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American Journal of Surgery, The, ISSN 0002-9610, 2013, Volume 205, Issue 4, pp. 387 - 396
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 348, Issue 1, pp. 156 - 166
Abstract The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) causes cancer cell death, but many cancers, including pancreatic cancer, are... 
Hematology, Oncology and Palliative Medicine | TRAIL | Pancreatic cancer | Triptolide | Death receptor | Apoptosis | MOMP | LMP | HEAT-SHOCK-PROTEIN-70 | INDUCED APOPTOSIS | MITOCHONDRIAL | RELEASE | CYTOCHROME-C | CATHEPSINS | ONCOLOGY | BAX | LIGAND | PROTEINS | MEMBRANE PERMEABILIZATION | Pancreatic Neoplasms - metabolism | Apoptosis - drug effects | Receptors, TNF-Related Apoptosis-Inducing Ligand - agonists | Humans | Caspase 8 - metabolism | Antineoplastic Agents, Alkylating - pharmacology | Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Caspase 8 - genetics | Mitochondrial Membranes - drug effects | Epoxy Compounds - pharmacology | Lysosomes - metabolism | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Transfection | RNA Interference | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | BH3 Interacting Domain Death Agonist Protein - metabolism | Diterpenes - pharmacology | Lysosomes - drug effects | Cell Survival - drug effects | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Pancreatic Neoplasms - pathology | bcl-2-Associated X Protein - metabolism | Pancreatic Neoplasms - genetics | Permeability | Mitochondrial Membranes - metabolism | Phenanthrenes - pharmacology | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Mice | Enzyme Activation | Drug Resistance, Neoplasm - drug effects | Studies | Cell culture | Pancreas | Binding sites | Index Medicus | triptolide | apoptosis | pancreatic cancer | death receptor
Journal Article
Surgery: Official Journal of the Society of University Surgeons, Central Surgical Association, and the American Association of Endocrine Surgeons, ISSN 0039-6060, 2014, Volume 156, Issue 2, pp. 270 - 279
Introduction Sorafenib is the only drug approved by the Food and Drug Administration for metastatic hepatocellular carcinoma (HCC). Triptolide, a diterpene... 
Surgery | SURGERY | APOPTOSIS | HEAT-SHOCK-PROTEIN-70 | INHIBITION | GROWTH | MOLECULAR TARGETED THERAPIES | PROLIFERATION | NF-KAPPA-B | CANCER | RAF/MEK/ERK PATHWAY | CELL-DEATH | Caspase 7 - metabolism | Niacinamide - analogs & derivatives | Prodrugs - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Sincalide - metabolism | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Diterpenes - administration & dosage | Epoxy Compounds - administration & dosage | Liver Neoplasms - pathology | Liver Neoplasms, Experimental - pathology | Organophosphates - administration & dosage | Cell Survival - drug effects | NF-kappa B p50 Subunit - metabolism | Translational Medical Research | Liver Neoplasms - drug therapy | Phenanthrenes - administration & dosage | Niacinamide - administration & dosage | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Liver Neoplasms, Experimental - drug therapy | Phenylurea Compounds - administration & dosage | Signal Transduction - drug effects | Mice, Nude | Models, Biological | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Carcinoma, Hepatocellular - metabolism | Antimitotic agents | Care and treatment | Hepatoma | Antineoplastic agents | Drug approval | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2019, Volume 294, Issue 27, pp. 10739 - 10739
Journal Article
Cancer Letters, ISSN 0304-3835, 2013, Volume 335, Issue 2, pp. 412 - 420
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 8/2017, Volume 432, Issue 1, pp. 67 - 78
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 06/2014, Volume 306, Issue 11, pp. G1011 - G1020
Pancreatic cancer is a devastating disease with a survival rate of <5%. Moreover, pancreatic cancer aggressiveness is closely related to high levels of... 
Glucose-regulated protein 78 | Autophagy | Pancreatic cancer | Triptolide | Apoptosis | Endoplasmic reticulum stress | DEATH PROGRAM | PHYSIOLOGY | autophagy | glucose-regulated protein 78 | INDUCED APOPTOSIS | GRP78 | apoptosis | triptolide | ENDOPLASMIC-RETICULUM STRESS | endoplasmic reticulum stress | NEGATIVE REGULATOR | BREAST-CANCER | COLON-CANCER | pancreatic cancer | HEPATOCELLULAR-CARCINOMA | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Pancreatic Neoplasms - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Epoxy Compounds - pharmacology | Endoplasmic Reticulum - drug effects | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Stress, Physiological - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Beclin-1 | Diterpenes - pharmacology | Unfolded Protein Response - drug effects | Membrane Proteins - genetics | Down-Regulation | Heat-Shock Proteins - metabolism | Endoplasmic Reticulum - physiology | Gene Silencing | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Phenanthrenes - pharmacology | Animals | Cell Line, Tumor | Chronic Disease | Protein folding | Oncology, Experimental | Cancer cells | Physiological aspects | Research | Endoplasmic reticulum | Health aspects | Cancer | Enzymes | Survivor | Oncology | Stress response | Index Medicus | Cancer Biology
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e77411 - e77411
Background: Minnelide, a pro-drug of triptolide, has recently emerged as a potent anticancer agent. The precise mechanisms of its cytotoxic effects remain... 
U-373MG GLIOMA-CELLS | MET AMPLIFICATION | PRECLINICAL MODELS | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | INDUCE APOPTOSIS | OVARIAN-CANCER | NF-KAPPA-B | RADIATION SENSITIZATION | TRIPTOLIDE | PANCREATIC-CANCER CELLS | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Transcription, Genetic - drug effects | Apoptosis - drug effects | Transcriptional Activation - drug effects | Lung Neoplasms - pathology | NF-kappa B - metabolism | Organophosphates - pharmacology | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Phenanthrenes - pharmacology | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Care and treatment | Carcinoma | Analysis | Heat shock proteins | Cholecystokinin | Lung cancer, Non-small cell | Health aspects | Apoptosis | Cancer | Cell proliferation | Animal models | Phosphorylation | Transcription factors | Genes | Lung cancer | Lung | Staining | Cytotoxicity | Kinases | Cancer therapies | Anticancer properties | Proteins | Surgery | Animal tissues | Triptolide | Tumor necrosis factor-TNF | NF-κB protein | Cell survival | Small cell lung carcinoma | Non-small cell lung carcinoma | Caspase | Hsp70 protein | Lung carcinoma | Gene expression | Survival | Substrates | Chemotherapy | Apaf-1 protein | Medical prognosis | Cell lines | Antitumor activity | In vivo methods and tests | APAF-1 gene | Viability | Index Medicus
Journal Article
Molecular Cancer, ISSN 1476-4598, 09/2013, Volume 12, Issue 1, pp. 105 - 105
Journal Article