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1. Full Text In Vivo Molecular Imaging
by Hideo Sajia and b and aDepartment of Patho-Functional Bioanalysis and bKyoto University Research Administration Office and Kyoto University and Graduate School of Pharmaceutical Sciences
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 10, pp. 1605 - 1615
In vivo molecular imaging is the visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and... 
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2. Full Text Application of radioisotopes for theranostics, a combination of diagnostics and therapy
by Saji, Hideo
Yakugaku Zasshi, ISSN 0031-6903, 04/2015, Volume 135, Issue 4, pp. 551 - 556
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3. Full Text In vivo fluorescence imaging of β-amyloid plaques with push-pull dimethylaminothiophene derivatives
by Watanabe, Hiroyuki and Ono, Masahiro and Saji, Hideo
Chemical Communications, ISSN 1359-7345, 2015, Volume 51, Issue 96, pp. 17124 - 17127
In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We... 
Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Fluorescent Dyes - pharmacokinetics | Fluorescence | Brain - metabolism | Tissue Distribution | Thiophenes - chemical synthesis | Animals | Amyloid beta-Peptides - metabolism | Mice | Molecular Structure | Amyloid beta-Peptides - chemistry | Thiophenes - chemistry | Index Medicus
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4. Full Text Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry
by Takai, Nozomi and Tanaka, Yukari and Inazawa, Kazuhiro and Saji, Hideo
Rapid Communications in Mass Spectrometry, ISSN 0951-4198, 07/2012, Volume 26, Issue 13, pp. 1549 - 1556
RATIONALE Recently, the requirement for a quantitative research method using imaging mass spectrometry (IMS) to be developed has been discussed. Specifically,... 
RADIATION-DOSIMETRY | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | BIODISTRIBUTION | RADIOLUMINOGRAPHY | TISSUE-SECTIONS | MALDI-TOF MS | PEPTIDES | SPECTROSCOPY | LASER-DESORPTION IONIZATION | RACLOPRIDE | RAT-BRAIN | METABOLITE | Raclopride - pharmacokinetics | Histological Techniques - methods | Dopamine Antagonists - pharmacokinetics | Linear Models | Male | Mice, Transgenic | Molecular Imaging - methods | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods | Tissue Distribution | Animals | Raclopride - analysis | Mice | Chromatography, Liquid - methods | Dopamine Antagonists - analysis | Index Medicus | Drugs | Reproduction | Imaging | Organs | Liquid chromatography | Mass spectrometry | Quantitative analysis | Pharmaceuticals
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5. Full Text Novel fluorescence probes based on the chalcone scaffold for in vitro staining of [beta]-amyloid plaques
by Watanabe, Hiroyuki and Saji, Hideo and Ono, Masahiro
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2018, Volume 28, Issue 19, p. 3242
The [beta]-amyloid (A[beta]) plaque is one of the neuropathological hallmarks in the Alzheimer's disease brain. The detection of A[beta] plaques with... 
Medical research | Medicine, Experimental | Fluorescence | Alzheimer's disease | Investigations
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6. Full Text Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice
by Morishita, Masaki and Takahashi, Yuki and Nishikawa, Makiya and Sano, Kohei and Kato, Kana and Yamashita, Takuma and Imai, Takafumi and Saji, Hideo and Takakura, Yoshinobu
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 02/2015, Volume 104, Issue 2, pp. 705 - 713
We previously succeeded in the visualization of tissue distribution of B16BL6 cells-derived exosomes by labeling with luciferase (gLuc)-LA, a fusion protein of... 
streptavidin | nanoparticles | pharmacokinetics | lactadherin | clearance | biomaterials | phospholipids | quantitative analysis | exosome | radioisotope | Nanoparticles | Lactadherin | Exosome | Streptavidin | Phospholipids | Clearance | Radioisotope | Pharmacokinetics | Biomaterials | Quantitative analysis | CELLS | CHEMISTRY, MEDICINAL | BIODISTRIBUTION | MATURATION | CHEMISTRY, MULTIDISCIPLINARY | EXTRACELLULAR VESICLES | PHARMACOLOGY & PHARMACY | LIPOSOMES | Exosomes - metabolism | Tissue Distribution - physiology | Tissue Distribution - drug effects | Injections, Intravenous | Recombinant Fusion Proteins - analysis | Male | Recombinant Fusion Proteins - metabolism | Biotin - analysis | Iodine Radioisotopes - administration & dosage | Animals | Iodine Radioisotopes - metabolism | Melanoma, Experimental | Streptavidin - metabolism | Streptavidin - analysis | Protein Binding | Biotin - metabolism | Mice | Mice, Inbred BALB C | Iodine Radioisotopes - analysis | Biotin - administration & dosage | Recombinant Fusion Proteins - administration & dosage | Biotin | Biological products | Genetic vectors | Analysis | Index Medicus
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7. Full Text Synthesis of a Novel Pyrazine⁻Pyridone Biheteroaryl-Based Fluorescence Sensor and Detection of Endogenous Labile Zinc Ions in Lung Cancer Cells
by Hagimori, Masayori and Taniura, Mana and Mizuyama, Naoko and Karimine, Yasushi and Kawakami, Shigeru and Saji, Hideo and Mukai, Takahiro
Sensors (Basel, Switzerland), ISSN 1424-8220, 05/2019, Volume 19, Issue 9, p. 2049
A small extent of endogenous labile zinc is involved in many vital physiological roles in living systems. However, its detailed functions have not been fully... 
low background fluorescence | sulfonyl group | cellular imaging | endogenous Zn2 | pyrazine–pyridone biheteroaryl
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8. Full Text Radioiodinated Peptidic Imaging Probes for in Vivo Detection of Membrane Type-1 Matrix Metalloproteinase in Cancers
by Kondo, Naoya and Temma, Takashi and Shimizu, Yoichi and Ono, Masahiro and Saji, Hideo
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2015, Volume 38, Issue 9, pp. 1375 - 1382
Membrane type-1 matrix metalloproteinase (MT1-MMP) plays pivotal roles in tumor progression and metastasis, and holds great promise as an early biomarker for... 
membrane type-1 matrix metalloproteinase (MT1-MMP) | peptide | in vivo imaging | Peptide | Membrane type-1 matrix metalloproteinase (MT1-MMP) | In vivo imaging | 1-MATRIX METALLOPROTEINASE | METASTASIS | RGD PEPTIDES | TUMORS | ALPHA(V)BETA INTEGRIN | BREAST-CANCER | PROGELATINASE | MT1-MMP | GASTRIC-CANCER | PHARMACOLOGY & PHARMACY | EXPRESSION | Neoplasms - metabolism | Peptides - blood | Iodine Radioisotopes | Humans | Peptides - pharmacokinetics | Male | Matrix Metalloproteinase 14 - metabolism | Peptides - pharmacology | Diagnostic Imaging | Animals | Plasma - chemistry | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Female | Mice | Mice, Inbred BALB C | Index Medicus
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9. Full Text An Activatable Fluorescent γ-Polyglutamic Acid Complex for Sentinel Lymph Node Imaging
by Hagimori, Masayori and Hatabe, Eri and Sano, Kohei and Miyazaki, Hirotaka and Sasaki, Hitoshi and Saji, Hideo and Mukai, Takahiro
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 3, pp. 297 - 302
Sentinel lymph nodes (SLN) are the first lymph nodes (LN) where cancer cells metastasize from the primary tumor. We designed fluorophore-quencher-based... 
self-assembly | sentinel lymph node | nanoparticle | activatable | fluorescence-based optical imaging | Self-assembly | Nanoparticle | Sentinel lymph node | Fluorescence-based optical imaging | Activatable | GOLD NANOPARTICLES | CELLS | DIAGNOSIS | ICG FLUORESCENCE | SURFACE-CHARGE | BREAST-CANCER | ULTRASOUND | IN-VIVO | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | CARCINOMA | Lymphatic Metastasis - diagnosis | Polyethyleneimine | Pentetic Acid | Humans | Fluorescence | Lysosomes | Male | Sentinel Lymph Node - diagnostic imaging | Neoplasms - diagnostic imaging | Polyamines | Nanoparticles | Particle Size | Polyglutamic Acid - analogs & derivatives | Dendrimers | Animals | Lymphatic Metastasis - diagnostic imaging | Rhodamines | Mice, Inbred BALB C | Neoplasms - pathology | Fluorescent Dyes | Optical Imaging - methods | Self assembly | Particle size | Lymphatic system | Lymph nodes | Acids | Microscopy | Biopsy | Fluorescence resonance energy transfer | Energy transfer | Fluorescence microscopy | Cancer | Index Medicus
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10. Full Text In vivo fluorescence imaging of β-amyloid plaques with push-pull dimethylaminothiophene derivativesElectronic supplementary information (ESI) available: Experimental details, and results of fluorescent spectra and brain uptake. See DOI: 10.1039/c5cc06628j
by Watanabe, Hiroyuki and Ono, Masahiro and Saji, Hideo
ISSN 1359-7345, 11/2015, Volume 51, Issue 96, pp. 17124 - 17127
In vivo fluorescence imaging of β-amyloid (Aβ) plaques in the brain is expected to be used as a new method for detecting Alzheimer's disease (AD). We... 
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11. Full Text Polyoxazoline multivalently conjugated with indocyanine green for sensitive in vivo photoacoustic imaging of tumors
by Kanazaki, Kengo and Sano, Kohei and Makino, Akira and Homma, Tsutomu and Ono, Masahiro and Saji, Hideo
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, pp. 33798 - 33798
Photoacoustic imaging, which enables high-resolution imaging in deep tissues, has lately attracted considerable attention. For tumor imaging, photoacoustic... 
Blood vessels | Permeability | Probes | Tumors
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12. Full Text Technetium-99m labeled pyridyl benzofuran derivatives as single photon emission computed tomography imaging probes for β-amyloid plaques in Alzheimer's brains
by Cheng, Yan and Ono, Masahiro and Kimura, Hiroyuki and Ueda, Masashi and Saji, Hideo
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2279 - 2286
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13. Full Text Brachytherapy with intratumoral injections of radiometal-labeled polymers that thermoresponsively self-aggregate in tumor tissues
by Sano, Kohei and Kanada, Yuko and Kanazaki, Kengo and Ding, Ning and Ono, Masahiro and Saji, Hideo
Journal of Nuclear Medicine, ISSN 0161-5505, 09/2017, Volume 58, Issue 9, pp. 1380 - 1385
Brachytherapy is a type of radiotherapy wherein titanium capsules containing therapeutic radioisotopes are implanted within tumor tissues, enabling high-dose... 
Brachytherapy | Polyoxazoline | Thermoresponsive polymer | Radiotherapy | SURGERY | SEEDS | THERAPY | thermoresponsive polymer | DELIVERY-SYSTEMS | PROSTATE-CANCER | radiotherapy | polyoxazoline | MICELLES | brachytherapy | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Temperature | Radiopharmaceuticals - chemistry | Radiopharmaceuticals - pharmacokinetics | Brachytherapy - methods | Polymerization | Male | Oxazoles - chemistry | Radiopharmaceuticals - administration & dosage | Tissue Distribution | Animals | Injections, Intralesional | Mice, Nude | Cell Line, Tumor | Indium Radioisotopes - therapeutic use | Mice | Mice, Inbred BALB C | Yttrium Radioisotopes - therapeutic use | Radiopharmaceuticals - therapeutic use | Surgical implants | Seeds | Radioisotopes | Oncology | Retention | Tissue | Mouse devices | Animal tissues | Anesthesia | Biocompatibility | Localization | Polymers | Radioactivity | Transition temperature | Organs | Implantation | Radiation therapy | Injection | Derivatives | Survival | Radiation dosage | Autoradiography | Transition temperatures | Prostate cancer | Prostate | Tumors | Cancer | Index Medicus
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14. Full Text Smart near-infrared fluorescence probes with donor-acceptor structure for in vivo detection of β-amyloid deposits
by Cui, Mengchao and Ono, Masahiro and Watanabe, Hiroyuki and Kimura, Hiroyuki and Liu, Boli and Saji, Hideo
Journal of the American Chemical Society, ISSN 0002-7863, 03/2014, Volume 136, Issue 9, pp. 3388 - 3394
The deposition of beta-amyloid (A beta) plaques in the parenchymal and cortical brain is accepted as the main pathological hallmark of Alzheimer's disease... 
CASCADE HYPOTHESIS | ALZHEIMERS-DISEASE | IMAGING AGENTS | CHEMISTRY, MULTIDISCIPLINARY | PITTSBURGH COMPOUND-B | BRAIN | PET | Fluorescent Dyes - chemical synthesis | Cell Line | Cell Survival - drug effects | Fluorescent Dyes - chemistry | Protein Structure, Secondary | Humans | Protein Multimerization | Peptide Fragments - chemistry | Animals | Fluorescent Dyes - toxicity | Infrared Rays | Drug Design | Mice | Amyloid beta-Peptides - chemistry | Optical Imaging - methods | Near infrared spectroscopy | Usage | Research | Blood-brain barrier | Amyloid beta-protein | Index Medicus
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15. Full Text Development of Technetium-99m-Labeled BODIPY-Based Probes Targeting Lipid Droplets Toward the Diagnosis of Hyperlipidemia-Related Diseases
by Shimizu, Y and Tanimura, K and Iikuni, S and Watanabe, H and Saji, H and Ono, M
MOLECULES, ISSN 1420-3049, 06/2019, Volume 24, Issue 12, p. 2283
Hyperlipidemia causes systemic lipid disorder, which leads to hepatic steatosis and atherosclerosis. Thus, it is necessary to detect these syndromes early and... 
hyperlipidemia | BODIPY | MRI | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | LIVER-DISEASE | CHEMISTRY, MULTIDISCIPLINARY | F-18-FDG UPTAKE | hydroxamamide | RADIOPHARMACEUTICALS | technetium-99m | BIOLOGY | AGENTS | CHELATING MOIETY | TC-99M COMPLEXES
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16. Full Text Comparison of 125I- and 111In-labeled peptide probes for in vivo detection of oxidized low-density lipoprotein in atherosclerotic plaques
by Temma, Takashi and Kondo, Naoya and Yoda, Keiko and Nishigori, Kantaro and Onoe, Satoru and Shiomi, Masashi and Ono, Masahiro and Saji, Hideo
Annals of Nuclear Medicine, ISSN 0914-7187, 7/2018, Volume 32, Issue 6, pp. 425 - 429
Oxidized low-density lipoprotein (OxLDL) plays a pivotal role in atherosclerotic plaque destabilization, which suggests its potential as a nuclear medical... 
Nuclear medical imaging | Medicine & Public Health | Oxidized low-density lipoprotein | WHHLMI rabbit | Atherosclerosis | Nuclear Medicine | Imaging / Radiology | Peptide | Myocardial infarction | Intravenous administration | Target recognition | Peptides | Accumulation | Diethylene triamine | Radiochemistry | Aorta | Inhibition | Probes | Plaques | Radioactivity | Rabbits | Medical imaging | Amino acid sequence | Stability analysis | Liquid chromatography | High-performance liquid chromatography | Low density lipoprotein | Acids | Arteriosclerosis | Infarction | In vivo methods and tests | In vitro methods and tests | Destabilization | Lipophilicity | Index Medicus
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17. Full Text Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer’s Disease
by Matsuura, Yuki and Ueda, Masashi and Higaki, Yusuke and Sano, Kohei and Saji, Hideo and Enomoto, Shuichi
Molecular Imaging and Biology, ISSN 1536-1632, 6/2019, Volume 21, Issue 3, pp. 519 - 528
In patients with Alzheimer’s disease (AD), the loss of cerebral nicotinic acetylcholine receptors (nAChRs) that are implicated in higher brain functions has... 
Medicine & Public Health | Alzheimer’s disease | 2-Deoxy-2-[ 18 F]fluoro- D -glucose ([ 18 F]FDG) | Nicotinic acetylcholine receptors | 5-[ 123 I]Iodo-3-[2( S )-azetidinylmethoxy]pyridine ([ 123 I]5IA) | Imaging / Radiology | APP/PS2 mice | I]Iodo-3-[2(S)-azetidinylmethoxy]pyridine | 2-Deoxy-2- | I]5IA | F]FDG | F]fluoro-D-glucose | Neuroimaging | Brain | Memory | Cognitive ability | Glutamic acid receptors | Glucose | Western blotting | Proteins | Receptors | Rodents | Tomography | Bioindicators | Alzheimer's disease | Age | Photon emission | Medical imaging | N-Methyl-D-aspartic acid receptors | Pattern recognition | Object recognition | Single photon emission computed tomography | Computer memory | Autoradiography | Presenilin 2 | Biomarkers | Acetylcholine receptors (nicotinic) | Mice | In vivo methods and tests | Acetylcholine
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18. Full Text Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo
by Nakase, Ikuhiko and Konishi, Yusuke and Ueda, Masashi and Saji, Hideo and Futaki, Shiroh
Journal of Controlled Release, ISSN 0168-3659, 04/2012, Volume 159, Issue 2, pp. 181 - 188
We investigated the biodistribution of arginine-rich cell-penetrating peptides (CPPs) in tumor-xenografted nude mice after intravenous injection of... 
Arginine-rich cell-penetrating peptide | In vivo fluorescent imaging | Drug delivery | Tumor accumulation | Biodistribution | Doxorubicin | FAB FRAGMENT | IMPROVES SURVIVAL | HUMAN BREAST-CANCER | PLASMA-MEMBRANE | CHEMISTRY, MULTIDISCIPLINARY | MACROMOLECULAR THERAPEUTICS | MEMBRANE-ASSOCIATED PROTEOGLYCANS | MACROPINOCYTOSIS | ADRIAMYCIN | PHARMACOLOGY & PHARMACY | PROTEINS | TARGETED DELIVERY | Doxorubicin - therapeutic use | Stereoisomerism | Humans | Cell-Penetrating Peptides - pharmacokinetics | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | tat Gene Products, Human Immunodeficiency Virus - chemistry | Tissue Distribution | Time Factors | Carrier Proteins - chemistry | Female | Antineoplastic Agents - pharmacokinetics | Oligopeptides - chemistry | Cell-Penetrating Peptides - chemistry | CHO Cells | Doxorubicin - administration & dosage | Cell Survival - drug effects | Cricetinae | Doxorubicin - pharmacokinetics | Xenograft Model Antitumor Assays | Microscopy, Confocal | Peptide Fragments - chemistry | Animals | Mice, Nude | Cell Proliferation - drug effects | Drug Carriers - pharmacokinetics | Mice | Mice, Inbred BALB C | HeLa Cells | Index Medicus | Tat protein | Antitumor agents | Glycosaminoglycans | Intravenous administration | imaging | Controlled release | Tumors
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19. Full Text Highly selective tau-SPECT imaging probes for detection of neurofibrillary tangles in Alzheimer's disease
by Ono, Masahiro and Watanabe, Hiroyuki and Kitada, Ayane and Matsumura, Kenji and Ihara, Masafumi and Saji, Hideo
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, pp. 34197 - 34197
Neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of Alzheimer's disease (AD) in... 
METAANALYSIS | THERAPY | BETA-AMYLOID PLAQUES | MULTIDISCIPLINARY SCIENCES | PROGRESS | BIOLOGICAL EVALUATION | TRACERS | PATHOLOGY | DERIVATIVES | PET | BRAIN | Neuroimaging | Brain | Medical imaging | Neurodegenerative diseases | Single photon emission computed tomography | Neurofibrillary tangles | Computed tomography | Tau protein | β-Amyloid | Alzheimers disease | Alzheimer's disease | Probes | Plaques | Radioactivity
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20. Full Text Activatable fluorescence imaging of macrophages in atherosclerotic plaques using iron oxide nanoparticles conjugated with indocyanine green
by Ikeda, Hiroyuki and Ishii, Akira and Sano, Kohei and Chihara, Hideo and Arai, Daisuke and Abekura, Yu and Nishi, Hidehisa and Ono, Masahiro and Saji, Hideo and Miyamoto, Susumu
Atherosclerosis, ISSN 0021-9150, 08/2018, Volume 275, pp. 1 - 10
Macrophages are key factors in the formation of unstable atherosclerotic plaques, which may be identified through macrophage imaging. We tested whether... 
Nanoparticles | Atherosclerosis | Macrophage | Plaque | Fluorescent imaging | CARDIAC & CARDIOVASCULAR SYSTEMS | ULTRASMALL SUPERPARAMAGNETIC PARTICLES | SIGNAL-TRANSDUCTION | ENDOTHELIAL-CELL ACTIVATION | AIF-1 EXPRESSION | POSITRON-EMISSION-TOMOGRAPHY | PROTEIN CORONA | INFLAMMATORY FACTOR-I | RABBIT ATHEROMA | MAGNETIC-RESONANCE | PERIPHERAL VASCULAR DISEASE | APOE(-/-) MICE | Evaluation | Iron compounds | Chemical tests and reagents | Ferric oxide | Fluorescence | Macrophages
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