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Scientific Reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 5244 - 11
High-grade serous ovarian carcinoma (HGSOC) is characterised by alterations in the p53 pathway. The expression levels of p53 isoforms have been shown to be... 
BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | P53-BETA | RESISTANCE | INDEPENDENT PROGNOSTIC MARKER | MUTATIONS | LESSONS | TP53 | DELTA-133P53 | Alternative splicing | Chemotherapy | Ovarian carcinoma | p53 Protein | Isoforms | Mutation | Gene expression | Survival | Tumors
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. LB-120 - LB-120
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2001, Volume 91, Issue 1, pp. 22 - 26
Loss of heterozygosity and mutations in the PTEN (MMAC1) tumor suppressor gene are frequent in endometrial carcinoma. Promoter hypermethylation has recently... 
PTEN | endometrial cancer | microsatellite instability | prognosis | methylation | Prognosis | Microsatellite instability | Endometrial cancer | Methylation
Journal Article
by George, Julie and Lim, Jing Shan and Jang, Se Jin and Cun, Yupeng and Ozretia, Luka and Kong, Gu and Leenders, Frauke and Lu, Xin and Fernández-Cuesta, Lynnette and Bosco, Graziella and Müller, Christian and Dahmen, Ilona and Jahchan, Nadine S and Park, Kwon-Sik and Yang, Dian and Karnezis, Anthony N and Vaka, Dedeepya and Torres, Angela and Wang, Maia Segura and Korbel, Jan O and Menon, Roopika and Chun, Sung-Min and Kim, Deokhoon and Wilkerson, Matt and Hayes, Neil and Engelmann, David and Pützer, Brigitte and Bos, Marc and Michels, Sebastian and Vlasic, Ignacija and Seidel, Danila and Pinther, Berit and Schaub, Philipp and Becker, Christian and Altmüller, Janine and Yokota, Jun and Kohno, Takashi and Iwakawa, Reika and Tsuta, Koji and Noguchi, Masayuki and Muley, Thomas and Hoffmann, Hans and Schnabel, Philipp A and Petersen, Iver and Chen, Yuan and Soltermann, Alex and Tischler, Verena and Choi, Chang-Min and Kim, Yong-Hee and Massion, Pierre P and Zou, Yong and Jovanovic, Dragana and Kontic, Milica and Wright, Gavin M and Russell, Prudence A and Solomon, Benjamin and Koch, Ina and Lindner, Michael and Muscarella, Lucia A and La Torre, Annamaria and Field, John K and Jakopovic, Marko and Knezevic, Jelena and Castaños-Vélez, Esmeralda and Roz, Luca and Pastorino, Ugo and Brustugun, Odd-Terje and Lund-Iversen, Marius and Thunnissen, Erik and Köhler, Jens and Schuler, Martin and Botling, Johan and Sandelin, Martin and Sanchez-Cespedes, Montserrat and Salvesen, Helga B and Achter, Viktor and Lang, Ulrich and Bogus, Magdalena and Schneider, Peter M and Zander, Thomas and Ansén, Sascha and Hallek, Michael and Wolf, Jürgen and Vingron, Martin and Yatabe, Yasushi and Travis, William D and Nürnberg, Peter and Reinhardt, Christian and Perner, Sven and Heukamp, Lukas and Büttner, Reinhard and Haas, Stefan A and Brambilla, Elisabeth and Peifer, Martin and Sage, Julien and Thomas, Roman K and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7563, pp. 47 - 53
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic... 
NEUROENDOCRINE TUMORS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GENES | CYCLE ARREST | NOTCH | C-KIT | MUTATIONS | CARCINOMA | Neurosecretory Systems - pathology | Receptors, Notch - metabolism | Chromosome Breakpoints | Genomics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Tumor Suppressor Proteins - genetics | Neurosecretory Systems - metabolism | Female | Nuclear Proteins - genetics | Disease Models, Animal | Lung Neoplasms - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Genome, Human - genetics | Small Cell Lung Carcinoma - pathology | Tumor Protein p73 | Animals | Cyclin D1 - genetics | Retinoblastoma Protein - genetics | Alleles | Cell Line, Tumor | Mice | Gene mutations | Analysis | Exome sequencing | Lung cancer, Small cell | Genetic aspects | Drug therapy | Cancer | Pathogenesis | Lung cancer | Genomes | Mutation | Kinases | Gene expression | Cancer therapies | Tumors | Clinical Medicine | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 371 - 375
Cervical cancer is responsible for 10-15% of cancer-related deaths in women worldwide(1,2). The aetiological role of infection with high-risk human papilloma... 
DOMAIN | CATALOG | FUSION | MULTIDISCIPLINARY SCIENCES | FRAMEWORK | HUMAN-PAPILLOMAVIRUS | SENSITIVE DETECTION | CANCER | EXPRESSION | SOMATIC MUTATIONS | DISCOVERY | F-Box-WD Repeat-Containing Protein 7 | Receptor, ErbB-2 - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - virology | Genomics | Humans | E1A-Associated p300 Protein - genetics | Core Binding Factor beta Subunit - genetics | Case-Control Studies | Papillomaviridae - genetics | Tumor Suppressor Protein p53 - genetics | DNA Mutational Analysis | Mitogen-Activated Protein Kinase 1 - genetics | Cell Cycle Proteins - genetics | Female | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Papillomaviridae - physiology | HLA-B Antigens - genetics | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-ets | Virus Integration - genetics | Proto-Oncogene Proteins - genetics | DNA Copy Number Variations - genetics | Transcriptome - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Uterine Cervical Neoplasms - genetics | Adenocarcinoma - virology | Genome, Human - genetics | Papillomavirus Infections - genetics | Exome - genetics | Uterine Cervical Neoplasms - virology | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Prevention | Gene mutations | Oncology, Experimental | Exome sequencing | Genetic aspects | Research | Cervical cancer | Cancer | Human papillomavirus | Mutation
Journal Article
by Kuchenbaecker, Karoline and Ramus, Susan and Tyrer, Jonathan and Lee, Anew and Shen, Howard C and Beesley, Jonathan and Lawrenson, Kate and McGuffog, Lesley and Healey, Sue and Lee, Janet M and Spindler, Tassja J and Lin, Yvonne G and Pejovic, Tanja and Bean, Yukie and Li, Qiyuan and Coetzee, Simon and Hazelett, Dennis and Miron, Alexander and Southey, Melissa and Terry, Mary Beth and Goldgar, David and Buys, Sauna and Janavicius, Ramunas and Dorfling, Cecilia and Rensburg, Elizabeth and Neuhausen, Susan and Ding, Yuan and Hansen, Thomas and Jønson, Lars and Gerdes, Anne-Marie and Ejlertsen, Bent and Barrowdale, Daniel and Dennis, Joe and Benítez, Javier and Osorio, Ana and Garcia, Maria Jose and Komenaka, Ian and Weitzel, Jeffrey and Ganschow, Pamela and Peterlongo, Paolo and Bernard, Loris and Viel, Alessana and Bonnani, Bernardo and Peissel, Bernard and Manoukian, Siranoush and Radice, Paolo and Papi, Laura and Ottini, Laura and Fostira, Florentia and Konstantopoulou, I and Garber, Judy and Frost, Debra and Perkins, Jo and Platte, Radka and Ellis, Steve and Godwin, Anew K and Schmutzler, Rita and Meindl, Alfons and Engel, Christoph and Sutter, Christian and Sinilnikova, Olga and Damiola, Francesca and Mazoyer, Sylvie and Stoppa-Lyonnet, Dominique and Claes, Kathleen B.M and De Leeneer, Kim and Kirk, Judy and Roiguez, Gustavo and Piedmonte, Marion and O'Malley, David M and Hoya, Miguel and Caldes, Trinidad and Aittomäki, Kristiina and Nevanlinna, Heli and Margriet, J. Collée and Rookus, Matti and Oosterwijk, Jan and Tihomirova, Laima and Tung, Nadine and Hamann, Ute and Isaccs, Claudine and Tischkowitz, Marc and Imyanitov, Evgeny and Caligo, Maria and Campbell, Ian and Hogervorst, Frans and Olah, E and Díez, Orland and Blanco, Ignacio and Brunet, Joan and Lazaro, Conxi and Pujana, Miguel and Jakubowska, Anna and Gronwald, Jacek and Lubinski, Jan and Sukiennicki, Grzegorz and Barkardottir, Rosa and Plante, Marie and Simard, Jacques and Soucy, Penny and ... and KConFab Investigators and EMBRACE and GEMO Study Collaborators and Breast Cancer Family Registry and Australian Ovarian Canc Study Grp and HEBON and Consortium Invest Modifiers BRCA1 and Australian Canc Study Ovarian Canc and Australian Cancer Study (Ovarian Cancer Investigators) and Australian Ovarian Cancer Study Group and Consortium of Investigators of Modifiers of BRCA1 and BRCA2 and the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Avdelningen för kliniska vetenskaper and Hälsouniversitetet
Nature Genetics, ISSN 1061-4036, 01/2015, Volume 47, Issue 2, pp. 164 - 171
Journal Article
Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, 11/2012, Volume 91, Issue 11, pp. 1286 - 1292
Journal Article
by Bojesen, Stig E and Pooley, Karen A and Johnatty, Sharon E and Beesley, Jonathan and Michailidou, Kyriaki and Tyrer, Jonathan P and Edwards, Stacey L and Pickett, Hilda A and Shen, Howard C and Smart, Chanel E and Hillman, Kristine M and Mai, Phuong L and Lawrenson, Kate and Stutz, Michael D and Lu, Yi and Karevan, Rod and Woods, Nicholas and Johnston, Rebecca L and French, Juliet D and Chen, Xiaoqing and Weischer, Maren and Nielsen, Sune F and Maranian, Melanie J and Ghoussaini, Maya and Ahmed, Shahana and Baynes, Caroline and Bolla, Manjeet K and Wang, Qin and Dennis, Joe and McGuffog, Lesley and Barrowdale, Daniel and Lee, Anew and Healey, Sue and Lush, Michael and Tessier, Daniel C and Vincent, Daniel and Bacot, Françis and Vergote, Ignace and Lambrechts, Sanina and Despierre, Evelyn and Risch, Harvey A and González-Neira, Anna and Rossing, Mary Anne and Pita, Guillermo and Doherty, Jennifer A and Alvarez, Nuria and Larson, Melissa C and Fridley, Brooke L and Schoof, Nils and Chang-Claude, Jenny and Cicek, Mine S and Peto, Julian and Kalli, Kimberly R and Broeks, Annegien and Armasu, Sebastian M and Schmidt, Marjanka K and Braaf, Linde M and Winterhoff, Boris and Nevanlinna, Heli and Konecny, Gottfried E and Lambrechts, Diether and Rogmann, Lisa and Guénel, Pascal and Teoman, Attila and Milne, Roger L and Garcia, Joaquin J and Cox, Angela and Shridhar, Vijayalakshmi and Burwinkel, Barbara and Marme, Frederik and Hein, Rebecca and Sawyer, Elinor J and Haiman, Christopher A and Wang-Gohrke, Shan and Anulis, Irene L and Moysich, Kirsten B and Hopper, John L and Odunsi, Kunle and Lindblom, Annika and Giles, Graham G and Brenner, Hermann and Simard, Jacques and Lurie, Galina and Fasching, Peter A and Carney, Michael E and Radice, Paolo and Wilkens, Lynne R and Swerdlow, Anthony and Goodman, Marc T and Brauch, Hiltrud and Garcia-Closas, Montserrat and Hillemanns, Peter and Winqvist, Robert and Dürst, Matthias and Devilee, Peter and Runnebaum, Ingo and Jakubowska, Anna and Lubinski, Jan and Mannermaa, Arto and Butzow, Ralf and ... and Gene Environm Interactimi Breast and Kathleen Cuningham Fdn Consortium and Australian Ovarian Canc Study and Epidemiological Study BRCA1 and Hereditary Breast Ovarian Canc Res and Genetic Modifiers Canc Risk BRCA1 and Australian Canc Study and Swedish Breast Canc Study SWE-BRCA and Medicinska fakulteten and Umeå universitet and Institutionen för strålningsvetenskaper
Nature genetics, ISSN 1061-4036, 2013, Volume 45, Issue 4, pp. 371 - 384
Journal Article