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AIDS Research and Human Retroviruses, ISSN 0889-2229, 07/2019, Volume 35, Issue 7, pp. 673 - 678
Human immunodeficiency virus-1 (HIV-1) protease sequences from 2,225 protease inhibitor (PI)-naïve HIV-1 subtype C-infected individuals collected over a... 
Sequence Notes
Journal Article
AIDS research and human retroviruses, ISSN 0889-2229, 04/2019, Volume 35, Issue 7, pp. 673 - 678
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1451 - 1456
Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five... 
thermodynamics | HIV | inhibitor | mutant | Protease | HIV Protease Inhibitors - pharmacology | Thermodynamics | HIV Protease - drug effects | HIV Protease - genetics | Inhibitory Concentration 50 | HIV Protease Inhibitors - chemistry | HIV-1 - enzymology | Molecular Docking Simulation | Kinetics | Mutation | HIV Protease - metabolism | protease | hiv
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2019, Volume 476, Issue 2, pp. 375 - 384
HIV protease is essential for processing the Gag polyprotein to produce infectious virions and is a major target in antiretroviral therapy. We have identified... 
SITE MUTATIONS | IMPACT | VARIANTS | VIRAL FITNESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REVERSE-TRANSCRIPTASE | IMMUNODEFICIENCY-VIRUS TYPE-1 | DRUG-RESISTANCE | DELETIONS | REGION
Journal Article
Journal Article
Protein Expression and Purification, ISSN 1046-5928, 12/2016, Volume 128, pp. 109 - 114
Vpu is one of four accessory proteins encoded by human immunodeficiency virus type I (HIV-1). Vpu modulates the expression of several cellular restriction... 
HIV-1 | Vpu | Purification | Solubilization | Over-expression | Refolding | CELLS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | DOWN-REGULATION | INHIBITION | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACCESSORY PROTEINS | IMMUNODEFICIENCY-VIRUS TYPE-1 | INTEGRAL MEMBRANE-PROTEIN | HIV-1 - metabolism | Inclusion Bodies - chemistry | Viral Regulatory and Accessory Proteins - biosynthesis | Escherichia coli | Humans | Viral Regulatory and Accessory Proteins - genetics | Human Immunodeficiency Virus Proteins - biosynthesis | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Histocompatibility Antigens Class II - chemistry | Recombinant Proteins - biosynthesis | HIV-1 - genetics | Antigens, Differentiation, B-Lymphocyte - chemistry | Recombinant Proteins - isolation & purification | Inclusion Bodies - genetics | GPI-Linked Proteins - chemistry | Human Immunodeficiency Virus Proteins - chemistry | Human Immunodeficiency Virus Proteins - isolation & purification | Human Immunodeficiency Virus Proteins - genetics | Antigens, CD - chemistry | Inclusion Bodies - metabolism | Viral Regulatory and Accessory Proteins - chemistry | Viral Regulatory and Accessory Proteins - isolation & purification | Drug discovery | HIV (Viruses) | Recombinant proteins | Cells | Enzyme-linked immunosorbent assay
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2013, Volume 21, Issue 7, pp. 1964 - 1971
Journal Article
The Protein Journal, ISSN 1572-3887, 12/2016, Volume 35, Issue 6, pp. 448 - 458
The energetics of ligand binding to human eukaryotic elongation factor 1 gamma (heEF1γ) was investigated using reduced glutathione (GSH), oxidised glutathione... 
Biochemistry, general | Chemistry | Glutathione-binding energetics | CHARMm-docking | Human eukaryotic elongation factor 1 gamma | Isothermal titration calorimetry | Molecular dynamics simulations | Homology modelling | Animal Anatomy / Morphology / Histology | Bioorganic Chemistry | Organic Chemistry | S-TRANSFERASE | DOMAIN | LIGAND-BINDING | TRANSFERASE A1-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CRYSTAL-STRUCTURES | C-TERMINAL HELIX | SACCHAROMYCES-CEREVISIAE | PROTEIN STRUCTURES | STRUCTURE PREDICTION | Temperature | Glutathione - metabolism | Humans | Glutathione Disulfide - metabolism | Thermodynamics | Peptide Elongation Factor 1 - genetics | Recombinant Proteins - metabolism | Gene Expression | Glutathione - analogs & derivatives | Protein Structure, Secondary | Glutathione Transferase - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Glutathione Transferase - chemistry | Molecular Dynamics Simulation | Hydrogen Bonding | Peptide Elongation Factor 1 - chemistry | Protein Binding | Calorimetry | Ligands | Glutathione - chemistry | Structural Homology, Protein | Glutathione Disulfide - chemistry | Kinetics | Peptide Elongation Factor 1 - metabolism | Thiols | Glutathione transferase | Hydrogen | Analysis | Force and energy | Molecular dynamics | Cells | Protein binding | Proteins | Gamma rays | Eukaryotes | Molecular biology
Journal Article