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1. Full Text Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
by Malik, Rainer and Chauhan, Ganesh and Traylor, Matthew and Sargurupremraj, Muralidharan and Okada, Yukinori and Mishra, Aniket and Rutten-Jacobs, Loes and Giese, Anne-Katrin and Van Der Laan, Sander W and Gretarsdottir, Solveig and Anderson, Christopher D and Chong, Michael and Adams, Hieab H. H and Ago, Tetsuro and Almgren, Peter and Amouyel, Philippe and Ay, Hakan and Bartz, Traci M and Benavente, Oscar R and Bevan, Steve and Boncoraglio, Giorgio B and Brown, Robert D and Butterworth, Adam S and Carrera, Caty and Carty, Cara L and Chasman, Daniel I and Chen, Wei-Min and Cole, John W and Correa, Adolfo and Cotlarciuc, Ioana and Cruchaga, Carlos and Danesh, John and De Bakker, Paul I. W and Destefano, Anita L and Den Hoed, Marcel and Duan, Qing and Engelter, Stefan T and Falcone, Guido J and Gottesman, Rebecca F and Grewal, Raji P and Gudnason, Vilmundur and Gustafsson, Stefan and Haessler, Jeffrey and Harris, Tamara B and Hassan, Ahamad and Havulinna, Aki S and Heckbert, Susan R and Holliday, Elizabeth G and Howard, George and Hsu, Fang-Chi and Hyacinth, Hyacinth I and Ikram, M. Arfan and Ingelsson, Erik and Irvin, Marguerite R and Jian, Xueqiu and Jiménez-Conde, Jordi and Johnson, Julie A and Jukema, J. Wouter and Kanai, Masahiro and Keene, Keith L and Kissela, Brett M and Kleindorfer, Dawn O and Kooperberg, Charles and Kubo, Michiaki and Lange, Leslie A and Langefeld, Carl D and Langenberg, Claudia and Launer, Lenore J and Lee, Jin-Moo and Lemmens, Robin and Leys, Didier and Lewis, Cathryn M and Lin, Wei-Yu and Lindgren, Arne G and Lorentzen, Erik and Magnusson, Patrik K and Maguire, Jane and Manichaikul, Ani and McArdle, Patrick F and Meschia, James F and Mitchell, Braxton D and Mosley, Thomas H and Nalls, Michael A and Ninomiya, Toshiharu and O'Donnell, Martin J and Psaty, Bruce M and Pulit, Sara L and Rannikmäe, Kristiina and Reiner, Alexander P and Rexrode, Kathryn M and Rice, Kenneth and Rich, Stephen S and Ridker, Paul M and Rost, Natalia S and Rothwell, Peter M and Rotter, Jerome I and Rundek, Tatjana and Sacco, Ralph L and Sakaue, Saori and Sale, Michele M and ... and AFGen Consortium and UK Young Lacunar DNA Study and EPIC-CVD Consortium and Int Stroke Genetics Consortium ISG and INVENT Consortium and Int Genomics Blood Pressure iGEN and MEGASTROKE Consortium and COMPASS Consortium and METASTROKE Consortium and EPIC-InterAct Consortium and Cohorts Heart Aging Res Genomic and BioBank Japan Cooperative Hosp Grp and NINDS Stroke Genetics Network Si and STARNET and Neurology Working Grp Charge Con and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and International Stroke Genetics Consortium (ISGC) and NINDS Stroke Genetics Network (SiGN) and International Genomics of Blood Pressure (iGEN-BP) Consortium and BioBank Japan Cooperative Hospital Group and Neurology Working Group of the CHARGE Consortium
Nature genetics, ISSN 1061-4036, 04/2018, Volume 50, Issue 4, pp. 524 - 537
HUMAN GENETIC-VARIATION | SMALL-VESSEL DISEASE | SUDDEN CARDIAC DEATH | SUSCEPTIBILITY LOCI | WHITE-MATTER HYPERINTENSITIES | ISCHEMIC-STROKE | COMPLEX TRAITS | CORONARY-ARTERY-DISEASE | HEMORRHAGIC STROKE | ATRIAL-FIBRILLATION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease | Genome-Wide Association Study | Epigenesis, Genetic | Humans | Risk Factors | Computational Biology | Databases, Genetic | Male | Genetic Loci | Gene Regulatory Networks | Stroke - physiopathology | INDEL Mutation | Stroke - genetics | Linkage Disequilibrium | Stroke - classification | Female | Models, Genetic | Polymorphism, Single Nucleotide | Stroke | Genes | Health risks | Risk | Cardiovascular disease | Genomes | Genetic diversity | Regression analysis | Loci | Meta-analysis | Consortia | Pleiotropy | Etiology | Blood pressure | Thromboembolism | Bioinformatics | Asians | Index Medicus | Medicinsk genetik | Basic Medicine | Medical Genetics | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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2. Full Text MEK1 and MEK2 inhibitors and cancer therapy: The long and winding road
by Caunt, Christopher J and Sale, Matthew J and Smith, Paul D and Cook, Simon J
Nature reviews. Cancer, ISSN 1474-175X, 09/2015, Volume 15, Issue 10, pp. 577 - 592
Life Sciences & Biomedicine | Oncology | Science & Technology | Neoplasms - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | MAP Kinase Signaling System - physiology | Signal Transduction - drug effects | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Humans | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Neoplasms - drug therapy | Care and treatment | Enzyme inhibitors | Patient outcomes | Innovations | Properties | Phosphotransferases | Cancer | Index Medicus
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3. Full Text Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies
by Traylor, Matthew, MSc and Farrall, Martin, FRCPath and Holliday, Elizabeth G, PhD and Sudlow, Cathie, FRCP and Hopewell, Jemma C, PhD and Cheng, Yu-Ching, PhD and Fornage, Myriam, PhD and Ikram, M Arfan, MD and Malik, Rainer, PhD and Bevan, Steve, PhD and Thorsteinsdottir, Unnur, PhD and Nalls, Mike A, PhD and Longstreth, WT, MD and Wiggins, Kerri L, MS and Yadav, Sunaina, MSc and Parati, Eugenio A, MD and DeStefano, Anita L, PhD and Worrall, Bradford B, MD and Kittner, Steven J, MD and Khan, Muhammad Saleem, MSc and Reiner, Alex P, MD and Helgadottir, Anna, MD and Achterberg, Sefanja, PhD and Fernandez-Cadenas, Israel, PhD and Abboud, Sherine, MD and Schmidt, Reinhold, MD and Walters, Matthew, MD and Chen, Wei-Min, PhD and Ringelstein, E Bernd, MD and O'Donnell, Martin, MD and Ho, Weang Kee, PhD and Pera, Joanna, MD and Lemmens, Robin, MD and Norrving, Bo, MD and Higgins, Peter, MRCP and Benn, Marianne, MD and Sale, Michele, PhD and Kuhlenbäumer, Gregor, MD and Doney, Alexander S F, PhD and Vicente, Astrid M, PhD and Delavaran, Hossein, MD and Algra, Ale, MD and Davies, Gail, PhD and Oliveira, Sofia A, PhD and Palmer, Colin N A, PhD and Deary, Ian, PhD and Schmidt, Helena, MD and Pandolfo, Massimo, MD and Montaner, Joan, MD and Carty, Cara, PhD and de Bakker, Paul I W, PhD and Kostulas, Konstantinos, MD and Ferro, Jose M, MD and van Zuydam, Natalie R, MSc and Valdimarsson, Einar, MD and Nordestgaard, Børge G, MD and Lindgren, Arne, MD and Thijs, Vincent, MD and Slowik, Agnieszka, MD and Saleheen, Danish, MD and Paré, Guillaume, MD and Berger, Klaus, MD and Thorleifsson, Gudmar, PhD and Hofman, Albert, MD and Mosley, Thomas H, PhD and Mitchell, Braxton D, PhD and Furie, Karen, MD and Clarke, Robert, FRCP and Levi, Christopher, MD and Seshadri, Sudha, MD and Gschwendtner, Andreas, MD and Boncoraglio, Giorgio B, MD and Sharma, Pankaj, PhD and Bis, Joshua C, PhD and Gretarsdottir, Solveig, PhD and Psaty, Bruce M and Rothwell, Peter M, FMedSci and Rosand, Jonathan, MD and Meschia, James F, MD and Stefansson, Kari, MD and Dichgans, Martin, MD and Markus, Hugh S, Dr and The Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2) and on behalf of the International Stroke Genetics Consortium and WTCCC 2 and Australian Stroke Genetics Collabo and Int Stroke Genetics Consortium and International Stroke Genetics Consortium and Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)
Lancet neurology, ISSN 1474-4422, 2012, Volume 11, Issue 11, pp. 951 - 962
Neurology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Genetic Predisposition to Disease - genetics | Humans | Risk Factors | Stroke - diagnosis | Brain Ischemia - genetics | Brain Ischemia - diagnosis | Databases, Genetic - trends | Genome-Wide Association Study - trends | Genome-Wide Association Study - methods | Stroke - genetics | Medical colleges | Nervous system diseases | Neurosciences | Behavioral health care | Oncology, Experimental | Genomics | Genomes | Research | Population genetics | Risk factors | Biometry | Beer | Stroke (Disease) | Ischemia | Medical genetics | Genetic research | Agriculture | Public health | Cancer | Index Medicus | Neurologi | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
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4. Full Text Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations
by Franceschini, Nora and Fox, Ervin and Zhang, Zhaogong and Edwards, Todd L and Nalls, Michael A and Sung, Yun Ju and Tayo, Bamidele O and Sun, Yan V and Gottesman, Omri and Adeyemo, Adebawole and Johnson, Andrew D and Young, J. Hunter and Rice, Ken and Duan, Qing and Chen, Fang and Li, Yun and Tang, Hua and Fornage, Myriam and Keene, Keith L and Andrews, Jeanette S and Smith, Jennifer A and Faul, Jessica D and Guangfa, Zhang and Guo, Wei and Liu, Yu and Murray, Sarah S and Musani, Solomon K and Srinivasan, Sathanur and Velez Edwards, Digna R and Wang, Heming and Becker, Lewis C and Bovet, Pascal and Bochud, Murielle and Broeckel, Ulrich and Burnier, Michel and Carty, Cara and Chasman, Daniel I and Ehret, Georg and Chen, Wei-Min and Chen, Guanjie and Chen, Wei and Ding, Jingzhong and Dreisbach, Albert W and Evans, Michele K and Guo, Xiuqing and Garcia, Melissa E and Jensen, Rich and Keller, Margaux F and Lettre, Guillaume and Lotay, Vaneet and Martin, Lisa W and Moore, Jason H and Morrison, Alanna C and Mosley, Thomas H and Ogunniyi, Adesola and Palmas, Walter and Papanicolaou, George and Penman, Alan and Polak, Joseph F and Ridker, Paul M and Salako, Babatunde and Singleton, Andrew B and Shriner, Daniel and Taylor, Kent D and Vasan, Ramachandran and Wiggins, Kerri and Williams, Scott M and Yanek, Lisa R and Zhao, Wei and Zonderman, Alan B and Becker, Diane M and Berenson, Gerald and Boerwinkle, Eric and Bottinger, Erwin and Cushman, Mary and Eaton, Charles and Nyberg, Fredrik and Heiss, Gerardo and Hirschhron, Joel N and Howard, Virginia J and Karczewsk, Konrad J and Lanktree, Matthew B and Liu, Kiang and Liu, Yongmei and Loos, Ruth and Margolis, Karen and Snyder, Michael and Go, Min Jin and Kim, Young Jin and Lee, Jong-Young and Jeon, Jae-Pil and Kim, Sung Soo and Han, Bok-Ghee and Cho, Yoon Shin and Sim, Xueling and Tay, Wan Ting and Ong, Rick Twee Hee and Seielstad, Mark and Liu, Jian Jun and Aung, Tin and ... and the Asian Genetic Epidemiology Network Consortium and Asian Genetic Epidemiology Network and Asian Genetic Epidemiology Network Consortium
American journal of human genetics, ISSN 0002-9297, 09/2013, Volume 93, Issue 3, pp. 545 - 554
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Quantitative Trait, Heritable | Blood Pressure - genetics | Humans | Africa | Genetic Loci - genetics | Databases, Genetic | Polymorphism, Single Nucleotide - genetics | African Continental Ancestry Group - genetics | Cohort Studies | Quantitative genetics | Genome-wide association studies | Physiological aspects | Blood pressure | Genetic aspects | Research | Population genetics | Cardiovascular disease | Genomes | Minority & ethnic groups | Meta-analysis | Index Medicus | Report
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5. Full Text Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling
by Cook, Simon J and Stuart, Kate and Gilley, Rebecca and Sale, Matthew J
The FEBS journal, ISSN 1742-464X, 12/2017, Volume 284, Issue 24, pp. 4177 - 4195
BH3‐only proteins | ERK1/2 | MEK1/2 | RAS | mitochondria | BIM | BCL2 | apoptosis | BRAF | DRP1 | BH3-only proteins | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | MAP Kinase Signaling System - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Humans | Neoplasm Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Indoles - administration & dosage | Mitochondrial Dynamics - physiology | Pyrroles - administration & dosage | Indoles - pharmacology | Oncogene Addiction | Pyrroles - therapeutic use | Aniline Compounds - administration & dosage | Aniline Compounds - pharmacology | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Sulfonamides - pharmacology | Neoplasms - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Pyrroles - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Mitochondrial Dynamics - drug effects | Sulfonamides - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Apoptosis Regulatory Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - physiology | Indoles - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aniline Compounds - therapeutic use | Apoptosis - physiology | Neoplasms - pathology | Sulfonamides - administration & dosage | Drug Screening Assays, Antitumor | Cell death | Utrophin | Stem cells | Physiological aspects | Biochemistry | DNA binding proteins | Gene expression | Transcription factors | Decisions | Kinases | Nuclei | Fission | Proteins | Signal transduction | Mitochondria | Receptors | Bcl-x protein | Cell fate | Tumorigenesis | Repressing | Starvation | Cell survival | Extracellular signal-regulated kinase | MAP kinase | Growth factor receptors | Organelles | Survival | Substrates | Mcl-1 protein | Golgi apparatus | Signaling | Proteomics | Endoplasmic reticulum | BIM protein | Phagocytosis | Endosomes | Cancer | Apoptosis | Index Medicus | State‐of‐the‐Art Review | 2 | ERK1 | MEK1
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