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1. Validation of Noninvasive Tracer Kinetic Analysis of ^sup 18^F-Florbetaben PET Using a Dual–Time-Window Acquisition Protocol
by Santiago Bullich and Henryk Barthel and Norman Koglin and Georg A Becker and Susan De Santi and Aleksandar Jovalekic and Andrew W Stephens and Osama Sabri
The Journal of Nuclear Medicine, ISSN 0161-5505, 07/2018, Volume 59, Issue 7, p. 1104
Accurate amyloid PET quantification is necessary for monitoring amyloid-β accumulation and response to therapy. Currently, most of the studies are analyzed... 
Computer simulation | Radioactive tracers | Blood | Blood flow | Image acquisition | Interpolation | Windows (intervals) | Simulation | Cerebral blood flow | Correlation analysis | Dementia disorders | Amyloid | Longitudinal studies | Modelling | Kinetics | Validation studies
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2. Application of the Centiloid transformation to ^sup 18^F-florbetaben
by Christopher Rowe and Vincent Dore and Gareth Jones and David Baxendale and Rachel Mulligan and Andrew Stephens and Susan De Santi and Colin Masters and Ludger Dinkelborg and Victor Villemagne
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 559
Objectives: A common quantitative output value for Aβ imaging across tracers and methods will improve clinical and research use. A method has recently been... 
Cerebellum | Elderly people | Neuroimaging | Brain | Nuclear medicine | Transformation | Pons | Cognitive ability | Older people | Tomography | Dementia disorders | Alzheimer's disease | Medical imaging | Neurodegenerative diseases | Cortex | Positron emission | Data processing | Fluorine isotopes | Injection | Disease control | Scaling | Alzheimers disease | Frontotemporal dementia | Elderly | Geriatrics | Tracers
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3. Optimal Reference Region to Measure Longitudinal Amyloid-ß Change with ^sup 18^F-Florbetaben PET
by Santiago Bullich and Victor L Villemagne and Ana M Catafau and Aleksandar Jovalekic and Norman Koglin and Christopher C Rowe and Susan De Santi
The Journal of Nuclear Medicine, ISSN 0161-5505, 08/2017, Volume 58, Issue 8, p. 1300
Accurate measurement of changes in amyloid-β (Aβ) deposition over time is important in longitudinal studies, particularly in anti-Aβ therapeutic trials. To... 
Measurement | Cerebellum | Pons | Medical imaging | Segmentation | Image processing | Change detection | Medical treatment | Cognitive ability | Cortex | Positron emission | Clinical trials | Substantia alba | Substantia grisea | Accumulation | Image segmentation | Magnetic resonance imaging | Correlation analysis | Tomography | Amyloid | Longitudinal studies | Deposition
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4. PET imaging of amyloid beta retention in sleep deprivation
by Gene-Jack Wang and Corinde Wiers and Ehsan Shokri Kojori and Sukru Demiral and Elsa Lindgren and Gregg Miller and Clara Freeman and Amna Zehra and Veronica Ramirez and Sung Won Kim and Dardo Tomasi and Helene Benveniste and Susan De Santi and Nora Volkow
The Journal of Nuclear Medicine, ISSN 0161-5505, 05/2017, Volume 58, p. 1253
Objectives: The brain's glymphatic system is implicated in the clearance of toxic waste products such as amyloid-beta peptide (Aβ) x- is more active during... 
Cerebellum | Brain | Nuclear medicine | Correlation coefficients | Scanners | Radioactive tracers | Cerebrospinal fluid | Accumulation | Sleep deprivation | Wakefulness | Older people | Aging | Tomography | Alzheimer's disease | Age | Binding | Deprivation | Statistical analysis | Positron emission | Toxic wastes | Cells | Image segmentation | Sleep | Body size | Biomarkers | Alzheimers disease
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5. Full Text FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease
by Mosconi, Lisa and Mistur, Rachel and Switalski, Remigiusz and Tsui, Wai Hon and Glodzik, Lidia and Li, Yi and Pirraglia, Elizabeth and De Santi, Susan and Reisberg, Barry and Wisniewski, Thomas and De Leon, Mony J
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 05/2009, Volume 36, Issue 5, pp. 811 - 822
We report the first clinicopathological series of longitudinal FDG-PET scans in post-mortem (PM) verified cognitively normal elderly (NL) followed to the onset... 
FDG-PET | Alzheimer's disease | Positron emission tomography | Early detection | Dementia | TOMOGRAPHY | DIAGNOSIS | CONVERSION | IMPAIRMENT | PREDICTION | MCI | DETERIORATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Dementia, Vascular - diagnostic imaging | Cognition Disorders - diagnostic imaging | Humans | Male | Positron-Emission Tomography - methods | Alzheimer Disease - diagnosis | Brain - metabolism | Lewy Body Disease - metabolism | Cognition Disorders - diagnosis | Hippocampus - metabolism | Dementia, Vascular - diagnosis | Autopsy | Aged, 80 and over | Glucose - metabolism | Female | Aged | Fluorodeoxyglucose F18 - pharmacology | Alzheimer Disease - diagnostic imaging | Medical colleges | Brain | Glucose metabolism | PET imaging | Physiological aspects | Development and progression | Glucose | Dextrose | Nuclear medicine | Neurobiology | Tomography | Alzheimers disease | Medical diagnosis | Metabolism
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6. Discourse analysis and applications
: studies in adult clinical populations
by Bloom, Ronald L
1994, ISBN 9780805813654, xiii, 247
Application of analytic discourse techniques to clinical practice is relatively recent. This book's contributors begin with the notion that systematic... 
Brain damage | Discourse analysis | Language | Patients | Rome
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7. Full Text Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
by Young, A.L and Marinescu, R.V and Oxtoby, N.P and Bocchetta, Martina and Yong, K and Firth, N.C and Cash, D.M and Thomas, David L and Dick, K.M and Cardoso, J and Swieten, John and Borroni, Barbara and Galimberti, Daniela and Masellis, Mario and Tartaglia, Maria Carmela and Rowe, James and Graff, C and Tagliavini, Fabrizio and Frisoni, Giovanni B and Laforce, Robert and Finger, Elizabeth and De Mendonça, Alexane and Sorbi, Sano and Warren, Jason and Crutch, S and Fox, Nick and Ourselin, Sebastien and Schott, J.M and Rohrer, Jonathan and Alexander, D.C and Genetic FTD Initiative GENFI and Alzheimer's Dis Neuroimaging Initi and Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Genetic FTD Initiative (GENFI) and The Genetic FTD Initiative (GENFI) and The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nature Communications, ISSN 2041-1723, 10/2018, Volume 9, Issue 1, pp. 4273 - 16
textabstractThe heterogeneity of neurodegenerative diseases is a key confound to disease understanding and treatment development, as study cohorts typically... 
COGNITIVE DECLINE | REPEAT EXPANSIONS | DEMENTIA | DEFINED SUBTYPES | MULTIDISCIPLINARY SCIENCES | SPORADIC ALZHEIMERS-DISEASE | ATROPHY PATTERNS | BIOMARKER CHANGES | MODEL | FRONTOTEMPORAL LOBAR DEGENERATION | HUNTINGTONS-DISEASE | Frontotemporal Dementia - genetics | Phenotype | Reproducibility of Results | Neurodegenerative Diseases - pathology | Time Factors | Humans | Genotype | Models, Neurological | Alzheimer Disease - genetics | Alzheimer Disease - pathology | Frontotemporal Dementia - pathology | Neurodegenerative Diseases - classification | Phenotypes | Medical imaging | Disease | Neurodegenerative diseases | Medical treatment | Inference | Trajectories | Patients | Subgroups | Complexity | Diseases | Neurological diseases | Heterogeneity | Learning algorithms | Neurodegeneration | Machine learning | Dementia disorders | Diagnostic systems | Frontotemporal dementia | Genotypes
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8. Full Text Maternal Family History of Alzheimer's Disease Predisposes to Reduced Brain Glucose Metabolism
by Lisa Mosconi and Miroslaw Brys and Remigiusz Switalski and Rachel Mistur and Lidia Glodzik and Elizabeth Pirraglia and Wai Tsui and Susan De Santi and Mony J. de Leon
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2007, Volume 104, Issue 48, pp. 19067 - 19072
Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether... 
Neurology | Parents | Predisposing factors | Parietal lobe | Mitochondrial DNA | Alzheimers disease | Family history | Positron emission tomography | Genotypes | Dementia | FDG-PET | POSTERIOR CINGULATE CORTEX | MCI | POSITRON-EMISSION-TOMOGRAPHY | DEMENTIA | GENETIC RISK | ABNORMALITIES | MULTIDISCIPLINARY SCIENCES | HYPOMETABOLISM | MILD COGNITIVE IMPAIRMENT | PREDICTION | Fluorodeoxyglucose F18 - pharmacokinetics | Genomic Imprinting | Apolipoprotein E4 - genetics | Humans | Middle Aged | Male | Risk | Positron-Emission Tomography | Mothers | Cerebral Cortex - metabolism | Fluorine Radioisotopes - pharmacokinetics | Aged, 80 and over | Alzheimer Disease - epidemiology | Female | Retrospective Studies | Genetic Predisposition to Disease | Genes, Mitochondrial | Cerebral Cortex - diagnostic imaging | Genetic Heterogeneity | Magnetic Resonance Imaging | Alzheimer Disease - metabolism | Brain Mapping | Glucose - metabolism | Aged | Alzheimer Disease - diagnostic imaging | Alzheimer Disease - genetics | Glucose metabolism | Research | Genetic susceptibility | Alzheimer's disease | Health aspects | Risk factors | Biological Sciences
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9. Full Text Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity
by Neda Jahanshad and Priya Rajagopalan and Xue Hua and Derrek P. Hibar and Talia M. Nir and Arthur W. Toga and Clifford R. Jack and Andrew J. Saykin and Robert C. Green and Michael W. Weiner and Sarah E. Medland and Grant W. Montgomery and Narelle K. Hansell and Katie L. McMahon and Greig I. de Zubicaray and Nicholas G. Martin and Margaret J. Wright and Paul M. Thompson and Alzheimer's Dis Neuroimaging Initi and Alzheimer’s Disease Neuroimaging Initiative and the Alzheimer's Disease Neuroimaging Initiative
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 12, pp. 4768 - 4773
Aberrant connectivity is implicated in many neurological and psychiatric disorders, including Alzheimer's disease and schizophrenia. However, other than a few... 
Neuroimaging | Quantitative genetics | Medical genetics | Connectivity | P values | Alzheimers disease | Twins | Connected regions | Human genetics | Dementia | Graph theory | Neuroimaging genetics | Multiple comparisons correction | HARDI tractography | Diffusion tensor imaging | COMMON VARIANTS | graph theory | multiple comparisons correction | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NETWORKS | neuroimaging genetics | AMYLOID PRECURSOR PROTEIN | BETA | ORGANIZATION | FLOOR PLATE | F-SPONDIN | diffusion tensor imaging | ASSOCIATION | BRAIN | Autistic Disorder - genetics | Severity of Illness Index | Brain - diagnostic imaging | Genome-Wide Association Study | Autistic Disorder - physiopathology | Brain - physiopathology | Extracellular Matrix Proteins - genetics | Humans | Twins, Dizygotic | Endosomal Sorting Complexes Required for Transport - genetics | Male | Ubiquitin-Conjugating Enzymes - genetics | Chromosomes, Human, Pair 11 - genetics | Twins, Monozygotic | Genetic Variation | Radiography | Magnetic Resonance Imaging | Adult | Female | Nedd4 Ubiquitin Protein Ligases | Alzheimer Disease - genetics | Ubiquitin-Protein Ligases - genetics | Autistic Disorder - diagnostic imaging | Genetic research | Genetic aspects | Mental illness | Methods | Biological Sciences
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10. 18F-Florbetaben PET beta-amyloid binding expressed in Centiloids
by Rowe, Christopher C and Doré, Vincent and Jones, Gareth and Baxendale, David and Mulligan, Rachel S and Bullich, Santiago and Stephens, Andrew W and De Santi, Susan and Masters, Colin L and Dinkelborg, Ludger and Villemagne, Victor L
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2017, Volume 44, Issue 12, pp. 2053 - 2059
PurposeThe Centiloid (CL) method enables quantitative values from Aβ-amyloid (Aβ) imaging to be expressed in a universal unit providing pathological,... 
Florbetaben | Alzheimer’s disease | Centiloid | Amyloid imaging | Standardization | Cerebellum | Binding | Neuroimaging | Neurodegenerative diseases | Positron emission | Image acquisition | Magnetic resonance imaging | β-Amyloid | Tomography | Diagnostic systems | Mathematical models | Alzheimer's disease | Tracers
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11. Full Text Surgery and brain atrophy in cognitively normal elderly subjects and subjects diagnosed with mild cognitive impairment
by Kline, Richard P and Pirraglia, Elizabeth and Cheng, Hao and De Santi, Susan and Li, Yi and Haile, Michael and De Leon, Mony J and Bekker, Alex and Alzheimer's Dis Neuroimaging Initi and Alzheimerʼs Disease Neuroimaging Initiative
Anesthesiology, ISSN 0003-3022, 03/2012, Volume 116, Issue 3, pp. 603 - 612
Background: Structural magnetic resonance imaging is used to longitudinally monitor the progression of Alzheimer disease from its presymptomatic to symptomatic... 
WHITE-MATTER | NONCARDIAC SURGERY | ALZHEIMERS-DISEASE | HIPPOCAMPAL | GREY-MATTER | ADULTS | ANESTHESIOLOGY | DYSFUNCTION | DECLINE | PREDICTION | Follow-Up Studies | Humans | Middle Aged | Male | Cognitive Dysfunction - pathology | Atrophy | Postoperative Complications - psychology | Aged, 80 and over | Brain - pathology | Cognition - physiology | Cognitive Dysfunction - psychology | Female | Aged | Cohort Studies | Databases, Factual | Postoperative Complications - pathology
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12. Full Text The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory
by Franzmeier, Nicolai and Rubinski, Anna and Neitzel, Julia and Ewers, Michael and Weiner, Michael W and Aisen, Paul and Petersen, Ronald and Jack, Clifford R and Jagust, William and Trojanowski, John Q and Toga, Arthur W and Beckett, Laurel and Green, Robert C and Saykin, Andrew J and Morris, John and Shaw, Leslie M and Khachaturian, Zaven and Sorensen, Greg and Kuller, Lew and Raichle, Marcus and Paul, Steven and Davies, Peter and Fillit, Howard and Hefti, Franz and Holtzman, David and Mesulam, Marek M and Potter, William and Snyder, Peter and Schwartz, Adam and Montine, Tom and Thomas, Ronald G and Donohue, Michael and Walter, Sarah and Gessert, Devon and Sather, Tamie and Jiminez, Gus and Harvey, Danielle and Bernstein, Matthew and Thompson, Paul and Schuff, Norbert and Borowski, Bret and Gunter, Jeff and Senjem, Matt and Vemuri, Prashanthi and Jones, David and Kantarci, Kejal and Ward, Chad and Koeppe, Robert A and Foster, Norm and Reiman, Eric M and Chen, Kewei and Mathis, Chet and Landau, Susan and Cairns, Nigel J and Householder, Erin and Taylor-Reinwald, Lisa and Lee, Virginia and Korecka, Magdalena and Figurski, Michal and Crawford, Karen and Neu, Scott and Foroud, Tatiana M and Potkin, Steven G and Shen, Li and Faber, Kelley and Kim, Sungeun and Nho, Kwangsik and Thal, Leon and Buckholtz, Neil and Albert, Marylyn and Frank, Richard and Hsiao, John and Kaye, Jeffrey and Quinn, Joseph and Lind, Betty and Carter, Raina and Dolen, Sara and Schneider, Lon S and Pawluczyk, Sonia and Beccera, Mauricio and Teodoro, Liberty and Spann, Bryan M and Brewer, James and Vanderswag, Helen and Fleisher, Adam and Heidebrink, Judith L and Lord, Joanne L and Mason, Sara S and Albers, Colleen S and Knopman, David and Johnson, Kris and Doody, Rachelle S and Villanueva-Meyer, Javier and Chowdhury, Munir and Rountree, Susan and Dang, Mimi and Stern, Yaakov and Honig, Lawrence S and Bell, Karen L and Ances, Beau and ... and Alzheimers Dis Neuroimaging Initia and Alzheimer’s Disease Neuroimaging Initiative (ADNI) and The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1766 - 12
The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is... 
COGNITIVE RESERVE | PROTEIN | CONNECTIVITY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | RISK | NEURODEGENERATION | PATHOLOGY | BRAIN | DECLINE | Brain - diagnostic imaging | Humans | Memory | Risk Factors | tau Proteins - metabolism | Male | Cognition | Positron-Emission Tomography | Genetic Variation | Magnetic Resonance Imaging | Endocytosis | Tumor Suppressor Proteins - genetics | Adaptor Proteins, Signal Transducing - genetics | Alleles | Alzheimer Disease - metabolism | Aged, 80 and over | Cytoskeleton - metabolism | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Nuclear Proteins - genetics | Brain | Cognitive ability | Health risks | Single-nucleotide polymorphism | Risk analysis | Gene polymorphism | Risk factors | Pathology | Tau protein | Autopsy | Dementia disorders | β-Amyloid | Cytoskeleton | Positron emission tomography | Alzheimer's disease | Polymorphism
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13. Full Text Discourse Analysis and Applications
: Studies in Adult Clinical Populations
by Loraine K. Obler and Jonathan S. Ehrlich and Ronald L. Bloom and Susan De Santi
06/2013, ISBN 9781138876408, 264
Application of analytic discourse techniques to clinical practice is relatively recent. This book's contributors begin with the notion that systematic... 
Psychiatry & Clinical Psychology - Adult | Language, Psychology of | Clinical Neuropsychology | Brain damage | Discourse analysis
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