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by Borghini, L and Png, E and Binder, A and Wright, VJ and Pinnock, E and de Groot, R and Hazelzet, J and Emonts, M and Van der Flier, M and Schlapbach, LJ and Anderson, S and Secka, F and Salas, A and Fink, C and Carrol, ED and Pollard, AJ and Coin, LJ and Kuijpers, TW and Martinon-Torres, F and Zenz, W and Levin, M and Hibberd, ML and Davila, S and Gormley, S and Hamilton, S and Herberg, J and Hourmat, B and Hoggart, C and Kaforou, M and Sancho-Shimizu, V and Abdulla, A and Agapow, P and Bartlett, M and Bellos, E and Eleftherohorinou, H and Galassini, R and Inwald, D and Mashbat, M and Menikou, S and Mustafa, S and Nadel, S and Rahman, R and Thakker, C and Bokhandi, S and Power, S and Barham, H and Pathan, N and Ridout, J and White, D and Thurston, S and Faust, S and Patel, S and McCorkell, J and Davies, P and Cratev, L and Navarra, H and Carter, S and Ramaiah, R and Patel, R and Tuffrey, C and Gribbin, A and McCready, S and Peters, M and Hardy, K and Standing, F and O'Neill, L and Abelake, E and Deep, A and Nsirim, E and Willis, L and Young, Z and Royad, C and White, S and Fortune, PM and Hudnott, P and Gonzalez, FA and Barral-Arca, R and Cebey-Lopez, M and Curras-Tuala, MJ and Garcia, N and Vicente, LG and Gomez-Carballa, A and Rial, JG and Beiroa, AG and Grande, AJ and Iglesias, PL and Santos, AEM and Martinon-Torres, N and Sanchez, JMM and Perez, BM and Pacheco, PO and Pardo-Seco, J and Pischedda, S and Calle, IR and Rodriguez-Tenreiro, C and Redondo-Collazo, L and Fernandez, SS and Silva, MDP and Vega, A and Reyes, SB and ... and EUCLIDS Consortium and EUCLIDS consortium
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 6966 - 15
Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we... 
KAPPA-B | SEQUENCE VARIATION | BINDING | MULTIDISCIPLINARY SCIENCES | GENOME | NF-κB protein | Phenotypes | Disease | Epithelial cells | Association analysis | Single-nucleotide polymorphism | Regulatory sequences | Vaccines | Genetic variance | Infectious diseases | Genotyping | RelA protein | Binding sites | Meningococcal disease
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 05/2018, Volume 23, Issue 5, pp. 580 - 582
Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of , discovered that cytosolic pathogens... 
MICROBIOLOGY | PARASITOLOGY | VIROLOGY | Complement System Proteins | Intestinal Mucosa | Bacteria | Autophagy | Immunity, Cellular | Humans | Resveratrol | Blood proteins | Index Medicus
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2011, Volume 208, Issue 10, pp. 2083 - 2098
Journal Article
Cell, ISSN 0092-8674, 02/2017, Volume 168, Issue 5, pp. 789 - 800.e10
The molecular basis of the incomplete penetrance of monogenic disorders is unclear. We describe here eight related individuals with autosomal recessive TIRAP... 
toll-like receptors | lipoteichoic acid | LTA | anti-LTA antibodies | primary immunodeficiency | TIRAP | incomplete clinical penetrance | staphylococcus aureus | SIGNAL-TRANSDUCTION | GENE | MYD88 DEFICIENCY | PYOGENIC BACTERIAL-INFECTIONS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRIMARY IMMUNODEFICIENCIES | STAPHYLOCOCCUS-AUREUS | TIR DOMAIN | CUTTING EDGE | TLR2 | CELL BIOLOGY | Membrane Glycoproteins - analysis | Humans | Receptors, Interleukin-1 - genetics | Lipopolysaccharides - metabolism | Male | Monocytes - metabolism | Lipopolysaccharides - immunology | Receptors, Interleukin-1 - deficiency | Teichoic Acids - metabolism | Female | Toll-Like Receptors - metabolism | Child | Macrophages - immunology | Fibroblasts - metabolism | Adaptive Immunity | Staphylococcal Infections - drug therapy | Staphylococcal Infections - genetics | Staphylococcal Infections - immunology | Protein Isoforms - analysis | Teichoic Acids - immunology | Phagocytes - metabolism | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Toll-Like Receptors - agonists | Membrane Glycoproteins - genetics | Receptors, Interleukin-1 - analysis | Point Mutation | Antibodies, Monoclonal - administration & dosage | Pedigree | Myeloid Differentiation Factor 88 - metabolism | Membrane Glycoproteins - deficiency | Protein Isoforms - genetics | Interleukins | Monoclonal antibodies | Organic acids | Autoimmunity | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 08/2012, Volume 209, Issue 9, pp. 1567 - 1582
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4889 - 4902
Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5844, pp. 1522 - 1527
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural... 
T lymphocytes | Double stranded RNA | Memory interference | Cell lines | Central nervous system | Fibroblasts | Human herpesvirus 1 | Viruses | Infections | Research Articles | Genetic mutation | TOLL-LIKE RECEPTOR-3 | DOUBLE-STRANDED-RNA | INTERFERON | VIRUS-INFECTION | NK CELLS | GENE | RECOGNITION | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | EXPRESSION | T-LYMPHOCYTES | Interferons - biosynthesis | Encephalitis, Herpes Simplex - immunology | Dendritic Cells - immunology | Humans | Child, Preschool | Infant | Herpesvirus 1, Human - physiology | Genes, Dominant | Toll-Like Receptor 3 - deficiency | Leukocytes, Mononuclear - immunology | Killer Cells, Natural - immunology | Encephalitis, Herpes Simplex - genetics | Female | Toll-Like Receptor 3 - genetics | Fibroblasts - metabolism | Fibroblasts - virology | Cell Line | Poly I-C - pharmacology | Immunity, Innate | Keratinocytes - immunology | Toll-Like Receptor 3 - physiology | Alleles | Fibroblasts - immunology | Heterozygote | Toll-Like Receptor 3 - chemistry | Mutation | CD8-Positive T-Lymphocytes - immunology | Receptors | Research | Immunity | Health aspects | Herpes simplex encephalitis | Encephalitis | Infectious diseases | Immunology | Gene expression | Herpes viruses | Index Medicus | Encephalitis, Herpes Simplex | Toll-Like Receptor 3 | Killer Cells, Natural | Dendritic Cells | Interferons | Keratinocytes | Leukocytes, Mononuclear | Immunity, Natural | Herpesvirus 1, Human | CD8-Positive T-Lymphocytes | Life Sciences | Poly I-C
Journal Article
Immunity, ISSN 1074-7613, 2010, Volume 33, Issue 3, pp. 400 - 411
Journal Article