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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, ISSN 0027-5107, 1986, Volume 163, Issue 1, pp. 3 - 13
A shuttle-vector system is described for the study of mutational specificity in mammalian cells. Using a plasmid (pGKTK) carrying the E. coli galactokinase... 
Transformation, Genetic | Cell Line | Animals | DNA Restriction Enzymes | Thymidine Kinase - genetics | Escherichia coli - genetics | Plasmids | Gene Expression Regulation | Galactokinase - genetics | Mice | Mutation | Genetic Vectors
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 1986, Volume 189, Issue 2, pp. 273 - 284
We have obtained via DNA sequence analysis a spectrum of 174 spontaneous mutations occurring in the lacI gene of Escherichia coli. The spectrum comprised base... 
Genes, Bacterial | Escherichia coli - genetics | Base Sequence | Cloning, Molecular | Repetitive Sequences, Nucleic Acid | Repressor Proteins - genetics | Mutation | Transcription Factors - genetics | Nucleic Acid Conformation | DNA Transposable Elements | DNA, Bacterial
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/1986, Volume 83, Issue 18, pp. 6945 - 6949
Mutation induced by ultraviolet light is predominantly targeted by UV photoproducts. Two primary candidates for the premutagenic lesion are the cyclobutane... 
Pyrimidine dimers | Mutagenesis | Nonsense mutation | DNA | Escherichia coli | Dimers | Lesions | Methylation | Genetic mutation | Sequencing
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 1987, Volume 198, Issue 2, pp. 187 - 202
We have analyzed the DNA sequence changes in a total of 409 ultraviolet light-induced mutations in the lacI gene of Escherichia coli: 227 in a Uvr+ and 182 in... 
Ultraviolet Rays | Escherichia coli - genetics | DNA Repair | DNA, Bacterial - radiation effects | Mutation | Base Sequence - radiation effects | Genes, Bacterial - radiation effects | DNA Transposable Elements
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/1987, Volume 84, Issue 17, pp. 6220 - 6224
We have determined the DNA sequence changes in 487 spontaneous mutations in the N-terminal part of the lacI gene in mutH, mutL, and mutS strains of Escherichia... 
DNA replication | rev genes | Nonsense mutation | Escherichia coli | Frameshift mutation | Nucleotide sequences | Nucleotides | Genetic mutation | DNA mismatch repair | Generally accepted auditing standards
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 11/1987, Volume 198, Issue 2, pp. 187 - 202
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1988, Volume 85, Issue 21, pp. 8126 - 8130
To investigate the mechanisms of spontaneous mutation in the Escherichia coli mutD5 mutator strain, 502 mutations generated in this strain in the N-terminal... 
Nucleic acid heteroduplexes | DNA replication | Transfection | Mutagenesis | rev genes | Proofreading | DNA | Nucleotides | Genetic mutation | DNA mismatch repair
Journal Article
MGG Molecular & General Genetics, ISSN 0026-8925, 10/1989, Volume 219, Issue 1-2, pp. 256 - 262
Journal Article
Carcinogenesis, ISSN 0143-3334, 1990, Volume 11, Issue 7, pp. 1087 - 1095
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 03/1992, Volume 174, Issue 6, pp. 1974 - 1982
Journal Article
Journal of Bacteriology, ISSN 0021-9193, 03/1992, Volume 174, Issue 6, p. 1974
  A mutation that suppressed the mutability of the Escherichia coli mutD5 was discovered in a mutD5 strain. The mutation, termed dnaE910, is discussed. 
Deoxyribonucleic acid | DNA | Genetics | Bacteria
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/1992, Volume 89, Issue 22, p. 11036
  The spectra of UV-induced mutations in the lacI gene of a wild-type and mfd strain of Escherichia coli has been analyzed. Study results provide in vivo... 
Ultraviolet radiation | Genetics | Research | Mutation
Journal Article
Mutation Research/Environmental Mutagenesis and Related Subjects, ISSN 0165-1161, 1993, Volume 292, Issue 2, pp. 175 - 185
The Escherichia coli dnaE and dnaQ gene encode, respectively, the α (polymerase) and ε (proofreading) subunits of DNA polymerase III. Mutations in these genes... 
Exonucleolytic proofreading | E. coli mutator strains | DNA polymerase | Papillation assay | dnaE gene | galK2 gene | dnaQ gene | GalK2 gene
Journal Article
Genetics, ISSN 0016-6731, 1993, Volume 134, Issue 4, pp. 1039 - 1044
The dnaE gene of Escherichia coli encodes the DNA polymerase (alpha subunit) of the main replicative enzyme, DNA polymerase III holoenzyme. We have previously... 
Amino Acid Sequence | Sequence Alignment | Escherichia coli - enzymology | DNA Polymerase III - genetics | Escherichia coli - genetics | Alleles | Cloning, Molecular | Molecular Sequence Data | Mutation | DNA, Bacterial | DNA polymerases | Genetic aspects | Nucleotide sequence | Observations | Escherichia coli | Analysis | Investigations
Journal Article
Genetics, ISSN 0016-6731, 08/1993, Volume 134, Issue 4, p. 1039
The dnaE gene of Escherichia coli encodes the DNA polymerase (alpha subunit) of the main replicative enzyme, DNA polymerase III holoenzyme. We have previously... 
Genetics | Bacteria | Research | Mutation
Journal Article
Genetics, ISSN 0016-6731, 08/1993, Volume 134, Issue 4, p. 1031
In a companion study we have described the isolation of a series of mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants... 
Genetics | Bacteria | Research | Mutation
Journal Article
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