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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 222 - 227
Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used... 
CELL LUNG-CANCER | RAS-TRANSFORMATION | OVEREXPRESSION | OXIDATIVE STRESS | HMTH1 | MESSENGER-RNA | GENE | MULTIDISCIPLINARY SCIENCES | HUMAN MUTT HOMOLOG | TUMORIGENESIS | SMALL-MOLECULE INHIBITION | ras Proteins - genetics | Colonic Neoplasms - genetics | Proto-Oncogene Proteins p21(ras) | Pyridines - chemistry | Colonic Neoplasms - drug therapy | Humans | Substrate Specificity | DNA Breaks, Single-Stranded - drug effects | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Phosphoric Monoester Hydrolases - biosynthesis | DNA Repair Enzymes - metabolism | Female | Antineoplastic Agents - pharmacology | DNA Repair Enzymes - antagonists & inhibitors | Homeostasis - drug effects | Aminoquinolines - pharmacology | DNA Repair Enzymes - chemistry | Disease Models, Animal | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Pyrazoles - pharmacology | Crystallization | Models, Molecular | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - chemistry | Mice, SCID | Nucleotides - metabolism | Xenograft Model Antitumor Assays | Animals | Colonic Neoplasms - pathology | DNA Repair | DNA Repair Enzymes - biosynthesis | Proteomics | Protein Conformation | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Crizotinib | Enzymes | Colon cancer | Physiological aspects | Genetic aspects | Research | Nucleotides | Studies | Oxidative stress | Inhibitor drugs | Medical prognosis | Homeostasis | Mutation | Kinases | Experiments | Cancer | Life Sciences | crizotinib | cancer | stereoselectivity | MTH1 | DNA repair | drug
Journal Article
Methods in molecular biology (Clifton, N.J.), 2019, Volume 2025, p. 191
Protein kinases are major targets for the development of new medicines and play key roles in cellular signaling. The flexible nature of these proteins,... 
Journal Article
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 57, pp. 7975 - 7978
Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of N-epsilon-methylated lysines on histones and play important roles in gene... 
JMJD3 | 5-METHYLCYTOSINE | MACROPHAGES | DNA | GENE-EXPRESSION | PROTEINS | CHEMISTRY, MULTIDISCIPLINARY | Histones | Gene expression | Lysine | Alkylation
Journal Article
ISSN 1359-7345, 7/2018, Volume 54, Issue 57, pp. 7975 - 7978
Jumonji domain-containing demethylases (JmjC-KDMs) catalyse demethylation of N -methylated lysines on histones and play important roles in gene regulation. We... 
Journal Article
Chemical Communications (Cambridge, England), ISSN 1359-7345, 7/2018, Volume 54, Issue 57, pp. 7975 - 7978
Biochemical studies on the histone lysyl demethylase KDM6B reveal it is capable of catalysing reactions on multiple lysine analogues, forming de-alkylated,... 
Chemistry
Journal Article
PLoS Biology, ISSN 1544-9173, 07/2010, Volume 8, Issue 7, p. e1000426
Long-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning... 
SUPPRESSES TUMOR-GROWTH | INHIBITORY AUTOPHOSPHORYLATION | CA-2+ CALMODULIN | CONFORMATIONAL ADAPTATION | CRYSTAL-STRUCTURE | ASSOCIATION DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | BIOLOGY | DEPENDENT PROTEIN-KINASE | ALPHA | CELL-CYCLE ARREST
Journal Article
FRONTIERS IN CHEMISTRY, ISSN 2296-2646, 08/2019, Volume 7
Enzymes that bind and process ubiquitin, a small 76-amino-acid protein, have been recognized as pharmacological targets in oncology, immunological disorders,... 
ubiquitin specific proteases | PROTEIN | proteomics | SPECIFICITY | UBIQUITIN | isoforms | deubiquitylating enzymes | CANCER | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | ACTIVITY-BASED PROBES | chemical biology | SMALL-MOLECULE INHIBITORS | CHEMISTRY | mass spectrometry | FUNCTIONAL PROTEOMICS
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2016, Volume 30, Issue 2, pp. 273 - 289
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2016, Volume 23, Issue 12, p. 1930
  Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally... 
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2016, Volume 23, Issue 12, pp. 1930 - 1940
Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active,... 
SYSTEM | LIMB | DOMAIN | EVOLUTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | P53 HOMOLOG | P63 | P73 | CELL BIOLOGY | Original Paper
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2008, Volume 426, pp. 221 - 246
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 7, pp. 2359 - 2367
ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL. ABL2 is involved in human neoplastic diseases and is... 
Journal Article