuji
Circulation Journal, ISSN 1346-9843, 2018, Volume 82, Issue 7, pp. 1892 - 1899
Background:Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in... 
Liver dysfunction | Obesity | Insulin resistance | Uric acid | Smoking | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOTHELIAL DYSFUNCTION | HEART-FAILURE | VISCERAL FAT ACCUMULATION | OXIDASE INHIBITION | MASS-SPECTROMETRY | HIGHLY SENSITIVE ASSAY | CARDIOVASCULAR-DISEASE | CHRONIC KIDNEY-DISEASE | URIC-ACID
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17. Full Text A novel α9 integrin ligand, XCL1/lymphotactin, is involved in the development of murine models of autoimmune diseases
by Matsumoto, Naoki and Kon, Shigeyuki and Nakatsuru, Takuya and Miyashita, Tomoe and Inui, Kyosuke and Saitoh, Kodai and Kitai, Yuichi and Muromoto, Ryuta and Kashiwakura, Jun-Ichi and Uede, Toshimitsu and Matsuda, Tadashi
Journal of Immunology, ISSN 0022-1767, 07/2017, Volume 199, Issue 1, pp. 82 - 90
The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin... 
NIH 3T3 Cells | Encephalomyelitis, Autoimmune, Experimental - physiopathology | Chemokines, C - metabolism | Mice, Inbred C57BL | Encephalomyelitis, Autoimmune, Experimental - immunology | Arthritis, Experimental - immunology | Integrin alpha Chains - metabolism | Cell Adhesion | Encephalomyelitis, Autoimmune, Experimental - therapy | Antibodies, Neutralizing - immunology | Animals | Chemokines, C - immunology | Integrin alpha Chains - immunology | Ligands | Mice | Rhabdomyosarcoma - immunology | Cell Movement | Disease Models, Animal | Animal models | Encephalomyelitis | Disease | Collagen (type II) | Rhabdomyosarcoma | Arthritis | Inflammation | Lymphotactin | Experimental allergic encephalomyelitis | Cell adhesion & migration | Diseases | Rodents | Neutralizing | In vivo methods and tests | Autoimmune diseases | Cell migration | Recombinant | Index Medicus | Abridged Index Medicus
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18. Full Text Formation of novel transition metal hydride complexes with ninefold hydrogen coordination
by Takagi, Shigeyuki and Iijima, Yuki and Sato, Toyoto and Saitoh, Hiroyuki and Ikeda, Kazutaka and Otomo, Toshiya and Miwa, Kazutoshi and Ikeshoji, Tamio and Orimo, Shin-Ichi
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 44253 - 44253
Ninefold coordination of hydrogen is very rare, and has been observed in two different hydride complexes comprising rhenium and technetium. Herein, based on a... 
AUGMENTED-WAVE METHOD | MOLECULAR-DYNAMICS | SUPERCONDUCTIVITY | ANION | TEMPERATURE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BONDS | POTASSIUM RHENIUM HYDRIDE | X-RAY-DIFFRACTION | Conduction | Compression | Tantalum | Hydrogen | Temperature effects | Tungsten | Lithium | Technetium | Cations | Rhenium | Gaps | Molybdenum
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19. Full Text True Boundary for the Formation of Homoleptic Transition‐Metal Hydride Complexes
by Takagi, Shigeyuki and Iijima, Yuki and Sato, Toyoto and Saitoh, Hiroyuki and Ikeda, Kazutaka and Otomo, Toshiya and Miwa, Kazutoshi and Ikeshoji, Tamio and Aoki, Katsutoshi and Orimo, Shin‐ichi
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2015, Volume 54, Issue 19, pp. 5650 - 5653
Despite many exploratory studies over the past several decades, the presently known transition metals that form homoleptic transition‐metal hydride complexes... 
hydrides | chromium | hydride ligands | transition metals | structure elucidations | DYNAMICS | CHEMISTRY, MULTIDISCIPLINARY | ELECTRONIC-STRUCTURE | Chromium | Hydrogen | Nuclear energy | Neutrons | Transition metals | Neutron diffraction | Coordination numbers | Mathematical analysis | Atomic properties | Formations | Hydrides | Boundaries | Bonding
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