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The Journal of Organic Chemistry, ISSN 0022-3263, 10/2017, Volume 82, Issue 19, pp. 10263 - 10270
A cobalt/copper-cocatalyzed facile synthesis of imidazo­[1,2-a:3,4-a′]­dipyridiniums from 2H-[1,2′-bipyridin]-2-ones and 2-bromoacetophenones is presented.... 
Usage | Catalysis | Chemical properties | Chemical synthesis | Imidazole
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 11/2019, Volume 28, Issue 11, pp. 1912 - 1922
To discover multifunctional agents for the treatment of Alzheimer’s disease (AD), a series of indanone–chalcone hybrid compounds were designed and synthesized... 
Biochemistry, general | Neuroprotective effects | Biomedicine | Alzheimer’s disease | MAO-B inhibition | Pharmacology/Toxicology | Indanone–chalcone hybrid molecules | A β 1–42 aggregation inhibition | Cell Biology
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 11/2019, Volume 28, Issue 11, p. 1912
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of indanone--chalcone hybrid compounds were designed and synthesized... 
Monoamine oxidase | Analysis | Alzheimer's disease
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 3/2019, Volume 55, Issue 2, pp. 265 - 268
Journal Article
Journal Article
Journal of China Pharmaceutical University, ISSN 1000-5048, 02/2018, Volume 49, Issue 1, pp. 10 - 19
Journal Article
Microchimica Acta, ISSN 0026-3672, 12/2019, Volume 186, Issue 12, pp. 1 - 7
A general approach is presented for synthesis of multicolored gold nanoparticles (GNPs) by Au(I)-mediated generation of interlocking rings in proteins and... 
Spiramycin | Rapid nucleation | Nanochemistry | Three color principle | Colorimetric analysis | Array | Gold nanoparticle synthesis | Chemistry | Analytical Chemistry | Microengineering | Characterization and Evaluation of Materials | Shuttle | Nanotechnology | Antibiotics discrimination
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2019, Volume 29, Issue 19, p. 126625
A series of 2-acetylphenol-donepezil hybrids was designed and synthesized based on multi-target-directed ligands strategy. The biological activities were... 
2-Acetylphenol-donepezil hybrids | Structure-active-relationship | Alzheimer’s disease | hMAO-B inhibition | eeAChE inhibition
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 06/2017, Volume 25, Issue 12, pp. 3006 - 3017
A new family of multitarget molecules able to interact with acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as with monoamino oxidase... 
MAO-B inhibitor | BuChE inhibitor | Alzheimer’s disease | 3,4-Dihydro-2(1H)-quinoline-O-alkylamines | Blood-brain barrier | MAO-A inhibitor | AChE inhibitor
Journal Article
RSC Advances, ISSN 2046-2069, 09/2019, Volume 9, Issue 48, pp. 28248 - 28252
A simple, rapid, sensitive, selective and label-free method is presented for the colorimetric determination of lincomycin (Lin) by using HAuCl4 and NaOH. Upon... 
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 02/2015, Volume 23, Issue 4, pp. 668 - 680
To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized... 
Neuroprotective effects | Scutellarein carbamate derivatives | Metal-chelating agents | Alzheimer's disease | Cholinesterase inhibitors | Antioxidant activity | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARBAMATE DERIVATIVES | CHEMISTRY, ORGANIC | CHOLINESTERASE-INHIBITORS | ACETYLCHOLINESTERASE | METALS | HYDROGEN-PEROXIDE | AGENTS | BRAIN | Neuroprotective Agents - therapeutic use | Cholinesterase Inhibitors - pharmacokinetics | Antioxidants - chemistry | Apigenin - therapeutic use | Humans | Cholinesterase Inhibitors - chemistry | Carbamates - pharmacokinetics | Carbamates - chemistry | Apigenin - chemistry | Chelating Agents - pharmacokinetics | Neuroprotective Agents - pharmacokinetics | Butyrylcholinesterase - metabolism | Glucuronates - therapeutic use | Glucuronates - chemistry | Chelating Agents - therapeutic use | Cell Line | Neuroprotective Agents - chemistry | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Rats | Apigenin - pharmacokinetics | Cognition - drug effects | Blood-Brain Barrier - metabolism | Glucuronates - pharmacokinetics | Antioxidants - therapeutic use | Animals | Alzheimer Disease - metabolism | Mice | Molecular Docking Simulation | Antioxidants - pharmacokinetics | Carbamates - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Acetylcholinesterase - metabolism | Antioxidants | Drug therapy | Index Medicus
Journal Article
Natural Product Research, ISSN 1478-6419, 02/2019, Volume 33, Issue 4, pp. 457 - 463
A new phenylpropanoid glycoside, named α-L-rhamnopyranosyl-(1↔2)-β-D-[4″-(8E)-7-(3,4-dihydroxyphenyl)-8-propenoate,... 
antiangiogenic activities | phenylpropanoid glycosides | Gynura cusimbua | CHEMISTRY, MEDICINAL | CHEMICAL-CONSTITUENTS | DITERPENOIDS | PHENYLETHANOID GLYCOSIDES | LEAVES | CHEMISTRY, APPLIED | STEM | Glycosides | Butanol | Zebrafish | Antiangiogenics
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 12/2019, Volume 183, p. 111737
A series of novel chalcone- -alkylamine derivatives were designed, synthesized and evaluated as multifunctional anti-Alzheimer's disease agents. Based on the... 
Precognitive effect | Rational design | Synthesis | Multi-functional agents | Alzheimer's disease | Chalcone-O-Alkylamine derivatives
Journal Article
Chemistry of Natural Compounds, ISSN 0009-3130, 9/2017, Volume 53, Issue 5, pp. 949 - 952
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2017, Volume 27, Issue 22, pp. 5053 - 5059
A series of novel phthalimide-alkylamine derivatives were synthesized and evaluated as multi-functions inhibitors for the treatment of Alzheimer’s disease... 
Phthalimide-alkylamine derivatives | MAO-B inhibitor | BuChE inhibitor | Alzheimer’s disease | Blood-brain barrier | AChE inhibitor
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2017, Volume 27, Issue 22, pp. 5046 - 5052
A series of 2-acetyl-5- -(amino-alkyl)phenol derivatives was designed, synthesized and evaluated as multi-function inhibitors for the treatment of Alzheimer’s... 
Alzheimer’s disease | Blood-brain barrier | 2-Acetyl-5-O-(amino-alkyl)phenol derivatives | Synthesized | Designed | Multi-target inhibitor
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 02/2019, Volume 10, Issue 2, pp. 1008 - 1024
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 01/2017, Volume 25, Issue 2, pp. 714 - 726
A series of homoisoflavonoid Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents against Alzheimer’s disease. It... 
Homoisoflavonoid | Acetylcholinesterase inhibitors | Monoamine oxidase B inhibitors | Multifunctional properties | Alzheimer’s disease | Mannich base derivatives
Journal Article
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