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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2019, Volume 116, Issue 22, pp. 11057 - 11062
Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of... 
Inflammation | Liver diseases | Nitric oxide | Analysis | Liver | Fibrosis | Stellate cells | Transformation | Guanylate cyclase | Cholesterol | Steatosis | Stimulators | Signal transduction | Signaling | Fatty liver | Microdialysis | Hepatocytes | Biomarkers | Smad7 protein | Biological Sciences | nitric oxide | soluble guanylate cyclase | praliciguat | NASH fibrosis
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2018, Volume 175, Issue 6, pp. 953 - 967
Background and Purpose Non‐alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome and is characterized by steatosis, inflammation... 
INHIBITION | PUBLICATION | OBESITY-INDUCED INFLAMMATION | CONCISE GUIDE | NITRIC-OXIDE | DOWN-REGULATION | CGMP | PHARMACOLOGY & PHARMACY | AUTOPHAGY | HEPATIC-FIBROSIS | ADIPOSE-TISSUE | Non-alcoholic Fatty Liver Disease - pathology | Liver Cirrhosis - prevention & control | Soluble Guanylyl Cyclase - drug effects | Cytokines - metabolism | Soluble Guanylyl Cyclase - metabolism | Mice, Inbred C57BL | Male | Non-alcoholic Fatty Liver Disease - drug therapy | Dose-Response Relationship, Drug | Animals | Cyclic GMP - metabolism | Diet, High-Fat | Polymerase Chain Reaction | Inflammation - prevention & control | Mice | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Disease Models, Animal | Evaluation | Enzymes | RNA | Liver | Amino acids | Inflammation | Transforming growth factors | Muscle proteins | Prevention | Analysis | Choline | Fibrosis | Heart diseases | Immunoassay | Animal models | Smooth muscle | Stimulation | Guanylate cyclase | Autophagy | High fat diet | Stimulators | Fatty liver | Actin | Rodents | Cyclic GMP | Metalloproteinase | Kidneys | Cytokines | Lung diseases | Muscles | Gene expression | Enzyme immunoassay | Coronary artery disease | Steatosis | Gelatinase A | Diet | Tumor necrosis factor | Collagen | Nitric oxide | Fats and oils | Metabolic disorders | Phagocytosis | Hypertrophy | Research Papers | Research Paper
Journal Article
American journal of physiology. Renal physiology, ISSN 1931-857X, 01/2020, Volume 318, Issue 1, pp. F148 - F159
Reduced nitric oxide (NO) and a decrease in cGMP signaling mediated by soluble guanylate cyclase (sGC) has been linked to the development of several... 
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2018, Volume 365, Issue 3, pp. 664 - 675
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate to cGMP upon binding of nitric oxide... 
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A16938 - A16938
IntroductionA number of diseases including hypertension, diabetes, heart failure, and pulmonary hypertension are associated with elevated reactive oxygen... 
Journal Article
Nitric Oxide, ISSN 1089-8603, 11/2014, Volume 42, pp. 131 - 132
Journal Article
PLoS ONE, ISSN 1932-6203, 2008, Volume 3, Issue 3, p. e1800
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2002, Volume 46, Issue 11, pp. 3422 - 3427
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2016, Volume 7, Issue 5, pp. 465 - 469
In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases... 
IWP-051 | nitric oxide | NO-independent stimulators | heme-dependent sGC stimulators | sGC | Soluble guanylate cyclase | FIBROSIS | CHEMISTRY, MEDICINAL | SOLUBLE GUANYLATE-CYCLASE
Journal Article
by G. Todd Milne and on behalf of the Ironwood team and Peter Sandner and Kathleen A. Lincoln and Paul C. Harrison and Hongxing Chen and Hong Wang and Holly Clifford and Hu Sheng Qian and Diane Wong and Chris Sarko and Ryan Fryer and Jeremy Richman and Glenn A. Reinhart and Carine M. Boustany and Steven S. Pullen and Henriette Andresen and Lise Román Moltzau and Alessandro Cataliotti and Finn Olav Levy and Robert Lukowski and Sandra Frankenreiter and Andreas Friebe and Timothy Calamaras and Robert Baumgartner and Angela McLaughlin and Mark Aronovitz and Wendy Baur and Guang-Rong Wang and Navin Kapur and Richard Karas and Robert Blanton and Stefan Hell and Scott A. Waldman and Jieru E. Lin and Francheska Colon-Gonzalez and Gilbert W. Kim and Erik S. Blomain and Dante Merlino and Adam Snook and Jeanette Erdmann and Jana Wobst and Thorsten Kessler and Heribert Schunkert and Ulrich Walter and Oliver Pagel and Elena Walter and Stepan Gambaryan and Albert Smolenski and Kerstin Jurk and Rene Zahedi and James R. Klinger and Raymond L. Benza and Paul A. Corris and David Langleben and Robert Naeije and Gérald Simonneau and Christian Meier and Pablo Colorado and Mi Kyung Chang and Dennis Busse and Marius M. Hoeper and Jaime L. Masferrer and Sarah Jacobson and Guang Liu and Renee Sarno and Sylvie Bernier and Ping Zhang and G. Todd Milne and Roger Flores-Costa and Mark Currie and Katherine Hall and Dorit Möhrle and Katrin Reimann and Steffen Wolter and Markus Wolters and Evanthia Mergia and Nicole Eichert and Hyun-Soon Geisler and Peter Ruth and Andreas Friebe and Robert Feil and Ulrike Zimmermann and Doris Koesling and Marlies Knipper and Lukas Rüttiger and Yasutake Tanaka and Atsuko Okamoto and Takashi Nojiri and Motofumi Kumazoe and Takeshi Tokudome and Koichi Miura and Jun Hino and Hiroshi Hosoda and Mikiya Miyazato and Kenji Kangawa and Vikas Kapil and Amrita Ahluwalia and Nazareno Paolocci and Philip Eaton and ...
BMC Pharmacology and Toxicology, 10/2017, Volume 18, Issue S1, pp. 1 - 35
Journal Article
Antimicrobial Agents & Chemotherapy, ISSN 0066-4804, 06/2007, Volume 51, Issue 6, pp. 1918 - 1925
The dissemination of AAC(6')-I-type acetyltransferases have rendered amikacin and other aminoglycosides all but useless in some parts of the world. Antisense... 
Journal Article
by Todd Milne, G and Sandner, Peter and Lincoln, Kathleen A and Harrison, Paul C and Chen, Hongxing and Wang, Hong and Clifford, Holly and Qian, Hu Sheng and Wong, Diane and Sarko, Chris and Fryer, Ryan and Richman, Jeremy and Reinhart, Glenn A and Boustany, Carine M and Pullen, Steven S and Andresen, Henriette and Moltzau, Lise Román and Cataliotti, Alessandro and Levy, Finn Olav and Lukowski, Robert and Frankenreiter, Sandra and Friebe, Andreas and Calamaras, Timothy and Baumgartner, Robert and McLaughlin, Angela and Aronovitz, Mark and Baur, Wendy and Wang, Guang-Rong and Kapur, Navin and Karas, Richard and Blanton, Robert and Hell, Stefan and Waldman, Scott A and Lin, Jieru E and Colon-Gonzalez, Francheska and Kim, Gilbert W and Blomain, Erik S and Merlino, Dante and Snook, Adam and Erdmann, Jeanette and Wobst, Jana and Kessler, Thorsten and Schunkert, Heribert and Walter, Ulrich and Pagel, Oliver and Walter, Elena and Gambaryan, Stepan and Smolenski, Albert and Jurk, Kerstin and Zahedi, Rene and Klinger, James R and Benza, Raymond L and Corris, Paul A and Langleben, David and Naeije, Robert and Simonneau, Gérald and Meier, Christian and Colorado, Pablo and Chang, Mi Kyung and Busse, Dennis and Hoeper, Marius M and Masferrer, Jaime L and Jacobson, Sarah and Liu, Guang and Sarno, Renee and Bernier, Sylvie and Zhang, Ping and Flores-Costa, Roger and Currie, Mark and Hall, Katherine and Möhrle, Dorit and Reimann, Katrin and Wolter, Steffen and Wolters, Markus and Mergia, Evanthia and Eichert, Nicole and Geisler, Hyun-Soon and Ruth, Peter and Feil, Robert and Zimmermann, Ulrike and Koesling, Doris and Knipper, Marlies and Rüttiger, Lukas and Tanaka, Yasutake and Okamoto, Atsuko and Nojiri, Takashi and Kumazoe, Motofumi and Tokudome, Takeshi and Miura, Koichi and Hino, Jun and Hosoda, Hiroshi and Miyazato, Mikiya and Kangawa, Kenji and Kapil, Vikas and Ahluwalia, Amrita and Paolocci, Nazareno and Eaton, Philip and Campbell, James C and Henning, Philipp and Franz, Eugen and ... and on behalf of the Ironwood team and RD-CURE consortium
BMC pharmacology & toxicology, ISSN 2050-6511, 10/2017, Volume 18, Issue Suppl 1, p. 64
Journal Article
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