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Journal of Bacteriology, ISSN 0021-9193, 06/2017, Volume 199, Issue 12, p. E00142
dGTP starvation, a newly discovered phenomenon in which Escherichia coli cells are starved specifically for the DNA precursor dGTP, leads to impaired growth... 
Starvation | Lethal effects | Transcription | Genes | Mortality | Operons | Biosynthesis | Mutants | Molecules | E coli | Cell death | Hypoxanthine | Deoxyribonucleic acid--DNA | Nutritional status
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 06/2016, Volume 198, Issue 11, p. 1631
  Our laboratory recently discovered that Escherichia coli cells starved for the DNA precursor dGTP are killed efficiently (dGTP starvation) in a manner... 
E coli | Biosynthesis | Gene expression | Deoxyribonucleic acid--DNA | Bacteriology
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2014, Volume 10, Issue 5
Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The... 
Protein research | Microbiological research | Escherichia coli | Physiological aspects | DNA binding proteins | Research | Guanosine triphosphatase | Protein-protein interactions
Journal Article
PLoS Genetics, ISSN 1553-7390, 05/2014, Volume 10, Issue 5
  Starvation of cells for the DNA building block dTTP is strikingly lethal (thymineless death, TLD), and this effect is observed in all organisms. The... 
Enzymes | E coli | Cloning | Gene expression | Deoxyribonucleic acid--DNA | Cancer | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 11/2013, Volume 110, Issue 46, pp. 18596 - 18596
The enzyme ribonucleotide reductase (RNR) plays a critical role in the production of deoxynucleoside-5'-triphosphates (dNTPs), the building blocks for DNA... 
Journal Article
Molecular Microbiology, ISSN 0950-382X, 05/2017, Volume 104, Issue 3, pp. 377 - 399
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 46, p. 18596
  The enzyme ribonucleotide reductase (RNR) plays a critical role in the production of deoxynucleoside-5'-triphosphates (dNTPs), the building blocks for DNA... 
Genotype & phenotype | E coli | Mutation | Deoxyribonucleic acid--DNA
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 06/2016, Volume 198, Issue 11, pp. 1631 - 1644
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 16, pp. 10418 - 10429
Journal Article
Molecular Microbiology, ISSN 0950-382X, 09/2011, Volume 81, Issue 5, p. 1221
The Escherichia coli dGTP triphosphohydrolase (dGTPase) encoded by the dgt gene catalyses the hydrolysis of dGTP to deoxyguanosine and triphosphate. The recent... 
Phosphates | E coli | Mutagenesis | Gene expression | Cells
Journal Article
Molecular Microbiology, ISSN 0950-382X, 09/2011, Volume 81, Issue 5, pp. 1221 - 1232
Journal Article
Molecular microbiology, ISSN 0950-382X, 9/2011, Volume 81, Issue 5, pp. 1221 - 1232
The Escherichia coli dGTP triphosphohydrolase (dGTPase) encoded by the dgt gene catalyzes the hydrolysis of dGTP to deoxyguanosine and triphosphate. The recent... 
dGTPase | nutritional shift | thymine starvation | thyA strains | salvage pathways | E. coli dgt
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2018, Volume 115, Issue 16, p. 4212
The fidelity of DNA replication is a critical factor in the rate at which cells incur mutations. Due to the antiparallel orientation of the two chromosomal DNA... 
Fidelity | Addition polymerization | DNA polymerase | Strands | DNA biosynthesis | Polymerase | Eukaryotes | E coli | Mutagenesis | Replicase | DNA replicase | Replication | Mutation | Deoxyribonucleic acid--DNA | Okazaki fragments | DNA-directed DNA polymerase
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 01/2011, Volume 193, Issue 1, p. 296
The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded ... subunit of the DNA polymerase III (Pol... 
Enzymes | E coli | DNA polymerase | Mutation
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 01/2011, Volume 193, Issue 1, pp. 296 - 300
The Escherichia coli dnaX36 mutant displays a mutator effect, reflecting a fidelity function of the dnaX-encoded tau subunit of the DNA polymerase III (Pol... 
Journal Article
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