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Nature Communications, ISSN 2041-1723, 06/2014, Volume 5, Issue 1, p. 4177
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2017, Volume 214, Issue 10, pp. 2901 - 2913
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 16, pp. 4817 - 4830
Purpose: EZH2 and EZH1, the catalytic components of polycomb repressive complex 2 (PRC2), trigger trimethylation of H3K27 (H3K27me3) to repress the... 
MULTIPLE-MYELOMA | APOPTOSIS | STEM-CELLS | ONCOLOGY | NUCLEAR RECEPTORS | B-CELL LYMPHOMAS | PROSTATE-CANCER | THERAPEUTIC TARGET | GROWTH | ACUTE MYELOID-LEUKEMIA | SOMATIC MUTATIONS | Polycomb Repressive Complex 2 - antagonists & inhibitors | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Polycomb Repressive Complex 2 - genetics | Humans | Male | Bortezomib - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pyridones - administration & dosage | Multiple Myeloma - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Proteasome Inhibitors - pharmacology | Proteasome Inhibitors - administration & dosage | Cells, Cultured | Mice, SCID | Multiple Myeloma - metabolism | Mice, Knockout | Drug Synergism | Xenograft Model Antitumor Assays | Animals | Bortezomib - administration & dosage | Cell Line, Tumor | Mice, Inbred NOD | Proteasome Endopeptidase Complex - metabolism | Polycomb Repressive Complex 2 - metabolism | Multiple Myeloma - genetics | Pyridones - pharmacology | Therapy | Biotechnology | Transcription | Pathogenesis | Multiple myeloma | Myc protein | E2F protein | Xenografts | Catalysis | Inhibition | Sensitizing | Bortezomib | Tumor cell lines | Ribonucleic acid--RNA | Proteasome inhibitors | Polycomb group proteins | Inhibitors | Protease inhibitors | Experimental design | Derepression | Cell lines | Epigenetics | Tumor suppressor genes | Methylation | Prostate cancer | Prostate | Tumors | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0154561 - e0154561
Journal Article
Blood, ISSN 0006-4971, 12/2011, Volume 118, Issue 25, pp. 6553 - 6561
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e84807
Tumor-initiating cells (TICs) play a central role in tumor development, metastasis, and recurrence. In the present study, we investigated the effect of... 
BREAST-CANCER CELLS | APOPTOSIS | STEM-CELLS | GLYPICAN-3 | INHIBITION | MARKER | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | EXPRESSION | Reactive Oxygen Species - metabolism | Neoplastic Stem Cells - drug effects | Cell Count | Spheroids, Cellular - pathology | Gene Expression Profiling | Glypicans - metabolism | Epithelial Cell Adhesion Molecule | Carcinoma, Hepatocellular - drug therapy | Flow Cytometry | Carcinoma, Hepatocellular - genetics | Antigens, Neoplasm - metabolism | Neoplastic Stem Cells - pathology | Liver Neoplasms - pathology | Spheroids, Cellular - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - enzymology | Aldehyde Dehydrogenase - metabolism | Intracellular Space - drug effects | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - enzymology | Enzyme Activation - drug effects | Mice, SCID | Cell Adhesion Molecules - metabolism | Glypicans - genetics | Disulfiram - therapeutic use | Carcinogenesis - drug effects | Carcinogenesis - pathology | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Intracellular Space - metabolism | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Disulfiram - pharmacology | Neoplastic Stem Cells - enzymology | Disulfiram | Genetic research | Development and progression | Hepatoma | Analysis | Genes | Flow cytometry | Nephrology | Dehydrogenases | 5-Fluorouracil | Epithelial cells | Brain cancer | Oxygen enrichment | Hepatocellular carcinoma | Activation | Aldehyde dehydrogenase | Metastases | Cell adhesion molecules | Liver cancer | Gastroenterology | Cell adhesion | Drug dosages | MAP kinase | Pharmacology | Tumorigenicity | Chemical compounds | Medicine | Signaling | Inhibitors | DNA microarrays | Cell lines | Stem cells | Heparan sulfate proteoglycans | Apoptosis
Journal Article
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, p. e12373
Background: Polycomb group (PcG) proteins play a crucial role in cellular senescence as key transcriptional regulators of the Ink4a/Arf tumor suppressor gene... 
X-INACTIVATION | INK4A-ARF LOCUS | HISTONE H2A | BMI-1 | HEMATOPOIETIC STEM-CELLS | BIOLOGY | GENE-EXPRESSION | ENHANCED SELF-RENEWAL | REPLICATIVE LIFE-SPAN | DEMETHYLASE JMJD3 CONTRIBUTES | CELLULAR SENESCENCE | Proto-Oncogene Proteins - metabolism | Cell Line | Cellular Senescence - genetics | Zinc Fingers | Oxidative Stress | Genetic Loci - genetics | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Antioxidants - pharmacology | Polycomb-Group Proteins | Gene Expression Regulation - drug effects | Animals | Polycomb Repressive Complex 1 | Repressor Proteins - deficiency | Fibroblasts - drug effects | Transcription, Genetic | Fibroblasts - cytology | Mice | Repressor Proteins - metabolism | Fibroblasts - metabolism | Genetic aspects | Genetic engineering | Genetic transcription | DNA binding proteins | Protein binding | Oxidative stress | Regulators | Reactive oxygen species | Senescence | Transcription factors | Laboratories | Gene regulation | INK4a protein | Kinases | Recruitment | Proteins | Antioxidants | Immunology | Cooperation | Fibroblasts | Aging | Zinc finger proteins | Cyclin-dependent kinase inhibitors | Binding | p16 Protein | INK4 protein | Embryo fibroblasts | RNA polymerase | Mammals | Gene expression | Embryos | Loci | Zinc | Medicine | Polycomb group proteins | Gene silencing | Insects | Stem cells | Epigenetics | Tumor suppressor genes | Cancer
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 1577 - 1577
Abstract Alternative pre-mRNA splicing is a key process of biological diversity and normal gene expression. More than 90% of human multi-exon genes undergo... 
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2013, Volume 210, Issue 12, pp. 2627 - 2639
Journal Article