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Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 7, pp. 511 - 517
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2019, Volume 15, Issue 7, pp. 666 - 668
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5... 
SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | Proteins | Complement activation | Inhibitors | Complement component C5 | Antibodies | Complement | Paroxysmal nocturnal hemoglobinuria | Optimization | Immune system
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e42657
Argyrins, produced by myxobacteria and actinomycetes, are cyclic octapeptides with antibacterial and antitumor activity. Here, we identify elongation factor G... 
ELUCIDATION | FUSIDIC ACID | MULTIDISCIPLINARY SCIENCES | PROTEASOME | RESISTANCE | EF-G | INHIBITORS | BACTERIAL PROTEIN-SYNTHESIS | MYXOBACTERIA | IMMUNOSUPPRESSIVE CYCLIC-PEPTIDES | RIBOSOME | Amino Acid Sequence | Humans | Molecular Sequence Data | Crystallography, X-Ray | Mutant Proteins - metabolism | Oligopeptides - metabolism | Pseudomonas aeruginosa - drug effects | Mammals | Microbial Sensitivity Tests | Saccharomyces cerevisiae - metabolism | Sequence Homology, Amino Acid | Animals | Mitochondrial Proteins - metabolism | Mutant Proteins - chemistry | Peptide Elongation Factor G - antagonists & inhibitors | Protein Binding - drug effects | Allosteric Site | Cell Line, Tumor | Conserved Sequence | Peptide Elongation Factor G - chemistry | Peptide Elongation Factor G - metabolism | Oligopeptides - pharmacology | Oligopeptides - chemistry | Burkholderia - drug effects | Antibiotics | Genomics | Amino acids | Protein biosynthesis | Genomes | Nucleotide sequencing | Electron transport | Cells | DNA sequencing | Biomedical research | Yeast | Fusidic acid | Cytotoxicity | Homology | Oncology | Crystallography | Gene sequencing | Anticancer properties | Mammalian cells | Proteins | Mitochondria | Allosteric properties | Cell cycle | Bacteria | Inhibition | Elongation | Binding | Translation | Tumor cells | Octapeptides | Permeability | Infectious diseases | Lymphocytes B | Protein synthesis | Natural products | Resistant mutant | Antitumor activity | Actinomycetes | Mutation
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 01/2020, Volume 16, Issue 1, pp. 50 - 50
The post-genomic era has seen many advances in our understanding of cancer pathways, yet resistance and tumor heterogeneity necessitate multiple approaches to... 
APOPTOSIS | EWS-FLI1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYTOKINE PRODUCTION INHIBITOR | TRANSCRIPTION | ENDOTOXIN | SENSITIVITY | MECHANISMS | LEUKEMIA | JTE-607 | FEATURES
Journal Article
Journal Article
Journal Article
Current Opinion in Biotechnology, ISSN 0958-1669, 2005, Volume 16, Issue 4, pp. 447 - 452
Arrays of immobilized proteins have been developed for the discovery and characterization of protein functions ranging from molecular recognition to enzymatic... 
GLASS | CHIP | ASSAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENZYMES | STRATEGY | BIOCHEMICAL RESEARCH METHODS | SURFACE | ENZYMATIC-ACTIVITY | IMMOBILIZATION | DNA-Binding Proteins - metabolism | Enzymes - chemistry | Humans | Protein Array Analysis | Protein Binding | DNA-Binding Proteins - chemistry | Enzymes - metabolism | Enzymes
Journal Article
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2007, Volume 382, pp. 239 - 248
Small molecules, such as metabolites and hormones, interact with proteins to regulate numerous biological pathways, which are often aberrant in disease. Small... 
Biological Products - chemistry | Biological Products - genetics | Biological Products - metabolism | Models, Molecular | Protein Array Analysis | Protein Binding | Gene Expression Profiling - methods | Proteomics - methods | Receptors, Drug - metabolism
Journal Article