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Nature, ISSN 0028-0836, 2019, Volume 571, Issue 7763, pp. 72 - 72
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e75245
Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of... 
SYNTHASE | ACTIVATION | EFFLUX PUMP | MYCOLIC ACIDS | PROTEIN | PERSISTENCE | MULTIDISCIPLINARY SCIENCES | INHIBITORS | DISCOVERY | TRANSFER-RNA-SYNTHETASE | ETHIONAMIDE | Drug Evaluation, Preclinical - methods | Antitubercular Agents - pharmacology | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Models, Molecular | Drug Discovery - methods | Aspartic Acid Endopeptidases - genetics | Mycobacterium tuberculosis - drug effects | Polyketide Synthases - chemistry | Aspartic Acid Endopeptidases - metabolism | Drug Resistance, Bacterial - physiology | Bacterial Proteins - metabolism | Molecular Structure | Drug Resistance, Bacterial - genetics | Polyketide Synthases - genetics | Sequence Analysis, DNA - methods | Mycobacterium tuberculosis - genetics | Drugs | Drug resistance in microorganisms | Tuberculosis | Genomics | Physiological aspects | Antitubercular agents | Genomes | Drug discovery | Drug therapy | Transfer RNA | Biomedical research | Target recognition | Laboratories | Genes | Identification | Biochemistry | Biosynthesis | Drug development | Drug screening | Gene sequencing | Proteins | Immunology | Public health | Efflux | Enzymes | tRNA | Secretion | Research & development--R&D | Cell walls | Aspartate-tRNA ligase | Crystallization | Protein biosynthesis | Biophysics | Permeability | Mutants | Polyketide synthase | Screening | Infectious diseases | Antibiotics | Resistant mutant | Ligands | Hypoxia | Mutation | Transporter | Scaffolds | Methods | Research & development | R&D
Journal Article
PLoS Pathogens, ISSN 1553-7366, 06/2015, Volume 11, Issue 6, p. e1005010
Cell growth and division are required for the progression of bacterial infections. Most rod-shaped bacteria grow by inserting new cell wall along their... 
TUBERCULOSIS | PBP1A | MICROBIOLOGY | VIRULENCE | PLATFORM | CELL-WALL SYNTHESIS | SMEGMATIS | VIROLOGY | GROWTH | PENICILLIN-BINDING PROTEINS | MUREIN | MORPHOLOGY | PARASITOLOGY | Cell growth | Tuberculosis | Bacterial infections | Bacteriology
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2009, Volume 5, Issue 7, pp. e1000500 - e1000500
While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is also under surveillance for... 
LISTERIA-MONOCYTOGENES | BACILLUS-CALMETTE-GUERIN | HUMAN MACROPHAGES | MICROBIOLOGY | INNATE IMMUNE-SYSTEM | ENHANCED PROTECTION | BACTERIAL PEPTIDOGLYCAN | CUTTING EDGE | VIROLOGY | TOLL-LIKE RECEPTORS | INTRACELLULAR BACTERIA | NF-KAPPA-B | PARASITOLOGY | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Interferon Regulatory Factors - metabolism | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | Tuberculosis - microbiology | Interferon Type I - immunology | Interferon Type I - biosynthesis | Interferon Type I - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Tuberculosis - metabolism | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Interferon Regulatory Factor-3 - immunology | Cell Line | Mice, Inbred C57BL | Bacterial Proteins - genetics | Nod2 Signaling Adaptor Protein - immunology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | Tuberculosis - immunology | Interferon Regulatory Factors - immunology | Macrophages - metabolism | Animals | Nod2 Signaling Adaptor Protein - metabolism | Interferon Regulatory Factor-3 - metabolism | Protein-Serine-Threonine Kinases - immunology | Mice | Mutation | Ubiquitin - immunology | Mycobacterium tuberculosis - genetics | Immune response | Tuberculosis | Mycobacterium tuberculosis | Physiological aspects | Causes of | Development and progression | Genetic aspects | Interferon | Research | Proteins | Microbiology | Listeria | Gram-positive bacteria | Bacteria | Standard deviation | Kinases | Gene expression | Real time | Experiments | Apoptosis
Journal Article