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Clinical Cancer Research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16 Supplement, pp. IA22 - IA22
Journal Article
The Journal of Pathology, ISSN 0022-3417, 01/2014, Volume 232, Issue 2, pp. 219 - 229
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6331, pp. 1324 - 1330
Activating mutations in , the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)-positive breast cancer. PI3Kα... 
Chromatin - metabolism | Receptors, Estrogen - metabolism | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | Epigenesis, Genetic | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - therapy | DNA-Binding Proteins - metabolism | MCF-7 Cells | HEK293 Cells | Female | Transcription, Genetic | Lysine - metabolism | Neoplasm Proteins - genetics | Pre-B-Cell Leukemia Transcription Factor 1 | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins - metabolism | Receptors, Estrogen - genetics | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 3-alpha - genetics | DNA-Binding Proteins - genetics | Hepatocyte Nuclear Factor 3-alpha - metabolism | Lysine - genetics | Animals | Breast Neoplasms - genetics | Metabolic Networks and Pathways | Mice, Nude | Mice | Protein Processing, Post-Translational | Epigenetic inheritance | Receptors | Estrogen | Breast cancer | Genetic aspects | Health aspects | Phosphotransferases | Drugs | Regulators | Chromatin | Transcription | Estrogens | Estrogen receptors | AKT protein | Activation | Drug resistance | Kinases | Recruitment | Signal transduction | Developmental stages | Histone methyltransferase | Inhibition | Activation analysis | 1-Phosphatidylinositol 3-kinase | Inhibitors | Lysine | Epigenetics | Breast | Mutation | Histone H3 | Tumors | Cancer | Index Medicus | Histones
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 4/2007, Volume 99, Issue 8, pp. 628 - 638
Journal Article
Nature, ISSN 0028-0836, 02/2018, Volume 554, Issue 7691, pp. 189 - 194
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 14, pp. 1594 - 1600
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 9, pp. 3761 - 3766
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2016, Volume 22, Issue 11, pp. 1303 - 1313
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 58 - 71
Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that... 
RAPAMYCIN | TARGET | FORKHEAD TRANSCRIPTION FACTOR | CELLS | INSULIN-RECEPTOR | ACTIVATION | ONCOLOGY | SIGNALING PATHWAY | PHOSPHORYLATION | UPSTREAM | HUMAN CANCER | CELL BIOLOGY | RNA, Small Interfering - genetics | Receptor, IGF Type 1 - metabolism | Protein Binding - genetics | Receptor, ErbB-3 - metabolism | Humans | Forkhead Transcription Factors - metabolism | Protein Binding - drug effects | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Receptor, ErbB-2 - antagonists & inhibitors | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Quinoxalines - therapeutic use | Carcinoma, Non-Small-Cell Lung - metabolism | Receptor, ErbB-3 - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Breast Neoplasms - drug therapy | Receptor, IGF Type 1 - genetics | Signal Transduction - drug effects | Mice, Nude | Models, Biological | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | Feedback, Physiological - physiology | Quinazolines - pharmacology | Proteins - antagonists & inhibitors | Neoplasms - metabolism | Gene Expression - drug effects | Multiprotein Complexes | Receptor, ErbB-2 - metabolism | Promoter Regions, Genetic - genetics | Proto-Oncogene Proteins c-akt - genetics | Breast Neoplasms - metabolism | Mechanistic Target of Rapamycin Complex 1 | Quinoxalines - pharmacology | Receptor, Insulin - genetics | Female | Forkhead Transcription Factors - antagonists & inhibitors | Gene Expression Regulation, Neoplastic - drug effects | Drug Therapy, Combination | Gene Expression Regulation, Neoplastic - physiology | Carcinoma, Non-Small-Cell Lung - pathology | Up-Regulation - genetics | Forkhead Transcription Factors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Breast Neoplasms - pathology | Protein Kinase Inhibitors - therapeutic use | Quinazolines - therapeutic use | Feedback, Physiological - drug effects | Receptor, Insulin - metabolism | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Benzylamines - pharmacology | Benzylamines - therapeutic use | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
Journal Article