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by Weinstein, John N and Akbani, Rehan and Broom, Bradley M and Wang, Wenyi and Verhaak, Roeland G. W and McConkey, David and Lerner, Seth and Morgan, Margaret and Creighton, Chad J and Smith, Carolyn and Cherniack, Andrew D and Kim, Jaegil and Pedamallu, Chandra Sekhar and Noble, Michael S and Al-Ahmadie, Hikmat A and Reuter, Victor E and Rosenberg, Jonathan E and F.Bajorin, Dean and Bochner, Bernard H and Solit, David B and Koppie, Theresa and Robinson, Brian and Gordenin, Dmitry A and Fargo, David and Klimczak, Leszek J and Roberts, Steven A and Au, Jessie and Laird, Peter W and Hinoue, Toshinori and Schultz, Nikolaus and Ramirez, Ricardo and Hansel, Donna and Hoadley, Katherine A and Kim, William Y and Damrauer, Jeffrey S and Baylin, Stephen B and Mungall, Andrew J and Robertson, A. Gordon and Chu, Andy and Kwiatkowski, David J and Sougnez, Carrie and Cibulskis, Kristian and Lichtenstein, Lee and Sivachenko, Andrey and Stewart, Chip and Lawrence, Michael S and Getz, Gad and Lander, Eric and Gabrie, Stacey B and Donehower, Lawrence and Carter, Scott L and Saksena, Gordon and Schumacher, Steven E and Freeman, Samuel S and Jung, Joonil and Bhatt, Ami S and Pugh, Trevor and Beroukhim, Rameen and Meyerson, Matthew and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Dhalla, Noreen and Hirst, Carrie and Holt, Robert A and Jones, Steven J. M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Wong, Tina and Wye, Natasja and Bowlby, Reanne and Chuah, Eric and Guin, Ranabir and Shen, Hui and Bootwalla, Moiz S and Triche Jr, Timothy and Lai, Phillip H and Van Den Berg, David J and Weisenberger, Daniel J and Balu, Saianand and Bodenheimer, Tom and Hoyle, Alan P and Jefferys, Stuart R and Meng, Shaowu and Mose, Lisle E and Simons, Janae V and Soloway, Mathew G and Wu, Junyuan and Parker, Joel S and Hayes, D. Neil and Roach, Jeffrey and Buda, Elizabeth and Jones, Corbin D and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7492, pp. 315 - 322
Journal Article
by Koboldt, Daniel C and Fulton, Robert S and McLellan, Michael D and Schmidt, Heather and Kalicki-Veizer, Joelle and McMichael, Joshua F and Fulton, Lucinda L and Dooling, David J and Ding, Li and Mardis, Elaine R and Wilson, Richard K and Ally, Adrian and Balasundaram, Miruna and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Coope, Robin J. N and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Hirst, Martin and Holt, Robert A and Lee, Darlene and Li, Haiyan I and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Pleasance, Erin and Robertson, A. Gordon and Schein, Jacqueline E and Shafiei, Arash and Sipahimalani, Payal and Slobodan, Jared R and Stoll, Dominik and Tam, Angela and Thiessen, Nina and Varhol, Richard J and Wye, Natasja and Zeng, Thomas and Zhao, Yongjun and Birol, Inanc and Jones, Steven J. M and Marra, Marco A and Cherniack, Andrew D and Saksena, Gordon and Onofrio, Robert C and Pho, Nam H and Carter, Scott L and Schumacher, Steven E and Tabak, Barbara and Hernandez, Bryan and Gentry, Jeff and Nguyen, Huy and Crenshaw, Andrew and Ardlie, Kristin and Beroukhim, Rameen and Winckler, Wendy and Getz, Gad and Gabriel, Stacey B and Meyerson, Matthew and Chin, Lynda and Kucherlapati, Raju and Hoadley, Katherine A and Auman, J. Todd and Fan, Cheng and Turman, Yidi J and Shi, Yan and Li, Ling and Topal, Michael D and He, Xiaping and Chao, Hann-Hsiang and Prat, Aleix and Silva, Grace O and Iglesia, Michael D and Zhao, Wei and Usary, Jerry and Berg, Jonathan S and Adams, Michael and Booker, Jessica and Wu, Junyuan and Gulabani, Anisha and Bodenheimer, Tom and Hoyle, Alan P and Simons, Janae V and Soloway, Matthew G and Mose, Lisle E and Jefferys, Stuart R and Balu, Saianand and Parker, Joel S and Hayes, D. Neil and Perou, Charles M and Malik, Simeen and Mahurkar, Swapna and Shen, Hui and Weisenberger, Daniel J and Triche Jr, Timothy and Lai, Phillip H and ... and Canc Genome Atlas Network and Cancer Genome Atlas Network and The Cancer Genome Atlas Network
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7418, pp. 61 - 70
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and... 
PATHWAYS | TARGET | BASAL-LIKE | SUPPRESSOR | PIK3CA GENE | SUBTYPES | MULTIDISCIPLINARY SCIENCES | HIGH-FREQUENCY | LUMINAL-B | CANCER | MUTATIONAL EVOLUTION | GATA3 Transcription Factor - genetics | Receptors, Estrogen - metabolism | Oligonucleotide Array Sequence Analysis | Genomics | Humans | Gene Expression Regulation, Neoplastic | Ovarian Neoplasms - pathology | Gene Expression Profiling | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | DNA Methylation | DNA Mutational Analysis | Female | Genes, BRCA1 | Genes, Neoplasm - genetics | Breast Neoplasms - classification | RNA, Messenger - genetics | Retinoblastoma Protein - metabolism | DNA Copy Number Variations - genetics | Genes, p53 - genetics | Mutation - genetics | Genetic Heterogeneity | Genome, Human - genetics | Phosphatidylinositol 3-Kinases - genetics | Exome - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Breast Neoplasms - pathology | Retinoblastoma Protein - genetics | Genes, erbB-2 - genetics | Proteomics | Protein Array Analysis | RNA, Neoplasm - genetics | MAP Kinase Kinase Kinase 1 - genetics | MicroRNAs - genetics | Breast tumors | Gene mutations | Oncology, Experimental | Genetic aspects | Research | Identification and classification | Cancer | Proteins | DNA methylation | Genetics | Breast cancer | Mutation | Càncer de mama | Oncologia | Oncology | Gene expression | Expressió gènica | Genòmica
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2013, Volume 21, Issue 7, pp. 2145 - 2155
The uPAR·uPA protein–protein interaction (PPI) is involved in signaling and proteolytic events that promote tumor invasion and metastasis. A previous study had... 
In vivo | Synthesis | Urokinase receptor | Virtual screening | Breast cancer | Metastasis | Protein–protein interaction inhibitors | Cancer | Protein-protein interaction inhibitors | Small Molecule Libraries - pharmacology | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Protein Interaction Maps - drug effects | Humans | Antineoplastic Agents - therapeutic use | Breast - metabolism | Breast Neoplasms - metabolism | Neoplasm Metastasis - drug therapy | Neoplasm Invasiveness - pathology | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Breast - pathology | Small Molecule Libraries - therapeutic use | Antineoplastic Agents - chemistry | Mice, SCID | Breast Neoplasms - drug therapy | Receptors, Urokinase Plasminogen Activator - antagonists & inhibitors | Receptors, Urokinase Plasminogen Activator - metabolism | Cell Movement - drug effects | Small Molecule Libraries - chemistry | Animals | Urokinase-Type Plasminogen Activator - metabolism | Breast - drug effects | Breast Neoplasms - pathology | Neoplasm Metastasis - pathology | Cell Line, Tumor | Mice, Inbred NOD | Mice | Small Molecule Libraries - pharmacokinetics | Medical colleges | Oncology, Experimental | Cellulose | Fluorescence | Liquid chromatography | Research | Sulfates | Cytokinins | Urokinase | Surface active agents | Heterocyclic compounds | Fluorescein | Diagnosis | Mass spectrometry
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2017, Volume 23, Issue 12, pp. 3003 - 3011
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122270
Pachymic acid (PA) is a purified triterpene extracted from medicinal fungus Poria cocos. In this paper, we investigated the anticancer effect of PA on human... 
POLY(ADP-RIBOSE) POLYMERASE | UNFOLDED PROTEIN RESPONSE | ENDOPLASMIC-RETICULUM-STRESS | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | GENE-EXPRESSION | PROTEOTOXIC STRESS | MEDIATED APOPTOSIS | PORIA-COCOS | ANTICANCER STRATEGY | CELL-DEATH | Transcription Factor CHOP - genetics | Pancreatic Neoplasms - metabolism | Triterpenes - pharmacology | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Deoxycytidine - pharmacology | Gene Expression Profiling | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Taurochenodeoxycholic Acid - pharmacology | Antineoplastic Agents - isolation & purification | Eukaryotic Initiation Factor-2 - metabolism | Female | Antineoplastic Agents - pharmacology | Poria - chemistry | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Signal Transduction | Pancreatic Neoplasms - pathology | Activating Transcription Factor 4 - genetics | Pancreas - drug effects | Pancreas - pathology | HSP70 Heat-Shock Proteins - genetics | Pancreatic Neoplasms - genetics | Pancreas - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Activating Transcription Factor 4 - metabolism | Mice, Nude | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Triterpenes - isolation & purification | Mice | Transcription Factor CHOP - metabolism | Deoxycytidine - analogs & derivatives | Drug Resistance, Neoplasm - drug effects | Stresses | Gemcitabine | Toxicity | Heat shock proteins | Activation | Hsp70 protein | Tauroursodeoxycholic acid | Gene expression | Tissues | Stress | Anticancer properties | Proteins | Chemotherapy | Acids | Protein folding | Pancreatic cancer | Biocompatibility | Endoplasmic reticulum | Cancer | Apoptosis | Heat shock
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 2292 - 2292
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47873
Background: Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers. We have recently... 
DEXTRAN SULFATE SODIUM | BREAST-CANCER | MULTIDISCIPLINARY SCIENCES | MALE ICR MICE | COLORECTAL ADENOMA | WATER-SOLUBLE EXTRACT | PRENEOPLASTIC LESIONS | COLON TUMORS | ABERRANT CRYPT FOCI | REI-SHI MYCELIA | CULTURED MEDIUM | Inflammation - chemically induced | Plant Extracts - chemistry | Colonic Neoplasms - diet therapy | Hyperplasia - chemically induced | Apoptosis - drug effects | Humans | Colitis - complications | Colitis - pathology | Colonic Neoplasms - chemically induced | Gastrointestinal Neoplasms - complications | Gastrointestinal Neoplasms - diet therapy | Neoplasms, Experimental - chemically induced | Colonic Neoplasms - metabolism | Carcinogens - toxicity | Plant Extracts - administration & dosage | Inflammation - diet therapy | Anti-Inflammatory Agents - administration & dosage | Colitis - drug therapy | Imidazoles - toxicity | Reishi - chemistry | Gene Expression Regulation, Neoplastic - drug effects | Hyperplasia - metabolism | Aminopyridines - toxicity | Neoplasms, Experimental - diet therapy | Dextran Sulfate - toxicity | Animals | Hyperplasia - diet therapy | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cell Transformation, Neoplastic - drug effects | Neoplasms, Experimental - metabolism | Immunohistochemistry | Care and treatment | Oncology, Experimental | Genes | Body weight | Cytochrome P-450 | Inflammation | Research | Macrophages | Sulfates | Carcinogenesis | Prevention | Dextran | Pyridine | Colitis | Cancer | Cell proliferation | Hyperplasia | Cyclin D1 | Epidemiology | Anticancer properties | Metastases | Carcinogens | Reporter gene | Rodents | Sodium sulfate | Animal tissues | Colon | Medical research | Pyridines | Ganoderma lucidum | Antiinflammatory agents | Mushrooms | Cytochrome P450 | CYP1A2 protein | Gene expression | Inflammatory bowel disease | Diet | Sodium | Large intestine | Infiltration | Cyclooxygenase-2 | Sulfate | Aberration
Journal Article