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by Webb, Thomas R., PhD and Erdmann, Jeanette, PhD and Stirrups, Kathleen E., PhD and Stitziel, Nathan O., MD, PhD and Masca, Nicholas G.D., PhD and Jansen, Henning, MD and Kanoni, Stavroula, PhD and Nelson, Christopher P., PhD and Ferrario, Paola G., PhD and König, Inke R., PhD and Eicher, John D., PhD and Johnson, Andrew D., PhD and Hamby, Stephen E., PhD and Betsholtz, Christer, PhD and Ruusalepp, Arno, MD, PhD and Franzén, Oscar, PhD and Schadt, Eric E., MD, PhD and Björkegren, Johan L.M., MD, PhD and Weeke, Peter E., MD, PhD and Auer, Paul L., PhD and Schick, Ursula M., PhD and Lu, Yingchang, MD, PhD and Zhang, He, PhD and Dube, Marie-Pierre, PhD and Goel, Anuj, MSc and Farrall, Martin, MD and Peloso, Gina M., PhD and Won, Hong-Hee, PhD and Do, Ron, PhD and van Iperen, Erik, MSc and Kruppa, Jochen, PhD and Mahajan, Anubha, PhD and Scott, Robert A., PhD and Willenborg, Christina, PhD and Braund, Peter S., PhD and van Capelleveen, Julian C., MD and Doney, Alex S.F., MD, PhD and Donnelly, Louise A., PhD and Asselta, Rosanna, PhD and Merlini, Pier A., MD and Duga, Stefano, PhD and Marziliano, Nicola, PhD and Denny, Josh C., MD, MS and Shaffer, Christian, BS and El-Mokhtari, Nour Eddine, MD and Franke, Andre, PhD and Heilmann, Stefanie, PhD and Hengstenberg, Christian, MD and Hoffmann, Per, PhD and Holmen, Oddgeir L., MD and Hveem, Kristian, MD, PhD and Jansson, Jan-Håkan, MD, PhD and Jöckel, Karl-Heinz, PhD and Kessler, Thorsten, MD and Kriebel, Jennifer, PhD and Laugwitz, Karl L., MD and Marouli, Eirini, MSc and Martinelli, Nicola, MD, PhD and McCarthy, Mark I., MD and Van Zuydam, Natalie R., PhD and Meisinger, Christa, MD, MPH and Esko, Tõnu, PhD and Mihailov, Evelin, MSc and Escher, Stefan A., PhD and Alver, Maris, MSc and Moebus, Susanne, PhD and Morris, Andrew D., MD and Virtamo, Jarma, MD, PhD and Nikpay, Majid, PhD and Olivieri, Oliviero, MD and Provost, Sylvie, MSc and AlQarawi, Alaa, BSc and Robertson, Neil R., MSc and Akinsansya, Karen O., PhD and Reilly, Dermot F., PhD and Vogt, Thomas F., PhD and Yin, Wu, PhD and Asselbergs, Folkert W., MD, PhD and Kooperberg, Charles, PhD and Jackson, Rebecca D., MD and Stahl, Eli, PhD and Müller-Nurasyid, Martina, PhD and Strauch, Konstantin, PhD and Varga, Tibor V., PhD and Waldenberger, Melanie, PhD and Zeng, Lingyao, MSc and Chowdhury, Rajiv, MD, PhD and Salomaa, Veikko, MD, PhD and Ford, Ian, PhD and Jukema, J. Wouter, MD, PhD and Amouyel, Philippe, MD, PhD and Kontto, Jukka, MSSc and Nordestgaard, Børge G., MD, DMSc and Ferrières, Jean, MD and Saleheen, Danish, MBBS, PhD and Sattar, Naveed, PhD and Surendran, Praveen, PhD and Wagner, Aline, MD, PhD and Young, Robin, PhD and Howson, Joanna M.M., PhD and ... and Wellcome Trust Case Control and MORGAM Investigators and Myocardial Infarction Genetics and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet and Medicin
Journal of the American College of Cardiology, ISSN 0735-1097, 2017, Volume 69, Issue 7, pp. 823 - 836
Abstract Background Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show... 
Cardiovascular | Internal Medicine | expression quantitative trait loci | genetics | genome-wide association | single nucleotide polymorphism | cholesteryl ester transfer protein | SR-BI | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CETP MASS | SUSCEPTIBILITY | RISK | PHOSPHOLIPASE A | VARIANT | SCAVENGER RECEPTOR | ABDOMINAL AORTIC-ANEURYSM | Genome-Wide Association Study | Gene Frequency | Humans | Coronary Artery Disease - genetics | Female | Male | Coronary Artery Disease - epidemiology | Genetic Pleiotropy | Polymorphism, Single Nucleotide | Genetic Loci | Odds Ratio | Case-Control Studies | Coronary heart disease | Analysis | Genealogy | Cardiovascular disease | Genomes | Metabolism | Gene expression | Blood | Risk factors | Studies | Celiac disease | Lipoproteins | Coronary vessels | Rheumatoid arthritis | Quality control | Calcification | Diabetes | Bioinformatics | LD, linkage disequilibrium | CETP, cholesteryl ester transfer protein | eQTL, expression quantitative trait locus | CAD, coronary artery disease | GWAS, genome-wide association study | BMI, body mass index | SNP, single nucleotide polymorphism | HDL, high-density lipoprotein | LDL, low-density lipoprotein | Original Investigation | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kardiologi | Medical Genetics | Medicinsk genetik | Clinical Medicine | Cardiac and Cardiovascular Systems | Medicinska och farmaceutiska grundvetenskaper
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2016, Volume 67, Issue 10, pp. 1200 - 1210
Abstract Background Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty... 
Cardiovascular | Internal Medicine | drug development | Mendelian randomization | metabolomics | cholesterol lowering | lipoproteins | COHORT PROFILE | CARDIAC & CARDIOVASCULAR SYSTEMS | BIOMARKER | VARIANTS | FATTY-ACID-COMPOSITION | RISK | TRIGLYCERIDES | LDL CHOLESTEROL | CORONARY-HEART-DISEASE | ASSOCIATION | EPIDEMIOLOGY | Hydroxymethylglutaryl CoA Reductases - drug effects | Mendelian Randomization Analysis - methods | Magnetic Resonance Spectroscopy - methods | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | United Kingdom | Cardiovascular Diseases - genetics | Forecasting | Metabolomics - methods | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Finland | Cardiovascular Diseases - blood | Adult | Female | Retrospective Studies | Hydroxymethylglutaryl CoA Reductases - blood | Hydroxymethylglutaryl CoA Reductases - genetics | Medical colleges | Metabolites | Pharmacy | Genomics | Genetic research | Drugstores | Fatty acids | Epidemiology | Statins | Public health | Cardiovascular agents | Lipids | Cholesterol | LDL-C, low-density lipoprotein cholesterol | CVD, cardiovascular disease | IDL, intermediate-density lipoprotein | VLDL, very-low-density lipoprotein | HMGCR, HMG-CoA reductase | NMR, nuclear magnetic resonance | HDL, high-density lipoprotein | Original Investigation
Journal Article
by Assimes, Themistocles L., MD, PhD and Hólm, Hilma, MD and Kathiresan, Sekar, MD and Reilly, Muredach P., MB and Thorleifsson, Gudmar, PhD and Voight, Benjamin F., PhD and Erdmann, Jeanette, PhD and Willenborg, Christina, MSc and Vaidya, Dhananjay, MBBS, PhD, MPH and Xie, Changchun, PhD and Patterson, Chris C., PhD and Morgan, Thomas M., MD and Burnett, Mary Susan, PhD and Li, Mingyao, PhD and Hlatky, Mark A., MD and Knowles, Joshua W., MD, PhD and Thompson, John R., PhD and Absher, Devin, PhD and Iribarren, Carlos, MD, MPH, PhD and Go, Alan, MD and Fortmann, Stephen P., MD and Sidney, Stephen, MD, MPH and Risch, Neil, PhD and Tang, Hua, PhD and Myers, Richard M., PhD and Berger, Klaus, MD and Stoll, Monika, PhD and Shah, Svati H., MD, MHS and Thorgeirsson, Gudmundur, MD, PhD and Andersen, Karl, MD, PhD and Havulinna, Aki S., MSc and Herrera, J. Enrique, MS and Faraday, Nauder, MD and Kim, Yoonhee, PhD and Kral, Brian G., MD, MPH and Mathias, Rasika A., ScD and Ruczinski, Ingo, PhD and Suktitipat, Bhoom, MD and Wilson, Alexander F., PhD and Yanek, Lisa R., MPH and Becker, Lewis C., MD and Linsel-Nitschke, Patrick, MD and Lieb, Wolfgang, MD and König, Inke R., PhD and Hengstenberg, Christian, MD and Fischer, Marcus, MD and Stark, Klaus, PhD and Reinhard, Wibke, MD and Winogradow, Janina, MD and Grassl, Martina, MD and Grosshennig, Anika, MSc and Preuss, Michael, MSc and Schreiber, Stefan, MD and Wichmann, H.-Erich, MD and Meisinger, Christa, MD, MPH and Yee, Jean, BS and Friedlander, Yechiel, PhD and Do, Ron, MSc and Meigs, James B., MD, MPH and Williams, Gordon, MD and Nathan, David M., MD and MacRae, Calum A., MD, PhD and Qu, Liming, MS and Wilensky, Robert L., MD and Matthai, William H., MD and Qasim, Atif N., MD and Hakonarson, Hakon, MD, PhD and Pichard, Augusto D., MD and Kent, Kenneth M., MD, PhD and Satler, Lowell, MD and Lindsay, Joseph M., MD and Waksman, Ron, MD and Knouff, Christopher W., MD, PhD and Waterworth, Dawn M., PhD and Walker, Max C., BSc and Mooser, Vincent E., MD and Marrugat, Jaume, MD, PhD and Lucas, Gavin, PhD and Subirana, Isaac, MSc and Sala, Joan, MD and Ramos, Rafael, MD, PhD and Martinelli, Nicola, MD and Olivieri, Oliviero, MD and Trabetti, Elisabetta, PhD and Malerba, Giovanni, PhD and Pignatti, Pier Franco, MD and Guiducci, Candace, BS and Mirel, Daniel, PhD and Parkin, Melissa, BS and Hirschhorn, Joel N., MD, PhD and Asselta, Rosanna, PhD and Duga, Stefano, PhD and Musunuru, Kiran, MD, PhD, MPH and Daly, Mark J., PhD and Purcell, Shaun, PhD and Eifert, Sandra, MD and Braund, Peter S., MSc and Wright, Benjamin J., PhD and Balmforth, Anthony J., PhD and Ball, Stephen G., PhD and ... and Cardiogenics and Wellcome Trust Case Control and Myocardial Infarction Genet and Wellcome Trust Case Control Consortium and Myocardial Infarction Genetics Consortium and Kardiovaskulär forskning - hypertoni and Cardiovascular Research - Hypertension and EpiHealth: Epidemiology for Health and Lund University and Lunds universitet and EXODIAB: Excellence in Diabetes Research in Sweden
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2010, Volume 56, Issue 19, pp. 1552 - 1563
Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery... 
Cardiovascular | Internal Medicine | coronary artery disease | polymorphism | KIF6 | kinesin-like protein 6 | myocardial infarction | OR | single nucleotide polymorphism | CI | CAD | Abbreviations and Acronyms | HR | odds ratio | SNP | hazard ratio | confidence interval | MI | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | GENOMEWIDE ASSOCIATION | GENOTYPE DATA | HEART-DISEASE | GENE VARIANTS | CHROMOSOME 9P21.3 | CARDIOVASCULAR-DISEASE | NONFATAL MYOCARDIAL-INFARCTION | HEALTH | Humans | Middle Aged | Risk Factors | Tryptophan - genetics | Male | Coronary Artery Disease - enzymology | Case-Control Studies | Internationality | Arginine - genetics | Coronary Artery Disease - genetics | Kinesin - genetics | Polymorphism, Single Nucleotide - genetics | Female | Coronary Artery Disease - epidemiology | Genome-Wide Association Study - methods | Hypertension | Medical colleges | Medical research | Genetic disorders | Environmental health | Chronic diseases | Family medicine | Coronary heart disease | Population genetics | Biometry | Anopheles | Medicine, Experimental | Genetic aspects | Diabetes | Cardiology | Public health | Medical informatics | Kinesin | Heart | Heart attacks | African Americans | Cardiovascular disease | Genomes | Proteins | Studies | Confidence intervals | Consortia | International organizations | Ischemia | Womens health | Atherosclerosis | Age | Hispanics | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | myocardial | Medicin och hälsovetenskap | infarction | Klinisk medicin
Journal Article
Journal Article
Heart Rhythm, ISSN 1547-5271, 2012, Volume 9, Issue 10, pp. 1627 - 1634
Journal Article
Journal Article
American Journal of Cardiology, The, ISSN 0002-9149, 2011, Volume 108, Issue 12, pp. 1735 - 1740
We examined the prevalence and prognostic impact of a positive T wave in lead aVR (aVRT+) on a standard electrocardiogram in the general population. Data were... 
Cardiovascular | HEART | CARDIAC & CARDIOVASCULAR SYSTEMS | ELECTROCARDIOGRAPHIC FINDINGS | ANGINA-PECTORIS | DISEASE | AMPLITUDE | PROGNOSTIC VALUE | LEFT-VENTRICULAR HYPERTROPHY | Humans | Middle Aged | Cardiovascular Diseases - mortality | Electrocardiography | Female | Male | Risk | Cardiovascular Diseases - diagnosis
Journal Article
Journal Article
Journal Article