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Hypertension, ISSN 0194-911X, 09/2019, Volume 74, Issue Suppl_1
Journal Article
2018, ISBN 9782889453726
For decades we have known that the overgrowth, hardening and scarring of tissues (so-called fibrosis) represents the final common pathway and best histological... 
collagen | treatment strategies | fibrogenesis | therapeutic targets | Fibrosis | pharmacology
eBook
Methods in Molecular Biology, ISSN 1064-3745, 2009, Volume 466, pp. 223 - 235
Fibrosis and sclerosis are widely recognized as hallmarks of progressive renal disease and are caused by the excessive accumulation of connective tissue,... 
Kidney collagen content | Hydroxyproline | Interstitial collagen subtypes | Kidney collagen concentration | Animals | Kidney - pathology | Humans | Mice, Inbred C57BL | Hydroxyproline - analysis | Kidney - chemistry | Protein Isoforms - analysis | Mice | Collagen - analysis | Electrophoresis, Polyacrylamide Gel - methods
Conference Proceeding
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 09/2019, Volume 317, Issue 3, pp. E606 - E615
Posttranslational modification of nucleosomal histones is a major determinant of chromatin structure and gene activity. In the present study, we hypothesized... 
kidney | PHYSIOLOGY | histones | INHIBITION | gene regulation | unilateral ureteric obstruction | PHOSPHORYLATION | H3K9 | UROLOGY & NEPHROLOGY | mass spectrometry | fibrosis | modifications
Journal Article
Circulation Journal, ISSN 1346-9843, 2014, Volume 78, Issue 3, pp. 542 - 552
Over the past few decades, research on the peptide hormone, relaxin, has significantly improved our understanding of its biological actions under physiological... 
Biomarkers | RELAX-AHF | Relaxin | RXFP1 | Acute heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | LIVER-TRANSPLANTATION | SPONTANEOUSLY HYPERTENSIVE-RATS | FIBROSIS IN-VIVO | MECHANICAL-PROPERTIES | RENAL FIBROSIS | RECOMBINANT HUMAN RELAXIN | REVERSES CARDIAC FIBROSIS | ACUTE MYOCARDIAL-INFARCTION | NITRIC-OXIDE | ISCHEMIA-REPERFUSION
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 07/2018, Volume 187, pp. 61 - 70
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2016, Volume 37, Issue 6, pp. 485 - 497
Journal Article
Journal of Hypertension, ISSN 0263-6352, 10/2018, Volume 36 Suppl 3, pp. e50 - e51
OBJECTIVES:Targeting the angiotensin type 2 receptor (AT2R) has demonstrated anti-fibrotic effects in various organs. However, there are limited AT2R selective... 
Usage | Care and treatment | Health aspects | Heart diseases | Ligands (Biochemistry) | Fibrosis
Journal Article
The FASEB Journal, ISSN 0892-6638, 12/2019, Volume 33, Issue 12, pp. 14717 - 14733
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 05/2019, Volume 487, pp. 66 - 74
Journal Article
Journal of Hypertension, ISSN 0263-6352, 10/2018, Volume 36 Suppl 3, pp. e57 - e57
OBJECTIVES:There is an urgent need to discover targets that can reverse established fibrosis that occurs with advanced ageing and in many disease states thus... 
Care and treatment | Proteases | Fibrosis | Development and progression | Genetic aspects | Cardiovascular diseases | Health aspects
Journal Article
Heart, ISSN 1355-6037, 06/2016, Volume 102, Issue Suppl 6, pp. A127 - A127
This study aimed to determine whether Hexarelin (HEX), a synthetic growth hormone secretagogue, preserves cardiac function and attenuates remodelling in mouse... 
Journal Article
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