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Biomedicines, ISSN 2227-9059, 02/2018, Volume 6, Issue 1, p. 22
The bone marrow (BM) niche encompasses multiple cells of mesenchymal and hematopoietic origin and represents a unique microenvironment that is poised to... 
Cell proliferation | Memory cells | Immunological memory | Cell survival | Mesenchyme | Tumor cells | Leukemia | Lymphocytes T | Leukocytes (neutrophilic) | Macrophages | Hematopoietic stem cells | Immunology | Overexpression | Stem cells | Plasma cells | Bone marrow | Colonization | Cancer | microenvironment | leukemia stem cell | immunotherapy | immune biomarker | prognosis | bone marrow | immune checkpoints
Journal Article
Stem Cell Research, ISSN 1873-5061, 08/2018, Volume 31, pp. 157 - 160
Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood characterized by expansion of clonal myelomonocytic cells and... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Female | Infant | Leukemia, Myelomonocytic, Juvenile - genetics | Mutation | Humans | Induced Pluripotent Stem Cells - metabolism | Cellular signal transduction | Genetic aspects | Research | Gene mutations | Leukemia | Stem cells
Journal Article
Frontiers in Pediatrics, ISSN 2296-2360, 11/2017, Volume 5, p. 248
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2009, Volume 106, Issue 23, pp. 9414 - 9418
Journal Article
Leukemia, ISSN 0887-6924, 04/2017, Volume 31, Issue 4, pp. 981 - 984
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 108
A complex interplay of intracellular signaling networks orchestrates normal cell growth and survival, including translation, transcription, proliferation, and... 
clinical trial | tyrosine kinase inhibitors | PI3K/mTOR | acute myeloid leukemia | acute lymphoblastic leukemia | non-Hodgkin lymphoma | Hodgkin lymphoma | pediatric | acute myeloid leukemia (AML) | Clinical Trial
Journal Article
Clinical Lymphoma, Myeloma and Leukemia, ISSN 2152-2650, 09/2018, Volume 18, pp. S6 - S8
Journal Article
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 2014, Volume 4, p. 55
Approximately two-thirds of children with acute myeloid leukemia (AML) are cured with intensive multi-agent chemotherapy. However, refractory and relapsed AML... 
Precision medicine | Targeted therapy | Demethylating agents | Monoclonal antibodies | Clinical trial | Acute myeloid leukemia | Pediatric | Tyrosine kinase inhibitors | tyrosine kinase inhibitors | targeted therapy | Clinical Trials as Topic | Antibodies, Monoclonal | Signal Transduction | monoclonal antibodies
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2014, Volume 371, Issue 11, pp. 1005 - 1015
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study,... 
MEDICINE, GENERAL & INTERNAL | MODELS | B-CELL PRECURSOR | INHIBITOR THERAPY | IMATINIB | PEDIATRIC ACUTE LEUKEMIAS | GENE FUSION | EXPRESSION | ETV6-NTRK3 FUSION TRANSCRIPTS | CRLF2 | DELETION | Oligonucleotide Array Sequence Analysis | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Humans | Child, Preschool | Infant | Male | Young Adult | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Heterografts | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Adult | Female | DNA, Neoplasm - analysis | Receptors, Cytokine - metabolism | Child | Philadelphia Chromosome | Receptors, Cytokine - genetics | Signal Transduction - genetics | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Animals | Protein Kinase Inhibitors - therapeutic use | Adolescent | Survival Analysis | Mice | Polymorphism, Single Nucleotide | Genome, Human | Protein-Tyrosine Kinases - antagonists & inhibitors | Development and progression | Care and treatment | Genetic aspects | Research | Lymphocytic leukemia | Tyrosine metabolism | Cell proliferation | Adolescence | Tyk2 protein | Leukemia | Genes | Clinical trials | Oncology | Genomes | Kinases | Cell activation | Janus kinase 2 | Xenografts | Teenagers | Children | Protein-tyrosine kinase | Age | Tyrosine | Young adults | Genomic analysis | Acute lymphatic leukemia | Stat5 protein | Lymphatic leukemia | Gene expression | Philadelphia chromosome | Interleukin 7 receptors | Thymic stromal lymphopoietin | Lymphocytes B | Cell lines
Journal Article