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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Artemisinins | Malaria | Half lives | Antimalarials | Peroxides | Parasites | Dosage | Ozonides | Blood | Blood plasma | 1,2,4-trioxolane | Antimalarial drug discovery | OZ277 | PHARMACODYNAMIC PROPERTIES | MULTIDISCIPLINARY SCIENCES | ARTEROLANE | TRIOXOLANE | 1-AMINOBENZOTRIAZOLE | antimalarial drug discovery | PEROXIDES | IN-VITRO ASSESSMENT | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | ARTEMISININ | Peroxides - administration & dosage | Plasmodium berghei - physiology | Male | Peroxides - therapeutic use | Peroxides - pharmacokinetics | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Heterocyclic Compounds - chemistry | Time Factors | Adamantane - therapeutic use | Adamantane - administration & dosage | Adamantane - pharmacokinetics | Artemisinins - chemistry | Adamantane - analogs & derivatives | Antimalarials - pharmacokinetics | Heterocyclic Compounds - administration & dosage | Drug Stability | Peroxides - chemistry | Rats | Treatment Outcome | Antimalarials - therapeutic use | Iron - metabolism | Rats, Sprague-Dawley | Animals | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Antimalarials - chemistry | Malaria - parasitology | Heterocyclic Compounds - pharmacokinetics | Mice | Adamantane - chemistry | Heterocyclic Compounds - therapeutic use | Malaria - drug therapy | Care and treatment | Composition | Health aspects | Malaria vaccine | Biological Sciences
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 798 - 798
Abstract INTRODUCTION: Innate immune sensors such as TLR2 are consistently overexpressed in bone marrow CD34+ cells from low risk MDS patients (pts), and a... 
Journal Article
Nature, ISSN 0028-0836, 08/2004, Volume 430, Issue 7002, pp. 900 - 904
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 227 - 227
Abstract INTRODUCTION: Alterations of innate immune signaling, including overexpression of TLR2, are common in MDS. Signaling mediated by this receptor results... 
Journal Article
Journal Article
Stroke, ISSN 0039-2499, 06/2019, Volume 50, Issue 6, pp. 1605 - 1611
Journal Article
Malaria Journal, ISSN 1475-2875, 2013, Volume 12, Issue 1, pp. 70 - 70
Journal Article
Malaria Journal, ISSN 1475-2875, 2012, Volume 11, Issue 1, pp. 270 - 270
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2014, Volume 58, Issue 10, pp. 5900 - 5908
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2011, Volume 108, Issue 11, p. 4400
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Drugs | Malaria | Erythrocytes | Clinical trials | Parasitic protozoa | Blood
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 03/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Journal Article
Nature, ISSN 0028-0836, 08/2004, Volume 430, Issue 7002, pp. 900 - 904
The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric... 
Journal Article
Journal Article
Plos Medicine, ISSN 1549-1676, 2016, Volume 13, Issue 10, p. e1002138
Journal Article