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Nature Medicine, ISSN 1078-8956, 10/2012, Volume 18, Issue 10, pp. 1570 - 1574
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57479 - e57479
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, pp. e0209509 - e0209509
Modulating the complement system is a promising strategy in drug discovery for disorders with uncontrolled complement activation. Although some of these... 
SERUM HALF-LIFE | IMMUNOGENICITY | PHARMACOKINETICS | COMPLEMENT INHIBITOR ECULIZUMAB | MULTIDISCIPLINARY SCIENCES | IN-VIVO | HEMOPHILIA-A | MONOCLONAL-ANTIBODY | EMICIZUMAB PROPHYLAXIS | DEPENDENT ANTIGEN-BINDING | THERAPEUTIC ANTIBODY | Endosomes - immunology | Protein Engineering - methods | Humans | Macaca fascicularis | Antibodies, Monoclonal - therapeutic use | Drug Discovery - methods | Complement Activation - immunology | Complement C5 - isolation & purification | Recombinant Proteins - isolation & purification | Time Factors | Complement C5 - immunology | Computer Simulation | Antibodies, Monoclonal - immunology | Complement Activation - drug effects | Histocompatibility Antigens Class I - immunology | Immune System Diseases - immunology | Antibody Affinity | Immune System Diseases - drug therapy | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Antibodies, Monoclonal - genetics | Animals | Receptors, Fc - immunology | Mutagenesis | Recombinant Proteins - immunology | Receptors, Fc - genetics | Mice | Complement C5 - antagonists & inhibitors | Hydrogen-Ion Concentration | Viral antibodies | Protein engineering | Usage | Physiological aspects | Antibodies | Genetic aspects | Research | Complement (Immunology) | Neonates | Plasma | Intravenous administration | Immune clearance | Disorders | Complement | Monkeys | Dosage | pH effects | Accumulation | Engineering | Salvage | Hemophilia | Recycling | Drug dosages | Binding | Antigens | Surface charge | Immunoglobulins | Fc receptors | Complement activation | Complement component C5 | Mutation | Endosomes | Neutralization | Pharmaceuticals | Polymorphism | Index Medicus | pH
Journal Article
Journal Article
Journal of Immunotoxicology, ISSN 1547-691X, 01/2019, Volume 16, Issue 1, pp. 125 - 132
Monoclonal antibody (mAb) drugs offer a number of valuable treatments. Many newly developed mAb drugs include artificial modification of amino acid sequences... 
Immunogenicity | antigen presentation | stimulation index | bromodeoxyuridine | flow cytometry | T-cell epitopes | helper T cells | monoclonal antibody drugs | RHEUMATOID-ARTHRITIS | CROHNS-DISEASE | ADALIMUMAB TREATMENT | PHASE-III | MAINTENANCE THERAPY | PLAQUE PSORIASIS | LONG-TERM SAFETY | INFLIXIMAB INDUCTION | SERUM-LEVELS | TOXICOLOGY | CLINICAL-RESPONSE
Journal Article
08/2018
The present invention provides anti-sclerostin antibodies and methods of using the same. In some embodiments, an isolated anti-sclerostin antibody of the... 
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS | METALLURGY | PEPTIDES | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
07/2018
본 발명은 항-C5 항체 및 그를 사용하는 방법을 제공한다. 일부 실시양태에서, 본 발명의 단리된 항-C5 항체는 산성 pH에서보다 중성 pH에서 더 높은 친화도하에 C5의 베타쇄 내의 에피토프에 결합한다. 본 발명은 또한 본 발명의 항-C5 항체를 암호화하는 단리된 핵산을 제공한다.... 
WINE | HYGIENE | ENZYMOLOGY | MICROORGANISMS OR ENZYMES | ORGANIC CHEMISTRY | MEDICAL OR VETERINARY SCIENCE | MICROBIOLOGY | HUMAN NECESSITIES | BEER | MUTATION OR GENETIC ENGINEERING | SPIRITS | COMPOSITIONS THEREOF | PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS | METALLURGY | PEPTIDES | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | BIOCHEMISTRY | CULTURE MEDIA | CHEMISTRY | VINEGAR
Patent
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