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1. Full Text Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
by Miyara, Makoto and Yoshioka, Yumiko and Kitoh, Akihiko and Shima, Tomoko and Wing, Kajsa and Niwa, Akira and Parizot, Christophe and Taflin, Cécile and Heike, Toshio and Valeyre, Dominique and Mathian, Alexis and Nakahata, Tatsutoshi and Yamaguchi, Tomoyuki and Nomura, Takashi and Ono, Masahiro and Amoura, Zahir and Gorochov, Guy and Sakaguchi, Shimon
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 899 - 911
FoxP3 is a key transcription factor for the development and function of natural CD4 regulatory T cells (Treg cells). Here we show that human FoxP3 CD4 T cells... 
MOLIMMUNO | CELLIMMUNO | POPULATION | IN-VITRO | REGULATORY CELLS | SUBPOPULATION | ARYL-HYDROCARBON RECEPTOR | HELPER-CELLS | PERIPHERAL-BLOOD | PROLIFERATION | IMMUNOLOGY | NAIVE | IDENTIFICATION | Forkhead Transcription Factors - biosynthesis | T-Lymphocytes, Regulatory - metabolism | Leukocyte Common Antigens - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Humans | CD4-Positive T-Lymphocytes - metabolism | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Leukocyte Common Antigens - immunology | Young Adult | Cell Differentiation - immunology | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Adolescent | Aged, 80 and over | Adult | Aged | Interleukin-2 Receptor alpha Subunit - immunology | Proteins | Automation | Disease | Cytokines | Cloning | DNA methylation | Autoimmune diseases | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus
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2. Full Text D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome
by Nishio, Yukiko, MD and Makiyama, Takeru, MD, PhD and Itoh, Hideki, MD, PhD and Sakaguchi, Tomoko, MD, PhD and Ohno, Seiko, MD, PhD and Gong, Yin-Zhi, MD, PhD and Yamamoto, Satoshi, MD and Ozawa, Tomoya, MD, PhD and Ding, Wei-Guang, MD, PhD and Toyoda, Futoshi, PhD and Kawamura, Mihoko, MD and Akao, Masaharu, MD, PhD and Matsuura, Hiroshi, MD, PhD and Kimura, Takeshi, MD, PhD and Kita, Toru, MD, PhD and Horie, Minoru, MD, PhD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2009, Volume 54, Issue 9, pp. 812 - 819
Objectives This study aims to address whether D85N, a KCNE1 polymorphism, is a gene variant that causes long QT syndrome (LQTS) phenotype. Background KCNE1... 
Cardiovascular | Internal Medicine | long QT syndrome | single nucleotide polymorphism | disease-causing variant | CARDIAC & CARDIOVASCULAR SYSTEMS | FORM | COMPOUND MUTATIONS | CARDIAC POTASSIUM CURRENT | I-KS | HERG | CHANNEL | RECTIFIER K+ CURRENT | TORSADE-DE-POINTES | DYSFUNCTION | Cricetinae | Humans | Middle Aged | Male | Case-Control Studies | Polymorphism, Genetic | Animals | Adolescent | Long QT Syndrome - genetics | Adult | Female | Aged | Mutation | Child | Potassium Channels, Voltage-Gated - genetics | Long QT syndrome | Respiratory agents | Genetic aspects | Universities and colleges | Hamsters | Medical colleges | Genes | Genetic polymorphisms | Cardiovascular agents | Electrocardiography | Cardiac arrhythmia | Index Medicus | Abridged Index Medicus
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3. Full Text Predictive factors for taxane acute pain syndrome determined by ordered logistic regression analysis
by Kanbayashi, Yuko and Sakaguchi, Kouichi and Nakatsukasa, Katsuhiko and Ouchi, Yoshimi and Tabuchi, Yusuke and Yoshioka, Tomoko and Ishikawa, Takeshi and Takayama, Koichi and Taguchi, Tetsuya
Supportive Care in Cancer, ISSN 0941-4355, 7/2019, Volume 27, Issue 7, pp. 2673 - 2677
This retrospective study was undertaken to identify predictive factors for developing taxane acute pain syndrome (TAPS) and to determine new strategies for... 
Pain Medicine | Nursing | Rehabilitation Medicine | Dexamethasone | Medicine & Public Health | Nursing Research | TAPS | Oncology | Taxanes | Nanoparticle albumin-bound paclitaxel | Dose | Chemotherapy | Breast cancer | Pain | Regression analysis | Analgesics
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4. Full Text PG-56 - Original diabetes education program including individual self-care plan “My Goals Sheet” ameliorates long-term glycemic control in patients with diabetes mellitus
by Ueno, Shinji and Tanaka, Nagaaki and Nagata, Takeru and Kubota, Soudai and Okamoto, Saki and Okamoto, Tomoko and Sakuramachi, Yui and Kuwata, Hitoshi and Watanabe, Kouin and Hyo, Takanori and Kouno, Chihiro and Hamasaki, Satoko and Menya, Tomoko and Sakaguchi, Mayuka and Kitatani, Naomi and Hashimoto, Hiroko and Hirasawa, Yoshikazu and Awa, Tomoko and Yabe, Daisuke and Hamamoto, Yoshiyuki and Kurose, Takeshi and Seino, Yutaka
Diabetes Research and Clinical Practice, ISSN 0168-8227, 10/2016, Volume 120, pp. S177 - S177
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5. Full Text Original diabetes education program including individual self-care plan “My Goals Sheet” ameliorates long-term glycemic control in patients with diabetes mellitus
by Ueno, Shinji and Tanaka, Nagaaki and Nagata, Takeru and Kubota, Soudai and Okamoto, Saki and Sakuramachi, Yui and Kuwata, Hitoshi and Watanabe, Kouin and Hyo, Takanori and Kouno, Chihiro and Hamasaki, Satoko and Menya, Tomoko and Sakaguchi, Mayuka and Kitatani, Naomi and Okamoto, Tomoko and Hashimoto, Hiroko and Hirasawa, Yoshikazu and Awa, Tomoko and Yabe, Daisuke and Hamamoto, Yoshiyuki and Kurose, Takeshi and Seino, Yutaka
Diabetes Research and Clinical Practice, ISSN 0168-8227, 2016, Volume 120, pp. S177 - S177
Endocrinology & Metabolism
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6. Full Text Truncating mutation in CSNK2B and myoclonic epilepsy
by Sakaguchi, Yuri and Uehara, Tomoko and Suzuki, Hisato and Kosaki, Kenjiro and Takenouchi, Toshiki
Human Mutation, ISSN 1059-7794, 11/2017, Volume 38, Issue 11, pp. 1611 - 1612
GENETICS & HEREDITY | Epilepsy | Genetic aspects | Index Medicus
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7. Full Text A Critical Link between Toll-Like Receptor 3 and Type II Interferon Signaling Pathways in Antiviral Innate Immunity
by Hideo Negishi and Tomoko Osawa and Kentaro Ogami and Xinshou Ouyang and Shinya Sakaguchi and Ryuji Koshiba and Hideyuki Yanai and Yoshinori Seko and Hiroshi Shitara and Keith Bishop and Hiromichi Yonekawa and Tomohiko Tamura and Tsuneyasu Kaisho and Choji Taya and Tadatsugu Taniguchi and Kenya Honda
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 51, pp. 20446 - 20451
A conundrum of innate antiviral immunity is how nucleic acid-sensing Toll-like receptors (TLRs) and RIG-I/MDA5 receptors cooperate during virus infection. The... 
Heart | Receptors | Messenger RNA | Cytokines | Liver | Antivirals | Toll like receptors | Viruses | Innate immunity | Infections | Coxsackievirus | Antiviral response | IFN-γ | Toll-like receptor 3 | Cytokine | cytokine | GAMMA | DOUBLE-STRANDED-RNA | ACTIVATION | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | coxsackievirus | MECHANISMS | antiviral response | VIRAL-INFECTION | COXSACKIEVIRUS B3 | IFN-gamma | PATTERN-RECOGNITION RECEPTORS | EXPRESSION | VIRUSES | DEAD Box Protein 58 | Virus Diseases - immunology | Toll-Like Receptor 3 - immunology | Interferon-gamma - metabolism | Immunity, Innate | Interferon Type I - immunology | Toll-Like Receptor 3 - metabolism | Interferon-Induced Helicase, IFIH1 | Mice, Knockout | Myocarditis - virology | Signal Transduction - immunology | Animals | Toll-Like Receptor 3 - deficiency | Interferon-gamma - immunology | Enterovirus - immunology | Interferon Type I - metabolism | Mice | DEAD-box RNA Helicases - metabolism | Myocarditis - immunology | Cell receptors | Immune response | Physiological aspects | Cellular signal transduction | Interferon | Research | Health aspects | Proteins | Signal transduction | Rodents | T cell receptors | Ribonucleic acid--RNA | Index Medicus | Biological Sciences
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8. Full Text The map-based sequence of the rice genome
by Sequencing Project, International Rice Genome and Int Rice Genome Sequencing Project and International Rice Genome Sequencing Project
Nature, ISSN 0028-0836, 08/2005, Volume 436, Issue 7052, pp. 793 - 800
Rice, one of the world's most important food plants, has important syntenic relationships with the other cereal species and is a model plant for the grasses.... 
ORYZA-SATIVA L | ARABIDOPSIS-THALIANA | DRAFT SEQUENCE | INDICA | ANNOTATION | MULTIDISCIPLINARY SCIENCES | GENES | TRANSPOSABLE ELEMENTS | JAPONICA RICE | MICRORNAS | CENTROMERE | Multigene Family - genetics | Genomics | Computational Biology | Molecular Sequence Data | International Cooperation | Genome, Plant | RNA, Untranslated - genetics | Sequence Analysis, DNA | Organelles - genetics | Cell Nucleus - genetics | Oryza - genetics | Centromere - genetics | Genes, Plant - genetics | Cloning, Molecular | DNA Transposable Elements - genetics | Polymorphism, Genetic - genetics | Chromosomes, Plant - genetics | Tandem Repeat Sequences - genetics | Chromosomes | Rice | Index Medicus
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9. Full Text Structural stability of flagellin subunit affects the rate of flagellin export in the absence of FliS chaperone
by Furukawa, Yukio and Inoue, Yumi and Sakaguchi, Aya and Mori, Yoko and Fukumura, Takuma and Miyata, Tomoko and Namba, Keiichi and Minamino, Tohru
Molecular Microbiology, ISSN 0950-382X, 11/2016, Volume 102, Issue 3, pp. 405 - 416
FliS chaperone binds to flagellin FliC in the cytoplasm and transfers FliC to a sorting platform of the flagellar type III export apparatus through the... 
ANTI-SIGMA FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETION SYSTEM | SALMONELLA-TYPHIMURIUM | SUBSTRATE COMPLEXES | FUNCTIONAL-ANALYSIS | III PROTEIN EXPORT | MICROBIOLOGY | FACTOR FLGM | TERMINAL CYTOPLASMIC DOMAIN | FILAMENT FORMATION | APPARATUS | Sigma Factor - metabolism | Flagella - metabolism | Molecular Chaperones - metabolism | Flagellin - biosynthesis | Flagellin - metabolism | Protein Binding | Bacterial Proteins - metabolism | Structure-Activity Relationship | Protein Transport | Salmonella typhimurium - metabolism | Proteolysis | Exports | Protein expression | Mutation | Microbiology | Protein folding | Index Medicus
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10. Full Text Co‐occurrence of Sturge–Weber syndrome and Klippel–Trenaunay–Weber syndrome phenotype: Consideration of the historical aspect
by Sakaguchi, Yuri and Takenouchi, Toshiki and Uehara, Tomoko and Kishi, Kazuo and Takahashi, Takao and Kosaki, Kenjiro
American Journal of Medical Genetics Part A, ISSN 1552-4825, 10/2017, Volume 173, Issue 10, pp. 2831 - 2833
GENETICS & HEREDITY | Index Medicus
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11. Full Text Dipeptide synthesis by internal adenylation domains of a multidomain enzyme involved in nonribosomal peptide synthesis
by Abe, Tomoko and Kobayashi, Kenta and Kawamura, Sho and Sakaguchi, Tatsuya and Shiiba, Kiwamu and Kobayashi, Michihiko
The Journal of General and Applied Microbiology, ISSN 0022-1260, 2019, Volume 65, Issue 1, pp. 1 - 10
The adenylation domain of nonribosomal peptide synthetase (NRPS) is responsible for its selective substrate recognition and activation of the substrate... 
nonribosomal peptide synthetase | peptide bond | superfamily of adenylate-forming enzymes | adenylation domain | RECOGNITION | SPECIFICITY | MECHANISM | CRYSTAL-STRUCTURE | MICROBIOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOSYNTHESIS | AMINO-ACID LIGASE | PURIFICATION | ENTEROBACTIN | SYNTHETASE | Enzymes | Cysteine | Thioesterase | AMP | Oligopeptides | Threonine | Peptides | Amino acids | Nitrogen | Glycine | Substrates | Domains | Synthesis | Acids | Carboxyl group | Peptide synthesis | Adenylation
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12. Full Text CNOT2 as the critical gene for phenotypes of 12q15 microdeletion syndrome
by Uehara, Tomoko and Takenouchi, Toshiki and Yamaguchi, Yu and Daimon, Yumi and Suzuki, Hisato and Sakaguchi, Yuri and Kosaki, Kenjiro
American Journal of Medical Genetics Part A, ISSN 1552-4825, 04/2019, Volume 179, Issue 4, pp. 659 - 662
Chromosome 12q15 microdeletion syndrome is characterized by intellectual disability and dysmorphic facial features, but the associations between each of the... 
developmental delay | nasal voice | chromosome 12q15 | CNOT2 | intellectual disability | PROTEIN | MESSENGER-RNA | GENETICS & HEREDITY | CCR4-NOT COMPLEX | Medical research | Phenotype | DNA microarrays | Analysis | Genes | Genetic research | Medicine, Experimental | Genetic aspects | Gene expression | NOT protein | Phenotypes | Enzymatic activity | Clonal deletion | Intellectual disabilities | Syndactyly | Chromosome 12 | Cleft lip/palate | Haploinsufficiency
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13. Full Text Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition
by Ishii, Kazunari and Hosokawa, Chisa and Hyodo, Tomoko and Sakaguchi, Kenta and Usami, Kimio and Shimamoto, Kenji and Hosono, Makoto and Yamazoe, Yuzuru and Murakami, Takamichi
Annals of Nuclear Medicine, ISSN 0914-7187, 1/2015, Volume 29, Issue 1, pp. 78 - 83
There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism... 
Glucose metabolism | Medicine & Public Health | Nuclear Medicine | Imaging / Radiology | Amyloid deposit | PET | Dementia with Lewy bodies | DIAGNOSIS | POSITRON-EMISSION-TOMOGRAPHY | ALZHEIMERS-DISEASE | BODY DISEASES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PARKINSONS-DISEASE DEMENTIA | Brain - diagnostic imaging | Humans | Male | Lewy Body Disease - diagnostic imaging | Brain - metabolism | Lewy Body Disease - metabolism | Amyloid - metabolism | Alzheimer Disease - metabolism | Radionuclide Imaging | Aged, 80 and over | Brain Mapping | Glucose - metabolism | Female | Fluorodeoxyglucose F18 | Aged | Alzheimer Disease - diagnostic imaging | Radiopharmaceuticals | Benzothiazoles | College teachers | Glucose | Alzheimer's disease | Dextrose | Index Medicus | Original
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14. Full Text Dysregulation of MAP kinase signaling pathways including p38MAPK, SAPK/JNK, and ERK1/2 in cultured rat cerebellar astrocytes exposed to diphenylarsinic acid
by Negishi, Takayuki and Matsumoto, Mami and Kobayashi, Yayoi and Kojima, Mikiya and Sakaguchi, Fumika and Takahata, Kazuaki and Kanehira, Tomoko and Arakaki, Rina and Aoyama, Yohei and Yoshida, Hikari and Yamada, Rena and Sumiyoshi, Nobutaka and Tashiro, Tomoko and Hirano, Seishiro and Yoshida, Kenji and Yukawa, Kazunori
Toxicological Sciences, ISSN 1096-6080, 04/2017, Volume 156, Issue 2, pp. 509 - 519
Diphenylarsinic acid (DPAA) was a major compound found in the arsenic poisoning incident that occurred in Kamisu, Ibaraki, Japan in 2003. People exposed to... 
Oxidative stress | MAP kinase | Astrocyte | Diphenylarsinic acid | Cytokine | cytokine | ACTIVATION | PHOSPHORYLATION | GLUTAMINASE-C | DEGRADATION-PRODUCT | DOWN-REGULATION | CELL-SURVIVAL | diphenylarsinic acid | METABOLISM | GLUTATHIONE | CHEMICAL WARFARE AGENTS | TOXICOLOGY | astrocyte | EXPRESSION | oxidative stress | Astrocytes - drug effects | Animals | MAP Kinase Signaling System - drug effects | Arsenicals - pharmacology | Cells, Cultured | Cerebellum - cytology | Cerebellum - drug effects | Rats | Astrocytes - enzymology | Cerebellum - enzymology | Blotting, Western | Immunoenzyme Techniques | Index Medicus
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