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1. Full Text An international perspective on hospitalized patients with viral community-acquired pneumonia
by Radovanovic, Dejan and Sotgiu, Giovanni and Jankovic, Mateja and Mahesh, Padukudru Anand and Marcos, Pedro Jorge and Abdalla, Mohamed I and Di Pasquale, Marta Francesca and Gramegna, Andrea and Terraneo, Silvia and Blasi, Francesco and Santus, Pierachille and Aliberti, Stefano and Reyes, Luis F and Reyes, Katherine and Restrepo, Marcos I and Aruj, Patricia Karina and Attorri, Silvia and Barimboim, Enrique and Caeiro, Juan Pablo and Garzón, María I and Cambursano, Victor Hugo and Ceccato, Adrian and Chertcoff, Julio and Cordon Díaz, Ariel and de Vedia, Lautaro and Ganaha, Maria Cristina and Lambert, Sandra and Lopardo, Gustavo and Luna, Carlos M and Malberti, Alessio Gerardo and Morcillo, Nora and Tartara, Silvina and Pensotti, Claudia and Pereyra, Betiana and Scapellato, Pablo Gustavo and Stagnaro, Juan Pablo and Shah, Sonali and Shah, Ray D and Lötsch, Felix and Thalhammer, Florian and Anseeuw, Kurt and Francois, Camille A and Van Braeckel, Eva and Vincent, Jean Louis and Djimon, Marcel Zannou and Aranha Nouér, Simone and Chipev, Peter and Encheva, Milena and Miteva, Darina and Petkova, Diana and Balkissou, Adamou Dodo and Pefura Yone, Eric Walter and Mbatchou Ngahane, Bertrand Hugo and Shen, Ning and Xu, Jin-fu and Bustamante Rico, Carlos Andres and Buitrago, Ricardo and Pereira Paternina, Fernando Jose and Kayembe Ntumba, Jean-Marie and Vladic-Carevic, Vesna and Jakopovic, Marko and Matkovic, Zinka and Mitrecic, Ivan and Bouchy Jacobsson, Marie-Laure and Bro Christensen, Anette and Bødtger, Uffe and Meyer, Christian Niels and Vestergaard Jensen, Andreas and El-Said Abd El-Wahhab, Ibrahim and Elsayed Morsy, Nesreen and Shafiek, Hanaa and Sobh, Eman and Abdulsemed, Kedir Abdella and Bertrand, Fabrice and Brun-Buisson, Christian and de Montmollin, Etienne and Fartoukh, Muriel and Messika, Jonathan and Tattevin, Pierre and Khoury, Abdo and Ebruke, Bernard and Dreher, Michael and Kolditz, Martin and Meisinger, Matthias and Pletz, Mathias W and Hagel, Stefan and Rupp, Jan and Schaberg, Tom and Spielmanns, Marc and Creutz, Petra and Suttorp, Norton and Siaw-Lartey, Beatrice and Dimakou, Katerina and Papapetrou, Dimosthenis and Tsigou, Evdoxia and Ampazis, Dimitrios and Kaimakamis, Evangelos and Bhatia, Mohit and Dhar, Raja and D’Souza, George and ... and GLIMP Study Grp and GLIMP Study Group
European Journal of Internal Medicine, ISSN 0953-6205, 02/2019, Volume 60, pp. 54 - 70
Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated... 
Oseltamivir | Viral pneumonia | Community acquired pneumonia | Influenza | Viral swab | Testing | PNEUMONIA | UNITED-STATES | ETIOLOGY | ADULTS | COINFECTION | MEDICINE, GENERAL & INTERNAL | STAPHYLOCOCCUS-AUREUS | INFECTION | CRITICALLY-ILL PATIENTS | VIRUSES | Prospective Studies | Community-Acquired Infections - epidemiology | Cross-Sectional Studies | Antiviral Agents - therapeutic use | Oseltamivir - therapeutic use | Humans | Middle Aged | Pneumonia, Viral - drug therapy | Influenza, Human - epidemiology | Logistic Models | Male | Hospitalization | Medication Adherence | Pneumonia, Viral - epidemiology | Community-Acquired Infections - drug therapy | Internationality | Aged, 80 and over | Female | Aged | Influenza, Human - drug therapy | Databases, Factual
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2. Full Text Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy
by Halter, Joerg P and Schuepbach, W. Michael M and Mandel, Hanna and Casali, Carlo and Orchard, Kim and Collin, Matthew and Valcarcel, David and Rovelli, Attilio and Filosto, Massimiliano and Dotti, Maria T and Marotta, Giuseppe and Pintos, Guillem and Barba, Pere and Accarino, Anna and Ferra, Christelle and Illa, Isabel and Beguin, Yves and Bakker, Jaap A and Boelens, Jaap J and de Coo, Irenaeus F. M and Fay, Keith and Sue, Carolyn M and Nachbaur, David and Zoller, Heinz and Sobreira, Claudia and Simoes, Belinda Pinto and Hammans, Simon R and Savage, David and Marti, Ramon and Chinnery, Patrick F and Elhasid, Ronit and Gratwohl, Alois and Hirano, Michio
Brain, ISSN 0006-8950, 10/2015, Volume 138, Issue 10, pp. 2847 - 2858
Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal... 
risk factors | mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) | MNGIE | thymidine phosphorylase | THYMIDINE PHOSPHORYLASE-DEFICIENCY | FANCONI-ANEMIA | allogeneic haematopoietic stem cell transplantation | Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | DISORDER | Multicenter Study | PATIENT | MUTATIONS | OUTCOMES | DELETIONS | outcome | NEUROSCIENCES | CLINICAL NEUROLOGY | Mitochondrial Encephalomyopathies - surgery | Body Weight | Follow-Up Studies | Humans | Neutrophils | Male | Neural Conduction - physiology | Treatment Outcome | Young Adult | Magnetic Resonance Imaging | Neurologic Examination | Adolescent | Survival Analysis | Brain - pathology | Adult | Female | Intestinal Pseudo-Obstruction - surgery | Retrospective Studies | Hematopoietic Stem Cell Transplantation - methods | Child | Thymidine Phosphorylase - metabolism | Transplantation, Homologous - methods | Original | 1070
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3. Full Text Intrafamilial phenotypic variability in four families with Anderson‐Fabry disease
by Rigoldi, M and Concolino, D and Morrone, A and Pieruzzi, F and Ravaglia, R and Furlan, F and Santus, F and Strisciuglio, P and Torti, G and Parini, R
Clinical Genetics, ISSN 0009-9163, 09/2014, Volume 86, Issue 3, pp. 258 - 263
We analysed the clinical history of 16 hemizygous males affected by Anderson‐Fabry Disease, from four families, to verify their intrafamilial phenotypic... 
genetic counselling | GLA gene | agalsidase alpha | Anderson‐Fabry disease | Fabry | phenotypic heterogeneity | alpha‐galactosidase deficiency | intrafamilial variability | agalsidase beta | Anderson-Fabry disease | Agalsidase beta | Alpha-galactosidase deficiency | Intrafamilial variability | Genetic counselling | Phenotypic heterogeneity | Agalsidase alpha | X-INACTIVATION | OUTCOME SURVEY | alpha-galactosidase deficiency | GENE | GENETICS & HEREDITY | MUTATIONS | ENZYME REPLACEMENT THERAPY | ALPHA-GALACTOSIDASE | Fabry Disease - genetics | Humans | Middle Aged | Male | Fabry Disease - pathology | Mutation, Missense - genetics | Hemizygote | Fabry Disease - mortality | Phenotype | Pedigree | Adult | Fabry Disease - drug therapy | Enzyme Replacement Therapy - statistics & numerical data | Development and progression | Fabry's disease | Medical research | Genotype & phenotype | Genetic disorders | Risk factors
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4. Full Text Randomized controlled trials and real life studies. Approaches and methodologies: a clinical point of view
by Saturni, S and Bellini, F and Braido, F and Paggiaro, P and Sanduzzi, A and Scichilone, N and Santus, P.A and Morandi, L and Papi, A
Pulmonary Pharmacology & Therapeutics, ISSN 1094-5539, 2014, Volume 27, Issue 2, pp. 129 - 138
Abstract Randomized Controlled Trials (RCTs) are the “gold standard” for evaluating treatment outcomes providing information on treatments “efficacy”. They are... 
Medical Education | Pulmonary/Respiratory | Real life studies | Randomized controlled trials | Asthma | COPD | COST-EFFECTIVENESS | PROPENSITY SCORE | INHALED CORTICOSTEROIDS | ASTHMA CONTROL | OBSTRUCTIVE PULMONARY-DISEASE | CIGARETTE-SMOKING | PRIMARY-CARE | SURVEILLANCE BIAS | RESPIRATORY SYSTEM | CONSORT STATEMENT | PHARMACOLOGY & PHARMACY | PRAGMATIC TRIALS | Asthma - therapy | Pulmonary Disease, Chronic Obstructive - therapy | Confounding Factors (Epidemiology) | Randomized Controlled Trials as Topic - methods | Research Design | Humans | Health aspects | Lung diseases, Obstructive | Methods
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5. Full Text Understanding the burden of pneumococcal disease in adults
by Blasi, F and Mantero, M and Santus, PierAchille and Tarsia, P
Clinical Microbiology and Infection, ISSN 1198-743X, 10/2012, Volume 18, Issue 5, pp. 7 - 14
causes different types of acute, invasive and non-invasive clinical infections, being the most frequently detected pathogen responsible for community-acquired... 
cost of disease | vaccine | Antibiotic resistance | infection prevention | Streptococcus pneumoniae | Infection prevention | Vaccine | Cost of disease | UNITED-STATES | INFECTIOUS DISEASES | COMMUNITY-ACQUIRED PNEUMONIA | MICROBIOLOGY | ANTIMICROBIAL RESISTANCE | PREVENTING PNEUMONIA | BACTERIAL PNEUMONIA | STREPTOCOCCUS-PNEUMONIAE | DOUBLE-BLIND TRIAL | CONJUGATE-VACCINE | MACROLIDE RESISTANCE | POLYSACCHARIDE VACCINE | Pneumococcal Infections - drug therapy | Streptococcus pneumoniae - drug effects | Community-Acquired Infections - epidemiology | Humans | Bacteremia - drug therapy | Drug Resistance, Bacterial | Pneumococcal Vaccines - administration & dosage | Anti-Bacterial Agents - therapeutic use | Pneumococcal Infections - epidemiology | Bacteremia - prevention & control | Community-Acquired Infections - drug therapy | Treatment Failure | Pneumococcal Infections - prevention & control | Pneumococcal Vaccines - immunology | Bacteremia - epidemiology | Anti-Bacterial Agents - pharmacology | Community-Acquired Infections - prevention & control | Drug resistance in microorganisms | Anti-infective agents | Respiratory agents | Pneumonia | Adults | Bacterial pneumonia
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6. Full Text Disease awareness in patients with COPD: Measurement and extent
by Baiardini, Ilaria and Rogliani, Paola and Rogliani, Paola and Santus, Pierachille and Corsico, Angelo G and Contoli, Marco and Scichilone, Nicola and Di Marco, Fabiano and Lessi, Patrizia and Scognamillo, Carla and Molinengo, Giorgia and Ferri, Fabio and Patella, Vincenzo and Fiorentino, Giuseppe and Fiorentino, Giuseppe and Carone, Mauro and Carone, Mauro and Braido, Fulvio
International journal of chronic obstructive pulmonary disease, ISSN 1176-9106, 2019, Volume 14, pp. 1 - 11
Background: Patient awareness of COPD refers to knowledge and acceptance of the disease and its treatment. Although it is relevant to management and outcomes,... 
Questionnaire | Patient satisfaction | Awareness | COPD | questionnaire | PERSPECTIVE | KNOWLEDGE | VALIDATION | CLASSIFICATION | ILLNESS | RELIABILITY | ADHERENCE | patient satisfaction | OBSTRUCTIVE PULMONARY-DISEASE | awareness | RESPIRATORY SYSTEM | VALIDITY
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7. Full Text Higher blood eosinophil levels after omalizumab treatment may be associated with poorer asthma outcomes
by Sposato, B and Sposato, Bruno and Scalese, Marco and Scalese, M and Milanese, M and Milanese, Manlio and Masieri, Simonetta and Masieri, S and Cavaliere, Carlo and Latorre, M and Latorre, Manuela and Scichilone, Nicola and Scichilone, N and Ricci, Alberto and Cresti, Alberto and Santus, Pierachille and Olivieri, Carmela and Olivieri, C and Perrella, A and Perrella, Antonio and Rogliani, Paola and Rogliani, P and Paggiaro, P and Paggiaro, Pierluigi and Migliorini, M.G and Di Tomassi, M and Camiciottoli, G and Maselli, R and Pelaia, G and Busceti, M.T and Sabato, E and Cagnazzo, M.G and Colombo, F and Palumbo, L and Ravazzi, A and Bucca, C and Caiaffa, M.F and Berra, A and Calabrese, C and Stanziola, A.A and Schino, P and Di Gioacchino, M and Cazzola, M and Segreti, A and Pastorello, E.A and Scibilia, G and Vianello, A and Marchi, M.R and Paladini, L and Baglioni, S and Abbritti, M and Almerigogna, F and Matucci, A and Vultaggio, A and Maggi, E and Maestrelli, P and Guarnieri, G and Steinhilber, G and Bonavia, M and Rottoli, P and Bargagli, E and Senna, G and Caminati, M and Macchia, L and Bellia, V and Novelli, F and Vergura, L and Rosati, Y and Folletti, I and Pio, R and Pio, A and Maccari, U and Maggiorelli, C and Scala, R and Vignale, L and Pulerà, N and Carpagnano, G.E and Foschino Barbaro, M.P and Omalizumab Italian Study Grp and Omalizumab Italian Study Group
The Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 05/2019, Volume 7, Issue 5, pp. 1643 - 1646
Elevated airway eosinophil counts can be detected in more than 50% of asthmatics and associated with more symptoms, frequent exacerbations, and greater airflow... 
BIOMARKERS | ALLERGY | IMMUNOLOGY | Respiratory tract | Leukocytes (eosinophilic) | Nitric oxide | Immunoglobulin E | Monoclonal antibodies | Blood | Asthma
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8. Full Text A Framework For Step Down Or Therapeutic Re-Organization For Withdrawal Of Inhaled Corticosteroids In Selected Patients With COPD: A Proposal For COPD Management
by Micheletto, C and Braido, F and Contoli, M and Di Marco, F and Santus, P
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ISSN 1178-2005, 2019, Volume 14, pp. 2185 - 2193
While chronic obstructive pulmonary disease (COPD) continues to be a major cause of morbidity and mortality, pharmacological therapy has a definite benefit on... 
CHRONIC-BRONCHITIS | BLOOD EOSINOPHILS | COMBINATION THERAPY | LAMA | FLUTICASONE FUROATE | exacerbation | OBSTRUCTIVE PULMONARY-DISEASE | SPUTUM EOSINOPHILIA | RESPIRATORY SYSTEM | LABA | PARALLEL-GROUP | DOUBLE-BLIND | EXACERBATIONS | AIRWAY EOSINOPHILIA | deprescribing | COPD | inhaled corticosteroids | Tiotropium | Lung diseases, Obstructive | Care and treatment | Corticosteroids | Mortality | Pharmaceutical industry | Health aspects | Switzerland
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9. Full Text Anxiety and depression in COPD patients: The roles of gender and disease severity
by Di Marco, Fabiano and Verga, Massimo and Reggente, Manuela and Maria Casanova, Francesca and Santus, Pierachille and Blasi, Francesco and Allegra, Luigi and Centanni, Stefano
Respiratory Medicine, ISSN 0954-6111, 2006, Volume 100, Issue 10, pp. 1767 - 1774
The aim of our study was to assess the prevalence of anxiety and depression in the whole chronic obstructive pulmonary disease (COPD) population and in... 
Depression | Anxiety | Dyspnea | COPD | Quality of life | CARDIAC & CARDIOVASCULAR SYSTEMS | dyspnea | PREVALENCE | CANCER | anxiety | OBSTRUCTIVE PULMONARY-DISEASE | IMPACT | THERAPY | INVENTORY | RESPIRATORY SYSTEM | ELDERLY PATIENTS | depression | QUALITY-OF-LIFE | SCALE | quality of life | Forced Expiratory Volume - physiology | Humans | Male | Dyspnea - etiology | Pulmonary Disease, Chronic Obstructive - physiopathology | Case-Control Studies | Depression - etiology | Pulmonary Disease, Chronic Obstructive - psychology | Sex Factors | Quality of Life | Female | Surveys and Questionnaires | Aged | Anxiety - etiology | Respiratory agents | Lung diseases, Obstructive | Depression, Mental | Prevalence studies (Epidemiology) | Studies | Psychological aspects | Hospitals | Disease | Oxygen therapy | Anxieties | Classification | Questionnaires | Males | Females | Chronic illnesses
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10. Full Text Inverse determination of the fatigue Strain Energy Density control radius for conventionally and additively manufactured rounded V-notches
by Benedetti, M and Santus, C and Berto, F
International Journal of Fatigue, ISSN 0142-1123, 09/2019, Volume 126, pp. 306 - 318
The Strain Energy Density (SED) fatigue criterion is based on a material control radius. The value of this length is therefore required for an accurate... 
Inverse search | SED | Control radius | V-notched specimen | Conventionally and additively manufactured alloys | CRITICAL DISTANCES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CRACK INITIATION | STRENGTH | BRITTLE-FRACTURE | ENGINEERING, MECHANICAL | FRACTURE ASSESSMENT | MEAN STRESS | STEEL | MULTIAXIAL FATIGUE | STRUCTURAL COMPONENTS | CRITERION | Numerical analysis | Alloys | Notched components | Flux density | Computer simulation | Fatigue strength | Notches
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11. An outbreak of severe invasive meningococcal disease due to a capsular switched Neisseria meningitidis hypervirulent strain B:cc11
by Stefanelli, P and Fazio, C and Vacca, P and Palmieri, A and Ambrosio, L and Neri, A and Piana, A and Castiglia, P and Argiolas, F and Santus, S and Masala, L and Steri, G and Riccardo, F and Iannazzo, S and Maraglino, F.P and D'Amario, C and Rezza, G
Clinical Microbiology and Infection, ISSN 1198-743X, 01/2019, Volume 25, Issue 1, pp. 111.e1 - 111.e4
Objectives: The aim was to investigate an outbreak of invasive meningococcal disease (IMD) in Southern Sardinia. Methods: Epidemiological and microbiological... 
Invasive meningococcal disease | Capsular switching | Outbreak | Whole-genome sequencing | Hypervirulent | Neisseria meningitides | Italy | INFECTIOUS DISEASES | MICROBIOLOGY | Neisseria meningitidis - pathogenicity | Meningococcal Infections - epidemiology | Meningococcal Infections - transmission | Humans | Middle Aged | Virulence | Antigens, Bacterial - immunology | Serogroup | Male | Meningococcal Infections - microbiology | Whole Genome Sequencing | Young Adult | Anti-Bacterial Agents - therapeutic use | Disease Outbreaks | Adolescent | Bacterial Capsules - genetics | Female | Italy - epidemiology | Neisseria meningitidis - genetics | Bacterial Capsules - immunology
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12. Full Text OP0006 Influence of autonomic nervous system dysfunction in the genesis of sleep disorders in fibromyalgia patients
by Rizzi, M and Radovanovic, D and Santus, P and Airoldi, A and Frassanito, F and Vanni, S and Cristiano, A and Casale, R and Furlan, R and Atzeni, F and Sarzi-Puttini, P
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2017, Volume 76, Issue Suppl 2, p. 52
BackgroundFibromyalgia (FM) is characterised by chronic musculoskeletal pain, autonomic nervous system (ANS) dysfunction, and disturbed sleep.ObjectivesThe aim... 
Fibromyalgia | Sleep (REM) | Nervous system | Heart rate | Sleep disorders | Intolerance | Body mass index | Pain | Autonomic nervous system | Syncope | Vagus nerve | Heart diseases | Sleep and wakefulness
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