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Nature Communications, ISSN 2041-1723, 09/2014, Volume 5, Issue 1, p. 4846
Human cancer genomes harbour a variety of alterations leading to the deregulation of key pathways in tumour cells. The genomic characterization of tumours has... 
ALK | RET | REARRANGEMENT | TRANSCRIPTS | PATHWAY | MULTIDISCIPLINARY SCIENCES | ETV6-NTRK3 GENE FUSION | MUTATIONS | IDENTIFICATION | EXPRESSION | DEFINE | Gene Fusion - genetics | Sequence Analysis, RNA | Neoplasms - genetics | Humans | Gene Expression Profiling | Genome, Human | Molecular Targeted Therapy | Phosphotransferases - genetics
Journal Article
Current Biology, ISSN 0960-9822, 04/2002, Volume 12, Issue 8, pp. 632 - 639
The mammalian target of rapamycin (mTOR) controls the translation machinery via activation of S6 kinases 1 and 2 (S6K1/2) and inhibition of the eukaryotic... 
Binding proteins | Genetic translation | Phosphotransferases | Protein binding
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 626 - 630
The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy. One... 
Enzymes | Cell growth | Glioma | RNA | Neurons | REPORTS | Methylation | Cellular differentiation | Genetic mutation | Heterologous transplantation | Tumors | TRANSFORMATION | GLIOBLASTOMA | MULTIDISCIPLINARY SCIENCES | INTEGRATED GENOMIC ANALYSIS | PHENOTYPE | ACUTE MYELOID-LEUKEMIA | MUTATIONS | ONCOMETABOLITE 2-HYDROXYGLUTARATE | BRAIN | Benzeneacetamides - toxicity | Protein Multimerization | Imidazoles - administration & dosage | Gene Expression Profiling | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - genetics | RNA Interference | Enzyme Inhibitors - toxicity | Glioma - pathology | Imidazoles - toxicity | Gene Expression Regulation, Neoplastic - drug effects | Benzeneacetamides - pharmacology | Mutant Proteins - antagonists & inhibitors | Glioma - enzymology | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Imidazoles - pharmacology | Mice, SCID | Benzeneacetamides - administration & dosage | Xenograft Model Antitumor Assays | Animals | Cell Differentiation - drug effects | Cell Transformation, Neoplastic | Isocitrate Dehydrogenase - chemistry | Mutant Proteins - chemistry | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Histones - metabolism | Glioma - drug therapy | Cell proliferation | Gene mutations | Gliomas | Growth | Cancer cells | Physiological aspects | Genetic aspects | Research | Cancer | Genes | Cells | Mutation | Drugs | Binding | Mutations | Inhibitors | Online | Delay
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 622 - 626
A number of human cancers harbor somatic point mutations in the genes encoding isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). These mutations alter... 
Molecules | Enzymes | Dehydrogenases | Blasts | Myeloid leukemia | REPORTS | Stem cells | Bone marrow cells | Cellular differentiation | Hematopoietic stem cells | Mesenchymal stem cells | ISOCITRATE DEHYDROGENASE | ONCOMETABOLITE 2-HYDROXYGLUTARATE | SUFFICIENT | MULTIDISCIPLINARY SCIENCES | HEMATOPOIETIC PROGENITORS | MUTATION | Cell Proliferation | Humans | Protein Multimerization | Crystallography, X-Ray | Erythropoiesis - drug effects | Isocitrate Dehydrogenase - antagonists & inhibitors | Molecular Targeted Therapy | Hematopoiesis - drug effects | Antineoplastic Agents - metabolism | Leukemia, Myeloid, Acute - enzymology | Phenylurea Compounds - chemistry | Enzyme Inhibitors - chemistry | Leukemia, Myeloid, Acute - drug therapy | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Mutant Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Sulfonamides - chemistry | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Isocitrate Dehydrogenase - genetics | Mutant Proteins - metabolism | Gene Expression Regulation, Leukemic | Antineoplastic Agents - chemistry | Sulfonamides - pharmacology | Point Mutation | Isocitrate Dehydrogenase - chemistry | Small Molecule Libraries | Mutant Proteins - chemistry | Allosteric Site | Sulfonamides - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Phenylurea Compounds - pharmacology | Leukemia, Erythroblastic, Acute | Leukemia, Myeloid, Acute - genetics | Leukemia | Cancer cells | Physiological aspects | Research | Oxidoreductases | Cell differentiation | Health aspects | Mutation | Cellular biology | Drug therapy | Cells
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 656 - 659
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 31, pp. 13894 - 13899
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 41, pp. 17774 - 17779
Journal Article
Current Biology, ISSN 0960-9822, 05/2003, Volume 13, Issue 10, pp. 797 - 806
Background: The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that controls cell growth and proliferation via the translation regulators... 
RAPAMYCIN | TARGET | MESSENGER-RNA TRANSLATION | SIGNALING PATHWAY | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR 4E-BINDING PROTEIN-1 | MAMMALIAN PROTEIN | CELL-GROWTH | P70 S6 KINASE | PHAS-I
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 954 - 954
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 41, p. 17774
  The α-, β-, and ...-protocadherins (Pcdhα, Pcdhβ, and Pcdh...) comprise a large family of single-pass transmembrane proteins predominantly expressed in the... 
Proteins | Membranes | Peptides | Amino acids | Cells
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 2004, Volume 15, Issue 2, pp. 147 - 159
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2010, Volume 107, Issue 31, p. 13894
  The clustered protocadherins (Pcdhs) are a large family of cadherin-like transmembrane proteins expressed in the nervous system. Stochastic expression of... 
Proteins | Phosphorylation | Neurons | Ribonucleic acid--RNA | Gene expression | Cells
Journal Article