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1. Full Text MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance
by Sale, Matthew J and Balmanno, Kathryn and Saxena, Jayeta and Ozono, Eiko and Wojdyla, Katarzyna and McIntyre, Rebecca E and Gilley, Rebecca and Woroniuk, Anna and Howarth, Karen D and Hughes, Gareth and Dry, Jonathan R and Arends, Mark J and Caro, Pilar and Oxley, David and Ashton, Susan and Adams, David J and Saez-Rodriguez, Julio and Smith, Paul D and Cook, Simon J
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1 - 22
Acquired resistance to MEK1/2 inhibitors (MEKi) arises through amplification of BRAFV600E or KRASG13D to reinstate ERK1/2 signalling. Here we show that... 
Cell proliferation | Amplification | Signaling | Senescence | Cell survival | Mesenchyme | Cell death | Withdrawal | Chemoresistance | Cell cycle | Extracellular signal-regulated kinase | Tumors
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2. Full Text MEK1 and MEK2 inhibitors and cancer therapy: The long and winding road
by Caunt, Christopher J and Sale, Matthew J and Smith, Paul D and Cook, Simon J
Nature Reviews Cancer, ISSN 1474-175X, 09/2015, Volume 15, Issue 10, pp. 577 - 592
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF,... 
CELL LUNG-CANCER | MUTATIONS CONFER RESISTANCE | ONCOLOGY | SELUMETINIB AZD6244 | ACQUIRED-RESISTANCE | OPEN-LABEL | NEGATIVE FEEDBACK | ANTITUMOR-ACTIVITY | SIGNAL-REGULATED KINASE | PHASE-I | I DOSE-ESCALATION | Neoplasms - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Signal Transduction - drug effects | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Humans | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Neoplasms - drug therapy | Care and treatment | Enzyme inhibitors | Patient outcomes | Innovations | Properties | Phosphotransferases | Cancer
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3. Full Text Understanding factors controlling depolymerization and polymerization in catalytic degradation of β-ether linked model lignin compounds by versatile peroxidaseElectronic supplementary information (ESI) available. See DOI: 10.1039/c6gc03379b
by Zeng, Jijiao and Mills, Matthew J. L and Simmons, Blake A and Kent, Michael S and Sale, Kenneth L
ISSN 1463-9262, 5/2017, Volume 19, Issue 9, pp. 2145 - 2154
Lignin is a major component of lignocellulosic biomass and is responsible for much of its recalcitrant nature. Enzymatic breakdown of lignin into valuable... 
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4. Full Text The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G1 cell-cycle arrest and not a direct effect on BIK protein stability
by Sale, Matthew J and Cook, Simon J
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 513 - 524
BIK (BCL2-interacting killer) is a pro-apoptotic BH3 (BCL2 homology domain 3)-only protein and a member of the BCL2 protein family. It was proposed recently... 
BCL2-interacting killer (BIK) | Extracellularsignal-regulated kinase 1/2 (ERK1/2) | BCL2-interacting mediator of cell death (BIM) | Cell cycle | Apoptosis | Proteasome | Cyclin-Dependent Kinase 6 - antagonists & inhibitors | Neoplasms - metabolism | Humans | Neoplasm Proteins - antagonists & inhibitors | G1 Phase - drug effects | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins - biosynthesis | Proteolysis - drug effects | Ubiquitination - drug effects | Bcl-2-Like Protein 11 | RNA Interference | Apoptosis Regulatory Proteins - genetics | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Cyclin-Dependent Kinase 4 - antagonists & inhibitors | Neoplasm Proteins - genetics | Apoptosis Regulatory Proteins - biosynthesis | Proto-Oncogene Proteins - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Membrane Proteins - genetics | Neoplasm Proteins - biosynthesis | Neoplasms - enzymology | Proteasome Endopeptidase Complex - chemistry | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Cyclin-Dependent Kinase 6 - metabolism | MAP Kinase Kinase 2 - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Apoptosis Regulatory Proteins - metabolism | Neoplasms - drug therapy | Membrane Proteins - biosynthesis | MAP Kinase Signaling System - drug effects | Membrane Proteins - antagonists & inhibitors | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Stability - drug effects | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Proteasome Endopeptidase Complex - metabolism
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5. Full Text Bone Turnover is Influenced by Short-Term Higher Protein Intake but not Dietary Energy Restriction
: 3689 Board #128 June 4, 9
by Anton-Solanas, Ana and Furber, Matthew J. W and Fraser, William D and Elliott-Sale, Kirsty J and van Someren, Ken A and Sale, Craig
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 05/2016, Volume 48, p. 1028
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6. Full Text Bone Turnover is Influenced by Short-Term Higher Protein Intake but not Dietary Energy Restriction: 3689 Board #128 June 4, 9: 30 AM - 11: 00 AM
by Anton-Solanas, Ana and Furber, Matthew J W and Fraser, William D and Elliott-Sale, Kirsty J and van Someren, Ken A and Sale, Craig
Medicine & Science in Sports & Exercise, ISSN 0195-9131, 05/2016, Volume 48, Issue 5S Suppl 1, pp. 1028 - 1028
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7. Full Text That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance
: Delaying resistance to ERK1/2 pathway inhibitors using BH3 mimetics
by Sale, Matthew J and Cook, Simon J
British Journal of Pharmacology, ISSN 0007-1188, 08/2013, Volume 169, Issue 8, pp. 1708 - 1722
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8. Full Text A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
by Palmer, N.D and McDonough, C.W and Hicks, P.J and Roh, B.H and Wing, M.R and Sandy An, S and Hester, J.M and Cooke, J.N and Bostrom, M.A and Rudock, M.E and Talbert, M.E and Lewis, J.P and Hottenga, J.J and Geus, de, E.J.C and Willemsen, G and Boomsma, D.I and Ferrara, A and Lu, L and Ziegler, J.T and Sale, M.M and Divers, J and Shriner, D and Adeyemo, A and Rotimi, C.N and Ng, M.C.Y and Langefeld, C.D and Freedman, B.I and Bowden, D.W and Posthuma, D and Penninx, B.W.J.H and Sladek, R and DIAGRAM Consortium and MAGIC Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Allmänmedicin and Näringsforskning and Umeå universitet and Medicin
PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29202
African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this... 
FASTING GLUCOSE | COMMON VARIANTS | TCF7L2 GENE | LARGE-SCALE ASSOCIATION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | LINKAGE ANALYSIS | STAGE RENAL-DISEASE | TISSUE FACTOR | HOMEODOMAIN PROTEIN | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | African Americans - genetics | Genotype | Male | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | Validation Studies as Topic | Adult | Female | Aged | Polymorphism, Single Nucleotide | Cohort Studies | Type 2 diabetes | Chronic kidney failure | Analysis | Genes | Genomics | African Americans | Genetic aspects | Genomes | Haplotypes | End-stage renal disease | Physicians | Science | Biochemistry | Single-nucleotide polymorphism | Epidemiology | Population genetics | Consortia | Precision medicine | Atherosclerosis | Genetics | Diabetes mellitus (non-insulin dependent) | Lupus | Diabetes mellitus | Gene expression | Minority & ethnic groups | Disease control | Loci | Nephropathy | Genotyping | Insulin resistance | Replication | Diabetes | Kidney diseases | Medical and Health Sciences | Medicin och hälsovetenskap
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9. Full Text The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance
by Sale, Matthew J and Cook, Simon J
Biochemical Journal, ISSN 0264-6021, 03/2013, Volume 450, Issue 2, pp. 285 - 294
Tumour cells typically exhibit a G(1) cell cycle arrest in response to the MEK1/2 [mitogen-activated protein kinase/ERK (extracellular-signal-regulated kinase)... 
Extracellular-signal-regulated kinase 1/2 (ERK1/2) | BRAF | Acquired resistance | BCL2-interacting mediator of cell death (BIM) | RAS | BCL2 homology domain 3 (BH3) mimetic | CANCER-CELLS | ACTIVATION | extracellular-signal-regulated kinase 1/2 (ERK1/2) | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFICIENTLY INDUCES APOPTOSIS | RAF KINASE | ABT-737 | acquired resistance | BRAF GENE | ERK1/2 | SIGNALING PATHWAY | BCL-2 FAMILY-MEMBERS | BH3-ONLY PROTEINS | MAP Kinase Kinase 1 - antagonists & inhibitors | Aniline Compounds - pharmacology | Humans | bcl-2-Associated X Protein - metabolism | Drug Resistance, Neoplasm | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Sulfonamides - pharmacology | MAP Kinase Signaling System | HT29 Cells | RNA Interference | MAP Kinase Kinase 2 - antagonists & inhibitors | Cell Death | Cell Line, Tumor | Benzimidazoles - pharmacology | Apoptosis
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10. Full Text The increase in BIK expression following ERK1/2 pathway inhibition is a consequence of G1cell-cycle arrest and not a direct effect on BIK protein stability
by Sale, Matthew J and Cook, Simon J
Biochemical Journal, ISSN 0264-6021, 05/2014, Volume 459, Issue 3, pp. 513 - 524
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11. Full Text Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
by Cook, Simon J and Stuart, Kate and Gilley, Rebecca and Sale, Matthew J
The FEBS Journal, ISSN 1742-464X, 12/2017, Volume 284, Issue 24, pp. 4177 - 4195
The ERK 1/2 signalling pathway is best known for its role in connecting activated growth factor receptors to changes in gene expression due to activated ERK... 
MEK | DRP | 1/2 | RAS | 3‐only proteins | mitochondria | BIM | apoptosis | BCL | BRAF | ERK | ERK1/2 | MEK1/2 | BCL2 | BH3-only proteins | DRP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | BH3-ONLY PROTEIN | REGULATED KINASE | BAD PHOSPHORYLATION | INHIBITS APOPTOSIS | ERK1/2-DEPENDENT PHOSPHORYLATION | MEDIATED ACTIVATION | HUMAN-MELANOMA CELLS | ERK2 PHOSPHORYLATION | MEMBRANE PERMEABILIZATION | Cell death | Utrophin | Stem cells | Physiological aspects | Biochemistry | DNA binding proteins | Gene expression | Transcription factors | Decisions | Kinases | Nuclei | Fission | Proteins | Signal transduction | Mitochondria | Receptors | Bcl-x protein | Cell fate | Tumorigenesis | Repressing | Starvation | Cell survival | Extracellular signal-regulated kinase | MAP kinase | Growth factor receptors | Organelles | Survival | Substrates | Mcl-1 protein | Golgi apparatus | Signaling | Proteomics | Endoplasmic reticulum | BIM protein | Phagocytosis | Endosomes | Cancer | Apoptosis | State‐of‐the‐Art Review | BH3‐only proteins | ERK1 | MEK1
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12. Full Text Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer
by Sale, Matthew J and Cook, Simon J
Biochemical Society Transactions, ISSN 0300-5127, 2014, Volume 42, Issue 4, pp. 776 - 783
Recent clinical data with BRAF and MEK1/2 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 1/2] inhibitors have... 
Extracellular-signal-regulated kinase 1/2 (ERK1/2) | Intrinsic resistance | BRAF | Acquired resistance | Mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK1/2) | RAS | extracellular-signal-regulated kinase 1/2 (ERK1/2) | intrinsic resistance | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK1/2) | FEEDBACK INHIBITION | acquired resistance | CONFER RESISTANCE | CELL-DEATH | SELECTIVE INHIBITOR | MELANOMA | RAF | SIGNAL-REGULATED KINASE | UP-REGULATION | MEDIATES RESISTANCE | MAP Kinase Kinase 1 - antagonists & inhibitors | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Neoplasms - enzymology | Drug Resistance, Neoplasm | MAP Kinase Kinase 1 - metabolism | Antineoplastic Agents - therapeutic use | MAP Kinase Kinase 2 - metabolism | Neoplasms - drug therapy | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism
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13. Full Text Structure of aryl O-demethylase offers molecular insight into a catalytic tyrosine-dependent mechanism
by Kohler, Amanda C and Mills, Matthew J. L and Adams, Paul D and Simmons, Blake A and Sale, Kenneth L and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2017, Volume 114, Issue 16, pp. E3205 - E3214
Some strains of soil and marine bacteria have evolved intricate metabolic pathways for using environmentally derived aromatics as a carbon source. Many of... 
Lignin | Demethylase | Biocatalysis | Tetrahydrofolate | Aryl metabolism | CATABOLISM | T-PROTEIN | RECOGNITION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | lignin | H-PROTEIN | biocatalysis | tetrahydrofolate | INHIBITION | aryl metabolism | KINETICS | GLYCINE-CLEAVAGE SYSTEM | demethylase | BINDING | Tyrosine | Methyltransferases | Physiological aspects | Tricarboxylic acid cycle | Amino acids | Homology | Optimization | Folic acid | Molecules | Demethylation | Syringate | Aromatic compounds | Bacteria | Catalysis | Reaction mechanisms | Carbon sources | Site location | Crystal structure | Tetrahydrofolic acid | Byproducts | Biofuels | Complex systems | Intermediates | Strain | Aromatics | Mutagenesis | Soil microorganisms | Metabolic pathways | dimethylase | BASIC BIOLOGICAL SCIENCES | Biological Sciences | Physical Sciences | PNAS Plus
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