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The Journal of Immunology, ISSN 0022-1767, 02/2006, Volume 176, Issue 3, pp. 1899 - 1907
Journal Article
The Journal of Immunology, ISSN 0022-1767, 07/1999, Volume 163, Issue 2, pp. 844 - 853
CD28 costimulation amplifies TCR-dependent signaling in activated T cells, however, the biochemical mechanism(s) by which this occurs is not precisely... 
B-CELLS | EXCHANGE FACTOR | PROTEIN-TYROSINE KINASES | PHOSPHORYLATION | VAV PROTOONCOGENE PRODUCT | NONOBESE DIABETIC MICE | T-CELL-RECEPTOR | IMMUNOLOGY | GENETIC-EVIDENCE | ANTIGEN RECEPTOR | RHO-FAMILY | Protein Kinases - metabolism | Phosphorylation | T-Lymphocytes - enzymology | ras-GRF1 | Protein-Tyrosine Kinases - metabolism | Humans | ZAP-70 Protein-Tyrosine Kinase | Phosphoproteins - metabolism | Proto-Oncogene Proteins - biosynthesis | Enzyme Activation - immunology | CD28 Antigens - metabolism | Protein-Tyrosine Kinases - physiology | Signal Transduction - immunology | Calcium-Calmodulin-Dependent Protein Kinases - biosynthesis | Proto-Oncogene Proteins c-vav | JNK Mitogen-Activated Protein Kinases | p38 Mitogen-Activated Protein Kinases | CD28 Antigens - physiology | Mitogen-Activated Protein Kinases | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Adjuvants, Immunologic - physiology | Oligonucleotides, Antisense - pharmacology | GTPase-Activating Proteins | Receptors, Antigen, T-Cell - metabolism | Jurkat Cells | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Receptors, Antigen, T-Cell - physiology | Guanine Nucleotide Exchange Factors | Drug Synergism | Membrane Proteins | Adaptor Proteins, Signal Transducing | Tyrosine - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Down-Regulation - immunology | Mice | Mice, Inbred BALB C | Oligodeoxyribonucleotides - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Cell Cycle Proteins
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e98151
Journal Article
PLoS ONE, 05/2014, Volume 9, Issue 5
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis,... 
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2006, Volume 176, Issue 3, pp. 1899 - 1907
TLR-induced innate immunity and inflammation are mediated by signaling cascades leading to activation of the MAPK family of Ser/Thr protein kinases, including... 
Journal Article
Diabetes, ISSN 0012-1797, 08/2003, Volume 52, Issue 8, pp. 1967 - 1975
Journal Article
Diabetes, ISSN 0012-1797, 08/2004, Volume 53, Issue 8, pp. 2003 - 2011
B-cells proliferate after B-cell receptor (BCR) stimulation and are deleted by activation-induced cell death (AICD) during negative selection. We report that... 
Journal Article
The Journal of Immunology, ISSN 0022-1767, 04/1999, Volume 162, Issue 7, pp. 3819 - 3829
Optimal T cell activation requires two signals, one generated by TCR and another by the CD28 costimulatory receptor, In this study, we investigated the... 
TRANSCRIPTIONAL ACTIVITY | INDUCED APOPTOSIS | PHOSPHORYLATION | MAP KINASE | JNK | CELLULAR STRESSES | TERNARY COMPLEX FACTORS | IMMUNOLOGY | TRANSDUCTION PATHWAY | UV-LIGHT | LYMPHOCYTES | T-Lymphocytes - enzymology | Humans | Proto-Oncogene Proteins c-jun - biosynthesis | Proto-Oncogene Proteins c-jun - antagonists & inhibitors | Cell Nucleus - enzymology | Signal Transduction - immunology | Calcium - physiology | Cell Nucleus - metabolism | T-Lymphocytes - drug effects | JNK Mitogen-Activated Protein Kinases | Receptors, Antigen, T-Cell - immunology | p38 Mitogen-Activated Protein Kinases | Mitogen-Activated Protein Kinases | Cyclic AMP Response Element-Binding Protein - biosynthesis | T-Lymphocytes - secretion | Jurkat Cells | Mice, Inbred C57BL | Cells, Cultured | Cytokines - secretion | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | CD28 Antigens - immunology | Imidazoles - pharmacology | CD3 Complex - metabolism | Drug Synergism | Animals | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Activating Transcription Factor 2 | CD3 Complex - immunology | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Cytokines - antagonists & inhibitors | Enzyme Activation | Cell Nucleus - drug effects | Calcium-Calmodulin-Dependent Protein Kinases - metabolism
Journal Article
Endocrinology, ISSN 0013-7227, 02/2004, Volume 145, Issue 2, pp. 627 - 638
Journal Article
International Immunology, ISSN 0953-8178, 03/2001, Volume 13, Issue 3, p. 377
  Previously, we reported that T cell hyporesponsiveness induced by TCR ligation is causal to autoimmune diabetes in NOD mice. Neonatal CD28 co-stimulation... 
Journal Article
Journal Article
International Immunology, ISSN 0953-8178, 2001, Volume 13, Issue 3, pp. 377 - 384
Previously, we reported that T cell hyporesponsiveness induced by TCR ligation is causal to autoimmune diabetes in NOD mice. Neonatal CD28 cc-stimulation... 
NOD mice | Signal transduction | T cell hyporesponsiveness | signal transduction | INTERLEUKIN-4 GENE | RECEPTOR | IMMUNOLOGY | PREVENTS | PATHWAY | NONOBESE DIABETIC MICE | DIFFERENTIAL ACTIVATION | PROMOTER ELEMENTS | ANERGY | COSTIMULATION | EXPRESSION | MAP Kinase Signaling System - physiology | Diabetes Mellitus, Type 1 - prevention & control | Clonal Anergy | rac1 GTP-Binding Protein - deficiency | NF-kappa B - metabolism | Proto-Oncogene Proteins p21(ras) - physiology | Transcription Factor AP-1 - metabolism | Autoimmune Diseases - genetics | Interleukin-4 - biosynthesis | MAP Kinase Signaling System - genetics | Female | Active Transport, Cell Nucleus | Diabetes Mellitus, Type 1 - immunology | Interleukin-4 - genetics | p38 Mitogen-Activated Protein Kinases | Promoter Regions, Genetic | Specific Pathogen-Free Organisms | Autoimmune Diseases - immunology | Diabetes Mellitus, Type 1 - genetics | Autoimmune Diseases - prevention & control | CD28 Antigens - immunology | DNA - metabolism | Mitogen-Activated Protein Kinases - deficiency | Interleukin-2 - genetics | Transcription, Genetic - physiology | Animals | Mitogen-Activated Protein Kinases - physiology | rac1 GTP-Binding Protein - physiology | Proto-Oncogene Proteins c-jun - metabolism | Protein Binding | Mice, Inbred NOD | Mitogen-Activated Protein Kinases - genetics | T-Lymphocytes - immunology | Mice | Interleukin-2 - biosynthesis | Lymphocyte Activation - physiology | Mitogen-Activated Protein Kinase 3 | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | rac1 GTP-Binding Protein - genetics
Journal Article
The American Journal of Medicine, ISSN 0002-9343, 02/1997, Volume 102, Issue 2, p. 178
  Antiendothelial cell antibodies in patients with primary Raynaud's phenomenon, limited systemic sclerosis (SS) or diffuse SS may help to determine the... 
Cellular biology | Disease | Medical disorders
Journal Article
Clinical and Diagnostic Laboratory Immunology, ISSN 1071-412X, 09/1997, Volume 4, Issue 5, pp. 519 - 521
Journal Article
Immunology Today, ISSN 0167-5699, 1998, Volume 19, Issue 10, pp. 468 - 473
Journal Article
Journal Article