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Journal of the American Chemical Society, ISSN 0002-7863, 11/2018, Volume 140, Issue 44, pp. 14528 - 14532
A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the... 
COPPER-COMPLEXES | SCISSION | DNA CLEAVAGE | RNA | MECHANISM | LIGANDS | NAPHTHALENE DIIMIDES | PROMOTER | CANCER | BINDING | CHEMISTRY, MULTIDISCIPLINARY | Communication
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 04/2019, Volume 116, Issue 4, pp. 709 - 721
Journal Article
BBA - General Subjects, ISSN 0304-4165, 05/2017, Volume 1861, Issue 5, pp. 1329 - 1340
Journal Article
Journal of The American Society for Mass Spectrometry, ISSN 1044-0305, 7/2014, Volume 25, Issue 7, pp. 1136 - 1145
Journal Article
Biotechnology and Bioengineering, ISSN 0006-3592, 04/2019, Volume 116, Issue 4, pp. 709 - 721
Journal Article
Structure, ISSN 0969-2126, 09/2016, Volume 24, Issue 9, pp. 1509 - 1522
The weak oligomerization exhibited by many transmembrane receptors has a profound effect on signal transduction. The phenomenon is difficult to characterize... 
receptor for advanced glycation end products | signal transduction | inflammation | diaphanous 1 | mass spectrometry | cancer | RAGE | NMR spectroscopy | diabetes | segmental labeling | hybrid method of structure determination | pattern recognition | RELAXATION DATA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CROSS-LINKING | HYDRODYNAMIC CALCULATIONS | GLOBULAR-PROTEINS | MASS-SPECTROMETRY | CELL BIOLOGY | BIOPHYSICS | CELL-SURFACE RECEPTOR | STRUCTURAL BASIS | PROTEIN-PROTEIN INTERACTIONS | CHEMICAL LIGATION | GLYCATION END-PRODUCTS | Adaptor Proteins, Signal Transducing - chemistry | Humans | Green Fluorescent Proteins - genetics | Antigens, Neoplasm - chemistry | Mitogen-Activated Protein Kinases - chemistry | Thermodynamics | HEK293 Cells | Antigens, Neoplasm - metabolism | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Binding Sites | Genes, Reporter | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Green Fluorescent Proteins - metabolism | Gene Expression | Cross-Linking Reagents - chemistry | Protein Structure, Secondary | Signal Transduction | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Bacterial Proteins - metabolism | Ligands | Luminescent Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Molecular Docking Simulation | Adaptor Proteins, Signal Transducing - metabolism | Maleimides - chemistry | Luminescent Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism | Oligomers | Nuclear magnetic resonance spectroscopy | Cellular signal transduction | Mass spectrometry | Analysis | Index Medicus
Journal Article
Journal Article
Arkivoc, ISSN 1551-7004, 02/2016, Volume 2016, Issue 3, pp. 145 - 160
We here report the synthesis and evaluation of constrained derivatives of a bisantrene isomer known to bind DNA when structured in G-quadruplex. Enhanced... 
Anthracene | Bisantrene | Fluorimetry | Mass spectrometry | DNA | G-quadruplex | TELOMERE | PROTEIN | RECOGNITION | CHEMISTRY, ORGANIC | fluorimetry | DNA QUADRUPLEX | FORMING REGION | LIGANDS | AFFINITY | PROMOTER REGION | mass spectrometry | bisantrene | IONIZATION MASS-SPECTROMETRY | BINDING
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 02/2019, Volume 37, Issue 3, pp. 551 - 11
The facile construction of metal-DNA complexes using 'Click' reactions is reported here. A series of 2′-propargyl-modified DNA oligonucleotides were initially... 
propargyl-DNA | DNA scaffold | metallic DNA | click reaction | DNA material | RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NANOSTRUCTURES | CLEAVAGE | HIGHLY EFFICIENT | NUCLEIC-ACIDS | PROBES | OLIGONUCLEOTIDES | NANOPARTICLES | IN-VITRO | BIOPHYSICS | CHEMISTRY | Index Medicus
Journal Article
Biotechnology and bioengineering, 11/2018
We have engineered an intein which spontaneously and reversibly forms a thiazoline ring at the native N-terminal Lys-Cys splice junction. We identified... 
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 01/2013, Volume 31, Issue sup1, pp. 129 - 130
The interactions between the nucleocapsid (NC) domain of the Gag polyprotein and the 5′-untranslated region (5′-UTR) of viral RNA play multifaceted roles in... 
Journal Article