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Cellular Physiology and Biochemistry, ISSN 1015-8987, 04/2018, Volume 46, Issue 1, pp. 203 - 212
Background/Aims: Hypoxia is a powerful stimulator of angiogenesis under physiological as well as pathological conditions. Normal endothelial cells (EC), such... 
Hypoxia | Cell survival | Endothelial Cells | BNIP3 | Multiple Myeloma | APOPTOSIS | PHYSIOLOGY | ANGIOGENESIS | BONE-MARROW | DOWN-REGULATION | AUTOPHAGY | CELL BIOLOGY | BREAST-CANCER CELLS | GROWTH | HIF-1-ALPHA | NF-KAPPA-B | EXPRESSION | Human Umbilical Vein Endothelial Cells | Cell Proliferation | Microtubule-Associated Proteins - metabolism | Humans | Glucose Transporter Type 1 - metabolism | Cell Hypoxia | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Membrane Proteins - metabolism | cdc25 Phosphatases - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Cell Survival | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Proto-Oncogene Proteins - genetics | Multiple Myeloma - metabolism | Multiple Myeloma - pathology | Glucose Transporter Type 1 - genetics | Membrane Proteins - antagonists & inhibitors | Endothelial Cells - cytology | Cell Line, Tumor | RNA, Small Interfering - metabolism | Laboratories | Multiple myeloma | Metastasis | Gene expression | Experiments | Autophagy | Proteins | Angiogenesis | Cell growth | Cell cycle | Bone marrow | Cancer | Apoptosis
Journal Article
Neoplasia, ISSN 1476-5586, 01/2019, Volume 21, Issue 1, pp. 93 - 105
Interactions of multiple myeloma (MM) cells with endothelial cells (ECs) enhance angiogenesis and MM progression. Here, we investigated the role of Notch... 
DLL4 | SIGNALING PATHWAYS | ONCOLOGY | VEGF | ENDOTHELIAL-CELLS | BONE-MARROW | MONOCLONAL GAMMOPATHY | PROLIFERATION | JAGGED1 | EXPRESSION | INHIBITS TUMOR-GROWTH | Immunohistochemistry | Propionates - pharmacology | Monoclonal Gammopathy of Undetermined Significance - drug therapy | RNA, Small Interfering - genetics | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Vascular Endothelial Growth Factor A - metabolism | Sulfones - pharmacology | Multiple Myeloma - drug therapy | RNA Interference | Monoclonal Gammopathy of Undetermined Significance - metabolism | Benzene Derivatives - pharmacology | Disease Models, Animal | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Multiple Myeloma - metabolism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Monoclonal Gammopathy of Undetermined Significance - pathology | Signal Transduction - drug effects | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Multiple Myeloma - genetics | Phenotypes | Leukocyte migration | Cytokines | Secretion | Therapeutic applications | Multiple myeloma | Monoclonal gammopathy | Gammopathy | Inflammation | Chemotaxis | Endothelial cells | Angiogenesis | Jagged1 protein | Vascular endothelial growth factor | Secretase | Cell migration
Journal Article
Journal of Hematology and Oncology, ISSN 1756-8722, 01/2019, Volume 12, Issue 1, pp. 4 - 10
Journal Article
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 29, pp. 20563 - 20577
The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine kinase that mediates intracellular metabolism, cell survival and actin... 
Angiogenesis | PP242 | Endothelial cells | MTOR | Multiple myeloma
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 17, pp. 13366 - 13381
The investigational drug MP0250 is a multi-specific DARPin molecule that simultaneously binds and neutralizes VEGF and HGF with high specificity and affinity.... 
Angiogenesis | DARPin | Dual inhibitor | Syngeneic mouse model | Multiple myeloma
Journal Article
OncoImmunology, ISSN 2162-4011, 01/2019, Volume 8, Issue 1, p. e1486949
Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8(+) T cells that come and go across the permeable capillaries.... 
endothelial cells | multiple myeloma | Bone marrow | MGUS | plasma cells | tumor immune evasion | CD8 T cells | PHAGOCYTOSIS | MACROPHAGES | MHC | PRESENTING MACHINERY | IMMUNOLOGY | COMPARTMENT | PLASMA-CELLS | MICROENVIRONMENT | ONCOLOGY | CROSS-PRESENTATION | ENDOGLIN CD105 | ANTIGEN
Journal Article
OncoImmunology, 01/2019, Volume 8, Issue 1
Endothelial cells (EC) line the bone marrow microvasculature and are in close contact with CD8 + T cells that come and go across the permeable capillaries.... 
endothelial cells | multiple myeloma | Bone marrow | MGUS | plasma cells | tumor immune evasion | CD8 T cells
Journal Article
WORLD JOURNAL OF STEM CELLS, ISSN 1948-0210, 01/2015, Volume 7, Issue 1, pp. 84 - 95
Multiple myeloma (MM) is a hematologic malignancy of monoclonal plasma cells which remains incurable despite recent advances in therapies. The presence of... 
PROGENITOR CELLS | Stemness | Bone marrow microenvironment | Multiple myeloma | NICHE | SELF-RENEWAL | DRUG-RESISTANCE | CANCER | PLASMA-CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ADHESION | BONE-MARROW MICROENVIRONMENT | Stem cells niche | Cancer stem cells | STROMAL CELLS | HEMATOPOIETIC STEM | Review
Journal Article
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