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1. Full Text Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936
by Dickie, David Alexander, PhD and Ritchie, Stuart J., PhD and Cox, Simon R., PhD and Sakka, Eleni, MSc and Royle, Natalie A., PhD and Aribisala, Benjamin S., PhD and Hernández, Maria del C. Valdés, PhD and Muñoz Maniega, Susana, PhD and Pattie, Alison, BSc and Corley, Janie, MA and Starr, John M., PhD/MD and Bastin, Mark E., PhD and Deary, Ian J., PhD/MD and Wardlaw, Joanna M., PhD/MD
Neurobiology of Aging, ISSN 0197-4580, 2015, Volume 42, pp. 116 - 123
Abstract Purpose To determine associations between multiple vascular risk factors (VRF) at ∼73 years and progression of white matter hyperintensities (WMH)... 
Neurology | Internal Medicine | White matter damage | Aging | White matter hyperintensities | MRI | Vascular risk factors | Blood Pressure | Hypertension | Smoking - adverse effects | Humans | Risk Factors | Male | Models, Statistical | Disease Progression | Aging - pathology | White Matter - pathology | Magnetic Resonance Imaging | White Matter - diagnostic imaging | Female | Aged | Cholesterol, HDL - deficiency | Cohort Studies | Specific gravity | Epidemiology | Risk factors | Anticholesteremic agents | Regular
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2. Full Text Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability
by Heye, Anna K and Thrippleton, Michael J and Armitage, Paul A and Valdés Hernández, Maria del C and Makin, Stephen D and Glatz, Andreas and Sakka, Eleni and Wardlaw, Joanna M
NeuroImage, ISSN 1053-8119, 01/2016, Volume 125, pp. 446 - 455
There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel... 
Dynamic contrast-enhanced MRI | Tracer kinetic modelling | Cerebral small vessel disease | Blood–brain barrier | Blood-brain barrier | SINGLE-PULSE OBSERVATION | SMALL VESSEL DISEASE | MULTIMODEL INFERENCE | HEALTHY-SUBJECTS | VOLUME | NEUROSCIENCES | NEUROIMAGING | WHITE-MATTER LESIONS | INPUT FUNCTION | IN-VIVO | PERFUSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuronavigation - methods | Capillary Permeability - physiology | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Brain Mapping - methods | Image Processing, Computer-Assisted - methods | Stroke - pathology | Blood-Brain Barrier - pathology | Contrast Media | Female | Aged | Image Enhancement - methods | Kinetics | Models | Permeability | Tracers (Biology) | Magnetic resonance imaging | Analysis | Contrast media | Studies | Stroke | Brain research | Research & development--R&D | Funding | Alzheimers disease | Blood | Methods | Acquisitions & mergers
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3. Full Text Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease
by Maraki, Maria I and Yannakoulia, Mary and Stamelou, Maria and Stefanis, Leonidas and Xiromerisiou, Georgia and Kosmidis, Mary H and Dardiotis, Efthimios and Hadjigeorgiou, Georgios M and Sakka, Paraskevi and Anastasiou, Costas A and Simopoulou, Eleni and Scarmeas, Nikolaos
Movement Disorders, ISSN 0885-3185, 01/2019, Volume 34, Issue 1, pp. 48 - 57
ABSTRACT Background The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal... 
neurodegeneration | Mediterranean | nutrition | prodromal | elderly | DEMENTIA | QUALITY | OLDER-ADULTS | RISK | GUT MICROBIOTA | DEPRESSIVE SYMPTOMS | PREVALENCE | CLINICAL NEUROLOGY | PATTERN | MDS RESEARCH CRITERIA | HEALTH | Parkinson's disease | Diet | Neurodegenerative diseases | Older people | Aging | Population studies | Dietary intake | Mental depression | Constipation | Movement disorders
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4. Full Text The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial
by Sandercock, Peter and Wardlaw, Joanna M and Lindley, Richard I and Dennis, Martin and Cohen, Geoff and Murray, Gordon and Innes, Karen and Venables, Graham and Czlonkowska, Anna and Kobayashi, Adam and Ricci, Stefano and Murray, Veronica and Berge, Eivind and Slot, Karsten Bruins and Hankey, Graeme J and Correia, Manuel and Peeters, Andre and Matz, Karl and Lyrer, Phillippe and Gubitz, Gord and Phillips, Stephen J and Arauz, Antonio and Baigent, Colin and Chadwick, David and Tyrrell, Pippa and Lowe, Gordon and Collins, Rory and Bath, Philip and Van Gijn, Jan and Gray, Richard and Hart, Robert and Yusuf, Salim and Clark, Alison and Perry, David and Soosay, Vera and Buchanan, David and Grant, Sheila and Sakka, Eleni and Drever, Jonathan and Walker, Pauli and Herath, Indee and Brown, Ann Leigh and Chmielnik, Paul and Armit, Christopher and Walton, Andrea and Hautvast, Mischa and Lewis, Steff and Heron, Graeme and Odusanya, Sylvia and Linksted, Pam and Kane, Ingrid and Whiteley, Will and Sellar, Robin and White, Philip and Keston, Peter and Farrell, Andrew and Morris, Zoe and Miranda, Hector and Blackwell, Lisa and IST 3 Collaborative Grp and IST-3 collaborative group
Lancet, The, ISSN 0140-6736, 2012, Volume 379, Issue 9834, pp. 2352 - 2363
Summary Background Thrombolysis is of net benefit in patients with acute ischaemic stroke, who are younger than 80 years of age and are treated within 4·5 h of... 
Internal Medicine | MORTALITY | MEDICINE, GENERAL & INTERNAL | OXFORDSHIRE | IMPACT | CASE-FATALITY | RISK-FACTORS | ALTEPLASE | DISEASE | BRAIN | STATISTICAL-ANALYSIS | Recombinant Proteins - therapeutic use | Age Distribution | Humans | Middle Aged | Male | Secondary Prevention | Tissue Plasminogen Activator - therapeutic use | Recombinant Proteins - adverse effects | Tissue Plasminogen Activator - adverse effects | Young Adult | Fibrinolytic Agents - adverse effects | Fibrinolytic Agents - therapeutic use | Thrombolytic Therapy - methods | Aged, 80 and over | Adult | Female | Severity of Illness Index | Stroke - prevention & control | Double-Blind Method | Drug Administration Schedule | Tissue Plasminogen Activator - administration & dosage | Treatment Outcome | Stroke - drug therapy | Recombinant Proteins - administration & dosage | Brain Ischemia - drug therapy | Adolescent | Aged | Fibrinolytic Agents - administration & dosage | Infusions, Intravenous | Thrombolytic Therapy - adverse effects | Care and treatment | Venous thrombosis | Thrombolytic drugs | Ischemia | Patient outcomes | Medical research | Brain | Stroke | Blood pressure | Grants | Councils
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5. Full Text Longitudinal multi-centre brain imaging studies: Guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing
by Wiseman, Stewart J and Meijboom, Rozanna and Valdés Hernández, Maria Del C and Pernet, Cyril and Sakka, Eleni and Job, Dominic and Waldman, Adam D and Wardlaw, Joanna M
Trials, ISSN 1745-6215, 01/2019, Volume 20, Issue 1, pp. 21 - 10
BackgroundResearch involving brain imaging is important for understanding common brain diseases. Study endpoints can include features and measures derived from... 
Study design | Longitudinal | Magnetic resonance imaging | Data sharing | Multi-centre | Big data | Guidelines | MEDICINE, RESEARCH & EXPERIMENTAL | TRIALS | DESIGN | QUALITY-CONTROL | RECOMMENDATIONS | DISEASE | INCREASING VALUE | Neuroimaging | Usage | Brain research | Analysis | Practice guidelines (Medicine) | Clinical trials | Research
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6. Full Text Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial
by Arba, Francesco, MD, PhD and Mair, Grant, MBChB and Carpenter, Trevor, PhD and Sakka, Eleni, BSc and Sandercock, Peter A.G., MD and Lindley, Richard I., MD and Inzitari, Domenico, MD and Wardlaw, Joanna M., MD and IST-3 Trial Collaborators
Journal of Stroke and Cerebrovascular Diseases, ISSN 1052-3057, 2017, Volume 26, Issue 7, pp. 1506 - 1513
Background Leukoaraiosis is associated with impaired cerebral perfusion, but the effect of individual and combined small-vessel disease (SVD) features on white... 
Neurology | Cardiovascular | white matter | cerebral blood flow | Cerebral small-vessel disease | CT perfusion | stroke | MRI | BLOOD-FLOW | NEUROSCIENCES | ACUTE ISCHEMIC-STROKE | MAGNETIC-RESONANCE | COAGULATION | PERIPHERAL VASCULAR DISEASE | LACUNAR STROKE | PERFUSION | DYSFUNCTION | ASSOCIATION | LEUKOARAIOSIS | Humans | Leukoencephalopathies - diagnostic imaging | Perfusion Imaging - methods | Risk Factors | Logistic Models | Male | Tomography, X-Ray Computed | Cerebrovascular Circulation | Leukoencephalopathies - physiopathology | Atrophy | Cerebral Small Vessel Diseases - complications | Magnetic Resonance Imaging | Cerebral Small Vessel Diseases - diagnostic imaging | Blood Flow Velocity | Leukoencephalopathies - etiology | Aged, 80 and over | Female | Aged | White Matter - blood supply | Odds Ratio | Leukoaraiosis | Cerebral Small Vessel Diseases - physiopathology | Hypertension | Medicine, Experimental | Medical research | CT imaging | Diagnostic imaging
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7. Full Text Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial
by Wardlaw, Joanna M and Sandercock, Peter and Cohen, Geoff and Farrall, Andrew and Lindley, Richard I and von Kummer, Rudiger and von Heijne, Anders and Bradey, Nick and Peeters, Andre and Cala, Lesley and Adami, Alessandro and Morris, Zoe and Potter, Gillian and Murray, Gordon and Whiteley, Will and Perry, David and Sakka, Eleni and IST-Collaborative Grp and IST-3 collaborative group
Lancet Neurology, The, ISSN 1474-4422, 2015, Volume 14, Issue 5, pp. 485 - 496
Summary Background Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However,... 
Neurology | PROUROKINASE | RISK-FACTORS | METAANALYSIS | TISSUE-PLASMINOGEN ACTIVATOR | COMPUTED-TOMOGRAPHY SCORE | THROMBOLYSIS | CLASSIFICATION | FRAILTY | RELIABILITY | CLINICAL NEUROLOGY | Single-Blind Method | Data Interpretation, Statistical | Outcome Assessment (Health Care) | Stroke - diagnostic imaging | Humans | Middle Aged | Male | Tissue Plasminogen Activator - administration & dosage | Stroke - drug therapy | Magnetic Resonance Imaging, Cine | Radiography | Stroke - pathology | Fibrinolytic Agents - pharmacology | Tissue Plasminogen Activator - pharmacology | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Thrombolytic Therapy - methods | Aged, 80 and over | Adult | Female | Aged | Fibrinolytic Agents - administration & dosage | Brain Ischemia - diagnostic imaging | Stroke (Disease) | Ischemia | Tissue plasminogen activator | Stroke | Signs | Medical prognosis | Age | Logistics
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8. Full Text Integrity of normal-appearing white matter: Influence of age, visible lesion burden and hypertension in patients with small-vessel disease
by Muñoz Maniega, Susana and Chappell, Francesca M and Valdés Hernández, Maria C and Armitage, Paul A and Makin, Stephen D and Heye, Anna K and Thrippleton, Michael J and Sakka, Eleni and Shuler, Kirsten and Dennis, Martin S and Wardlaw, Joanna M
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 2/2017, Volume 37, Issue 2, pp. 644 - 656
White matter hyperintensities accumulate with age and occur in patients with stroke, but their pathogenesis is poorly understood. We measured multiple magnetic... 
blood-brain barrier | diffusion tensor imaging | ageing | cerebrovascular disease | Magnetic resonance imaging | HYPERINTENSITIES | METAANALYSIS | DEMENTIA | MRI | NEUROSCIENCES | BRAIN-BARRIER PERMEABILITY | DIFFUSION-TENSOR | ENDOCRINOLOGY & METABOLISM | MAGNETIC-RESONANCE | CEREBRAL-BLOOD-FLOW | HEMATOLOGY | AGING BRAIN | LEUKOARAIOSIS | Brain - diagnostic imaging | Prospective Studies | Vascular Diseases - pathology | Stroke - diagnostic imaging | Humans | Middle Aged | Magnetic Resonance Imaging - methods | Male | Hypertension - pathology | Vascular Diseases - diagnostic imaging | White Matter - pathology | Diffusion Tensor Imaging - methods | Stroke - pathology | Blood-Brain Barrier - pathology | White Matter - diagnostic imaging | Blood-Brain Barrier - diagnostic imaging | Anisotropy | Aged, 80 and over | Aging | Brain - pathology | Adult | Female | Aged | Hypertension - diagnostic imaging | blood–brain barrier | Original
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